This document discusses melanoma, providing information on:
- The clinical criteria used to recognize melanoma including asymmetry, irregular borders, multiple colors, size, and evolution.
- The most common histological variants of melanoma.
- Important prognostic factors for melanoma like Breslow thickness and Clark level of invasion.
- Precursor lesions to melanoma like common acquired nevi, congenital nevi, and dysplastic nevi.
- The importance of dermoscopy in the diagnosis of melanoma.
- Rare histological variants like animal melanoma and desmoplastic melanoma.
Rhabdomyosarcoma is a malignant mesenchymal tumor with features of skeletal muscle. It is the most common childhood and adolescent soft tissue sarcoma, frequently involving the head and neck in children.
Ischemic condition affecting the eye.
The ischemia can occur secondary to systemically problem [or] particulary the eye.
Many retinal vascular disorders {like CRAO,CRVO,Diabetic retinopathy,Hypertensive Retinopathy} shows ischemic signs.
Rhabdomyosarcoma is a malignant mesenchymal tumor with features of skeletal muscle. It is the most common childhood and adolescent soft tissue sarcoma, frequently involving the head and neck in children.
Ischemic condition affecting the eye.
The ischemia can occur secondary to systemically problem [or] particulary the eye.
Many retinal vascular disorders {like CRAO,CRVO,Diabetic retinopathy,Hypertensive Retinopathy} shows ischemic signs.
DR WANI'S TALK ON CRVO FOR RESIDENTS KLE 14 JAN 2023.pptxvbwani
This detailed talk about central retinal vein occlusion deals with all aspects of the disease
It deals with incidence and prevalence, risk factors and clinical features
It also deals with classification, importance of recognizing the ischemic type and the means to recognize it .
It deals with historical studies that gave nformation abour natural course and treatment options
sEveral studies that were conducted to treat CRVO are dealt with in which emphasis is given to anti VEGF drugs
Using a diamond knife, set at 90% of corneal thickness at (90 degrees meridian), at 8 mm optic zone, a radial incision was done and corneal pockets were created. A 6.0 nylon preloaded spatula was then inserted into the corneal pocket and in a counterclockwise direction rotated in 3600 to create a deep stromal tunnel
Endophthalmitis is an inflammation of the interior of the eye. It is a possible complication of all intraocular surgeries, particularly cataract surgery, with possible loss of vision and the eye itself.
AMBLYOPIA
Presenter : Dr Nikhil Agrawal (1st year resident)
Moderator : Dr Ekta Gupta
DHIR HOSPITAL POST GRADUATE INSTITUTE OF OPHTHALMOLOGY
BHIWANI-127021
Email: education@dhirhospital.com
DR WANI'S TALK ON CRVO FOR RESIDENTS KLE 14 JAN 2023.pptxvbwani
This detailed talk about central retinal vein occlusion deals with all aspects of the disease
It deals with incidence and prevalence, risk factors and clinical features
It also deals with classification, importance of recognizing the ischemic type and the means to recognize it .
It deals with historical studies that gave nformation abour natural course and treatment options
sEveral studies that were conducted to treat CRVO are dealt with in which emphasis is given to anti VEGF drugs
Using a diamond knife, set at 90% of corneal thickness at (90 degrees meridian), at 8 mm optic zone, a radial incision was done and corneal pockets were created. A 6.0 nylon preloaded spatula was then inserted into the corneal pocket and in a counterclockwise direction rotated in 3600 to create a deep stromal tunnel
Endophthalmitis is an inflammation of the interior of the eye. It is a possible complication of all intraocular surgeries, particularly cataract surgery, with possible loss of vision and the eye itself.
AMBLYOPIA
Presenter : Dr Nikhil Agrawal (1st year resident)
Moderator : Dr Ekta Gupta
DHIR HOSPITAL POST GRADUATE INSTITUTE OF OPHTHALMOLOGY
BHIWANI-127021
Email: education@dhirhospital.com
Squamous cell carcinoma is the second-most common
cancer of the skin (after basal cell carcinoma but more
common than melanoma). It usually occurs in areas exposed to the sun. Sunlight exposure and immunosuppression are risk factors for SCC of the skin, with chronic sun exposure being the strongest environmental risk factor
Melanoma
Cutaneous Melanoma
also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes.
