C–H bond hydroxylation at non heme carboxylate-bridged diiron centers
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This unit provides an overview of how Nature has inspired the development of novel diiron bridged complexes for use in C–H Hydroxylation. Contributed by Omar Villanueva and Cora MacBeth, Emory University, 2014
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Elastic properties of various poly(hydroxybutyrate) (PHB) molecular conformations were examined using molecular mechanics calculations. Force-distance functions and Young's moduli were computed by stretching PHB molecules. Unwinding the helical conformation is initially characterized by a Young's modulus of 1.8 GPa. At higher strains, the helix transforms into a highly extended twisted form. In contrast to paraffins, planar PHB is bent, attaining maximum length in straightened but twisted conformations. Single-chain moduli depend on chain extension. Computed data were used to analyze elastic response of tie molecules in the interlamellar region of semi-crystalline PHB and how their
CH 105_Topic IV_Bioinorganic Chemistry_.pdf
This document discusses bioinorganic chemistry concepts related to oxygen transport and binding. It begins by outlining the relevance of bioinorganic chemistry and how oxygen is a key player. It then discusses hemoglobin and its reversible oxygen binding, explaining the differential binding abilities of hemoglobin and myoglobin. The document attributes this difference to their structural properties. It further explores the cooperativity effect in hemoglobin due to structural changes upon oxygen binding. In summary, the document examines how inorganic elements and oxygen play important roles in biological processes related to respiration and energy transduction.
Fielding_DoctoralResearch
Andrew Fielding's doctoral research focused on understanding the mechanism of O2 activation and catalysis by two similar catechol dioxygenases: Fe(II)-homoprotocatechuate 2,3-dioxygenase (Fe-HPCD) and Mn(II)-MndD. He prepared and characterized the cobalt-substituted variant of HPCD, which showed higher activity than Mn- or Fe-HPCD despite Co(II) being a poorer reducing agent. Using electron-poor substrate analogs, he was able to trap and characterize three O2 intermediates by EPR, providing new insights into dioxygenase mechanisms. Comparing the properties of different metal-substituted enzymes allowed full characterization
2- Chemistry of Life I
The document provides information about an upcoming chemistry lab class including required dress and that there are no assignments due the first week. It then summarizes the key topics to be covered in Chapter 2 including the four major classes of organic compounds (carbohydrates, lipids, proteins, nucleic acids). Carbohydrates are discussed in detail, noting that they are made of carbon, hydrogen, and oxygen and can exist as monosaccharides (simple sugars), disaccharides, or polysaccharides. Examples such as glycogen, starch, and cellulose are provided.
CMBHEngineeringandPurificationPEDS
This document summarizes the engineering and characterization of a soluble cytoplasmic subcomplex (C-MBH) of the membrane-bound respiratory hydrogenase (MBH) from the hyperthermophilic archaeon Pyrococcus furiosus. The researchers engineered a P. furiosus strain that differentially expresses the 14-gene MBH operon, producing a 4-subunit C-MBH complex containing an affinity tag. They purified the C-MBH using affinity chromatography without detergent. The purified C-MBH had catalytic activity and generated hydrogen from the physiological electron donor reduced ferredoxin, optimally at 60°C. This is the first report of engineering and characterizing a soluble
Green synthesis of iron-organic framework Fe-BTC using direct ultrasound to r...
Metal-organic framework materials (MOFs) comprise organic bridges and metal centers (as connection points). MOFs have unique properties such as crystal structure, large specific surface area, flexible structural framework, and can change the size and shape of pores and diverse chemical functional groups inside the pores. In this study, metal-organic framework materials based on iron (Fe) and the organic ligand H3BTC were successfully synthesized by ultrasonic method and evaluated for their ability to remove MB dye through Investigate the effects of MB concentration, pH, isotherm model, and adsorption kinetics. With a size of about 100 - 200 nm and an excitation wavelength in the ultraviolet region, the synthesized material shows potential in environmental treatment when the adsorption efficiency reaches over 60% after just 10 minutes and over 80% both processes under sunlight conditions. In addition, the synthesized material is also evaluated to have selective adsorption with Methylene Blue dye.
