This document discusses several central nervous system stimulants and hallucinogens. It describes their mechanisms of action, therapeutic uses, and adverse effects. Key stimulants discussed include caffeine, nicotine, cocaine, amphetamines, atomoxetine, methylphenidate, and modafinil. Hallucinogens covered are LSD, PCP, THC, and rimonabant. Therapeutic uses include treatment of ADHD, narcolepsy, and obesity. Adverse effects can include dependence, withdrawal symptoms, anxiety, increased heart rate and blood pressure, psychosis, and seizures.
Sedative-hypnotic drugs reduce anxiety and induce sleep by depressing activity in the central nervous system. The main classes are benzodiazepines, barbiturates, and newer non-benzodiazepine agents. Benzodiazepines have largely replaced barbiturates due to their wider therapeutic index, lower risk of interactions and dependence, and the availability of antagonists. Both benzodiazepines and barbiturates work by enhancing the effects of the inhibitory neurotransmitter GABA.
Factors affecting action of Disinfectants and Factors Affecting Choice Of Ant...Ms. Pooja Bhandare
PHARMACEUTICAL MICROBIOLOGY (BP303T)Unit-III. Factors affecting action of Disinfectants and Factors Affecting Choice Of Antimicrobial Agent: Concentration of the disinfectant.
Chemical Structure of the disinfectant.
Formulation of the disinfectant.
Interfering substances in the environment.
pH of the surrounding.
Potentiation and antagonism of the disinfectants.
Surface Tension.
Temperature.
Time of Contact.
Type and no. of microbes present.
FACTORS AFFECTING CHOICE OF ANTIMICROBIAL AGENT:
Properties of chemical agents
Environment
Types of microorganisms
Intended application
Toxicity agents
Culture state
This document discusses the management of epilepsy. It begins with an introduction to epilepsy, describing the types of seizures and classifications of antiepileptic drugs. It then discusses the structures of common epilepsy drugs, how some are synthesized, and how epilepsy is clinically managed. The document also provides a brief history of antiepileptic drug therapy and discusses some newer drugs that have been released in recent years to treat epilepsy.
Cardiac glycosides like digoxin are used to treat heart failure and cardiac arrhythmias. They work by inhibiting sodium-potassium ATPase, increasing intracellular calcium levels, and enhancing cardiac contractility. Common side effects include nausea, arrhythmias, and toxicity at high levels. While they were once a standard treatment, newer heart failure drugs like ACE inhibitors, ARBs, beta blockers, and diuretics are now preferred due to their better safety profiles. Digitalis remains an option when symptoms are not adequately controlled by other treatments.
1) Cardiac glycosides are plant compounds that have beneficial and toxic effects on the heart. They work by inhibiting sodium-potassium pumps in cardiac muscle cells.
2) Key sources of cardiac glycosides include foxglove (Digitalis purpurea), squill bulbs, and seeds from Strophanthus plants. These sources contain glycosides like digoxin, digitoxin, and ouabain.
3) Cardiac glycosides increase the force of cardiac muscle contractions and the strength of the heart's pumping action, making them useful for treating congestive heart failure.
Sedative-hypnotic drugs reduce anxiety and induce sleep by depressing activity in the central nervous system. The main classes are benzodiazepines, barbiturates, and newer non-benzodiazepine agents. Benzodiazepines have largely replaced barbiturates due to their wider therapeutic index, lower risk of interactions and dependence, and the availability of antagonists. Both benzodiazepines and barbiturates work by enhancing the effects of the inhibitory neurotransmitter GABA.
Factors affecting action of Disinfectants and Factors Affecting Choice Of Ant...Ms. Pooja Bhandare
PHARMACEUTICAL MICROBIOLOGY (BP303T)Unit-III. Factors affecting action of Disinfectants and Factors Affecting Choice Of Antimicrobial Agent: Concentration of the disinfectant.
Chemical Structure of the disinfectant.
Formulation of the disinfectant.
Interfering substances in the environment.
pH of the surrounding.
Potentiation and antagonism of the disinfectants.
Surface Tension.
Temperature.
Time of Contact.
Type and no. of microbes present.
FACTORS AFFECTING CHOICE OF ANTIMICROBIAL AGENT:
Properties of chemical agents
Environment
Types of microorganisms
Intended application
Toxicity agents
Culture state
This document discusses the management of epilepsy. It begins with an introduction to epilepsy, describing the types of seizures and classifications of antiepileptic drugs. It then discusses the structures of common epilepsy drugs, how some are synthesized, and how epilepsy is clinically managed. The document also provides a brief history of antiepileptic drug therapy and discusses some newer drugs that have been released in recent years to treat epilepsy.
Cardiac glycosides like digoxin are used to treat heart failure and cardiac arrhythmias. They work by inhibiting sodium-potassium ATPase, increasing intracellular calcium levels, and enhancing cardiac contractility. Common side effects include nausea, arrhythmias, and toxicity at high levels. While they were once a standard treatment, newer heart failure drugs like ACE inhibitors, ARBs, beta blockers, and diuretics are now preferred due to their better safety profiles. Digitalis remains an option when symptoms are not adequately controlled by other treatments.
1) Cardiac glycosides are plant compounds that have beneficial and toxic effects on the heart. They work by inhibiting sodium-potassium pumps in cardiac muscle cells.
2) Key sources of cardiac glycosides include foxglove (Digitalis purpurea), squill bulbs, and seeds from Strophanthus plants. These sources contain glycosides like digoxin, digitoxin, and ouabain.
3) Cardiac glycosides increase the force of cardiac muscle contractions and the strength of the heart's pumping action, making them useful for treating congestive heart failure.
1. The document discusses narcotic analgesics and narcotic antagonists, including their mechanisms of action, examples, and uses.
2. It describes the three main opioid receptors and their roles in pain management. Morphine and its analogues are discussed in terms of important structural features that determine their activity.
3. Individual narcotic analgesics like morphine sulfate, codeine, meperidine hydrochloride, and narcotic antagonists such as nalorphine hydrochloride are explained in terms of their therapeutic uses.
This document provides an overview of general anesthetics, including their definition, mechanisms of action, stages of anesthesia, classifications, and examples. It discusses inhalational anesthetics like nitrous oxide, halothane, sevoflurane and desflurane, outlining their properties such as potency, solubility, and side effects. It also reviews intravenous anesthetics including thiopental, propofol, ketamine and etomidate, noting their mechanisms, onsets, durations and side effect profiles. The document is intended to educate about the different types of general anesthetics used in surgery to induce reversible unconsciousness and muscle relaxation.
This document discusses surface and interfacial phenomena. It defines interfaces and divides them into solid and liquid interfaces. Liquid interfaces deal with liquid-gas or liquid-liquid phases and have applications in infiltration, biopharmaceuticals, and suspensions/emulsions. Surface tension exists between solid-gas and liquid-gas phases, while interfacial tension exists between immiscible liquids. Various methods are described to measure surface tension, interfacial tension, and surface free energy. Surfactants are also discussed, including how they lower tensions and are used in products. Adsorption at interfaces and isotherms are briefly covered.
This document discusses drugs that act on the central nervous system (CNS), specifically sedative-hypnotic drugs. It covers the classification of CNS depressants like benzodiazepines and barbiturates. It describes their mechanisms of action, effects on the CNS, cardiovascular system, respiratory system, and liver. It also discusses their therapeutic uses, adverse effects, dependence and abuse potential, as well as management of overdoses.