Classification Of Melanoma
I : De novo melanoma
A. Melanoma in situ (MIS)
B. Lentigo maligna melanoma (LMM)
C. Superficial spreading melanoma (SSM)
D. Nodular melanoma (NM)
E. Acral-lentiginous melanoma (ALM)
F. Melanoma of the mucous membranes
G. Desmoplastic melanoma
II Melanoma arising from precursors
Melanoma arising in dysplastic nevomelanocytic nevi
B. Melanoma arising in congenital nevomelanocytic nevi
C. Melanoma arising in common NMN
Etiology And Pathogenesis
The etiology and pathogenesis of cutaneous melanoma are unknown.
Epidemiologic studies demonstrate a role for genetic predisposition and sun exposure in melanoma development.
The major genes involved in melanoma development reside on chromosome 9p21.
Etiology
UVR, mostly of the UVB spectrum (290–320 nm) that induces mutations in suppressor genes. The propensity for multiple BCC may be inherited. Associated with mutations in the PTCH gene in many cases.
Predisposing Factors
Genetic markers (CDKN2a mutation)
Skin type I/II
Family history of dysplastic nevi or melanoma
Personal history of melanoma
Ultraviolet irradiation, particularly sunburns during childhood and intermittent burning exposures
Number (>50) and size (>5 mm) of melanocytic nevi
Congenital nevi
Number of dysplastic nevi (>5)
Dysplastic melanocytic nevus syndrome
Immune suppression (debatable)
Number (>50) and size (>5 mm) of melanocytic nevi
Congenital nevi
Number of dysplastic nevi (>5)
Dysplastic melanocytic nevus syndrome
Immune suppression (debatable)
Six Signs of Malignant Melanoma (ABCDE Rule):
A- Asymmetry in shape—one-half unlike the other half.
B- Border is irregular—edges irregularly scalloped, notched, sharply defined.
C- Color is not uniform; mottled—haphazard display of colors; all shades of brown, black, gray, red, and white.
D- Diameter is usually large.
E- Elevation is almost always present and is irregular—surface distortion is assessed by side-lighting. others use E for Enlargement— a history of an increase in the size of lesion is one of the most important signs of malignant melanoma.
Lentigo Maligna Melanoma (LMM)
Dr Patrick Treacy on Diagnosis and Treatment of Malignant Melanoma Dr. Patrick J. Treacy
A 23-year-old Siberian female patient presented with a changing lesion on her abdomen. The patient stated the lesion was present for about two years and it started
off from within a freckle, which started to grow larger and somewhat darken in appearance. It had the clinical appearance of a melanoma and the dermoscopy three-point checklist (designed to allow non-experts not to miss detection of melanomas) was used to determine whether this had a high likelihood of malignancy. It included:
Asymmetry: asymmetry of colour and structure in one or
two perpendicular axes
Atypical network: pigment network with irregular holes
and thick lines
Blue-white structures: there was some evidence of blue-
white veil and regression structures
Dr Patrick Treacy shares some of his most challenging cases.
This month he talks about treating Cutaneous Malignant Melanoma. Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes. They typically occur in the skin but may rarely occur in the mouth, intestines, or eye. In women they most commonly occur on the legs, while in men they are most common on the back. Sometimes they develop from a mole with concerning changes including an increase in size, irregular edges, change in color, itchiness, or skin breakdown
We all Know that the most dangerous medical condition in our modern life is cancer!
There are two types of this awful condition, BENIGN and MALIGNANT. The first is safe
and can be removed by many ways without large effects on the patients, but the last
one is very killing and can cause a lot of consequences on the patient, even death.
In my report, I will discuss one of the cancer's types that occur in the human body,
which is "Melanocytes tumors".
I mentioned everything about Melanocytes tumor, starting with signs and symptoms,
and finishing with diagnosis and treatment.
The Melanocytes are found in two areas of the human body, (Eye and skin). It can be
hidden for a lot of time without discovering by patients or doctors, so all people need
to be checked every month or years to be sure that they are safe from this killing
condition.
Also, this condition can be normal without problems and found in all people
approximately, such we called it "Nevus" or "Shama" in Arabic language which is one of
the beauty sings.
