Chlorine was discovered in 1774 and named in 1810. It is a yellow-green gas that is heavier than air and has a pungent odor. Chlorine is widely used for water purification and in household cleaning products. Exposure to chlorine can irritate the skin, eyes, and respiratory system, and cause coughing, chest pain, and fluid in the lungs. If exposed, quickly leave the area, remove clothing, and wash the entire body with soap and water. Seek medical help immediately.
Chlorine is the non-metallic chemical element, symbol Cl, Chlorine is a highly poisonous, greenish yellow gas, about two and a half times as dense as air, and with a strong, sharp, choking odor.
Chlorine is the most abundant member of the halogen family of periodic table elements. Chlorine is an important chemical in our day-to-day life. Chlorine is a clear amber-colored liquid about 1.5 times heavier than water.
Chlorine is the non-metallic chemical element, symbol Cl, Chlorine is a highly poisonous, greenish yellow gas, about two and a half times as dense as air, and with a strong, sharp, choking odor.
Chlorine is the most abundant member of the halogen family of periodic table elements. Chlorine is an important chemical in our day-to-day life. Chlorine is a clear amber-colored liquid about 1.5 times heavier than water.
Chlorine is one of the most active of all elements.
It combines with all elements except the noble gases of Group 18 of the periodic table. Chlorine does not undergo combustion, although it does support combustion in much the same way as does oxygen. This module highlights the importance of chlorine.
Chlorine is the non-metallic chemical element, symbol Cl, Chlorine is a highly
poisonous, greenish yellow gas, about two and a half times as dense as air, and
with a strong, sharp, choking odor. It was, in fact, one of the first poisonous gases
used in warfare—in 1915 during World War I.one of roughly 90 basic building
blocks of matter. Naturally chemically reactive, chlorine’s tendency to combine
with other elements and compounds has been used to produce thousands of
essential products.
Profitable Business Ideas in Manufacturing of Chlorinated Paraffin Wax (CPW) ...Ajjay Kumar Gupta
Profitable Business Ideas in Manufacturing of Chlorinated Paraffin Wax (CPW) Industry. Opportunities in Chlorinated Paraffin’s Project.
Chlorinated Heavy Normal paraffin is a replacement of chlorinated paraffin wax. The method of manufacturing of both the products is the same and so is the end-use. Apart from above the best part of Chlorinated Heavy Normal Paraffin is that in this product maximum Chlorination which can be achieved is 70% while in chlorinated paraffin wax it is 60%. It is used as secondary plasticizer for Polyvinyl Chloride resins, plasticizer extender in synthetic rubber, Nitrocellulose, polystyrene etc. It is also used for impregnating textile and fabrics of all kinds as a flame retardant. It also finds application in paint industry for manufacturing of fire proof paints. It is widely used in foundry industry.
For More Details, Click Here:- https://niir.org/profile-project-reports/profiles/petroleum-petroleum-products-refining-greases-lube-oil-brake-fluid-automotive-amp-industrial-lubricants-gear-oils-wax-amp-wax-products-paraffin-wax-polishes-bitumen-base-oil-crude-oil-fuel-oils-lubricating-oils-gear-oils-kerosene/z,,18,46,a/index.html?_sort_by=default
Contact us:
Niir Project Consultancy Services
An ISO 9001:2015 Company
106-E, Kamla Nagar, Opp. Spark Mall,
New Delhi-110007, India.
Email: npcs.ei@gmail.com , info@entrepreneurindia.co
Tel: +91-11-23843955, 23845654, 23845886, 8800733955
Mobile: +91-9811043595
Website: www.entrepreneurindia.co , www.niir.org
It deals with biological water quality improvement through disinfection, disinfectants and disinfection kinetics, chlorine and other commonly used disinfectants, breakpoint chlorination and chlorination system
Chlorine is one of the most active of all elements.
It combines with all elements except the noble gases of Group 18 of the periodic table. Chlorine does not undergo combustion, although it does support combustion in much the same way as does oxygen. This module highlights the importance of chlorine.
