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Similarities between MHC class I and
MHC class II
Both are synthesized in rough endoplasmic
reticulum
Both are found on the surface of APC surface
Both are encoded by genes in HLA locus
In both class I and class II, expression of genes is
co-dominant
Difference between MHC class I and
MHC class II
MHC class I MHC class II
1. Have 8-10 amino acids Have 13-18 amino acids
2. Peptide binding domain
alpha1, alpha2
Peptide binding domain alpha1,
beta1
3. Present antigen to CD 8 T- cells Present antigen to CD 4 T- cells
4. Found on all surfaces of
nucleated cells
Found on surface of APCs and
activated T cells
5. Composed of one peptide
encoded in HLA locus and beta 2
microglobullin
Composed of two peptide
encoded by HLA locus
6. Bind with endogenous antigen Bind with exogenous antigen
7. Has no invariant chain Has invariant chain
Cont…
MHC class I MHC class II
8. After binding to CD 8 T
cells, cytokines are
produced that lead to the
lysis of entire cell
After binding to CD4 T cells
it triggers B cell response
which result in antibody
formation
Special thanks
• Prof. Mramba Nyindo-tutor at kcmu college
• All BSc. Health laboratory science year two
students(2016/17) at kcmu college.
PREPARED BY PETER R. MASSAWE BSc HEALTH
LABORATORY STUDENT at kcmu college year two
2016/17
massawepeter124@gmail.com

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SIMILARITIES BETWEEN CLASS I AND CLASS II

  • 1. Similarities between MHC class I and MHC class II Both are synthesized in rough endoplasmic reticulum Both are found on the surface of APC surface Both are encoded by genes in HLA locus In both class I and class II, expression of genes is co-dominant
  • 2. Difference between MHC class I and MHC class II MHC class I MHC class II 1. Have 8-10 amino acids Have 13-18 amino acids 2. Peptide binding domain alpha1, alpha2 Peptide binding domain alpha1, beta1 3. Present antigen to CD 8 T- cells Present antigen to CD 4 T- cells 4. Found on all surfaces of nucleated cells Found on surface of APCs and activated T cells 5. Composed of one peptide encoded in HLA locus and beta 2 microglobullin Composed of two peptide encoded by HLA locus 6. Bind with endogenous antigen Bind with exogenous antigen 7. Has no invariant chain Has invariant chain
  • 3. Cont… MHC class I MHC class II 8. After binding to CD 8 T cells, cytokines are produced that lead to the lysis of entire cell After binding to CD4 T cells it triggers B cell response which result in antibody formation
  • 4. Special thanks • Prof. Mramba Nyindo-tutor at kcmu college • All BSc. Health laboratory science year two students(2016/17) at kcmu college. PREPARED BY PETER R. MASSAWE BSc HEALTH LABORATORY STUDENT at kcmu college year two 2016/17 massawepeter124@gmail.com