Malignant melanoma is one of the most aggressive neoplasms of the skin. It originates from the melanocytes, which are cells derived embryologically from the neural crest and migrate to the epidermal basal layer. It is characterized by producing pigmentation as well as being susceptible to metastasis. We report the case of a 36-year-old female patient with advanced clinical stage and distant commitment. The biopsy confirmed the presence of Grade III invasive nodular cutaneous melanoma in the left subscapular region with lymph node metastasis with reactive hyperplasia. An exploratory research is carried out with the bibliographic review in scientific journals with evidence level II–IV. In portals PubMed, Redalyc, BVS, and UpToDate. 81241 met criteria 2248 of which 629 were chosen for having access to the full text and of these 496 are more current (as of 2008), and in the end, 27 articles were selected that met all the inclusion criteria to this article. Due to the increase in the incidence of this disease in recent years and its poor prognosis in short to medium term, it is important to know and follow-up on patients with known risk factors for this disease such as the presence of previous nevi, with emphasis on measures of prevention.
SANDRI G. La Nutrizione Clinica al S.Eugenio. ASMaD 2017Gianfranco Tammaro
DOTT. GIANCARLO SANDRI - Convegno "Il Presente ed il Futuro della Nutrizione Clinica" - 24/03/2017 - Sala Rita Levi Montalcini - Ospedale S.Eugenio - ROMA
Sito ASMaD: http://www.asmad.net
Canale Youtube: https://youtu.be/O7NcSQjnRR4
GASBARRINI A. Nutrizione Clinica e Gastroenterologia. ASMaD 2017Gianfranco Tammaro
PROF. ANTONIO GASBARRINI - Convegno "Il Presente ed il Futuro della Nutrizione Clinica" - 24/03/2017 - Sala Rita Levi Montalcini - Ospedale S.Eugenio - ROMA
Sito ASMaD: http://www.asmad.net
Canale Youtube: https://youtu.be/FYlsQzE8xfk
PALLAGROSI R. Gli Alimenti a fini medici speciali: nuova definizione e normat...Gianfranco Tammaro
DOTT.SSA ROBERTA PALLAGROSI - Convegno "Il Presente ed il Futuro della Nutrizione Clinica" - 24/03/2017 - Sala Rita Levi Montalcini - Ospedale S.Eugenio - ROMA
Sito ASMaD: http://www.asmad.net
Canale Youtube: https://youtu.be/86dXMRSe6hQ
DE SANTIS D. Il Supporto Nutrizionale in Ospedale: ieri, oggi, domani. ASMaD ...Gianfranco Tammaro
CPSI DANIELA DE SANTIS - Convegno "Il Presente ed il Futuro della Nutrizione Clinica" - 24/03/2017 - Sala Rita Levi Montalcini - Ospedale S.Eugenio - ROMA
Sito ASMaD: http://www.asmad.net
Canale Youtube: https://youtu.be/VhUPt78wU4Y
Giorgetti G.M. Il Supporto Nutrizionale in Ospedale: ieri, oggi, domani. ASMa...Gianfranco Tammaro
DOTT. GIAN MARCO GIORGETTI - Convegno "Il Presente ed il Futuro della Nutrizione Clinica" - 24/03/2017 - Sala Rita Levi Montalcini - Ospedale S.Eugenio - ROMA
Sito ASMaD: http://www.asmad.net
Canale Youtube: https://youtu.be/hDOnIcyTagc
Franceschi F. Il Ruolo del Gastroenterologo nel DEA. ASMaD 2016Gianfranco Tammaro
PROF. FRANCESCO FRANCESCHI - 3° Giornata Master ECM in Gastroenterologia 2016 (25/11/2016) - Fondazione Santa Lucia - Sala Congressi - Roma
Sito: www.asmad.net
Canale Youtube: https://youtu.be/NZzctPkJiGI
Gasbarrini A. Microbiota, Antibiotici e Probiotici in Gastroenterologia. ASMa...Gianfranco Tammaro
PROF. ANTONIO GASBARRINI - 3° Giornata Master ECM in Gastroenterologia 2016 (25/11/2016) - Fondazione Santa Lucia - Sala Congressi - Roma
Sito: www.asmad.net
Canale Youtube: https://youtu.be/ouYcXg_ZtJM
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
2. ll melanoma è un tumore maligno che
origina
dai melanociti della cute e delle mucose,
dai melanociti che costituiscono i nevi
e, molto più raramente,
dai melanociti posti in sedi extracutanee
(occhio, orecchio interno, meningi,
mesenchima viscerale).
3. CRITERI CLINICI X IL RICONOSCIMENTO
A asimmetria
B bordi irregolari
C colori multipli
D dimensioni
E evoluzione intesa come cambiamento
12. CLARK
Livello I: Melanoma in situ: il tumore è
nell'epidermide al di sopra di una lamina basale
intatta;
Livello II: il tumore invade il derma papillare;
Livello III: il tumore arriva fino all'interfaccia tra
derma papillare e derma reticolare, senza
infiltrare quest'ultimo;
Livello IV: il tumore invade il derma reticolare;
Livello V: il tumore invade il tessuto
sottocutaneo.