Chlorine is the non-metallic chemical element, symbol Cl, Chlorine is a highly
poisonous, greenish yellow gas, about two and a half times as dense as air, and
with a strong, sharp, choking odor. It was, in fact, one of the first poisonous gases
used in warfare—in 1915 during World War I.one of roughly 90 basic building
blocks of matter. Naturally chemically reactive, chlorine’s tendency to combine
with other elements and compounds has been used to produce thousands of
essential products.
Profitable Business Ideas in Manufacturing of Chlorinated Paraffin Wax (CPW) ...Ajjay Kumar Gupta
Profitable Business Ideas in Manufacturing of Chlorinated Paraffin Wax (CPW) Industry. Opportunities in Chlorinated Paraffin’s Project.
Chlorinated Heavy Normal paraffin is a replacement of chlorinated paraffin wax. The method of manufacturing of both the products is the same and so is the end-use. Apart from above the best part of Chlorinated Heavy Normal Paraffin is that in this product maximum Chlorination which can be achieved is 70% while in chlorinated paraffin wax it is 60%. It is used as secondary plasticizer for Polyvinyl Chloride resins, plasticizer extender in synthetic rubber, Nitrocellulose, polystyrene etc. It is also used for impregnating textile and fabrics of all kinds as a flame retardant. It also finds application in paint industry for manufacturing of fire proof paints. It is widely used in foundry industry.
For More Details, Click Here:- https://niir.org/profile-project-reports/profiles/petroleum-petroleum-products-refining-greases-lube-oil-brake-fluid-automotive-amp-industrial-lubricants-gear-oils-wax-amp-wax-products-paraffin-wax-polishes-bitumen-base-oil-crude-oil-fuel-oils-lubricating-oils-gear-oils-kerosene/z,,18,46,a/index.html?_sort_by=default
Contact us:
Niir Project Consultancy Services
An ISO 9001:2015 Company
106-E, Kamla Nagar, Opp. Spark Mall,
New Delhi-110007, India.
Email: npcs.ei@gmail.com , info@entrepreneurindia.co
Tel: +91-11-23843955, 23845654, 23845886, 8800733955
Mobile: +91-9811043595
Website: www.entrepreneurindia.co , www.niir.org
It deals with biological water quality improvement through disinfection, disinfectants and disinfection kinetics, chlorine and other commonly used disinfectants, breakpoint chlorination and chlorination system
Chloromethanes namely methyl chloride (CH3Cl), methylene chloride (CH2Cl2), Chloroform (CHCl3) and Carbon Tetrachloride (CCl4) are produced by direct chlorination of Cl2 in a gas phase reaction without any catalyst.
Why is chlorine dioxide better than chlorine in treating waterGO2International
Although chlorine dioxide and chlorine are both oxidizing agents, ClO2 has a higher oxidation capacity making it at least 2.6 times more powerful per ppm.
In biology, poisons are substances that can cause death, injury or harm to organs, tissues, cells, and DNA usually by chemical reactions or other activity on the molecular scales, when an organism is exposed to a sufficient quantity.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
2. Discovered in 1774 by Carl Wilhelm Scheele, who mistakenly
thought it contained oxygen. Chlorine was given its name in 1810 by
Humphry Davy, who insisted that it was in fact an element. The
name chlorine is derived from chloros, meaning green, referring to
the color of the gas.
Chlorine in Periodic Table
Symbol: Cl Atomic number: 17
Electron configuration: [Ne] 3s23p5 Electronegativity: 3.16
Boiling point: -34.04 °C Atomic mass: 35.453 ± 0.002 u
Chlorine gas can be recognized by its pungent, irritating odor,
which is like the odor of bleach. The strong smell may provide
adequate warning to people that they are exposed.
INTRODUCTION
3. Chlorine (Cl2) is among the ten highest volume chemicals
manufactured in the United States. It is produced commercially by
electrolysis of sodium chloride brine. Chlorine is used in industry
and in household cleaning products. Chlorine was also the first
poison gas to be used as a weapon during World War I.
Chlorine is a yellow-green gas at room temperature.