One pot synthesis of cu(ii) 2,2′ bipyridyl complexes of 5-hydroxy-hydurilic acid
This document describes the one-pot synthesis of two new copper(II) complexes containing the ligands 5-hydroxy-hydurilic acid (complex 1) and alloxanic acid (complex 2) from the reaction of a barbiturate derivative (LH4) with Cu(II) 2,2'-bipyridyl complexes. It also reports the synthesis of a third complex (complex 3) from the reaction of LH4 with copper nitrate that retains the ligand framework. The complexes were characterized using X-ray crystallography, spectroscopy, and electrochemistry. Complexes 1 and 3 were found to cleave DNA and showed cytotoxic activity against cancer cells, while complex 2 was insoluble and not
One pot synthesis of cu(ii) 2,2′ bipyridyl complexes of 5-hydroxy-hydurilic acid
This document describes the one-pot synthesis of three copper(II) complexes with 2,2'-bipyridine and derivatives of a barbiturate ligand. Complex 1 contains 5-hydroxy-hydurilic acid, complex 2 contains alloxanic acid, and complex 3 retains the original barbiturate ligand framework. The complexes were characterized using X-ray crystallography, spectroscopy, and thermal analysis. Their interactions with DNA were studied through absorption and emission titrations as well as circular dichroism. Complexes 1 and 3 were found to cleave plasmid DNA. Their cytotoxicity against T-cell lymphoma cells was also evaluated.
Chemoinformatics
This document provides an overview of the field of chemoinformatics. It defines chemoinformatics as the combination of chemistry and information technology used to process and analyze chemical data. The document discusses common representations of molecules including 1D, 2D, and 3D formats. It also outlines several common file formats used in chemoinformatics like Mol, SDF, and SMILES. Finally, it describes several important chemical databases, including PubChem, ChemBank, ChEMBL, and DrugBank, and gives examples of chemoinformatics applications such as virtual screening and QSAR modeling.
Encyclopedia of physical science and technology polymers 2001
This document provides a table of contents for an encyclopedia on physical science and technology. It lists 14 articles related to polymers, including biopolymers, macromolecules, plastics engineering, polymer processing, and polymers with various electronic, mechanical, photoresponsive, and thermal properties. Each article is 1-3 pages long and provides information on a specific topic within the subject area of polymers.
Catalyst Advancements in Microbial Fuel Cells: Pioneering Renewable Energy So...
Microbial Fuel Cells (MFCs) harness the power of microorganisms to convert organic matter into electricity while treating wastewater. By utilizing various biomass sources like wood, food waste, and sewage sludge, MFCs offer a sustainable solution for renewable energy production without competing with food sources. Originally conceptualized in 1911 by Potter, MFC technology has evolved, utilizing catalysts like Escherichia coli and Saccharomyces cerevisiae, and electrodes such as platinum. Over time, advancements have led to the elimination of artificial mediators, with bacteria directly transferring electrons to electrodes. MFCs stand as a promising avenue for clean energy generation, aligning with the imperative to mitigate climate change and reduce reliance on fossil fuels.
Similar to C–H bond hydroxylation at non heme carboxylate-bridged diiron centers (20)
The Influence of a New-Synthesized Complex Compounds of Ni (II), Cu (II) And ...
The Influence of a New-Synthesized Complex Compounds of Ni (II), Cu (II) And ...
Biocompatible Molybdenum Complexes Based on Terephthalic Acid and Derived fro...
Biocompatible Molybdenum Complexes Based on Terephthalic Acid and Derived fro...
Green synthesis of iron-organic framework Fe-BTC using direct ultrasound to r...
Green synthesis of iron-organic framework Fe-BTC using direct ultrasound to r...
One pot synthesis of cu(ii) 2,2′ bipyridyl complexes of 5-hydroxy-hydurilic acid
One pot synthesis of cu(ii) 2,2′ bipyridyl complexes of 5-hydroxy-hydurilic acid
One pot synthesis of cu(ii) 2,2′ bipyridyl complexes of 5-hydroxy-hydurilic acid
One pot synthesis of cu(ii) 2,2′ bipyridyl complexes of 5-hydroxy-hydurilic acid
Encyclopedia of physical science and technology polymers 2001
Encyclopedia of physical science and technology polymers 2001
Catalyst Advancements in Microbial Fuel Cells: Pioneering Renewable Energy So...