13. Breslow Sopravvivenza a 10 anni
_
< 1mm 91%
1,01-2,0mm 78%
2,01-4,0mm 62%
> 4mm 38%
14. Eleven Independent Clinicopathologic Prognostic
Markers for Cutaneous Melanoma
Age at Diagnosis
Gender
Growth phase (radial vs vertical)
Thickness
Level of invasion
Presence of ulceration
Presence and density of tumor infiltrating lymphocytes
Regression
Presence of microsatellites
Presence of vascular and lymphatic invasion
Presence and quantity of mitotic figures
16. La dermoscopia (o microscopia a
epiluminiscenza) é una tecnica
diagnostica per esaminare in vivo lesioni
cutanee, ingrandite di 10-20 volte. Si
tratta di un'apparecchiatura che utilizza:
olio che, applicato sulla lesione rende il
derma più trasparente; un obiettivo, che
posto a diretto contatto con la lesione
tramite l'olio potenzia l'esame in vivo
delle strutture della giunzione dermo-
epidermica; una sorgente di luce e una
lente d'ingrandimento.
22. Proliferazione
melanocitaria atipica
Intraepidermica
suggestiva per forma
iniziale di melanoma in
situ
associata ad intenso
infiltrato infiammatorio
del derma papillare-
reticolare
Margini di escissione
chirurgica indenni
25. ATYPICAL MOLE SYNDROME AND DYSPLASTIC NEVI:
IDENTIFICATION OF POPULATIONS AT RISK FOR
DEVELOPING MELANOMA
J.H. Silva, B.C.Soares de Sa et Al. CLINICS 2011 March
In 1820, Norris described what is currently considered in a family
predisposed to melanoma.
In 1978 Clark reported an increase incidence of cutaneous melanoma
in families with multiple melanocytic lesions, introducing the
melanoma tumor progression model from melanocytic nevi, and
used the term B_Kmole syndrome, from the initials of the patients
surnames. Now the terms AMS,Dysplastic Nevus Syndrome and
Familial Atypical Multiple-Mole Syndrome (FAMMS) have been
employed.
In 1985, Elder extended the theory of nevus-melanoma for sporadic
dysplastic nevi as a possible precursor of sporadic melanoma
26. 1984-2008 A.B.Ackerman
"The perplexing story of the dysplastic nevus and the dysplastic nevus
syndrome can be comprehended only in the context of understanding
the consistent lack of a repeatable definition of dysplasia and the
persistent failure to provide reliable criteria for clinical and
histopathologic diagnosis of dysplastic nevus. As a consequence of
these rickety underpinnings, it was inevitable that the edifice would
collapse, and it did in less than 15 years. The epitaph for dysplastic
nevus was written in 1992, and that was published in the Journal of
the American Medical Association in 1992. In that report, the panel
stated that the term dysplastic nevus had outlived its usefulness and
should be abandoned. We concur and advise further that the
concepts of dysplasia, dysplastic melanocytes, dysplastic nevus, and
the dysplastic nevus syndrome not only be abandoned now, but that
they also not be supplanted by equally opaque notions, such as
cytologic and architectural atypia, nevus with histologic dysplasia,
clinically atypical mole, and atypical mole syndrome.
Resolving Quandaries in Dermatology, Pathology and Dermatopathology. pp 88. Promethean
Medical Press/Waverly, 1995.
27.
28. Several studies have shown that the
presence of dysplastic nevi considerably
increases the risk of developing
melanoma, which demonstrates that these
lesions, aside from being precursors to
disease are also important risk markers
29. Atypical moles differ from common acquired melanocytic
nevi in several respects, including diameter and lack of
pigment uniformity. Confusion exists because some atypical
moles cannot be clinically distinguished from melanoma. The
clinical and histologic appearances of atypical moles occurring
in a familial setting appear to overlap with sporadically
occurring atypical moles.
The US National Institutes of Health Consensus Conference
on the diagnosis and treatment of early melanoma defined a
syndrome of familial atypical mole and melanoma (FAMM).