Anticholinergic drugs work by blocking the effects of the neurotransmitter acetylcholine at muscarinic receptors in the central and peripheral nervous systems. The main anticholinergic drugs discussed are atropine, glycopyrrolate, and scopolamine. Atropine is a naturally occurring tertiary amine that can cross the blood-brain barrier and exert central effects. Glycopyrrolate is a synthetic quaternary ammonium compound that does not cross the blood-brain barrier and lacks central effects. Scopolamine is similar to atropine but is more potent and lipid soluble, allowing it to more easily cross the blood-brain barrier and exert greater central antimuscarinic effects than atrop
INCLUDES SPREADING COEFFICIENT AND ITS THEORY AND ALSO FEW OF ITS APPLICATION IN PHARMACEUTICAL FIELD
WILL BE HELPFUL FOR B PHARMACY STUDENTS
INCLUDES HOW IT IS DERIVED AND ALSO HOW IT IS RELATED TO SPREADING OF A CREAM OR OINTMENT ON OUR SKIN
IMPORTANCE OF SPREADING COEFFICIENT
This document provides an overview of sedative and hypnotic drugs. It begins with definitions of sedatives, hypnotics, and anxiolytics. It then discusses the history of sedative drugs from antiquity through modern times. It covers the classification, mechanisms of action, pharmacokinetics, therapeutic uses and adverse effects of major classes of sedative-hypnotics including barbiturates and benzodiazepines.
Evaluation of Bactericidal and BacteriostaticRajsingh467604
What are disinfectants?
As per the definition given by WHO ( World health organization ) : a disinfectant is a chemical agent, which destroys or inhibits growth of pathogenic microorganisms in the non-sporing or vegetative state.
Why Evaluation?
Evaluation of disinfectants is used to check the ability or efficacy of any disinfectant against specific microorganisms to establish its effectiveness.
Evaluation tests of bactericide.
1. RIDEAL WALKER TEST
This test is also known as the phenol coefficient test,in which any chemical is compared with phenol for its antimicrobial activity.
The result is shown in the form of phenol coefficient.
▪ If a phenol coefficient of a given test disinfectant is less than 1, it means that disinfectant is less effective than phenol.
▪ If a phenol coefficient of a given test disinfectant is more than 1, it means that disinfectant is more effective than phenol.
Procedure
1.1 Different dilutions of the test disinfectant and phenol are prepared and 5 ml of each dilution is inoculated with 0.5ml of the 24 hour growth culture of the organisms.
1.2 All tubes(Disinfectant + organisms & phenol + organisms) are placed in a water bath ( at 17.5° C)
1.3 Subcultures of each reaction mixture are taken and transferred to 5ml sterile broth at an interval of 2.5 minutes from zero to 10 mintues.
1.4 Broth tubes are incubated at 37° C for 2 to 3 days & examined for the presence or absence of the growth.
1.5 Then the Rideal Walker coefficient is calculated :
2. CHICK MARTIN TEST.
CHICK MARTIN test is performed in the much similar way as the RIDEAL Walker test but with a little variation.
Principle : This test is carried out in the presence of organic matter like 3% human feces or dried yeast.
Procedure
2.1 Serial dilutions of test solution and phenol is prepared in distilled water.
2.2 To this 3% yeast suspension is also added.
2.3 To this solution the S. typhi is added
2.4 After contact time of 30 mins the above mixture is transferred to the freshly prepared 10 ml of broth.
2.5 The test tubes are incubated at 37°C for 48 hours.
2.6 Presence or absence of the growth is calculated.
Evaluation tests of Bacteriostatic.
1. Tube dilution & Agar plate Method
1.1 The chemical agent is incorporated into nutrient broth or agar medium and inoculated with test micro-organisms.
1.2 These tubes are incubated at 30° TO 35°C for 2 to 3 days and then the results in the form of turbidity or colonies are observed.
1.3 The results are recorded and the activity of the given disinfectant is compared.
2. Cup plate method
2.1 Agar is melted and cooled at 45° Celsius.
2.2 Then inoculated with test micro-organisms and poured into a sterile petri plate.
2.3 In the cup plate method, when the inoculated agar has solidified, holes around 8mm in diameter are cut in the medium with a steel cork borer.
2.4 Now the antimicrobial agents are directly placed in the holes.
This document discusses various antimicrobial agents used to control microbial growth, including antiseptics and disinfectants. It describes how antimicrobials can be categorized based on their spectrum of activity (narrow vs broad) and mechanism of action (bactericidal vs bacteriostatic). The origins and requirements of antiseptics and disinfectants are outlined. Various classes of antiseptic agents are classified and examples from each class are provided, with a focus on halogens such as iodine, chlorine, and chlorhexidine.
The document outlines various methods used to test the efficacy of disinfectants, including carrier tests, suspension tests, and practical tests. Carrier tests involve contaminating a thread with bacteria and exposing it to disinfectants. Suspension tests measure a disinfectant's ability to kill bacteria suspended in its solution. Practical tests evaluate disinfectants under real-world conditions. The document also describes the phenol coefficient test, which compares a disinfectant's effectiveness to that of phenol, and the filter paper test, which detects zones of bacterial inhibition around treated disks.
Physicochemical parameters in relation to Biological activitiesSKarthigaSVCP
This document discusses various physicochemical parameters that influence drug solubility, ionization, and biological activity. It defines key concepts like solubility, partition coefficient, ionization, protein binding, hydrogen bonding, and stereochemistry. Solubility depends on interactions between solute and solvent properties. Partition coefficient indicates how drugs distribute between aqueous and lipid phases. Ionization influences whether drugs are charged or uncharged. Protein binding, hydrogen bonding, and complexation impact how drugs interact with biological targets and receptors. Stereochemistry, including conformational, optical, and geometrical isomers, also influences pharmacological properties and effects. Understanding these physicochemical parameters is important for drug design and development.
When phases exist together, the boundary between two of them is known as interface.
When the phase is in contact with atmosphere it is termed as surface.
This document discusses bronchodilators, which are drugs that relax and open the airways to ease breathing. It covers the pathology of bronchospasm in asthma and different classes of bronchodilators including sympathomimetics like salbutamol and terbutaline, methylxanthine derivatives like aminophylline and theophylline, and anticholinergics like ipratropium and tiotropium. It provides dosing information for various drug formulations and delivery devices used to treat asthma such as metered dose inhalers and nebulizers.
Bronchial asthma is a chronic inflammatory disease of the airways characterized by bronchospasm and airway hyperresponsiveness. Several drugs are used to treat asthma including bronchodilators like beta-2 agonists which relax airway smooth muscle, corticosteroids which reduce airway inflammation, and leukotriene antagonists which block inflammatory mediators. Theophylline is a methylxanthine bronchodilator that works by inhibiting phosphodiesterase and antagonizing adenosine receptors to relax smooth muscle and reduce airway constriction.
Carbamazepine is an anticonvulsant.
It works by decreasing nerve impulses that cause seizures and nerve pain, such as trigeminal neuralgia and diabetic neuropathy.
Carbamazepine is also used to treat bipolar disorder.
This document discusses adrenergic antagonists, which are drugs that block adrenergic receptors to inhibit the functions of epinephrine, norepinephrine, and dopamine. It classifies them as alpha or beta blockers and provides examples of each. Key drugs discussed include tolazoline, phentolamine, phenoxybenzamine, prazosin, dihydroergotamine, methysergide, propranolol, metoprolol, atenolol, betaxolol, esmolol, metaprolol, and carvedilol. Their structures, mechanisms of action, and clinical uses for conditions like hypertension and cardiac issues are summarized. The synthesis of tolazoline and
This document summarizes information about benzodiazepines. It discusses their core chemical structure as a fusion of benzene and diazepine rings, with different substitutions leading to different benzodiazepines. It provides examples like diazepam, nitrazepam, and clonazepam. The document outlines the history of benzodiazepines from their synthesis in the 1950s-60s and increasing use as alternatives to barbiturates. It also covers their classification, mechanism of action involving GABA receptors, advantages, structure-activity relationships, and indications like alcohol withdrawal, anxiety, and insomnia.