Chlorine has a pungent, irritating odor similar to bleach that is
detectable at low concentrations.
The density of chlorine gas is approximately 2.5 times greater than
air, which will cause it to initially remain near the ground in areas
with little air movement.
Chlorine is not flammable, but may react explosively or form
explosive compounds with many common substances.
Chlorine is slightly water soluble, and reacts with moisture to form
hypochlorous acid (HClO) and hydrochloric acid (HCl).
Chlorine is commonly pressurized and cooled for storage and
shipment as an amber-colored liquid.
MORE ABOUT CHLORINE
4. Chlorine is an important chemical in water purification,
in disinfectants, in bleach and in mustard gas.
Chlorine is also used widely in the manufacture of many products
and items directly or indirectly, i.e. in paper product production,
antiseptic, dyestuffs, food, insecticides, paints, petroleum
products, plastics, medicines, textiles, solvents, and many other
consumer products.
It is used to kill bacteria and other microbes from drinking water
supplies.
Chlorine is involved in beaching wood pulp for paper making,
bleach is also used industrially to remove ink from recycle paper.
Chlorine often imparts many desired properties in an organic
compound when it is substituted for hydrogen (synthetic rubber),
so it is widely use in organic chemistry, in the production of
chlorates, chloroform, carbon tetrachloride, and in
the bromine extraction.
APPLICATIONS
5. Chlorine dissolves when mixed with water. It can also escape
from water and enter air under certain conditions. Most direct
releases of chlorine to the environment are to air and to surface
water.
Once in air or in water, chlorine reacts with other chemicals. It
combines with inorganic material in water to form chloride salts,
and with organic material in water to form chlorinated organic
chemicals.
Because of its reactivity chlorine is not likely to move through the
ground and enter groundwater.
Plants and animals are not likely to store chlorine. However,
laboratory studies show that repeat exposure to chlorine in air
can affect the immune system, the blood, the heart, and the
respiratory system of animals.
Chlorine causes environmental harm at low levels. Chlorine is
especially harmful to organisms living in water and in soil.
ENVIRONMENTAL EFFECTS OF CHLORINE
6. Chlorine is a highly reactive gas. It is a naturally occurring element.
The largest users of chlorine are companies that make ethylene
dichloride and other chlorinated solvents, polyvinyl chloride (PVC)
resins, chlorofluorocarbons, and propylene oxide. Paper companies
use chlorine to bleach paper. Water and wastewater treatment
plants use chlorine to reduce water levels of microrganisms that can
spread disease to humans (disinfection).
Exposure to chlorine can occur in the workplace or in the
environment following releases to air, water, or land. People who use
laundry bleach and swimming pool chemicals containing chlorine
products are usually not exposed to chlorine itself. Chlorine is
generally found only in industrial settings.
Chlorine enters the body breathed in with contaminated air or when
consumed with contaminated food or water. It does not remain in
the body, due to its reactivity.
HEALTH EFFECTS OF CHLORINE
7. Effects of chlorine on human health depend on how the amount of
chlorine that is present, and the length and frequency of exposure.
Effects also depend on the health of a person or condition of the
environment when exposure occurs.
Breathing small amounts of chlorine for short periods of time
adversely affects the human respiratory system. Effects differ from
coughing and chest pain, to water retention in the lungs. Chlorine
irritates the skin, the eyes, and the respiratory system. These
effects are not likely to occur at levels of chlorine that are normally
found in the environment.
Human health effects associated with breathing or otherwise
consuming small amounts of chlorine over long periods of time are
not known. Some studies show that workers develop adverse effects
from repeat inhalation exposure to chlorine, but others will not.
HEALTH EFFECTS OF CHLORINE C O N T I N U E . .
8. People’s risk for exposure depends on how close they are to the
place where the chlorine was released.
If chlorine gas is released into the air, people may be exposed
through skin contact or eye contact. They also may be exposed by
breathing air that contains chlorine.
If chlorine liquid is released into water, people may be exposed by
touching or drinking water that contains chlorine.
If chlorine liquid comes into contact with food, people may be
exposed by eating the contaminated food.
