This document presents a case report of a 55-year-old man who presented with sudden vision loss in his right eye. On examination, he was found to have signs consistent with central retinal artery occlusion (CRAO), including a cherry red spot and attenuated retinal arterioles. The patient had risk factors of hypertension and smoking. He was informed that the visual prognosis is generally poor for CRAO presenting more than 48 hours after onset. He was referred to a cardiologist given the risk of life-threatening cardiac complications associated with CRAO. The document then reviews the epidemiology, causes, clinical features, investigations, and management approaches for CRAO, emphasizing the importance of prompt referral for evaluation of underlying cardiac conditions
Central Retinal Artery Occlusion (CRAO) for undergraduate MBBS Students.
Covers the basics of Aetiology, pathophysiology, clinical features, types, associated conditions and management of CRAO.
Also encompasses salient points for PGMEE
Retinal vasculitis refers to the inflammation of the retinal vessel resulting in evident clinical manifestations i.e. vascular sheathing, leakage and occlusion. This presentation covers the etiology, pathogenesis, clinical features, diagnosis and management of this spectrum of retinal disease.
Central Retinal Artery Occlusion (CRAO) for undergraduate MBBS Students.
Covers the basics of Aetiology, pathophysiology, clinical features, types, associated conditions and management of CRAO.
Also encompasses salient points for PGMEE
Retinal vasculitis refers to the inflammation of the retinal vessel resulting in evident clinical manifestations i.e. vascular sheathing, leakage and occlusion. This presentation covers the etiology, pathogenesis, clinical features, diagnosis and management of this spectrum of retinal disease.
Exudative retinal detachment develops when fluid collects in the subretinal space.
The subretinal space between the photoreceptors and the retinal pigment epithelium is the remnant of the embryonic optic vesicle.
In the developed eye the subretinal space is of minimal size, but it can reopen under pathological conditions that disrupt the integrity of blood-retinal barrier.
Inflammatory, infectious, infiltrative, neoplastic, vascular, and degenerative conditions may be associated with blood-retinal barrier breakdown and the sequential development of exudative retinal detachment.
This elaborate on the pathogenesis and the differential diagnosis of exudative retinal detachment and specifically discuss the spectrum of diseases associated with exudative retinal detachment in uveitis clinics.
Coats' disease, (also known as exudative retinitis or retinal telangiectasis, sometimes spelled Coates' disease), is a rare congenital, nonhereditary eye disorder, causing full or partial blindness, characterized by abnormal development of blood vessels behind the retina.
Exudative retinal detachment develops when fluid collects in the subretinal space.
The subretinal space between the photoreceptors and the retinal pigment epithelium is the remnant of the embryonic optic vesicle.
In the developed eye the subretinal space is of minimal size, but it can reopen under pathological conditions that disrupt the integrity of blood-retinal barrier.
Inflammatory, infectious, infiltrative, neoplastic, vascular, and degenerative conditions may be associated with blood-retinal barrier breakdown and the sequential development of exudative retinal detachment.
This elaborate on the pathogenesis and the differential diagnosis of exudative retinal detachment and specifically discuss the spectrum of diseases associated with exudative retinal detachment in uveitis clinics.
Coats' disease, (also known as exudative retinitis or retinal telangiectasis, sometimes spelled Coates' disease), is a rare congenital, nonhereditary eye disorder, causing full or partial blindness, characterized by abnormal development of blood vessels behind the retina.
Hypertensive retinopathy is a very important topic for PG examinations of all types. Especially, the fundal changes are important; Keith and Wegner Grading is also a repeated topic in PG. This slide represents all information in a compressed fashion. Have fun!
First Five Star Deluxe Hotel in Coimbatore with the largest ball room in South India, 254 guest rooms, 15 meeting rooms, roof top swimming pool, entertainment centre, 4 restaurants, 3 bars, a Ganesha temple to bless the couple who gets wedded. A meditation centre, peacock lawn, cinema hall for preview, a international SPA, club longue, exhibition centre and the latest talk of the town Night Club- VERTIGO.
If you are planning a wedding, a fun-filled birthday party, or a corporate event, we are here to make it an unforgettable memory.
http://www.hanlonconventioncentre.ca/
Retinal Arterial Obstructions is a common eye disease that causes loss of vision due to the blockage of the blood flow, runs into the retina which is to be found in the back of your eye.
