This document discusses cancer pain management. It notes that 50-90% of oncology inpatients and 35% of outpatients report breakthrough cancer pain. Common causes of cancer pain include bone metastases, visceral metastases, and neuropathic pain. Barriers to effective pain management include clinical, patient-related, and system-related factors as well as racial and ethnic barriers. A thorough pain assessment considers intensity, location, quality, timeline, alleviating factors, and prior medications. Opioids are the mainstay of cancer pain treatment, with short-acting opioids used for breakthrough pain and long-acting for persistent pain.
CME presentation made on 10th Nov 2012. Discusses a Radiation Oncologist's perspectives of cancer pain management, shortcomings of WHO pain ladder, ASTRO guidelines for metastatic bone pain.
Carle General Surgery Grand Rounds presentation on palliative care symptom management, specifically pain, nausea, constipation, and malignant bowel obstruction.
Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomized, open-label, phase 3 trial
Cancer hurts!
The misconception that a cancer patient is doomed to endure pain must be corrected. Cancer has pain and cancer pain has a cure. To manage cancer pain, we need to have a multidisciplinary approach.
Pain is the production (out put ) of the brain.
Pain is invisible disease, we can’t see it like other disease, such as struma, fracture or blind.
What you have to do is to believe what ever the patient says.
Pain is what ever the patient says it is
Pain is invisible diseases, but is real for patient.
Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Surface MalignanciesMary Ondinee Manalo Igot
The prognosis of most peritoneal surface malignancies were previously dismal. However, with the incorporation of HIPEC to standard of care, we have been seeing doubling of survival for select malignancies. Appropriate patient selection is crucial.
CME presentation made on 10th Nov 2012. Discusses a Radiation Oncologist's perspectives of cancer pain management, shortcomings of WHO pain ladder, ASTRO guidelines for metastatic bone pain.
Carle General Surgery Grand Rounds presentation on palliative care symptom management, specifically pain, nausea, constipation, and malignant bowel obstruction.
Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomized, open-label, phase 3 trial
Cancer hurts!
The misconception that a cancer patient is doomed to endure pain must be corrected. Cancer has pain and cancer pain has a cure. To manage cancer pain, we need to have a multidisciplinary approach.
Pain is the production (out put ) of the brain.
Pain is invisible disease, we can’t see it like other disease, such as struma, fracture or blind.
What you have to do is to believe what ever the patient says.
Pain is what ever the patient says it is
Pain is invisible diseases, but is real for patient.
Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Surface MalignanciesMary Ondinee Manalo Igot
The prognosis of most peritoneal surface malignancies were previously dismal. However, with the incorporation of HIPEC to standard of care, we have been seeing doubling of survival for select malignancies. Appropriate patient selection is crucial.
Pain definition, Pain pathways, pain modulation, the endorphin system, Types of Pain, current trend of Drugs used for pain management. New Drugs for pain
Building on the lecture I gave (and uploaded) "Palliative Care: what every primary care doctor should know" I built this talk. It is geared for 1st year medical students who are learning anatomy, physiology, and perhaps some pharmacology and pathophysiology.
In this talk, I do not explicitly address hospice care - as that was provided in an online chapter for students at UMass. I will later upload another slide set on that topic.
I hope you enjoy it.
FYI- the link to the youtube video: http://www.youtube.com/watch?v=XHtHXGhTIC4
Link to PDF of the slide show: https://files.me.com/s.mak/8fzat6
this is an important topic in palliative care. a form of care each of us may need when we suffer terminal illness and severe trauma at one point in our life time.
Post operative pain management has no specific criteria. Lots of methods and procedures are suggested with various types of drugs. It is just a guideline for management of pain after surgery.
a detailed description of pain and therpaeutic options available and clinical assessment of pain, approach to the patient with pain, assessment of intensity of pain, nsaids and opioids, tca. WHO pain ladder, chronic opioid therapy
Presentation given by me and Dr. Novack about assessing and managing delirium in patients receiving palliative care and hospice care.
Original presentation was shared with NHPCO - this is a version of the slides provided there.
This presentation JoAnne Nowak and I gave for NHPCO last spring addresses the prevention, assessment and treatment of delirium - particularly in hospice and palliative care settings.
These are the slides I presented at RWJ School of Medicine Grand Rounds, University Day when new faculty were inducted into the Master Educator's Guild.
In this talk about integrative medicine, I outline the need to teach clinicians - doctors, nurses, holistic healers, psychologists, naturopaths, etc. - about deep healing. We are taught to deconstruct the human into anatomic parts, cells, physiology in order to cure. But to heal, we need to help a person reintegrate all those parts - and rediscover themselves - as a person with family, hopes, dreams, beliefs, culture, tradition, hobbies.
We seek healthcare not for the experience of healthcare, but because the process helps us live more fully, and enjoy the things we love. This reintegration can happen at any stage of life and illness. It is holism. It is deep healing.
