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Ken-Won Miller
Howard University
Nutrition Care Management 1
Dr. Castor
Introduction
                  
 This presentation will focus mainly on the role of
  calcium intake and the manifestations of calcium
  deficiencies.
Nutrients
                     
 Nutrients are essential and all play a key role to
  survival of the human organism.
 Water
 Energy yielding nutrients
      Carbohydrates, Protein, Lipids (Fat)
 Vitamins (organic)
      Fat soluble, Water soluble
 Minerals (inorganic)
      Macro, Trace
Minerals
                 
     Macro-minerals        Trace minerals.
 Calcium              Manganese
 Phosphorus           Copper
 Magnesium            Iodine
 Sodium               Zinc
 Potassium            Cobalt
 Chloride             Fluoride
 Sulfur               Selenium
What is Calcium
                 
 Calcium is the most abundant mineral in the body
 This mineral is naturally found in foods, added to some,
  available as a dietary supplement, and present in some
  medicines
 Most of the body’s calcium is found in bones and teeth.
       Estimated to be 99% of calcium in the body
 Approx 1.5-2% of the body weight
 An adequate intake helps grow a healthy skeleton in
  early life and minimize bone loss later in life
Calcium in Bones
               
 Calcium salts form crystals called hydroxyapatite on
  a matrix of the protein collagen.
 Mineralization of calcium, phosphorus, and other
  minerals crystallize and harden the bones.
 The bones gain strength and rigidity as they harden.
Calcium in Bones
               
 Bones are not like solid rock
 Bones gain and lose minerals continuously in an
  ongoing process of remodeling.
 The balance between bone resorption and deposition
  changes with aging.
 The lack of homeostasis can lead to manifestations of
  clinical problems and cause a disease state.
Calcium in Body Fluids
           
 %1 of the body’s calcium circulates in the fluid as
  ionized calcium that is vital to life.
 The serum calcium is highly regulated and doesn’t
  fluctuate with variations in dietary intakes
 Calcium also activates a protein called calmodulin
      Calmodulin (a inactive protein) is activated by calcium
      It then becomes a messenger that tells other proteins
       what to do and serves as an interpreter for hormone and
       nerve mediated messages arriving at cells
Calcium in Body Fluids
           
 vascular contraction and vasodilatation
 muscle function
 nerve transmission
 intracellular signaling
 hormonal secretion
 Role in maintaining normal blood pressure
Recommended Dietary Allowance (RDA):

                                                             
 RDAs for the amounts of calcium required for bone health and to maintain adequate rates of calcium retention in healthy people.

                    Table 1: Recommended Dietary Allowances (RDAs) for Calcium [1]

                    Age          Male       Female             Pregnant              Lactating
                    0–6          200 mg     200 mg
                    months*

                    7–12         260 mg     260 mg
                    months*

                    1–3 years    700 mg     700 mg


                    4–8 years    1,000 mg   1,000 mg


                    9–13 years   1,300 mg   1,300 mg


                    14–18 years 1,300 mg    1,300 mg           1,300 mg              1,300 mg


                    19–50 years 1,000 mg    1,000 mg           1,000 mg              1,000 mg


                    51–70 years 1,000 mg    1,200 mg


                    71+ years    1,200 mg   1,200 mg


* Adequate Intake (AI)
Foods that Contain Calcium
                                  
 Calcium is found in a variety of foods.
 Dairy Foods
    Milk, yogurt, and cheese are the most popular choice in the US.
 Leafy Greens
    Kale, broccoli, and Chinese cabbage are vegetable source
 Fish
    Canned sardines and salmon
    Most grains (such as breads, pastas, and unfortified cereals),
     while not rich in calcium, add significant amounts of calcium to
     the diet because people eat them often in large amounts.
 Fortified foods
    Breakfast cereals, fruit juices, soy(Silk) and rice beverages, and
     tofu.
Medicines that Contain Calcium
                        
 The two main forms of calcium in supplements are
  carbonate and citrate
 Calcium carbonate is found in some over-the-counter
  antacid products, such as Tums® and Rolaids®.
Calcium Balance
                 
 Homeostasis of calcium is one of the body’s most
  important priorities.
 Bone tissue is used as a reservoir and a source of calcium,
  to maintain constant concentrations of calcium in muscles,
  blood, and intercellular fluids.
 Vitamin D and other hormones play a essential role as
  well in balancing levels
 Three organs play a key role in calcium levels
     1.   The intestines
     2.   Bones
     3.   Kidneys
Calcium Balance
              
 Parathormone (Parathyroid hormone)
      A hormone from the parathyroid glands that regulates
       blood calcium by raising it when levels fall too low
 Calcitonin
      A hormone from the thyroid gland that regulates blood
       calcium by lowering it when levels rise too high