This document discusses various agents used to treat cough. It begins by describing the pathophysiology of cough and differentiating between acute, chronic, and subacute cough. It then categorizes cough medications as peripherally or centrally acting. Peripherally acting medications include demulcents, mucosal anesthetics, bronchodilators, expectorants, and miscellaneous agents. Centrally acting medications include opioid/narcotics and non-opioid/non-narcotics. Specific medications are discussed under each category along with their mechanisms of action, pharmacokinetics, indications, and side effects. The document provides detailed information on commonly used antitussive medications to treat cough.
Sterility indicators are used to check the quality and monitoring of sterilization processes. They can indicate whether microbial growth occurs or sterilization was effective. There are several types of sterility indicators for different sterilization methods including dry heat, moist heat, gaseous, radiation, and filtration sterilization. Physical indicators monitor parameters like temperature and pressure. Chemical indicators involve temperature sensitive solutions or chemicals that change color. Biological indicators use microbes like Bacillus species to determine sterilization effectiveness by observing growth or no growth.
This document discusses several central nervous system stimulants and hallucinogens, including their mechanisms of action, therapeutic uses, and adverse effects. Methylxanthines like caffeine act as adenosine receptor antagonists and phosphodiesterase inhibitors, producing stimulation. Nicotine acts on nicotinic acetylcholine receptors. Cocaine and amphetamines inhibit monoamine reuptake. LSD is a serotonin agonist that can induce hallucinations. THC is the main psychoactive component in marijuana and acts through cannabinoid receptors. Many have therapeutic uses for conditions like ADHD, narcolepsy, and obesity but also carry risks of dependence and abuse.
Stimulants work by acting on the central nervous system (CNS) to increase alertness and cognitive function. Stimulants can be prescription medications or illicit substances, such as Cocaine. Stimulants may be taken orally, snorted, or injected. If you have a Stimulant addiction, seek help today.
1. The document discusses narcotic analgesics and narcotic antagonists, including their mechanisms of action, examples, and uses.
2. It describes the three main opioid receptors and their roles in pain management. Morphine and its analogues are discussed in terms of important structural features that determine their activity.
3. Individual narcotic analgesics like morphine sulfate, codeine, meperidine hydrochloride, and narcotic antagonists such as nalorphine hydrochloride are explained in terms of their therapeutic uses.
This document provides an overview of general anesthetics, including their definition, mechanisms of action, stages of anesthesia, classifications, and examples. It discusses inhalational anesthetics like nitrous oxide, halothane, sevoflurane and desflurane, outlining their properties such as potency, solubility, and side effects. It also reviews intravenous anesthetics including thiopental, propofol, ketamine and etomidate, noting their mechanisms, onsets, durations and side effect profiles. The document is intended to educate about the different types of general anesthetics used in surgery to induce reversible unconsciousness and muscle relaxation.
This document discusses surface and interfacial phenomena. It defines interfaces and divides them into solid and liquid interfaces. Liquid interfaces deal with liquid-gas or liquid-liquid phases and have applications in infiltration, biopharmaceuticals, and suspensions/emulsions. Surface tension exists between solid-gas and liquid-gas phases, while interfacial tension exists between immiscible liquids. Various methods are described to measure surface tension, interfacial tension, and surface free energy. Surfactants are also discussed, including how they lower tensions and are used in products. Adsorption at interfaces and isotherms are briefly covered.
This document discusses drugs that act on the central nervous system (CNS), specifically sedative-hypnotic drugs. It covers the classification of CNS depressants like benzodiazepines and barbiturates. It describes their mechanisms of action, effects on the CNS, cardiovascular system, respiratory system, and liver. It also discusses their therapeutic uses, adverse effects, dependence and abuse potential, as well as management of overdoses.
Anticholinergic drugs work by blocking the effects of the neurotransmitter acetylcholine at muscarinic receptors in the central and peripheral nervous systems. The main anticholinergic drugs discussed are atropine, glycopyrrolate, and scopolamine. Atropine is a naturally occurring tertiary amine that can cross the blood-brain barrier and exert central effects. Glycopyrrolate is a synthetic quaternary ammonium compound that does not cross the blood-brain barrier and lacks central effects. Scopolamine is similar to atropine but is more potent and lipid soluble, allowing it to more easily cross the blood-brain barrier and exert greater central antimuscarinic effects than atrop
INCLUDES SPREADING COEFFICIENT AND ITS THEORY AND ALSO FEW OF ITS APPLICATION IN PHARMACEUTICAL FIELD
WILL BE HELPFUL FOR B PHARMACY STUDENTS
INCLUDES HOW IT IS DERIVED AND ALSO HOW IT IS RELATED TO SPREADING OF A CREAM OR OINTMENT ON OUR SKIN
IMPORTANCE OF SPREADING COEFFICIENT
This document provides an overview of sedative and hypnotic drugs. It begins with definitions of sedatives, hypnotics, and anxiolytics. It then discusses the history of sedative drugs from antiquity through modern times. It covers the classification, mechanisms of action, pharmacokinetics, therapeutic uses and adverse effects of major classes of sedative-hypnotics including barbiturates and benzodiazepines.
Evaluation of Bactericidal and BacteriostaticRajsingh467604
What are disinfectants?
As per the definition given by WHO ( World health organization ) : a disinfectant is a chemical agent, which destroys or inhibits growth of pathogenic microorganisms in the non-sporing or vegetative state.
Why Evaluation?
Evaluation of disinfectants is used to check the ability or efficacy of any disinfectant against specific microorganisms to establish its effectiveness.
Evaluation tests of bactericide.
1. RIDEAL WALKER TEST
This test is also known as the phenol coefficient test,in which any chemical is compared with phenol for its antimicrobial activity.
The result is shown in the form of phenol coefficient.
▪ If a phenol coefficient of a given test disinfectant is less than 1, it means that disinfectant is less effective than phenol.
▪ If a phenol coefficient of a given test disinfectant is more than 1, it means that disinfectant is more effective than phenol.
Procedure
1.1 Different dilutions of the test disinfectant and phenol are prepared and 5 ml of each dilution is inoculated with 0.5ml of the 24 hour growth culture of the organisms.
1.2 All tubes(Disinfectant + organisms & phenol + organisms) are placed in a water bath ( at 17.5° C)
1.3 Subcultures of each reaction mixture are taken and transferred to 5ml sterile broth at an interval of 2.5 minutes from zero to 10 mintues.
1.4 Broth tubes are incubated at 37° C for 2 to 3 days & examined for the presence or absence of the growth.
1.5 Then the Rideal Walker coefficient is calculated :
2. CHICK MARTIN TEST.
CHICK MARTIN test is performed in the much similar way as the RIDEAL Walker test but with a little variation.
Principle : This test is carried out in the presence of organic matter like 3% human feces or dried yeast.
Procedure
2.1 Serial dilutions of test solution and phenol is prepared in distilled water.
2.2 To this 3% yeast suspension is also added.
2.3 To this solution the S. typhi is added
2.4 After contact time of 30 mins the above mixture is transferred to the freshly prepared 10 ml of broth.
2.5 The test tubes are incubated at 37°C for 48 hours.
2.6 Presence or absence of the growth is calculated.
Evaluation tests of Bacteriostatic.
1. Tube dilution & Agar plate Method
1.1 The chemical agent is incorporated into nutrient broth or agar medium and inoculated with test micro-organisms.
1.2 These tubes are incubated at 30° TO 35°C for 2 to 3 days and then the results in the form of turbidity or colonies are observed.
1.3 The results are recorded and the activity of the given disinfectant is compared.
2. Cup plate method
2.1 Agar is melted and cooled at 45° Celsius.
2.2 Then inoculated with test micro-organisms and poured into a sterile petri plate.
2.3 In the cup plate method, when the inoculated agar has solidified, holes around 8mm in diameter are cut in the medium with a steel cork borer.