Chlorine gas is heavier than air, so it would settle in low -lying
areas.
HOW CAN PEOPLE BE EXPOSED TO CHLORINE
9. The health effects resulting from
most chlorine exposures begin within
seconds to minutes. The severity of the
signs and symptoms caused by chlorine
will vary according to amount, route and
duration of exposure.
Inhalation: Most chlorine exposures
occur via inhalation. Low level exposures
to chlorine in air will cause
eye/skin/airway irritation, sore throat
and cough. Chlorine's odor provides
adequate early warning of its presence,
but also causes olfactory fatigue or
adaptation, reducing awareness of one's
prolonged exposure at low
concentrations
IMMEDIATE SYMPTOMS OF
CHLORINE EXPOSURE
10. Ingestion: Since chlorine is a gas at
room temperature, it is unlikely that a
severe exposure will result from
ingestion. However, ingestion of chlorine
dissolved in water (e.g., sodium
hypochlorite or household bleach) will
cause corrosive tissue damage of the
gastrointestinal tract.
Eye/Dermal Contact: Low level
exposures to chlorine gas will cause eye
and skin irritation. Higher exposures may
result in severe chemical burns or
ulcerations. Exposure to compressed
liquid chlorine may cause frostbite of
the skin and eyes
IMMEDIATE SYMPTOMS OF
CHLORINE EXPOSURE C O N T I N U E . .
11. During or immediately after exposure to
dangerous concentrations of chlorine, the
following signs and symptoms may develop:
Blurred vision
Burning pain, redness, and blisters on the skin if
exposed to gas. Skin injuries similar to frostbite can
occur if it is exposed to liquid chlorine
Burning sensation in the nose, throat, and eyes
Coughing and Chest tightness
Fluid in the lungs (pulmonary edema) that may be
delayed for a few hours
Nausea and vomiting
Watery eyes
Showing these signs or symptoms does not
necessarily mean that a person has been
exposed to chlorine.
IMMEDIATE SYMPTOMS OF
CHLORINE EXPOSURE C O N T I N U E . .
12. Leave the area where the chlorine was
released and get to fresh air. Quickly
moving to an area where fresh air is
available is highly effective in reducing
exposure to chlorine.
If the chlorine release was outdoors, move away
from the area where the chlorine was released.
Go to the highest ground possible, because
chlorine is heavier than air and will sink to low-
lying areas.
If the chlorine release was indoors, get out of
the building.
If you think you may have been exposed,
remove your clothing, rapidly wash your
entire body with soap and water, and get
medical care as quickly as possible.
HOW PEOPLE CAN PROTECT THEMSELVES
13. Removing and disposing of clothing:
Quickly take off clothing that has liquid chlorine on
it. Any clothing that has to be pulled over the head
should be cut off the body instead of pulled over the
head. If possible, seal the clothing in a plastic bag.
Then seal the first plastic bag in a second plastic
bag. Removing and sealing the clothing in this way
will help protect you and other people from any
chemicals that might be on your clothes.
If you placed your clothes in plastic bags, inform
either the local or state health department or
emergency personnel upon their arrival. Do not
handle the plastic bags.
If you are helping other people remove their
clothing, try to avoid touching any contaminated
areas, and remove the clothing as quickly as
possible.
HOW PEOPLE CAN PROTECT THEMSELVES
C O N T I N U E …
14. Washing the body:
As quickly as possible, wash your entire body with
large amounts of soap and water. Washing with
soap and water will help protect people from any
chemicals on their bodies.
If your eyes are burning or your vision is blurred,
rinse your eyes with plain water for 10 to 15
minutes. If you wear contacts, remove them before
rinsing your eyes, and place them in the bags with
the contaminated clothing. Do not put the contacts
back in your eyes. If you wear eyeglasses, wash
them with soap and water. You can put the
eyeglasses back on after you wash them.
If you have swallowed (ingested) chlorine, do
not induce vomiting or drink fluids.
Seek medical attention right away. Consider
dialing 911 and explaining what has
happened
HOW PEOPLE CAN PROTECT THEMSELVES
C O N T I N U E …