Retinal artery occlusion is an ophthalmic emergency which requires urgent management. Its a vision threatening condition which requires prompt diagnosis.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
2. Patient History
A 55 year old man
Resident of Murree
lower middle class socio-ecnomicaly
Married
Shopkeeper by profession
Presented with a history of sudden loss of vision in his right eye 7 days
3. Patient was alright 5 days back when he suddenly
developed loss of vision in right eye
The loss of vision was sudden, painless and severe
Not accompanied by any other symptoms
no history of transient visual loss, no history of scalp
tenderness, weight loss, jaw claudication, headache,
polymyalgia rheumatic and fever
4. Patient consulted local health care provider who gave
him some eye drops but the vision didn’t improve…… so
the health care provider advised him to go to some big
hospital in Rawalpindi, patient went to Amanat Eye
Hospital where he was investigated and now he is
seeking a second opinion
Past medical history
Smoker one pack of cigarettes / day since his youth
hypertensive on medication since last 7-8 years
Past surgical history insignificant
5. GPE
Anxious looking middle aged man
pulse regular 90 beats / min
BP 160/95 mm Hg,
carotid and superficial temporal artery pulses palpable
no carotid bruit
Systemic examination otherwise unremarkable
6. Ocular examination
Right eye vision PL+
Pupil very sluggish RAPD +
early lens changes
Fundoscopy:
macular edema with cherry red spot
Narrowed irregular arterioles and venules
A whitish small mass on the disc (calcific embolus)
Left vision 6/9
Not significant except early lens changes
7.
8.
9.
10.
11.
12. D/D sudden loss of vision
CRVO
RD
Vitreous hemorrhage
ON
AION
CRAO
15. CRAO is among the most dramatic problems encountered
by an ophthalmologist
Sudden
Severe
Permanent
Life threatening implications
16. In 1859, Van Graefe first described central retinal artery occlusion
(CRAO) in a patient with endocarditis due to embolic valvular
vegetations
in 1868, Mauthner suggested that spasmodic contractions could
lead to retinal artery occlusion.
In1881 Samelsohn advocated treatment with nitrate inhalation
In 1888 Mules did AC paracenteses for CRAO
17. Incidence of CRAO
0.85/100,000 per year. Of these patients, 1-2% present with bilateral
involvement.
Mortality
Life expectancy of patients with CRAO is 5.5 years compared to
15.4 years for an age-matched population without CRAO.
18. Sex
Men are affected slightly more frequently than women.
Age
The mean age of presentation is in the early 60s, although a few
cases have been reported in patients younger than 30 years
19. Retinal Survival Time
Electrophysiologic and histopathologic examination showed that
the retina of rhesus monkeys suffered no detectable damage with
CRAO of 97 min
But beyond that time, the longer the duration of CRAO, the more
extensive the irreversible damage.
The study suggested that CRAO lasting for about 240 min
results in massive irreversible retinal damage.
(Sohan Singh Hayreh et al 2004)
20. Causes
Atheroma thrombosis related at the level of lamina cribrosa
Carotid embolism (cholesterol, calcific, fibrinoplatelet)
Cardiac embolism from the heart and its valves may consist of
calcific material, vegetations in bacterial endocarditis and
thrombus from the left side of the heart
Giant cell arteritis (temporal)
Periarteritis associated with dermatomyositis, systemic lupus
erythematosus, polyarteritis nodosa, Wegener granulomatosis and
Behçet syndrome
Sickling haemoglobinopathies.
Retinal migraine may very rarely be responsible for retinal artery
occlusion in young individuals.
21. Atherosclerosis-related thrombosis
Atherosclerosis-related thrombosis at lamina cribrosa is by
far the most common cause of CRAO (80% of cases).
Atherosclerosis is characterized by focal intimal thickening
(smooth muscle origin cells, connective tissue and lipid-
containing foam cells)
The incidence of atherosclerosis increases with age and is
accelerated by hypertension, hyperlipidaemia, diabetes,
oral contraceptives.
Other risk factors include obesity, tobacco smoking and a
sedentary lifestyle
22. Carotid embolism
Embolus originates from atheromatous plaque at the carotid bifurcation,
embolic material from the heart and carotid arteries has a direct route to the
eye. types:
1 Cholesterol emboli (Hollenhorst plaques) appear as intermittent showers of
minute, refractile, yellow-orange crystals, located at arteriolar bifurcations
2 Calcific emboli originate from atheromatous plaques or calcified heart
valves. usually single, white, non-scintillating and on or close to the disc result in
permanent occlusion
3 Fibrin-platelet emboli are dull grey, elongated particles which are usually
multiple usually result in amaurosis fugax
23.
24. Pathologic changes
inner layer edema and pyknosis of the ganglion cell nuclei.
Ischemic necrosis results, and the retina becomes opacified which is
most dense in the posterior pole due to increased thickness of the
nerve fiber layer and ganglion cells in this region.
Foveola assumes a cherry-red spot appearance because of the
foveolar retina is nourished by the choriocapillaris and RPE and
choroid are intact
The late stage shows a homogenous scar replacing the inner layer
of the retina
25. Clinical Features
It is characterized by a severe loss of vision associated with an afferent
pupillary conduction defect.
Some patients may give a history of amaurosis fugax involving transient
loss of vision lasting seconds to minutes but which may last up to 2
hours. The vision usually returns to baseline after an episode of
amaurosis fugax.
