The cerebral cortex is the outer layer of gray matter covering the hemispheres. It is typically 2-3mm thick and covers the gyri and sulci. The neocortex makes up most of the cerebral cortex and has six layers containing 10-14 billion neurons. The allocortex is a more primitive area located in the medial temporal lobes involved in olfaction and emotional reactions. Key areas of the cerebral cortex include the prefrontal, somatosensory, visual, auditory, and motor cortices which are involved in executive functions, sensory processing, vision, hearing, language, and motor control respectively.

1. CEREBRAL CORTEX
Aditya Johan .R, M.Fis

2. • The cerebral cortex is the outer covering of
gray matter over the hemispheres
• This is typically 2- 3 mm thick, covering the
gyri and sulci

3. • Most of the cerebral cortex is
neocortex.
• There are phylogenetically older
areas of cortex termed the allocortex
• These more primitive areas are
located in the medial temporal lobes
and are involved with olfaction and
survival functions such as visceral
and emotional reactions

4. • In turn, the allocortex has two
components: the paleocortex
and archicortex.
• The paleocortex includes the
piriform lobe, specialized for
olfaction, and the entorhinal
cortex.
• The archicortex consists of the
hippocampus, which is a three-
layered cortex dealing with
encoding declarative memory
and spatial functions

5. • The neocortex represents the great majority of the cerebral cortex. It
has six layers and contains between 10 and 14 billion neurons
• Layer I is the molecular layer, which contains very few neurons
• layer II the external granular layer
• layer III the external pyramidal layer
• layer IV the internal granular layer
• layer V the internal pyramidal layer
• layer VI the multiform, or fusiform layer

7. • Functionally, the layers of the cerebral cortex can be divided into
three parts
• The supragranular layers consist of layers I to III.
• The supragranular layers are the primary origin and termination of
intracortical connections, which are either associational (i.e., with
other areas of the same hemisphere), or commissural (i.e.,
connections to the opposite hemisphere, primarily through the
corpus callosum)

8. • The internal granular layer, layer IV, receives thalamocortical
connections, especially from the specific thalamic nuclei. This is most
prominent in the primary sensory cortices
• The infragranular layers, layers V and VI, primarily connect the
cerebral cortex with subcortical regions.
• These layers are most developed in motor cortical areas.
• The motor areas have extremely small or non-existent granular layers
and are often called "agranular cortex".
• Layer V gives rise to all of the principal cortical efferent projections to
basal ganglia, brain stem and spinal cord.
• Layer VI, the multiform or fusiform layer, projects primarily to the
thalamus

9. • There are several identifiable cell types in the
cerebral cortex.
• The pyramidal cells are the main cell type
within layers III and V.
• These cells can be extremely large in layer V
of the motor cortex, giving rise to most
corticobulbar and corticospinal fibers
• The largest of these neurons are called "Betz
cells"

12. BROADMAN AREA

13. Prefrontal Cortex
• The prefrontal cortex is extremely well developed in humans
• There are two main portions of this cortex
• The dorsolateral prefrontal cortex (DLPC; mostly areas 9 and 10) and
the orbitomedial prefrontal cortex (especially areas 11 and 12)
• The DLPC is primarily involved in executive functions.
• These include working memory, judgment, planning, sequencing of
activity, abstract reasoning and dividing attention.
• The orbitomedial prefrontal cortex is involved in impulse control,
personality, reactivity to the surroundings and mood

14. Somatosensory Cortex
• Primary somatosensory cortex (areas 3,1,2) is located in the post
central gyrus
• Neurons within each cortical site (particularly layer IV) are arranged in
columns representing specific body regions
• The secondary somatosensory cortex (area 40) is in the lower parietal
lobe
• This responds to sensory stimuli bilaterally, although with much less
precision than the primary cortex
• The somatosensory association cortex (areas 5 and 7) is directly
posterior to the sensory cortex in the superior parietal lobes
• This receives synthesized connections from the primary and
secondary sensory cortices.

15. Visual cortex
• The primary visual cortex (area 17) also called the striate cortex
• Lesions of the occipital lobe would cause cortical blindness and
difficulty tracking objects
• the visual association areas (areas 18 and 19), where signals are
interpreted and form is recognized
• Selective lesions of these association areas will produce an inability to
recognize objects even when they may be seen

17. Auditory Cortex
• The primary auditory cortices (area 41) are on the transverse
temporal gyri, extending into the lateral fissures
• These gyri are situated on the upper part of the superior temporal
gyri
• Unilateral cortical lesions do not effect hearing because of completely
bilateral sound representation
• There are auditory association areas surrounding the primary
auditory cortex (area 42).
• These areas are involved in the interpretation of sound.
• In the dominant hemisphere the cortex surrounding the auditory
cortex (area 22) is required for understanding language (Wernicke's
area)

18. • Lesions of the opercular and triangular portions of the inferior frontal
gyrus (areas 44 and 45), called Broca's area in the dominant
hemisphere, produce expressive or motor aphasia.
• These patients have difficulty in generating spoken or written
language

19. Motor Cortex
• The primary motor cortex (area 4) is in the precentral gyrus.
• This is the origin of most of the corticospinal tract and a large number
of cortical bulbar fibers
• This also has projections to the thalamus and basal ganglion
• Lesions produce spastic contralateral weakness, which is most
prominent in the distal extremities
• The premotor cortex (area 6) is immediately anterior to the motor
cortex and has many of the same connections as the motor cortex.
• This region receives input from the sensory association cortex as well
as feedback from the basal ganglia via the VA and VL of the thalamus

21. Association and Commissural Fibers

22. Association and Commissural Fibers
• Regions of the cerebral cortex are tied together by bundles of white
matter fibers
• There are association bundles that connect one part of the cortex to
another
• These association fibers typically arise from layer III and terminate in
layers I and II
• Commissural fibers connect one hemisphere with the other.
• The largest commissural connection is the corpus callosum
• Damage to this pathway can produce a "split brain "in some
individuals, where an individual may literally appear to have two
minds

23. HOMUNCULUS MOTOR AND SENSORY