Catalyst Advancements in Microbial Fuel Cells: Pioneering Renewable Energy So...
More from Daniel Morton
CH Functionalizations on Electron-Deficient Aromatics in the synthesis of Pi-...
This document discusses the use of C-H functionalization catalysis to incorporate electron-deficient moieties into conjugated materials without needing to first install reactive halides or stannanes. Electron-deficient moieties are important for electronic materials as they can tune optical properties and transport characteristics. Direct C-H functionalization avoids harsh halogenation steps and bypasses instability issues of stannanes. Examples are given of one-pot syntheses using this approach to obtain up to 96% yields of differentially substituted electron-accepting building blocks. Challenges include controlling reaction selectivity when multiple C-H bonds on a moiety could potentially react.
Collagen triple helix stability
Collagen is made up of the repeating pattern Glycine-X-Y, where X and Y are commonly L-proline (Pro) and 4(R)-hydroxy-l-proline (Hyp), respectively. By substituting X and Y with a fluorine probe, stereoelectronic effects can be observed and compared to the effects of hydrogen bonding which has been predicted to be the main contributor to the collagen triple helix strength.
Contributed by: Alexandra Zudova, Samuel Broadbent (Undergraduates), University of Utah, 2013
Bio inspired metal-oxo catalysts for c–h bond functionalization
Metal-oxo complexes are important species in the activation of strong C–H bonds in biological systems. The high reactivity of metal-oxo complexes results from the way their valence electrons are arranged, and this arrangement depends strongly on the geometry around the metal center.
Contributed by: A.S. Borovik and Sarah Cook, University of California-Irvine, 2014
Fischer and schrock carbenes
A carbene is any neutral carbon species which contains a non-bonding valance pair of electrons.
Contributed by Alison Brown & Nathan Buehler, Undergraduates, University of Utah
Hammett parameters
The document discusses the Hammett plot, which is a linear free-energy relationship analysis used to model the electronic effects of substituents on aromatic systems. It describes how σ values are derived from ionization reactions to indicate whether a substituent is electron-donating or electron-withdrawing. These σ values can then be used to analyze reaction mechanisms and optimize reaction conditions for similar processes. Examples are given of how split Hammett plots reveal changing mechanisms depending on the electronic nature of the substituent. Problems involving interpreting ρ values in Hammett plots to determine reaction pathways are also presented.
Aryl fluorination
Organic Pedagogical Electronic Network
Aryl Fluorination
This document summarizes aryl fluorination, an important reaction for introducing fluorine groups onto aromatic rings. It notes that two of the top 10 grossing drugs, Lipitor and Reserdal, contain aryl fluorines. The mechanism proceeds through oxidation of an aryl group to a high valent metal species, followed by transmetalation and reductive elimination to introduce the fluorine. Examples are given of stoichiometric and catalytic aryl fluorination reactions using Selectfluor and silver oxide catalysts.
Allylic strain
The allylic position is the atom bound to a double bonded atom. The substituents on the allylic carbon and the doubly bonded atoms can result in allylic strain.
Contributed by: Sophia Robinson, (Undergraduate), Physical Organic Chemistry I, CHEM 7240 (Sigman), University of Utah, 2015
1 3-dipolar-cycloadditions
A 1,3-dipolar cycloaddition is a fascinating and diverse reaction that can be used in stepwise syntheses of large molecules, such as masked aldol reactions, and has potential biological applications. While it is an incredibly useful reactions, is also has a simple mechanism.
Contributed by: Created by Alexandra Kent and Judy Zhu (Undergraduates)Edited by Margaret Hilton
Honors Organic Chemistry
University of Utah
Heck redox relay
This document summarizes work on the Heck reaction and redox-relay Heck reaction. It provides background on the Heck reaction and its applications. It then discusses chain-walking in the Heck reaction where the palladium catalyst migrates down an alkyl chain, producing alkene isomers. It introduces Sigman's work developing a redox-relay Heck reaction where chain-walking of palladium is controlled by an alcohol thermodynamic sink on the substrate, transferring unsaturation to form aldehydes or ketones. It is authored by Margaret Hilton from the Sigman Lab at the University of Utah in 2014.