Absorption of Calcium
          
Calcium is absorbed by all parts of the small
 intestine
Two mechanisms of absorption
        Active transport and passive diffusion
It is best absorbed in an acidic medium
Lactose and vitamin D enhances calcium
 absorption
The efficiency of absorption decreases as
 calcium intake increases
Likelihood of Deficiency
           
 Dietary surveys indicate that many people do not meet the
  Adequate Intake for calcium, especially women
 Consuming foods to maintain adequate vitamin D status
  improve absorption

 Dietary inadequacy is not likely if protein and calcium intake
  are adequate
 Stimulants in coffee and tea can discreetly increase calcium
  excretion and reduce absorption in the GI tract
 Phytic acid found in whole-grain breads can decrease
  availability
Lab Values for Nutritional
            Assessment
                          
 The normal levels for ionized (free) Ca2+
    4.64-5.28 mg/dL
 The normal levels for total serum Ca2+ (bound and
  unbound)
    8.6-10 mg/dL
 Status is related to many factors, including vit D, vit
  K, phosphate, parathyroid function, and medications
Lab Values for Nutritional
           Assessment
                           
 Hypercalcemia (High Calcium Levels)
   Associated with endocrine disorders, malignancy, and
    hypervitaminosis D
 Hypocalcemia (Low Calcium Levels)
   Associated with Vit D deficiency and inadequate hepatic or
    renal activation of Vit D, hypoparathyroidism, magnesium
    deficiency, renal failure, and nephrotic syndrome
Hypoparathyroidism
            
 Hypoparathyroidism is the
  result of a decrease in
  production of parathyroid
  hormones by the parathyroid
  glands located behind the
  thyroid glands in the neck.

 Usually occurs after a surgery
  where the parathyroid glands
  are removed.


 The result is a low level of
  calcium in the blood or
  hypocalcemia.
Assessment Tools
                 
 Dual-Energy X-ray absorptiometry (DXA) is thought to be
  one of the best tools for assessing bone mineral density
 Very important in early detection, treatment, and
  monitoring of osteoporosis
      Preferred approach for measuring BMD
      Measures bone mineral content at axial and appendicular sites
      Monitors changes over time
      Low radiation exposure
      Superior quality control procedures
 Computerized tomography (CT) scans measure variances
  in tissue density. This method is less precise and accurate
  than DXA
Osteoporosis (Adult
        Bone Loss)
            
 Disease in which the bones become porous and
  fragile due to a loss of minerals
 Bone strength is a function of two factors
         Bone mineral density and bone quality
 BMD is determined by peak bone mass and BQ
  relates to bone architecture, bone turnover,
  mineralization, and the accumulation of damage to
  the bone
 Peak in bone mass= late 20’s early 30’s
Classification
                   
 Primary-not related to other disease
         Mostly seen in middle aged females and older
          men/females
         Males have greater bone mass
 Secondary-identifiable cause other than age or
  menopause is present
         Cushing’s syndrome, myeloma, hyperthyroidism,
          amenorrhea, medicines( thiazide diuretics and heparin)
Osteoporosis
                                
•   Leads to a greater risk of fractures
•   Fractures in the hip, vertebrae, pelvis,
    humerus, distal forearm
•   Females more likely to have fractures
Five Steps to Optimize Bone Health
                        
1. Maintain a balance diet rich in calcium and vitamin
   D.
2. Participate in regular, weight-bearing exercise.
3. Practice a healthy lifestyle with no smoking or
   excessive alcohol intake
4. Talk to health care professional about bone health
5. If indicated, obtain bone mineral density testing
   and take medication, if appropriate
In conclusion
                  
 Calcium is the most abundant mineral in the body
  and is mostly found in bones and teeth.
 %1 of the body’s calcium circulates in the fluid as
  ionized calcium that is vital to life and homeostasis
 Many people become deficient in calcium especially
  those suffering from illness and the elderly
 It is important for dietitians to thoroughly evaluate
  patients for calcium defiency and provide
  nutritional intervention if needed.
References
                             
 Chung M, Balk EM, Brendel M, et al. Vitamin D and Calcium: A Systematic Review
  of Health Outcomes. Rockville (MD): Agency for Healthcare Research and Quality
  (US); 2009 Aug. (Evidence Reports/Technology Assessments, No. 183.) 1,
  Introduction. Available from: http://www.ncbi.nlm.nih.gov/books/NBK32605/

 National Institutes of Health. Optimal calcium intake. NIH Consensus Statement:
  1994;12:1-31. [PubMed abstract]

 2 Overview of Calcium." Dietary Reference Intakes for Calcium and Vitamin D.
  Washington, DC: The National Academies Press, 2011.

 Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu
  RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA.
  Clarification of DRIs for calcium and vitamin D across age groups. J Am Diet Assoc.
  2011 Oct;111(10):1467. [PubMed abstract]

   U.S. Department of Agriculture, Agricultural Research Service. 2011. USDA National
    Nutrient Database for Standard Reference, Release 24. Nutrient Data Laboratory Home
    Page,http://www.ars.usda.gov/ba/bhnrc/ndl.

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Clinical evaluation calcium

  • 1. Ken-Won Miller Howard University Nutrition Care Management 1 Dr. Castor
  • 2. Introduction   This presentation will focus mainly on the role of calcium intake and the manifestations of calcium deficiencies.
  • 3. Nutrients   Nutrients are essential and all play a key role to survival of the human organism.  Water  Energy yielding nutrients  Carbohydrates, Protein, Lipids (Fat)  Vitamins (organic)  Fat soluble, Water soluble  Minerals (inorganic)  Macro, Trace
  • 4. Minerals  Macro-minerals Trace minerals.  Calcium  Manganese  Phosphorus  Copper  Magnesium  Iodine  Sodium  Zinc  Potassium  Cobalt  Chloride  Fluoride  Sulfur  Selenium
  • 5. What is Calcium   Calcium is the most abundant mineral in the body  This mineral is naturally found in foods, added to some, available as a dietary supplement, and present in some medicines  Most of the body’s calcium is found in bones and teeth.  Estimated to be 99% of calcium in the body  Approx 1.5-2% of the body weight  An adequate intake helps grow a healthy skeleton in early life and minimize bone loss later in life
  • 6. Calcium in Bones   Calcium salts form crystals called hydroxyapatite on a matrix of the protein collagen.  Mineralization of calcium, phosphorus, and other minerals crystallize and harden the bones.  The bones gain strength and rigidity as they harden.
  • 7. Calcium in Bones   Bones are not like solid rock  Bones gain and lose minerals continuously in an ongoing process of remodeling.  The balance between bone resorption and deposition changes with aging.  The lack of homeostasis can lead to manifestations of clinical problems and cause a disease state.
  • 8. Calcium in Body Fluids   %1 of the body’s calcium circulates in the fluid as ionized calcium that is vital to life.  The serum calcium is highly regulated and doesn’t fluctuate with variations in dietary intakes  Calcium also activates a protein called calmodulin  Calmodulin (a inactive protein) is activated by calcium  It then becomes a messenger that tells other proteins what to do and serves as an interpreter for hormone and nerve mediated messages arriving at cells
  • 9. Calcium in Body Fluids   vascular contraction and vasodilatation  muscle function  nerve transmission  intracellular signaling  hormonal secretion  Role in maintaining normal blood pressure
  • 10. Recommended Dietary Allowance (RDA):  RDAs for the amounts of calcium required for bone health and to maintain adequate rates of calcium retention in healthy people. Table 1: Recommended Dietary Allowances (RDAs) for Calcium [1] Age Male Female Pregnant Lactating 0–6 200 mg 200 mg months* 7–12 260 mg 260 mg months* 1–3 years 700 mg 700 mg 4–8 years 1,000 mg 1,000 mg 9–13 years 1,300 mg 1,300 mg 14–18 years 1,300 mg 1,300 mg 1,300 mg 1,300 mg 19–50 years 1,000 mg 1,000 mg 1,000 mg 1,000 mg 51–70 years 1,000 mg 1,200 mg 71+ years 1,200 mg 1,200 mg * Adequate Intake (AI)
  • 11. Foods that Contain Calcium   Calcium is found in a variety of foods.  Dairy Foods  Milk, yogurt, and cheese are the most popular choice in the US.  Leafy Greens  Kale, broccoli, and Chinese cabbage are vegetable source  Fish  Canned sardines and salmon  Most grains (such as breads, pastas, and unfortified cereals), while not rich in calcium, add significant amounts of calcium to the diet because people eat them often in large amounts.  Fortified foods  Breakfast cereals, fruit juices, soy(Silk) and rice beverages, and tofu.
  • 12. Medicines that Contain Calcium   The two main forms of calcium in supplements are carbonate and citrate  Calcium carbonate is found in some over-the-counter antacid products, such as Tums® and Rolaids®.
  • 13. Calcium Balance   Homeostasis of calcium is one of the body’s most important priorities.  Bone tissue is used as a reservoir and a source of calcium, to maintain constant concentrations of calcium in muscles, blood, and intercellular fluids.  Vitamin D and other hormones play a essential role as well in balancing levels  Three organs play a key role in calcium levels 1. The intestines 2. Bones 3. Kidneys
  • 14. Calcium Balance   Parathormone (Parathyroid hormone)  A hormone from the parathyroid glands that regulates blood calcium by raising it when levels fall too low  Calcitonin  A hormone from the thyroid gland that regulates blood calcium by lowering it when levels rise too high
  • 15.