2.4 Now the antimicrobial agents are directly placed in the holes.
This document discusses various antimicrobial agents used to control microbial growth, including antiseptics and disinfectants. It describes how antimicrobials can be categorized based on their spectrum of activity (narrow vs broad) and mechanism of action (bactericidal vs bacteriostatic). The origins and requirements of antiseptics and disinfectants are outlined. Various classes of antiseptic agents are classified and examples from each class are provided, with a focus on halogens such as iodine, chlorine, and chlorhexidine.
The document outlines various methods used to test the efficacy of disinfectants, including carrier tests, suspension tests, and practical tests. Carrier tests involve contaminating a thread with bacteria and exposing it to disinfectants. Suspension tests measure a disinfectant's ability to kill bacteria suspended in its solution. Practical tests evaluate disinfectants under real-world conditions. The document also describes the phenol coefficient test, which compares a disinfectant's effectiveness to that of phenol, and the filter paper test, which detects zones of bacterial inhibition around treated disks.
Physicochemical parameters in relation to Biological activitiesSKarthigaSVCP
This document discusses various physicochemical parameters that influence drug solubility, ionization, and biological activity. It defines key concepts like solubility, partition coefficient, ionization, protein binding, hydrogen bonding, and stereochemistry. Solubility depends on interactions between solute and solvent properties. Partition coefficient indicates how drugs distribute between aqueous and lipid phases. Ionization influences whether drugs are charged or uncharged. Protein binding, hydrogen bonding, and complexation impact how drugs interact with biological targets and receptors. Stereochemistry, including conformational, optical, and geometrical isomers, also influences pharmacological properties and effects. Understanding these physicochemical parameters is important for drug design and development.
When phases exist together, the boundary between two of them is known as interface.
When the phase is in contact with atmosphere it is termed as surface.
This document discusses bronchodilators, which are drugs that relax and open the airways to ease breathing. It covers the pathology of bronchospasm in asthma and different classes of bronchodilators including sympathomimetics like salbutamol and terbutaline, methylxanthine derivatives like aminophylline and theophylline, and anticholinergics like ipratropium and tiotropium. It provides dosing information for various drug formulations and delivery devices used to treat asthma such as metered dose inhalers and nebulizers.
Bronchial asthma is a chronic inflammatory disease of the airways characterized by bronchospasm and airway hyperresponsiveness. Several drugs are used to treat asthma including bronchodilators like beta-2 agonists which relax airway smooth muscle, corticosteroids which reduce airway inflammation, and leukotriene antagonists which block inflammatory mediators. Theophylline is a methylxanthine bronchodilator that works by inhibiting phosphodiesterase and antagonizing adenosine receptors to relax smooth muscle and reduce airway constriction.
Carbamazepine is an anticonvulsant.
It works by decreasing nerve impulses that cause seizures and nerve pain, such as trigeminal neuralgia and diabetic neuropathy.
Carbamazepine is also used to treat bipolar disorder.
This document discusses adrenergic antagonists, which are drugs that block adrenergic receptors to inhibit the functions of epinephrine, norepinephrine, and dopamine. It classifies them as alpha or beta blockers and provides examples of each. Key drugs discussed include tolazoline, phentolamine, phenoxybenzamine, prazosin, dihydroergotamine, methysergide, propranolol, metoprolol, atenolol, betaxolol, esmolol, metaprolol, and carvedilol. Their structures, mechanisms of action, and clinical uses for conditions like hypertension and cardiac issues are summarized. The synthesis of tolazoline and
This document summarizes information about benzodiazepines. It discusses their core chemical structure as a fusion of benzene and diazepine rings, with different substitutions leading to different benzodiazepines. It provides examples like diazepam, nitrazepam, and clonazepam. The document outlines the history of benzodiazepines from their synthesis in the 1950s-60s and increasing use as alternatives to barbiturates. It also covers their classification, mechanism of action involving GABA receptors, advantages, structure-activity relationships, and indications like alcohol withdrawal, anxiety, and insomnia.
This document discusses various agents used to treat cough. It begins by describing the pathophysiology of cough and differentiating between acute, chronic, and subacute cough. It then categorizes cough medications as peripherally or centrally acting. Peripherally acting medications include demulcents, mucosal anesthetics, bronchodilators, expectorants, and miscellaneous agents. Centrally acting medications include opioid/narcotics and non-opioid/non-narcotics. Specific medications are discussed under each category along with their mechanisms of action, pharmacokinetics, indications, and side effects. The document provides detailed information on commonly used antitussive medications to treat cough.
Sterility indicators are used to check the quality and monitoring of sterilization processes. They can indicate whether microbial growth occurs or sterilization was effective. There are several types of sterility indicators for different sterilization methods including dry heat, moist heat, gaseous, radiation, and filtration sterilization. Physical indicators monitor parameters like temperature and pressure. Chemical indicators involve temperature sensitive solutions or chemicals that change color. Biological indicators use microbes like Bacillus species to determine sterilization effectiveness by observing growth or no growth.
This document discusses several central nervous system stimulants and hallucinogens, including their mechanisms of action, therapeutic uses, and adverse effects. Methylxanthines like caffeine act as adenosine receptor antagonists and phosphodiesterase inhibitors, producing stimulation. Nicotine acts on nicotinic acetylcholine receptors. Cocaine and amphetamines inhibit monoamine reuptake. LSD is a serotonin agonist that can induce hallucinations. THC is the main psychoactive component in marijuana and acts through cannabinoid receptors. Many have therapeutic uses for conditions like ADHD, narcolepsy, and obesity but also carry risks of dependence and abuse.
Stimulants work by acting on the central nervous system (CNS) to increase alertness and cognitive function. Stimulants can be prescription medications or illicit substances, such as Cocaine. Stimulants may be taken orally, snorted, or injected. If you have a Stimulant addiction, seek help today.
This document discusses several central nervous system stimulants and hallucinogens. It describes their mechanisms of action, effects, uses, and adverse reactions. CNS stimulants discussed include caffeine, nicotine, cocaine, amphetamines, and methylphenidate. They generally act by increasing neurotransmitters like dopamine and norepinephrine. Hallucinogens covered are LSD, THC, and phencyclidine. They produce profound changes in thought and mood by acting on serotonin and other receptors. Both classes can cause dependence and adverse effects at high doses.
This document discusses central nervous system stimulants. It defines CNS stimulants as compounds that increase low levels of physiological activity. Some important CNS stimulants are classified as psychomotor stimulants like nicotine, cocaine, amphetamine, and methylphenidate which cause excitement and euphoria. Hallucinogens like LSD and THC affect thought, perception, and mood. Common therapeutic uses of CNS stimulants include treating obesity, ADHD, and narcolepsy. The document then discusses the mechanisms of action, effects, uses, and adverse effects of specific stimulants like nicotine, cocaine, amphetamine, methylphenidate, LSD
This document discusses CNS stimulants and cognition enhancers. It describes various psychomotor stimulants like amphetamines, cocaine, nicotine, and hallucinogens. It discusses their mechanisms of action, effects on the CNS and sympathetic nervous system, therapeutic uses, and adverse effects. It also covers cognition enhancers used for conditions like dementia and Alzheimer's disease. These include cholinergic activators like donepezil and memantine, as well as supplements like Ginkgo biloba. The document provides an overview of how cognition enhancers work to improve brain function and memory.
1. The document discusses several classes of central nervous system stimulants including methylxanthines, nicotine, cocaine, amphetamines, and hallucinogens.
2. Methylxanthines like caffeine and theophylline are phosphodiesterase inhibitors that increase levels of cyclic nucleotides, and they also block adenosine receptors. Nicotine stimulates ganglia at low doses but blocks them at high doses.
3. Cocaine, amphetamines, and MDMA prolong the actions of neurotransmitters like dopamine and serotonin, producing euphoria. Hallucinogens profoundly alter mood and thought patterns while sparing motor function.
The document summarizes four psychomotor stimulants:
1. Methylxanthines like caffeine work by increasing calcium levels and inhibiting phosphodiesterase. Caffeine is widely consumed in drinks like coffee and tea and causes increased alertness but high doses cause anxiety.