Stability and reactions of n heterocyclic carbenes
1) N-heterocyclic carbenes (NHCs) are stable two-coordinate carbon compounds that were first synthesized in 1991. Their stability is due to mesomeric and inductive effects from the nitrogen atoms that make the carbenes strong π-donors and weak σ-acceptors.
2) The thermodynamics of dissociation were studied for a bis(benzimidazol-2-ylidene), finding an enthalpy of 13.7 kcal/mol and entropy of 30.4 cal/mol*K. NHCs were also ranked based on their acidity.
3) NHCs form stable complexes with transition metals and have applications in organomet
Pyridine CH functionalization
This unit provides an overview of the different strategies that have been develop to selectively functionalize the 2,3 and 4 positions of pyridine units.
Contributed by the Sarpong Group, UC-Berkeley, 2013
Brønsted catalysis
The Brønsted catalysis relationship is a Linear Free Energy Relationship (LFER) that relates ionization of an acid or base which catalyzes a reaction and the rate of the reaction.
Contributed by: Quincy Davis, Jonathan Greenhalgh, Joshua Visser (Undergraduates), University of Utah, 2016
Quantum Tunneling in Organic Chemistry
Tunneling is a phenomenon of Quantum Mechanics in which particles, with a small amount of probability, are able to “tunnel” or travel through a large, finite potential energy (PE) barrier instead of traveling over the barrier as Classic Mechanics dictates should occur.
Contributed by: Mark O’Dair, Undergraduate, University of Utah, 2014
The Prins-Pinacol Reaction
The Prins-Pinacol reaction is a two-step process that begins with the Prins reaction, where an alkene attacks an aldehyde activated by a Lewis acid to form a cationic intermediate. This is followed by a pinacol rearrangement, where a methyl shift pushes the cation onto an oxygen. The reaction forms complex natural product backbones and allows stereoselective tetrahydropyran synthesis. Driving forces include increased stability of the carbocation intermediate and relief of ring strain. The Lewis acid activates the aldehyde for attack.
Solvation Effects on pKa Values
When substrates are put in solution, the solvent molecules can organize themselves around a charged species to stabilize it. Solvents can stabilize a charge most effectively when the charge on the substrate is easy to get to.
Contributed by: Jamie Allen, Jacqueline Pasek-Allen, Sarah Lefave (Undergraduates), University of Utah, 2016
Solvation effects on reactions
Solvation can be defined as any stabilizing interaction of a solute (or solute moiety) and the solvent. These interactions can be weak, purely electrostatic, as is the case with non-polar solutes and solvents, or more significant, involving the interactions between dipole moments or between dipoles and formal charges.
Contributed by: Anton S. Klimenko (Undergraduate), Department of Chemistry, The University of Utah, 2016
Hyperconjugation
Hyperconjugation is the donation of a sigma bond into an adjacent empty or partially filled p orbital, which results in an increased stability of the molecule.
Contributed by: Samuel Redstone (Undergraduate), University of Utah, 2016
Hammett Plots in the World of Enzymes
A substituent effect is the change in a molecule’s reactivity when a substituent on the molecule is changed. In 1935, Louis Hammett designed a scale to measure influence of various substituents (X) at the meta- or para- positions on the acidity of benzoic acid.
Contributed by: Erika Aoyama and Megan Browning, University of Utah, 2016
Anomeric effect
The anomeric effect was discovered in 1955 with the work of J.T. Edward, N.-J. Chu, and R.U. Lemieux.
Contributed by: Cody F. Bender, Charles E. Price (Undergraduates), University of Utah, 2016
Marcus theory
An overview of the use of the Marcus Theory to calculate the energies of transition states.
Contributed by: Elizabeth Greenhalgh, Amanda Bischoff, and Matthew Sigman, University of Utah, 2015
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CH Functionalizations on Electron-Deficient Aromatics in the synthesis of Pi-...
