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Cell junction & Junctional complexes
- 6. “Objectives Different types ofcell junctions Functions of different types of cell junctions
- 7. Connection between theneighboring cells or contact between cell and extracellular matrix Cell junction
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- 12. Zonula occludens/ Tight junction Zonulaadherens/ Adherent junction Macula adherens/ Desmosome Gap junction Hemidesmosome
- 13. Zonula occludens Zonula adherens Maculaadherens Gap junction
- 14. Belt Something that occludes Somethingthat adheres Spot Desmos- bond Soma- body Zonula occludens (tight junction) Zonula adherens Macula adherens (desmosome)
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- 16. Also called tightjunction Most apical of the junctions A continuous ribbon-like structure Forms a seal between adjacent cells Zonula occludens (contd.)
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- 20. Seals adjacent cellsto one another Controls passage of molecules between cells Separate apical and basolateral membrane domain Forms different blood barrier Zonula occludens (contd.)
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- 22. Zonula occludens (contd.) Blood-thymicbarrier Tight junction Reticulo-epithelial cell Enothelial cell
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- 26. Also called adherentjunction Immediately below zonula occludens Also encircles epithelial cells Firmly anchor a cell to its neighbor cells Zonula adherens (contd.)
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- 29. Provide point linkingto the cytoskeleton of adjacent cells Strengthen and stabilizes nearby tight junction Zonula adherens (contd.)
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- 31. Also called desmosome Inlateral domain of cell membrane Does encircles epithelial cells Macula adherens (contd.)
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- 34. Provide point ofstrong intermediate filament coupling between adjacent cells Strengthen the tissue Macula adherens (contd.)
- 35. Macula adherens (contd.) Maculaadherens in skin
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- 37. A communicating junction Inlateral domain of cell membrane Permit exchange of molecules and ions Gap junction (contd.)
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- 40. Allows direct transportof small molecules and ions from one cell to another Gap junction (contd.)
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- 42. Anchoring junction In basaldomain of cell membrane Resembles half desmosome Hemidesmosome (contd.)
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- 45. Anchor cytoskeleton ofcell to the basal lamina Hemidesmosome (contd.)
- 46. Points Zonula occludens Zonula adherens Macula adherens Hemidesmosome Gapjunction Major transmembr-ane protein Occludin, claudin and junctional adhesion molecules E-cadherin, catenin complexes Desmoglein and desmocollin Integrins Connexin Cytoskeletal components Actin filaments Actin filaments Intermediat e filaments Intermediate filaments None Channel protein Absent Absent Absent Absent Present Communication Not possible Not possible Not possible Not possible Possible Function Acts as a barrier Adheres the adjacent cells Provides strong attachments between two cells Adheres the cell to the basal lamina Allows direct transmission of small molecules Summary
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