2. Nicotine stimulates ganglia at low doses but blocks them at high doses. It causes hypertension, appetite suppression, and increased heart rate.
3. Cocaine blocks neurotransmitter reuptake, prolonging their effects. It causes euphoria but also hallucinations, paranoia, and increased heart rate.
4. Amphetamines release catecholamines and inhibit their breakdown. They are used
This document summarizes CNS stimulants, including their mechanisms of action, effects, and uses. It discusses two main groups - psychomotor stimulants and hallucinogens. Psychomotor stimulants like caffeine, nicotine, cocaine, and varenicline act on the CNS to increase alertness and motor activity. They can cause euphoria but have little effect on the brainstem and spinal cord. Hallucinogens profoundly alter mood and thought patterns. The document provides details on the mechanisms, effects, pharmacokinetics, therapeutic uses and adverse effects of several specific psychomotor stimulants.
The document discusses various classes of central nervous system stimulants including their mechanisms of action, effects, uses, and examples. It covers analeptic, respiratory, convulsant, psychomotor and sympathomimetic stimulants as well as methylxanthines such as caffeine and theophylline. Examples discussed include amphetamines, cocaine, nicotine and other stimulants.
The document discusses various classes of central nervous system stimulants including their mechanisms of action, effects, uses, and examples. It covers analeptic, respiratory, convulsant, psychomotor and sympathomimetic stimulants as well as methylxanthines such as caffeine and theophylline. Examples discussed include amphetamines, cocaine, nicotine and other stimulants.
The document discusses various classes of central nervous system stimulants including their mechanisms of action, effects, uses, and examples. It covers analeptic, respiratory, convulsant, psychomotor and sympathomimetic stimulants as well as methylxanthines such as caffeine and theophylline. Examples discussed include amphetamines, cocaine, nicotine and other stimulants.
Stimulants are substances that increase behavioral activity when administered. They are classified as psychomotor stimulants or hallucinogens. Psychomotor stimulants like cocaine, amphetamines, and nicotine cause excitement, euphoria and increased motor activity by increasing the neurotransmitters dopamine and norepinephrine. Hallucinogens affect thought patterns and mood but have little effect on the brain stem and spinal cord. Common stimulants include caffeine, nicotine, cocaine, amphetamines, and methylphenidate.
6 Pharmacology I CNS Stimulants NK, trimmed.pptxAhmad Kharousheh
This document discusses two groups of central nervous system stimulants: psychomotor stimulants and hallucinogens. Psychomotor stimulants such as caffeine, nicotine, cocaine, and amphetamines cause excitement, euphoria and increase motor activity. Hallucinogens like LSD profoundly alter thought patterns and mood but have little effect on the brainstem and spinal cord. While some CNS stimulants have therapeutic uses, many are also important drugs of abuse due to their addictive properties.
This document discusses the biological basis of tobacco addiction and implications for treatment. It begins by explaining why people begin abusing drugs, such as for pleasure, stress relief, or peer pressure. It then defines addiction and dependence, outlining the diagnostic criteria. The document discusses how nicotine acts in the brain through acetylcholine receptors to stimulate the reward pathway. Genetic and conditioning factors that contribute to addiction are also reviewed. The text closes by summarizing withdrawal symptoms and different pharmacological treatments used to aid smoking cessation.
The reward pathway involves dopamine release in the nucleus accumbens mediated by the mesolimbic pathway. Drugs of abuse mimic neurotransmitters like endorphins, anandamide, acetylcholine, and dopamine to directly stimulate brain receptors and cause dopamine release. Repeated exposure leads to neuroadaptations and the transition from impulsive to compulsive drug use driven by craving and withdrawal. Stimulants like cocaine block reuptake of dopamine while cannabinoids activate endogenous cannabinoid receptors. The reward circuitry is interconnected with systems regulating hunger and sex.
CNS stimulants and cognitive enhancers can be classified into several groups based on their mechanisms and effects. CNS stimulants include convulsants like strychnine which block glycine receptors and induce tonic convulsions. Analectics like doxapram stimulate respiration. Psycho stimulants such as amphetamines and methylphenidate increase dopamine and norepinephrine in the synaptic cleft. Caffeine is a mild stimulant. Cognitive enhancers for conditions like Alzheimer's work by various mechanisms including increasing acetylcholine through acetylcholinesterase inhibitors like donepezil, stimulating NMDA receptors with memantine, or providing antioxidant support.
This document summarizes various psychoactive drugs, their effects on the brain, and mechanisms of addiction. It discusses how drugs like caffeine, nicotine, alcohol, opioids, cocaine, amphetamines, cannabis, and benzodiazepines activate the brain's reward system and become reinforcing. Repeated use can lead to changes in the brain that result in tolerance, dependence, withdrawal, and compulsive drug seeking behavior. Treatment aims to manage cravings and withdrawal through tapering, replacement therapies, counseling, and support groups.
Central nervous system stimulants work by increasing levels of neurotransmitters like dopamine and norepinephrine. They cause initial feelings of euphoria and increased alertness and energy. However, regular use can lead to tolerance and dependence. Common stimulants include caffeine, nicotine, cocaine, and amphetamines. They are used both medically to treat conditions like ADHD, obesity, and narcolepsy, as well as recreationally for their mood enhancing effects. However, stimulants also carry health risks like increased blood pressure, anxiety, and addiction. Their effects are mediated through interactions with neurotransmitter systems in the brain.
The document discusses drug dependence and abuse, providing definitions and examples. It summarizes that dependence involves compulsive drug craving and can occur after repeated drug use, while addiction involves compulsive, uncontrolled behavior to obtain drugs despite negative consequences. It then categorizes examples of commonly abused drugs based on their dependence liability and mechanisms of action, including opioids, cannabis, benzodiazepines, cocaine, amphetamines, nicotine, and alcohol. Treatment approaches aim to alleviate withdrawal symptoms through substitution or block drug effects and cravings.
HIV attacks and weakens the immune system by destroying CD4+ T cells. It progresses through three stages: acute infection, clinical latency, and AIDS. HIV is transmitted through bodily fluids and can be prevented through condom use, PrEP, and harm reduction programs. Diagnosis involves antibody and viral load tests. Treatment is lifelong antiretroviral therapy which suppresses the virus but can cause side effects. Pharmacists play a role by dispensing ART, preventing interactions, and educating patients. Despite progress, efforts are still needed to develop more effective prevention and treatment options like a vaccine in order to end the global HIV epidemic.
Cellulose is a polysaccharide composed of glucose units linked together by beta-1,4-glycosidic bonds. It is the main component of plant cell walls and is produced by plants and some bacteria through biosynthesis. In plants, cellulose synthesis occurs on plasma membrane-bound rosette terminal complexes that polymerize glucose residues from UDP-glucose to form cellulose chains. These chains then assemble into crystalline microfibrils in the cell wall. Cellulose is widely used to produce derivatives like cellulose esters and rayon. Rayon is a regenerated cellulose fiber produced through a chemical process involving wood pulp. It has the same molecular structure as cellulose. Catgut is prepared from the natural
Gels are semisolid systems consisting of small particles suspended in a liquid that is given structure through the addition of a gelling agent. This causes a high degree of physical or chemical cross-linking that results in high viscosity and a semi-solid state. Gels can be single or multiphase depending on if the components are uniformly distributed or separated. Common gelling agents include carbomers, cellulose derivatives, and natural gums. Gels are used topically in products like acne treatments, anti-inflammatories, and vaginal medications due to their ability to maintain drug levels at application sites.
Pesticides are chemical agents used to control or eliminate pests. Natural and artificial controls are used to control pests. Natural controls include predators and changing environmental conditions. Artificial controls include mechanical, agricultural, chemical and biological methods. Common types of pesticides include insecticides, herbicides, fungicides and rodenticides. Many plants contain chemical constituents that make them effective pesticides, such as nicotine from tobacco, rotenone from Derris roots, and azadirachtin from neem. These plant-derived pesticides can control insects, fungi, weeds and rodents in a natural way.