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Bio inspired metal-oxo catalysts for c–h bond functionalization
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Recently uploaded
Cytokines and their role in immune regulation.pptx
This presentation covers the content and information on "Cytokines " and their role in immune regulation .
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Slides from talk:
Aleš Zamuda: Randomised Optimisation Algorithms in DAPHNE .
Austrian-Slovenian HPC Meeting 2024 – ASHPC24, Seeblickhotel Grundlsee in Austria, 10–13 June 2024
https://ashpc.eu/
Compexometric titration/Chelatorphy titration/chelating titration
Classification
Metal ion ion indicators
Masking and demasking reagents
Estimation of Magnisium sulphate
Calcium gluconate
Complexometric Titration/ chelatometry titration/chelating titration, introduction, Types-
1.Direct Titration
2.Back Titration
3.Replacement Titration
4.Indirect Titration
Masking agent, Demasking agents
formation of complex
comparition between masking and demasking agents,
Indicators/Metal ion indicators/ Metallochromic indicators/pM indicators,
Visual Technique,PM indicators (metallochromic), Indicators of pH, Redox Indicators
Instrumental Techniques-Photometry
Potentiometry
Miscellaneous methods.
Complex titration with EDTA.
The binding of cosmological structures by massless topological defects
Assuming spherical symmetry and weak field, it is shown that if one solves the Poisson equation or the Einstein field
equations sourced by a topological defect, i.e. a singularity of a very specific form, the result is a localized gravitational
field capable of driving flat rotation (i.e. Keplerian circular orbits at a constant speed for all radii) of test masses on a thin
spherical shell without any underlying mass. Moreover, a large-scale structure which exploits this solution by assembling
concentrically a number of such topological defects can establish a flat stellar or galactic rotation curve, and can also deflect
light in the same manner as an equipotential (isothermal) sphere. Thus, the need for dark matter or modified gravity theory is
mitigated, at least in part.
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...University of Maribor
Slides from talk:
Aleš Zamuda: Remote Sensing and Computational, Evolutionary, Supercomputing, and Intelligent Systems.
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Inter-Society Networking Panel GRSS/MTT-S/CIS Panel Session: Promoting Connection and Cooperation
https://www.etran.rs/2024/en/home-english/Travis Hills' Endeavors in Minnesota: Fostering Environmental and Economic Pr...
Travis Hills of Minnesota developed a method to convert waste into high-value dry fertilizer, significantly enriching soil quality. By providing farmers with a valuable resource derived from waste, Travis Hills helps enhance farm profitability while promoting environmental stewardship. Travis Hills' sustainable practices lead to cost savings and increased revenue for farmers by improving resource efficiency and reducing waste.
在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样
学校原件一模一样【微信：741003700 】《(salfor毕业证书)索尔福德大学毕业证》【微信：741003700 】学位证，留信认证（真实可查，永久存档）原件一模一样纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
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Immersive Learning That Works: Research Grounding and Paths Forward
We will metaverse into the essence of immersive learning, into its three dimensions and conceptual models. This approach encompasses elements from teaching methodologies to social involvement, through organizational concerns and technologies. Challenging the perception of learning as knowledge transfer, we introduce a 'Uses, Practices & Strategies' model operationalized by the 'Immersive Learning Brain' and ‘Immersion Cube’ frameworks. This approach offers a comprehensive guide through the intricacies of immersive educational experiences and spotlighting research frontiers, along the immersion dimensions of system, narrative, and agency. Our discourse extends to stakeholders beyond the academic sphere, addressing the interests of technologists, instructional designers, and policymakers. We span various contexts, from formal education to organizational transformation to the new horizon of an AI-pervasive society. This keynote aims to unite the iLRN community in a collaborative journey towards a future where immersive learning research and practice coalesce, paving the way for innovative educational research and practice landscapes.
3D Hybrid PIC simulation of the plasma expansion (ISSS-14)
3D Particle-In-Cell (PIC) algorithm,
Plasma expansion in the dipole magnetic field.
Unlocking the mysteries of reproduction: Exploring fecundity and gonadosomati...