26. The retina appears whjte and edcmatous, especially at the posterior
pole where the nerve fibre and ganglion cell layers are thickest.
The foveola is devoid of these layers, which are relocated in the peri-
foveolar retina, the orange reflex from the intact choroidal vessels
beneath the foveola stands out in contrast to the surrounding opaque
retina, giving rise to the 'cherry-red spot' appearance
27. marked narrowing of the retinal arterioles associated with
irregularities in their calibre.
Sludging and segmentation of the blood column may be 'seen in
both arterioles and venules.
if the occlusion persists, the retinal haze and the 'cherry-red spot'
disappear after a few weeks
arterioles, however, remain attenuated and eventually the optic
disc becomes atrophic and pale
Between 1% and 5% of eves with central retinal artery occlusion
develop rubeosis iridis, which may be complicated by neovascular
glaucoma
28.
29. In about one in five cases, a portion of the papillomacular bundle is
supplied by one or more cilioretinal arterioles from the ciliary
circulation, and in these cases central vision may be preserved.
30. Systemic examination in a patient of CRAO should specially
include
Pulse particularly to detect atrial fibrillation.
Blood pressure for hypertension
Cardiac auscultation arrhythmias and murmurs
Carotid examination.
a Palpation of severe or complete stenosis is associated with a diminished or absent carotid
pulse.
b Auscultation over a partial stenosis gives rise to a bruit, best detected with the bell of the
stethoscope.
31. Investigations to be carried out in patients of CRAO
ECG to detect arrhythmia and other cardiac disease.
Erythrocyte sedimentation rate and C-reactive protein to detect the
remote possibility of GCA.
Other blood tests include FBC, random glucose, lipids, urea and
electrolytes.
Carotid duplex scanning is a non-invasive screening test involving a
combination of high-resolution real-time ultrasonography with Doppler
flow analysis.
If significant stenosis is present, surgical management may be
considered
32. Treatment
Usually occlusions are incomplete so it is recommended to treat
patients who present with in 48 hours of occlusion
1 Adoption of a supine posture might improve ocular perfusion.
2 Ocular massage using a three-mirror contact lens (allows direct
artery visualization) for approximately 10 seconds, aiming to achieve
central retinal artery pulsation, followed by 5 seconds of release. The
aim is to mechanically collapse the arterial lumen and cause changes
in arterial flow. Self-massage through closed eyelids can be continued
by the patient.
3 Anterior chamber paracentesis should be carried out in most cases.
Instil povidone-iodine 5% and topical antibiotic prior to the procedure
and a short course of antibiotic afterwards.
4 Topical timolol 0.5% and intravenous acetazolamide 500 mg to
achieve a more sustained lowering of intraocular pressure.
33. 5 Sublingual isosorbide dinitrate to induce vasodilation.
6 ‘Rebreathing’ into a paper bag in order to elevate blood carbon
dioxide and respiratory acidosis, as this may promote vasodilation.
7 Breathing a high oxygen (95%) and carbon dioxide (5%)
mixture,‘carbogen’ for a possible dual effect of retarding ischaemia
and vasodilation.
8 Hyperosmotic agents. Mannitol or glycerol have been used for their
possibly more rapid IOP-lowering
34. 9 Transluminal Nd:YAG laser embolysis
when an occluding embolus is visible laser Embolectomy can be done
The embolus is ejected into the vitreous via a hole in the arteriole. The main
complication is vitreous haemorrhage.
10 Thrombolysis.
Thrombolytic agents have been used for the treatment of CRAO
route of admiration maybe
local arterial (internal carotid and ophthalmic) or intravenous infusion.
35. Treatment of carotid disease
In patients with a localized stenosis of the artery, endarterectomy
significantly reduces the risk of subsequent stroke. In experienced
hands this operation carries a mortality of less than 1%, although the
incidence of morbidity is higher.
If endarterectomy is contraindicated, medical treatment with drugs
that reduce platelet stickiness (aspirin, dipyridamole) or
anticoagulants may be used to reducing the frequency of transient
ischaemic attacks and the risk of a major stroke.
36. Coming back to our patient
Patient had presented 48 hours after occlusion and all
ophthalmological investigations had been carried out…..
He was informed of the poor visual prognosis.
He was also informed about the possible life threatening
complications
and referred to a cardiologist
37. Take home message
Do not treat if patient presents 48 hours after occlusion
Treatment to salvage vision generally do not produce significant
changes in the patient's vision
don’t take heroic measure
These patients have a significantly reduced survival rate, and the
main cause of mortality is cardiac. Therefore, prompt referral to a
cardiologist is indicated.
Central retinal artery occlusion may be caused by GCA; if
undetected, the patient can develop severe, bilateral vision loss.
Adoption of healthy life style may prevent CRAO
38. Words of wisdom from
Prof Sohan Sing Hayreh
CRAO……..diagnosis is easy ….. its
management, however,
remains highly uncertain and controversial