Papaveraceae family (poppy capsule + sanguinaria) .pptxAhmadShafiq43
The document summarizes information about two plants from the Papaveraceae family: Sanguinaria canadensis (bloodroot) and Papaver somniferum (opium poppy). It provides details on their botanical names, parts used, sensory characteristics, major chemical constituents, uses, and dosages. Both plants contain alkaloids with medicinal properties. Bloodroot contains sanguinarine and is used as an emetic and expectorant. Opium poppy contains morphine, codeine, and thebaine and its latex is used as an analgesic, sedative, and to treat diarrhea.
Diagnostic tools for disease evaluation.pdfAhmadShafiq43
This document provides information on various diagnostic tools used for disease evaluation. It describes X-ray scanners, magnetic resonance imaging scanners, computerized tomography scanners, positron emission tomography scans, blood analyzers, urine analyzers, blood pressure monitors, spirometers, ophthalmoscopes, ultrasounds, and biopsies. Each tool is used to examine a different part of the body or test a specific bodily function to aid in disease diagnosis.
The digestive system breaks down food, absorbs nutrients, and eliminates waste. It includes the mouth, esophagus, stomach, small intestine, large intestine, liver, gallbladder and pancreas. Food is ingested, propelled through the system, and undergoes both mechanical and chemical digestion. Nutrients are absorbed through the intestinal walls and waste is eliminated as feces. Glands and organs secrete enzymes and hormones to regulate digestion.
Fungi are eukaryotic organisms that were historically classified as plants but are now recognized as a distinct kingdom. They differ from plants in that they lack chlorophyll and their cell walls contain chitin rather than cellulose. Fungi reproduce both sexually through the formation of spores like zygospores or basidiospores, and asexually through budding or the formation of conidia. Major groups of fungi include molds, mushrooms, and yeasts. Molds form branching filaments called hyphae that allow them to absorb nutrients, while mushrooms form visible fruiting bodies above ground. Yeasts are single-celled fungi that reproduce by budding.
This document provides information about the pharmacognostical study of Aloe vera leaves and latex. It discusses the botanical name, common names, geographical source, sensory characteristics, major chemical constituents including anthraquinone glycosides and specific compounds like aloin, uses as a laxative and for skin benefits, dose, safety concerns, interactions, and phytochemical group of Aloe vera. It also provides references for further information.
hematic appreciation test is a psychological assessment tool used to measure an individual's appreciation and understanding of specific themes or topics. This test helps to evaluate an individual's ability to connect different ideas and concepts within a given theme, as well as their overall comprehension and interpretation skills. The results of the test can provide valuable insights into an individual's cognitive abilities, creativity, and critical thinking skills
The debris of the ‘last major merger’ is dynamically youngSérgio Sacani
The Milky Way’s (MW) inner stellar halo contains an [Fe/H]-rich component with highly eccentric orbits, often referred to as the
‘last major merger.’ Hypotheses for the origin of this component include Gaia-Sausage/Enceladus (GSE), where the progenitor
collided with the MW proto-disc 8–11 Gyr ago, and the Virgo Radial Merger (VRM), where the progenitor collided with the
MW disc within the last 3 Gyr. These two scenarios make different predictions about observable structure in local phase space,
because the morphology of debris depends on how long it has had to phase mix. The recently identified phase-space folds in Gaia
DR3 have positive caustic velocities, making them fundamentally different than the phase-mixed chevrons found in simulations
at late times. Roughly 20 per cent of the stars in the prograde local stellar halo are associated with the observed caustics. Based
on a simple phase-mixing model, the observed number of caustics are consistent with a merger that occurred 1–2 Gyr ago.
We also compare the observed phase-space distribution to FIRE-2 Latte simulations of GSE-like mergers, using a quantitative
measurement of phase mixing (2D causticality). The observed local phase-space distribution best matches the simulated data
1–2 Gyr after collision, and certainly not later than 3 Gyr. This is further evidence that the progenitor of the ‘last major merger’
did not collide with the MW proto-disc at early times, as is thought for the GSE, but instead collided with the MW disc within
the last few Gyr, consistent with the body of work surrounding the VRM.
Authoring a personal GPT for your research and practice: How we created the Q...Leonel Morgado
Thematic analysis in qualitative research is a time-consuming and systematic task, typically done using teams. Team members must ground their activities on common understandings of the major concepts underlying the thematic analysis, and define criteria for its development. However, conceptual misunderstandings, equivocations, and lack of adherence to criteria are challenges to the quality and speed of this process. Given the distributed and uncertain nature of this process, we wondered if the tasks in thematic analysis could be supported by readily available artificial intelligence chatbots. Our early efforts point to potential benefits: not just saving time in the coding process but better adherence to criteria and grounding, by increasing triangulation between humans and artificial intelligence. This tutorial will provide a description and demonstration of the process we followed, as two academic researchers, to develop a custom ChatGPT to assist with qualitative coding in the thematic data analysis process of immersive learning accounts in a survey of the academic literature: QUAL-E Immersive Learning Thematic Analysis Helper. In the hands-on time, participants will try out QUAL-E and develop their ideas for their own qualitative coding ChatGPT. Participants that have the paid ChatGPT Plus subscription can create a draft of their assistants. The organizers will provide course materials and slide deck that participants will be able to utilize to continue development of their custom GPT. The paid subscription to ChatGPT Plus is not required to participate in this workshop, just for trying out personal GPTs during it.
The cost of acquiring information by natural selectionCarl Bergstrom
This is a short talk that I gave at the Banff International Research Station workshop on Modeling and Theory in Population Biology. The idea is to try to understand how the burden of natural selection relates to the amount of information that selection puts into the genome.
It's based on the first part of this research paper:
The cost of information acquisition by natural selection
Ryan Seamus McGee, Olivia Kosterlitz, Artem Kaznatcheev, Benjamin Kerr, Carl T. Bergstrom
bioRxiv 2022.07.02.498577; doi: https://doi.org/10.1101/2022.07.02.498577
Current Ms word generated power point presentation covers major details about the micronuclei test. It's significance and assays to conduct it. It is used to detect the micronuclei formation inside the cells of nearly every multicellular organism. It's formation takes place during chromosomal sepration at metaphase.
ESR spectroscopy in liquid food and beverages.pptxPRIYANKA PATEL
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
When I was asked to give a companion lecture in support of ‘The Philosophy of Science’ (https://shorturl.at/4pUXz) I decided not to walk through the detail of the many methodologies in order of use. Instead, I chose to employ a long standing, and ongoing, scientific development as an exemplar. And so, I chose the ever evolving story of Thermodynamics as a scientific investigation at its best.
Conducted over a period of >200 years, Thermodynamics R&D, and application, benefitted from the highest levels of professionalism, collaboration, and technical thoroughness. New layers of application, methodology, and practice were made possible by the progressive advance of technology. In turn, this has seen measurement and modelling accuracy continually improved at a micro and macro level.
Perhaps most importantly, Thermodynamics rapidly became a primary tool in the advance of applied science/engineering/technology, spanning micro-tech, to aerospace and cosmology. I can think of no better a story to illustrate the breadth of scientific methodologies and applications at their best.
Or: Beyond linear.
Abstract: Equivariant neural networks are neural networks that incorporate symmetries. The nonlinear activation functions in these networks result in interesting nonlinear equivariant maps between simple representations, and motivate the key player of this talk: piecewise linear representation theory.
Disclaimer: No one is perfect, so please mind that there might be mistakes and typos.
dtubbenhauer@gmail.com
Corrected slides: dtubbenhauer.com/talks.html
(June 12, 2024) Webinar: Development of PET theranostics targeting the molecu...Scintica Instrumentation
Targeting Hsp90 and its pathogen Orthologs with Tethered Inhibitors as a Diagnostic and Therapeutic Strategy for cancer and infectious diseases with Dr. Timothy Haystead.
