The document summarizes the Columbian Exchange that occurred between the Old World and New World following Christopher Columbus' discovery of the Americas. Key aspects of the exchange included the transportation of domesticated animals, crops, and diseases between the hemispheres. Native populations in the Americas declined drastically due to introduced European diseases, with estimates of declines as high as 90% within 100 years of contact. This population decline impacted the availability of labor and led Europeans to import slaves from Africa. The exchange of foods and crops went on to dramatically impact global diets, economies, and populations over subsequent centuries.