  • 16. Absorption of Calcium  Calcium is absorbed by all parts of the small intestine Two mechanisms of absorption  Active transport and passive diffusion It is best absorbed in an acidic medium Lactose and vitamin D enhances calcium absorption The efficiency of absorption decreases as calcium intake increases
  • 17. Likelihood of Deficiency   Dietary surveys indicate that many people do not meet the Adequate Intake for calcium, especially women  Consuming foods to maintain adequate vitamin D status improve absorption  Dietary inadequacy is not likely if protein and calcium intake are adequate  Stimulants in coffee and tea can discreetly increase calcium excretion and reduce absorption in the GI tract  Phytic acid found in whole-grain breads can decrease availability
  • 18. Lab Values for Nutritional Assessment   The normal levels for ionized (free) Ca2+  4.64-5.28 mg/dL  The normal levels for total serum Ca2+ (bound and unbound)  8.6-10 mg/dL  Status is related to many factors, including vit D, vit K, phosphate, parathyroid function, and medications
  • 19. Lab Values for Nutritional Assessment   Hypercalcemia (High Calcium Levels)  Associated with endocrine disorders, malignancy, and hypervitaminosis D  Hypocalcemia (Low Calcium Levels)  Associated with Vit D deficiency and inadequate hepatic or renal activation of Vit D, hypoparathyroidism, magnesium deficiency, renal failure, and nephrotic syndrome
  • 20. Hypoparathyroidism   Hypoparathyroidism is the result of a decrease in production of parathyroid hormones by the parathyroid glands located behind the thyroid glands in the neck.  Usually occurs after a surgery where the parathyroid glands are removed.  The result is a low level of calcium in the blood or hypocalcemia.
  • 21. Assessment Tools   Dual-Energy X-ray absorptiometry (DXA) is thought to be one of the best tools for assessing bone mineral density  Very important in early detection, treatment, and monitoring of osteoporosis  Preferred approach for measuring BMD  Measures bone mineral content at axial and appendicular sites  Monitors changes over time  Low radiation exposure  Superior quality control procedures  Computerized tomography (CT) scans measure variances in tissue density. This method is less precise and accurate than DXA
  • 22. Osteoporosis (Adult Bone Loss)   Disease in which the bones become porous and fragile due to a loss of minerals  Bone strength is a function of two factors  Bone mineral density and bone quality  BMD is determined by peak bone mass and BQ relates to bone architecture, bone turnover, mineralization, and the accumulation of damage to the bone  Peak in bone mass= late 20’s early 30’s
  • 23. Classification   Primary-not related to other disease  Mostly seen in middle aged females and older men/females  Males have greater bone mass  Secondary-identifiable cause other than age or menopause is present  Cushing’s syndrome, myeloma, hyperthyroidism, amenorrhea, medicines( thiazide diuretics and heparin)
  • 24. Osteoporosis  • Leads to a greater risk of fractures • Fractures in the hip, vertebrae, pelvis, humerus, distal forearm • Females more likely to have fractures
  • 25. Five Steps to Optimize Bone Health  1. Maintain a balance diet rich in calcium and vitamin D. 2. Participate in regular, weight-bearing exercise. 3. Practice a healthy lifestyle with no smoking or excessive alcohol intake 4. Talk to health care professional about bone health 5. If indicated, obtain bone mineral density testing and take medication, if appropriate
  • 26. In conclusion   Calcium is the most abundant mineral in the body and is mostly found in bones and teeth.  %1 of the body’s calcium circulates in the fluid as ionized calcium that is vital to life and homeostasis  Many people become deficient in calcium especially those suffering from illness and the elderly  It is important for dietitians to thoroughly evaluate patients for calcium defiency and provide nutritional intervention if needed.
  • 27. References   Chung M, Balk EM, Brendel M, et al. Vitamin D and Calcium: A Systematic Review of Health Outcomes. Rockville (MD): Agency for Healthcare Research and Quality (US); 2009 Aug. (Evidence Reports/Technology Assessments, No. 183.) 1, Introduction. Available from: http://www.ncbi.nlm.nih.gov/books/NBK32605/  National Institutes of Health. Optimal calcium intake. NIH Consensus Statement: 1994;12:1-31. [PubMed abstract]  2 Overview of Calcium." Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: The National Academies Press, 2011.  Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA. Clarification of DRIs for calcium and vitamin D across age groups. J Am Diet Assoc. 2011 Oct;111(10):1467. [PubMed abstract]  U.S. Department of Agriculture, Agricultural Research Service. 2011. USDA National Nutrient Database for Standard Reference, Release 24. Nutrient Data Laboratory Home Page,http://www.ars.usda.gov/ba/bhnrc/ndl.