The pygmy halfbeak Dermogenys colletei, is known for its viviparous nature, this presents an intriguing case of relatively low fecundity, raising questions about potential compensatory reproductive strategies employed by this species. Our study delves into the examination of fecundity and the Gonadosomatic Index (GSI) in the Pygmy Halfbeak, D. colletei (Meisner, 2001), an intriguing viviparous fish indigenous to Sarawak, Borneo. We hypothesize that the Pygmy halfbeak, D. colletei, may exhibit unique reproductive adaptations to offset its low fecundity, thus enhancing its survival and fitness. To address this, we conducted a comprehensive study utilizing 28 mature female specimens of D. colletei, carefully measuring fecundity and GSI to shed light on the reproductive adaptations of this species. Our findings reveal that D. colletei indeed exhibits low fecundity, with a mean of 16.76 ± 2.01, and a mean GSI of 12.83 ± 1.27, providing crucial insights into the reproductive mechanisms at play in this species. These results underscore the existence of unique reproductive strategies in D. colletei, enabling its adaptation and persistence in Borneo's diverse aquatic ecosystems, and call for further ecological research to elucidate these mechanisms. This study lends to a better understanding of viviparous fish in Borneo and contributes to the broader field of aquatic ecology, enhancing our knowledge of species adaptations to unique ecological challenges.
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
Although Artemia has been known to man for centuries, its use as a food for the culture of larval organisms apparently began only in the 1930s, when several investigators found that it made an excellent food for newly hatched fish larvae (Litvinenko et al., 2023). As aquaculture developed in the 1960s and ‘70s, the use of Artemia also became more widespread, due both to its convenience and to its nutritional value for larval organisms (Arenas-Pardo et al., 2024). The fact that Artemia dormant cysts can be stored for long periods in cans, and then used as an off-the-shelf food requiring only 24 h of incubation makes them the most convenient, least labor-intensive, live food available for aquaculture (Sorgeloos & Roubach, 2021). The nutritional value of Artemia, especially for marine organisms, is not constant, but varies both geographically and temporally. During the last decade, however, both the causes of Artemia nutritional variability and methods to improve poorquality Artemia have been identified (Loufi et al., 2024).
Brine shrimp (Artemia spp.) are used in marine aquaculture worldwide. Annually, more than 2,000 metric tons of dry cysts are used for cultivation of fish, crustacean, and shellfish larva. Brine shrimp are important to aquaculture because newly hatched brine shrimp nauplii (larvae) provide a food source for many fish fry (Mozanzadeh et al., 2021). Culture and harvesting of brine shrimp eggs represents another aspect of the aquaculture industry. Nauplii and metanauplii of Artemia, commonly known as brine shrimp, play a crucial role in aquaculture due to their nutritional value and suitability as live feed for many aquatic species, particularly in larval stages (Sorgeloos & Roubach, 2021).
8.Isolation of pure cultures and preservation of cultures.pdf
Isolation of pure culture, its various method.
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
The technology uses reclaimed CO₂ as the dyeing medium in a closed loop process. When pressurized, CO₂ becomes supercritical (SC-CO₂). In this state CO₂ has a very high solvent power, allowing the dye to dissolve easily.
Shallowest Oil Discovery of Turkiye.pptx
The Petroleum System of the Çukurova Field - the Shallowest Oil Discovery of Türkiye, Adana
SAR of Medicinal Chemistry 1st by dk.pdf
In this presentation include the prototype drug SAR on thus or with their examples .
Syllabus of Second Year B. Pharmacy
2019 PATTERN.
Authoring a personal GPT for your research and practice: How we created the Q...
