This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD3 IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD3 as well as the biological activity of IL2. under in vitro conditions, IL2-FuP efficiently initiated T-cell activation and stimulated LAKs as well as CTLs. Its potency was superior but not qualitatively different from that of a mixture of anti-EGFR and IL2 This immunocytokine was designed for treating Hodgkin's lymphoma.

1. cd3 antibody
• This antibody-cytokine fusion protein was achieved by
conjugating/fusing the Anti-CD3 IgG to IL2. It was expressed in CHO
and purified with affinity chromatography. The immunocytokine
retains the ability to bind the CD3 as well as the biological activity of
IL2. under in vitro conditions, IL2-FuP efficiently initiated T-cell
activation and stimulated LAKs as well as CTLs. Its potency was
superior but not qualitatively different from that of a mixture of anti-
EGFR and IL2 This immunocytokine was designed for treating
Hodgkin's lymphoma.
cd3
antibody

2. • Specifications
• TargetCD3
• Molecule ClassIL2-IgGa
• Species ReactivityHuman
• HostMouse
• Expression HostCHO
• CloneOKT3
• Related DiseaseHodgkin's lymphoma
• Cytokines 1IL2
• Cytokines 1 DescriptionInterleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for
immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
• Cytokine 1 SpeciesHuman
• ApplicationsThis product can be used therapeutically to deliver biologically active ligands to a desired tissue.
• Target
• Alternative NamesCD3E; CD3e molecule; epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon
• Entrez Gene ID916
• UniProt IDP07766

3. • For lab research use only, not for diagnostic, therapeutic or any in
vivo human use.