The document provides an overview of major artists and artistic developments during the High Renaissance and Mannerism periods in the 15th-17th centuries. Key figures discussed include Leonardo da Vinci, Michelangelo, Raphael, and Titian. Their most famous works incorporating developments in areas like anatomy, perspective, and new styles are described, as well as architectural achievements of the time. The emergence of Mannerism as a more elegant and sophisticated style is also covered.