The criteria for FAMM syndrome are as follows:
The occurrence of malignant melanoma in 1 or more first- or
second-degree relatives
The presence of numerous (often >50) melanocytic nevi, some
of which are clinically atypical
Many of the associated nevi showing certain histologic
features (see Histologic Findings)
30. Dysplastic nevus (atypical nevus)
Gisele Gargantini Rezze, Alexandre Leon, Joao Duprat
Abstract: Atypical nevum (dysplastic) is considered an
important factor associated with increased risk of
developing cutaneous melanoma. It is believed that
atypical nevi are precursor lesions ofcutaneous
melanoma.They may be present in patients with multiple
melanocytic nevi (atypical nevus syndrome) or isolated
and in small numbers in a non-familial context. The disease
usually begins at puberty and predominates
in young people. It has a predilection for sun-exposed
areas, especially the trunk. The major challenge
in relation to atypical nevi lies in the controversy of defining
its nomenclature, clinical diagnosis, dermoscopic
criteria, histopathological diagnosis and molecular aspects.
This review aims at bringing knowledge,
facilitating comprehension and clarifying doubts about
atypical nevus. An Bras Dermatol. 2010;85(6):863-71.
32. dm.4,8x4,00mm dm.5,00x4,3mm
Ing.30X Ing.30X
Gomito sx
03-05-2010 22-11-2010
SSM a cellule fusate ed epitelioidi,in
fase di crescita radiale infiltrante il
derma papillare II
Clark, Breslw.0,22mm
33. dm. 11,2x8,2mm
15-02-2011,
Interscapolare
paravert. Dx,
Melanoma in situ, IClark
15-02-2011
sottoscapolaresx
20X
Nevo
displastico con
focali aree di
trasformazione
melanomatosa 20X
in situ, IClark dm. 8,00x6,5mm
34. Ing.30X
09-02-2010 Melanoma a diffusione superficiale
della pianta piede sx, Clark:II, Breslow:0,3 mm.
Ing.30X
30X dm.3,8x3,1mm
ANAMNESI:dal febbraio 2004 ad oggi:
1)Nevo melanocitico giunzionale displastico
2)Melanoma della gamba dx insorto su nevo
dm 4,8x4,00 23-11-2010
Clark:III; Breslow 0,5mm
3) vari nevi composti
26-11-2009
Ing.30X
dm:4,4x4,2
10-04-2012: Nevo Composto
dm 4,7x4,4
35. Ing. 15X
Melanoma infiltrante il
28-11-2008 derma papillare, II
Clark, Breslow 0,45mm
Ing.20X
dm. 10,9x6,6mm
24-04-2009 dm. 7,3x6,2mm
Nevo melanocitico giunzionale
con aspetti displastici
36. dm. 3,1x2,9mm Ing.30X dm. 3,2x3,0mm Ing.30X
12-01-2009 05-05-2009
dm. 3,4x3,2 mm Ing.30X
reg. tibiale
ant.dx. SSM
infiltrante il
derma
papillare,
II
Clark, Breslo 28-01-2010
w 0,15mm
37. dm. 3,7x3,3mm 19-07-2007 , ginocchio
interno sx ,
Ing. 30X
22-05-2008
SSM, in fase di crescita radiale II
Clark, 0,25 Breslow
Ing. 30X dm.4,00x3,3mm
38. dm.2,2x2,00mm
24-09-2010
caviglia sx
dm.2,7x2,6mm
Ing. 50X
SSM in fase di crescita
radiale a cellule
epitelioidi, infiltrante il
derma papillare
II Clark, Breslow : 0,4mm
28-01-2011
Ing. 50X
40. VivaCamTM Macroscopic Camera Option
Clinical Photograph
of a Lesion
3mm x 3mm
VivaBlockTM
10mm x 10mm
VivaCamTM
Image
41. K. Busam, C. Charles, A. Marghoob, MSKCC
Image taken at the papillary dermis of the biopsy-proven nevus component (A) of previous
nevus shown in the previous slide. Notice the organized nests of nevomelanocytes within the
superficial dermis, consistent with a benign lesion. 500 µm field of view.
43. ANIMAL MELANOMA: di recente codifica. E’ un
Melanoma che sintetizza pigmento. E’ una variante
istopatologica rara, così chiamato per la prominente
produzione di melanina, che appare simile ad una
variante di melanoma osservata nei cavalli grigi
MELANOMA DESMOPLASTICO: forma rara di
Melanoma, caratterizzato dalla tendenza ad infiltrare i
vasi sanguigni, a diffondersi per invasione
perineurale e per l’alta frequenza con la quale
recidiva localmente.