3. Therapeutic Indications and
Contraindications for CNS Stimulants
Obesity (anorectic agents).
Attention Deficit Hyperactivity Disorder (ADHD); lack
the ability to be involved in any one activity for longer
than a few minutes.
Narcolepsy: It is a relatively rare sleep disorder, that is
characterized by uncontrollable bouts of sleepiness
during the day. It is sometimes accompanied by
catalepsy, a loss in muscle control, or even paralysis
brought on by strong emotion, such as laughter.
Contraindications:
patients with anorexia, insomnia, asthenia, psychopathic
personality, a history of homicidal or suicidal tendenci3
es.
4. 1. Psychomotor stimulants
A. Methylxanthines
1. Theophylline (found in tea): long-acting,
prescribed for night-time asthma
2. Theobromine: found in cocoa.
3. Caffeine: (short-acting) the most widely
consumed
found in coffee (200 mg/cup),
carbonated soft drinks (60 mg/can),
cocoa and chocolate
4
5. Mechanism of action: include
several mechanism have been proposed
Mechanism of action of methylxanthine
1-It inhibits phosphodiesterase enz. → ↑ cAMP
2- Adenosine (A1, A2 and A3) receptors antagonist
almost equally, which explains many of its cardiac effects
A2 receptors antagonist responsible for CNS stimulation
& smooth muscles relaxation
↓calcium in
Smooth muscles
↑ calcium in
CNS & heart
5
6. Actions
6
a. CNS:
decrease in fatigue, increased alertness: 100-200 mg caffeine in 1 or 2
cups of coffees
Anxiety & tremors- 1.5 g of caffeine: 12-15 cups of coffee
Spinal cord stimulation: 2-5 g (very high dose)
Tolerance can rapidly develop
Withdrawal symptoms: feeling of fatigue & sedation.
b. CVS: at high dose of caffeine +ve inotropic and chronotropic
effects on the heart, ↑COP
c. Diuretic action: mild ↑ urinary output of Na+, Cl- and K+
d. Gastric mucosa: all methylxanthines stimulate secretion of HCl
e. Respiratory smooth muscle: bronchodilator, Rx asthma
replaced by β-agonists, corticosteroids.
7. Pharmacokinetics
The methylxanthines are well absorbed orally.
Caffeine distributes throughout the body, including
the brain. The drugs cross the placenta to the fetus
and is secreted into the mother's milk.
All are metabolized in the liver, generally by the
CYP1A2 pathway, the metabolites are then excreted
in the urine.
Adverse effects
Moderate doses: insomnia, anxiety, agitation
High doses: emesis, convulsion
Lethal dose (10 gm of caffeine): cardiac arrhythmia
Suddenly stop: lethargy, irritability, headache
7
8. B. Nicotine:
Nicotine is the active ingredient in tobacco.
Used in smoking cessation therapy,
Nicotine remains important, because:
it is 2nd only to caffeine as the most widely used CNS
stimulant
and 2nd only to alcohol as the most abused drug.
Actions of Nicotine:
Low dose: ganglionic depolarization
High dose: ganglionic blockade
8
9. Actions of Nicotine
9
I. CNS:
1. Low dose: euphoria, arousal, relaxation, improves
attention, learning, problem solving and reaction time.
2. High dose: CNS paralysis, severe hypotension
(medullary paralysis)
II. Peripheral effects:
Stimulation of sympathetic ganglia and adrenal
medulla→↑ BP and HR (harmful in HTN patients)
Stimulation of parasympathetic ganglia→↑ motor
activity of the bowel
At higher doses, BP falls & activating ceases in both
GIT and bladder
10. Pharmacokinetics:
10
highly lipid soluble absorbed everywhere (oral
mucosa, lung, GIT, skin).
Crosses the placental membrane, secreted with milk.
Most cigarettes contain 6-8 mg of nicotine, by
inhaling tobacco smoke, the average smoker takes in
1 to 2 mg of nicotine per cigarette.
the acute lethal dose is 60 mg,
90% of nicotine inhaled in smoke is absorbed.
Tolerance to toxic effects of nicotine develops rapidly.
11. Adverse effects:
CNS; irritability and tremors
Intestinal cramps, diarrhea
↑HR & BP
Withdrawal syndrome:
nicotine is addictive substance
physical dependence on nicotine
develops rapidly and can be
severe.
Bupropion: can reduce the
craving for cigarettes
Transdermal patch and chewing
gum containing nicotine
11
12. C. Varenicline
12
Partial agonist at Nicotinic receptor in CNS.
It produces less euphoric effects than those
produced by nicotine itself (nicotine is full agonist at
these receptors).
Thus, it is useful as an adjunct in the management of
smoking cessation in patients with nicotine
withdrawal symptom.
SE: Nausea, change in taste, vomiting, abdominal
pain, flatulence, and constipation.
Serious side-effects, including suicidal behavior and
depression
13. D. Cocaine (highly addictive drug)
Mechanism of action:
blockade of reuptake of the
monoamines (NE, serotonin
and dopamine).
Thus, potentiates and
prolongs the CNS and
peripheral actions of these
monoamines.
Only clinical use as local
anesthetics.
13
14. Action:
Initially produces the intense
euphoria by prolongation of
dopaminergic effects in the
brain’s pleasure system (limbic
system) producing the “Rush”.
This follows by dysphoria in few
minutes as it is degraded by
plasma estrases
Chronic intake of cocaine depletes dopamine.
This depletion triggers the vicious cycle of craving for
cocaine.
14
15. Pharmacological effects:
15
a. CNS-behavioral effects result from powerful
stimulation of cortex and brain stem.
Cocaine acutely increases mental awareness and
produces a feeling of wellbeing and euphoria similar to
that produced by amphetamine.
Like amphetamine, cocaine can produce hallucinations
and delusions of paranoia or grandiosity.
Cocaine increases motor activity, and at high doses, it
causes tremors and convulsions, followed by
respiratory and vasomotor depression.
16. b. Sympathetic NS: peripherally potentiate the action
of NE→ fight or flight
c. Hyperthermia:
impair sweating & cutaneous vasodilation
↓Perception of thermal discomfort
d. local anesthetic action: blockade of voltage-
activated Na+ channel.
Cocaine is the only LA that causes vasoconstriction,
chronic inhalation of cocaine powder → necrosis and
perforation of the nasal septum
Cocaine is often self-administered by chewing,
intranasal snorting, smoking, or intravenous (IV)
injection.
Pharmacological effects :
16
17. Adverse effects:
Anxiety reaction that includes: hypertension,
tachycardia, sweating, and paranoia.
Because of the irritability, many users take cocaine with alcohol.
A product of cocaine metabolites and ethanol is cocaethylene,
which is also psychoactive and cause cardiotoxicity.
Depression: Like all stimulant drugs, cocaine stimulation of the
CNS is followed by a period of mental depression.
Addicts withdrawing from cocaine exhibit physical and
emotional depression as well as agitation.
The latter symptom can be treated with benzodiazepines or
phenothiazines.
Toxic effects:
Seizures treated by I.V diazepam
Fatal cardiac arrhythmias treated by propranolol 17
18. E. Amphetamine
18
Is a non catecholamine, (shows neurologic and clinical
effects quite similar to those of cocaine).
dextroamphetamine is the major member of this class
compounds.
methamphetamine (speed) is a derivative of
amphetamine that can be smoked and it is preferred
by many abusers.
Methylenedioxymethamphetamine (also known as
MDMA, or Ecstasy) is a synthetic derivative of
methamphetamine with both stimulant and
hallucinogenic properties.
19. Mechanism of action:
19
Amphetamine, act by
releasing intracellular
stores of catecholamines.
also inhibits MAO, high
level catecholamines are
readily released into
synaptic spaces.