Thematic analysis in qualitative research is a time-consuming and systematic task, typically done using teams. Team members must ground their activities on common understandings of the major concepts underlying the thematic analysis, and define criteria for its development. However, conceptual misunderstandings, equivocations, and lack of adherence to criteria are challenges to the quality and speed of this process. Given the distributed and uncertain nature of this process, we wondered if the tasks in thematic analysis could be supported by readily available artificial intelligence chatbots. Our early efforts point to potential benefits: not just saving time in the coding process but better adherence to criteria and grounding, by increasing triangulation between humans and artificial intelligence. This tutorial will provide a description and demonstration of the process we followed, as two academic researchers, to develop a custom ChatGPT to assist with qualitative coding in the thematic data analysis process of immersive learning accounts in a survey of the academic literature: QUAL-E Immersive Learning Thematic Analysis Helper. In the hands-on time, participants will try out QUAL-E and develop their ideas for their own qualitative coding ChatGPT. Participants that have the paid ChatGPT Plus subscription can create a draft of their assistants. The organizers will provide course materials and slide deck that participants will be able to utilize to continue development of their custom GPT. The paid subscription to ChatGPT Plus is not required to participate in this workshop, just for trying out personal GPTs during it.
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Cytokines and their role in immune regulation.pptx
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The binding of cosmological structures by massless topological defects
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mô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốt
mô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốt
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Immersive Learning That Works: Research Grounding and Paths Forward
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3D Hybrid PIC simulation of the plasma expansion (ISSS-14)
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Unlocking the mysteries of reproduction: Exploring fecundity and gonadosomati...
Unlocking the mysteries of reproduction: Exploring fecundity and gonadosomati...
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
8.Isolation of pure cultures and preservation of cultures.pdf
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waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
Authoring a personal GPT for your research and practice: How we created the Q...
Authoring a personal GPT for your research and practice: How we created the Q...
C–H bond hydroxylation at non heme carboxylate-bridged diiron centers
- 1. Organic Pedagogical Electronic Network C–H bond Hydroxylation at Non-Heme Carboxylate-Bridged Diiron Centers Omar Villanueva, Cora MacBeth Emory University
- 2. C–H bond Hydroxylation at Carboxylate-Bridged Diiron Centers (1)Friedle, S. et al. Chem. Soc. Rev., 2010, 39, 2768-2779. (2)Kopp, D. A. et al. Curr. Opin. Chem. Biol., 2002, 6, 568-576. In biology, a family of metalloproteins called bacterial multicomponent monooxygenases (BMMs) catalyze the hydroxylation of strong C–H bonds using dioxygen (O2) as the oxidant. Soluble methane monooxygenase (sMMO) is one of the most widely-studied protein in this family which converts methane (CH4) to methanol (CH3OH) using O2. The soluble hydroxylase component (sMMOH) is responsible for dioxygen activation and substrate hydroxylation. In particular MMOH contains a carboxylate-bridged non-heme diiron active site.1 Overview: General Reaction Active site of sMMOH in its reduced state2
- 3. Mechanistic Overview Overall changes in the diiron core upon activating dioxygen: (1)Rosenzweig, A. C. et al. Nature, 1993, 366, 537. (2)Tshuva E. Y. et al. Chem. Rev., 2004, 104, 987-1012. Detailed Mechanism:
- 4. Synthetic Models – Bioinspired Catalyst Design (1) Du Bois, J. et al. Coord. Chem. Rev. 2000, 443, 200-202. (2) Jones, M. B. et al. Inorg. Chem. 2011, 50, 6402-6405. Synthetic carboxylate-bridged diiron(II) complexes have been extensively studied as both structural and functional models of these active sites.1 Jones et al. report a diiron(II) complex (shown above) containing two bridging amidate ligands as a functional model of diiron(II) hydroxylase.2 These studies suggest bridging amidate ligands may be used in synthetic functional models of diiron enzymes that activate dioxygen and C-H bonds
- 5. Problems Nature has evolved to allow diiron carboxylate-bridged systems such as in MMOH to selectively convert methane to methanol in methanotrophic bacteria. 1. Compare the active site of MMOH to those metalloenzymes that host a non- heme mononuclear iron center. What are the major differences in their motifs that dictate the differences in reactivity? 1. Modeling the chemistry of non-heme diiron proteins such as MMOH is very challenging. In functional synthetic models of MMOH, what are the key components that allow for similar catalytic reactivity such as in the protein?
- 6. This work is licensed under a Creative Commons Attribution- ShareAlike 4.0 International License. Contributed by: Omar Villanueva, Cora MacBeth Emory University, 2014