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Chronic Kidney Disease What You Need to Know Phil Ramos, MD, MSCI Denver Nephrologists, P.C.
Objectives ,[object Object],[object Object],[object Object],[object Object],[object Object]
The Kidney ,[object Object],[object Object],[object Object],[object Object]
The Nephron ,[object Object],[object Object],[object Object],[object Object]
Other Important Functions ,[object Object],[object Object],[object Object],[object Object]
Estimating Kidney Function ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What is Chronic Kidney Disease ,[object Object],[object Object],[object Object],[object Object],National Kidney Foundation (NKF).  Am J Kidney Dis.  2002;39(2 suppl 1):S1-S266.
CKD Progresses in Stages (Defined by eGFR) NKF.  Am J Kidney Dis.  2002;39(2 suppl 1):S1-S266.  CKD Stage Description GFR  (mL/min/1.73 m 2 ) 1 Kidney damage with normal or    GFR  90 2 Kidney damage with  mild    GFR 60-89 3 Moderate    GFR 30-59 4 Severe    GFR 15-29 5 Kidney failure <15 or dialysis
The Epidemic of CKD ,[object Object],[object Object],[object Object]
CKD Is a Growing Epidemic CKD  Stage Number of Individuals*  1  90 3.6 million   2 60-89   6.5 million     3 30-59 15.5 million 4 15-29 700,000 5 <15 or dialysis 500,000 GFR (mL/min/1.73 m 2 ) *Coresh et al. JAMA; 298 (17): 2038 (2007) United States Renal Data System, 2008
Risk Factors for CKD ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Diabetic Kidney Disease
Hypertension Kidney Disease
Medication Risk Factors: NSAID’s ,[object Object],[object Object],[object Object],[object Object],Gooch, K. et. al. Am J Med 2007;120.
NSAID’s ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Signs/Symptoms of CKD ,[object Object],[object Object],[object Object],[object Object],[object Object]
Signs/Symptoms of End Stage Renal Disease (ESRD) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Signs/Symptoms of End Stage Renal Disease (ESRD) ,[object Object],[object Object],[object Object]
Blood and Urine Results in CKD/ESRD ,[object Object],[object Object],[object Object],[object Object],[object Object]
Urinary Tract Obstruction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Kidney Cysts ,[object Object],[object Object]
Which Patients Should Be  Screened  for CKD? Levey et al.  Ann Intern Med . 2003;139:137-147.  USRDS. 1999 Annual Data Report. Available at: www.usrds.org. Susceptibility Risk Factors Progression Factors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Primary Goals of Management in CKD ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Primary Goals of Management in CKD ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ESRD and Hemodialysis ,[object Object],[object Object],[object Object],[object Object]
ESRD and Peritoneal Dialysis ,[object Object],[object Object],[object Object],[object Object]
Renal Transplantation ,[object Object],[object Object],[object Object]
Prevention of CKD Most Important ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 

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Chronic Kidney Disease - What You Need to Know

  • 1. Chronic Kidney Disease What You Need to Know Phil Ramos, MD, MSCI Denver Nephrologists, P.C.
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  • 8. CKD Progresses in Stages (Defined by eGFR) NKF. Am J Kidney Dis. 2002;39(2 suppl 1):S1-S266. CKD Stage Description GFR (mL/min/1.73 m 2 ) 1 Kidney damage with normal or  GFR  90 2 Kidney damage with mild  GFR 60-89 3 Moderate  GFR 30-59 4 Severe  GFR 15-29 5 Kidney failure <15 or dialysis
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  • 10. CKD Is a Growing Epidemic CKD Stage Number of Individuals* 1  90 3.6 million 2 60-89 6.5 million 3 30-59 15.5 million 4 15-29 700,000 5 <15 or dialysis 500,000 GFR (mL/min/1.73 m 2 ) *Coresh et al. JAMA; 298 (17): 2038 (2007) United States Renal Data System, 2008
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Editor's Notes

  1. Majority of Stage 3-4 patients are dying from CV deaths