20. Actions:
20
a. CNS: the major behavioral effects of amphetamine
result from a combination of its dopamine and NE
release enhancing properties.
Amphetamine stimulates the entire cerebrospinal
axis, brainstem, and medulla.
This leads to increase alertness, decrease fatigue,
depressed appetite, and insomnia.
b. Sympathetic Nervous System: indirectly stimulating
the receptors through NE release.
21. Adverse effects:
21
The amphetamines may cause addiction, dependence,
tolerance, and drug seeking behavior.
a. CNS: insomnia, irritability, weakness, dizziness, tremor,
hyperactive reflex, confusion, delirium, panic states, and
suicidal tendencies, especially in mentally ill patients.
-Chronic amphetamine use produces a state of “amphetamine
psychosis” that resembles the psychotic episodes associated
with schizophrenia.
-Whereas long-term amphetamine is associated with psychic
and physical dependence, tolerance to its effects may occur
within few weeks.
22. Adverse effects:
22
The anorectic effect of amphetamine is due to its action
in the lateral hypothalamic feeding center.
b. CVS: palpitations, cardiac arrhythmia, HTN, anginal
pain, and circulatory collapse. Headache, chills, and
excess sweating may also occur.
c. GIT: anorexia, nausea, vomiting, abdominal cramps,
and diarrhea.
Overdoses are treated with chlorpromazine or
haloperidol, with urine acidification to enhance
excretion.
Contraindications: HTN, CV diseases, glaucoma,
hyperthyroidism, patients with a history of drug abuse
23. F. Atomoxetine
23
It is a NE reuptake inhibitor (should not be taken by
individual on MAO inhibitors).
Approved for ADHD (significant problems
of attention, hyperactivity, or acting impulsively) in
children and adults.
SE: Nausea, Xerostomia (dry mouth), appetite loss,
Insomnia, Irritability, hypertension and Hostility.
It is not habit forming and is not a controlled
substance.
24. G. Methylphenidate
24
It has CNS stimulant properties similar to those of
amphetamine and may also lead to abuse.
Methylphenidate is a more potent dopamine transport
inhibitor than cocaine, thus making more dopamine
available.
It has less potential for abuse than cocaine, because it
enters the brain much more slowly than cocaine and,
does not increase dopamine levels as rapidly.
25. Therapeutic uses:
25
Methylphenidate and its active isomer,
(Dexmethylphenidate), have been used for several
decades in the treatment of ADHD in children aged 6
to 16.
It is also effective in the treatment of narcolepsy.
26. Adverse reactions:
26
GIT effects are the most common; abdominal pain
and nausea.
Other reactions include anorexia, insomnia,
nervousness, and fever.
In seizure patients, methylphenidate seems to
increase the seizure frequency, especially if the
patient is taking antidepressants.
Methylphenidate is contraindicated in patients with
glaucoma.
27. Narcolepsy: (day time sleepiness)
27
Amphetamine, methylphenidate.
Recently, a new drug, modafinil (wakefulness-
promoting agent) and its R-enantiomer derivative,
armodafinil, have become available to treat
narcolepsy.
Modafinil produces fewer psychoactive and
euphoric effects as well as, alterations in mood,
perception, thinking, and feelings typical of other
CNS stimulants.
28. H. Picrotoxin (cocculin)
28
Is a poisonous crystalline plant compound.
It acts as a non-competitive channel blocker for
the GABAA receptor chloride channels.
Infusion of picrotoxin has stimulant and convulsant
effects.
Used to counter barbiturate poisoning, that can occur
during general anesthesia or during a large intake
outside of the hospital.
29. II. Hallucinogens (psychotomimetic)
29
A few drugs have the ability to induce altered
perceptual states reminiscent of dreams, are
in the
accompanied by bright, colourful changes
environment and by a plasticity of constantly
changing shapes and colour.
The individual under the influence of these drugs is
incapable of normal decision making, because the
drug interferes with rational thought.
30. A. Lysergic acid diethylamide (LSD)
Multiple sites in the CNS are affected by (LSD) and
shows serotonin (5-HT) agonist.
It produces hallucinations with a dreamlike state (LSD
trip).
Activation of the sympathetic nervous system occurs,
which causes pupillary dilation, increased BP,
piloerection, and increased body temperature.
Uses: treatment of alcoholism, pain and cluster
headache relief, end-of-life anxiety, for spiritual
purposes, and to enhance creativity.
30
31. Adverse effects:
31
Include hyperreflexia, nausea, and muscular weakness.
High doses may produce long-lasting psychotic
changes in susceptible individuals.
Temporarily impair the ability to make sensible
judgments and understand common dangers,
temporary confusion, difficulty with abstract thinking, or
signs of impaired memory and attention span, thus
making the user more susceptible to accidents and
personal injury.
32. B. Tetrahydrocannabinol (THC)
32
The main psychoactive alkaloid contained in marijuana is
tetrahydrocannabinol (THC), which is available as
dronabinol.
THC can produce euphoria, followed by drowsiness and
relaxation.
Affect short-term memory and mental activity, decreases
muscle strength and impairs highly skilled motor activity,
such as that required to drive a car.
SE: appetite stimulation, xerostomia, visual hallucinations,
delusions, and enhancement of sensory activity.
33. Mechanism of action:
33
THC receptors, designated CB1 receptors, have been
found on inhibitory presynaptic nerve terminals.
CB1 is coupled to a G protein.
Interestingly, endocannabinoids have been identified in
the CNS.
These compounds, which bind to the CB1 receptors, are
membrane-derived and are synthesized on demand, and
they may act as local neuromodulators.
The action of THC is believed to be mediated through the
CB1 receptors but is still under investigation.
34. Pharmacokinetics:
34
The effects of THC appear immediately after the drug is
smoked, but maximum effects take about 20 minutes.
By 3 hours, the effects largely disappear.
Dronabinol is administered orally and has a peak effect in
2 to 4 hours. Its psychoactive effects can last up to 6 hours,
but its appetite-stimulant effects may persist for 24 hours.
It is highly lipid soluble and has a large volume of
distribution.
THC itself is extensively metabolized by the mixed-function
oxidases.
Elimination: is largely through the biliary route.
35. Therapeutic uses of Dronabinol
35
As an appetite stimulant for patients with acquired
immunodeficiency syndrome who are losing weight.
It is also sometimes given for the severe emesis caused
by some cancer chemotherapeutic agents.
Adverse effects:
Include increased heart rate, decreased blood pressure,
and reddening of the conjunctiva.
At high doses, a toxic psychosis develops. Tolerance and
mild physical dependence occur with continued, frequent
use of the drug.
36. C. Rimonabant:
36
Cannabinoid receptor 1 (CB1) antagonist
is an anorectic antiobesity drug that use to treat
obesity (decrease appetite and body weight in
humans).
induces psychiatric disturbances, such as anxiety
and depression, during clinical trials.
37. D. Phencyclidine:
37
Phencyclidine (also known as PCP, or “angel dust”).
inhibits the reuptake of dopamine, 5-HT, and NE.
The major action of phencyclidine is to block the ion
channel regulated by the NMDA subtype of glutamate
receptor.
recreational dissociative drug produces analgesia and
anesthesia, can be ingested, smoked, inhaled or injected.
Phencyclidine causes anticholinergic activity with severe
changes in body image, loss of ego boundaries, paranoia,
depersonalization. Hallucinations, euphoria, and suicidal
impulses also reported.
38. Q: A very agitated young male was brought to the
38
emergency room by
examination revealed
the police. Psychiatric
that he had snorted
cocaine several times in the past few days, the
last time being 10 hours previously. He was given
a drug which seated him and fell asleep. The
drug very likely used to counter this patient’s
apparent cocaine withdrawal was:
A: Phenobarbital
C: Cocaine
B: Lorazepam
D: Salbutamol
E: Adrenaline