This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD20 IgG to RLI. It was expressed in CHO and purified with affinity chromatography.

1. cd20 antibody
• This antibody-cytokine fusion protein was achieved by
conjugating/fusing the Anti-CD20 IgG to RLI. It was expressed in CHO
and purified with affinity chromatography. The immunocytokine
retains the ability to bind the CD20 as well as the biological activity of
RLI. Anti-CD20-RLI kept its binding capacity to CD20, CD16 and IL15
receptor and therefore fully retained both antibody effector functions
(ADCC and CDC), and the cytokine potential of RLI. In a severe
combined immunodeficiency (SCID) mouse model of disseminated
residual lymphoma, anti-CD20-RLI was found to induce long-term
survival of 90% of mice up to at least 120 days whereas RLI and RTX,
alone or in combination, just delayed the disease onset. This
immunocytokine was designed for treating leukemias, lymphomas,
rheumatoid arthritis, and other autoimmune diseases.

2. • Specifications
• TargetCD20
• Molecule ClassL Kappa; IgG2-RLI
• Species ReactivityHuman
• HostChimeric (Human-Mouse)
• Expression HostCHO
• CloneRituximab
• Related DiseaseLeukemias, Lymphomas, Rheumatoid arthritis, and other autoimmune diseases
• Cytokines 1RLI
• Cytokines 1 DescriptionATP binding cassette E1 (ABCE1, also RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding
cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked
oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction
with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumor cell
proliferation and antiapoptosis.
• Cytokine 1 SpeciesHuman
• ApplicationsThis product can be used therapeutically to deliver biologically active ligands to a desired tissue.

3. • Target
• Alternative NamesMS4A1; membrane-spanning 4-domains; subfamily
A; member 1; B1; S7; Bp35; CD20
• Entrez Gene ID931
• UniProt IDA0A024R507

4. • For lab research use only, not for diagnostic, therapeutic or any in
vivo human use.