A lecture given at a Primary Care Conference in Massachusetts - on the important role primary care physicians could play in ensuring good palliative care for patients, communication, hospice, myths & realities
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
2. • 50 to 90 percent of oncology inpatients report
breakthrough pain
• 35 percent of community based oncology practices
patients report breakthrough pain
• 1 in 3 patients with active cancer report pain
• 3 out of 4 of patients with advanced cancer report pain
Prevalence of Cancer Pain
3. • Bone metastases
• Visceral metastases
• Immobility
• Neuropathic pain
• Soft tissue
• Constipation
• Esophagitis
• Lymphedema
• Muscle cramps
• Chronic postoperative scar
• Adapted from Twycross R, Harcourt J, Bergl S: A survey of pain in patients with advanced cancer.
J Pain Symptom Manage 1996;12:273-282.
Common Causes
4. Physical Emotional Existential
• Increased catabolic demands: Depression Suffering –
poor wound healing, weakness, muscle Anxiety “why me?”
breakdown Decreased
• Decreased limb movement: intimacy
Suicidality
increased risk of DVT/PE
• Respiratory effects:
shallow breathing, tachypnea, cough
suppression increasing risk of pneumonia and
atelectasis
• Sodium and water retention Decreased
gastrointestinal mobility
• Tachycardia and elevated blood pressure
• Decreased functional status
• Increased chronic pain
Effects of under treated pain
8. What about for patients who cannot self-report?
Intensity
9. Category Cause Symptom Examples
Physiologic Brief exposure to a Rapid yet brief pain Touching a pin or hot
noxious stimulus perception object
Somatic or visceral tissue Moderate to severe pain, Surgical pain,
Nociceptive/infla
injury with mediators described as crushing or traumatic pain, sickle
mmatory
having an impact on stabbing cell crisis
intact nervous tissue
Damage or dysfunction Severe lancinating,
Neuropathy, CRPS.
Neuropathic of peripheral nerves or burning or electrical
Postherpetic Neuralgia
CNS shock like pain
Combinations of Low back pain, back
Combined somatic and
Mixed symptoms; soft tissue plus surgery pain
nervous tissue injury
radicular pain
Pain Quality
14. Short-acting Long-acting
• Hydrocodone/APAP
• Transdermal fentanyl
• Oxycodone +/- APAP
• methadone
• Morphine
• morphine ER
• Hydromorphone
• oxycodone ER
• Oral transmucosal fentanyl
• Cmax ~ 45 min
Cmax and T1/2 vary based on
• T1/2 ~ 4 hours
formulation and drug
• Except fentanyl
Opioid Pharmacology
15. • Conjugated by liver
• 90-95% excreted in urine
• Dehydration, renal failure, severe hepatic failure
• Decrease interval/dosing size
• If oliguria/anuria
• STOP routine dosing (basal rate) of morphine
• Use ONLY PRN
Opioid pharmacology
16. What is the half life (range) for opioids?
• 2-4 hours
How many half lives to get to steady state?
• 4-5
What do you base your scheduled dosing on: Cmax or T1/2?
• T1/2
What do you base your breakthrough dosing on: Cmax or T1/2?
• Cmax
Opioid Pharmacology
18. What is the challenge
with Step 2 of the
ladder?
WHO Step-Ladder
19. Hector G - 65 yo man with colon cancer and bone metastases
Your colleague first started Mr. G on hydrocodone 5 mg +
acetaminophen 325 mg one tablet by mouth every 4 hours prn for
his hip and rib pain. He also ordered senna + docusate 2 tabs po
qday to prevent opioid‐induced constipation.
Today, he tells you he is taking the Vicodin 1 tablet every 4 hours
around the clock (including at night). His pain is generally
constant, aching and he rates it as 5/10, but worsens to 8/10 with
certain positions and movements.
• How will you titrate his opioid pain medication?
Case – part 1 - outpatient
20. • Convert from Vicodin to Morphine
• How to convert to a combination of long- and short-
acting morphine (the latter for breakthrough pain)?
• What co-analgesics and other treatments might you
choose?
Case – Part 1
21. • Hector comes to hospital for a procedure. He is made
NPO. His pain has been well managed. How do you
manage his pain?
• Home regimen: MSContin 30mg BID, Roxanol 10mg q2
hours prn, requiring 2 – 4 doses per day.
• What if he were on Oxycodone/Oxycontin instead?
Case – Part 2 – NPO inpatient
22. • Mr. G presents to the ER after several days of escalating hip
and rib pain, despite taking the maximum dose of morphine he
was prescribed as an outpatient. “I can’t take it anymore.” You
admit him for pain management while trying to treat his
escalating pain.
• Home medications: MSContin PO 30mg bid, Morphine liquid
10mg PO q2 hours prn (taking every dose)
In addition to imaging him, calling radiation oncology
for evaluation, how do you manage his pain?
Case – part 3
23. • This is as much of a
crisis as a code (JAMA
2008;299(12):1457-1467. doi:
10.1001/jama.299.12.1457)
• http://jama.ama-
assn.org/content/299/12/1457.full.
pdf
Pain crisis
25. • Choosing to be CMO does not automatically increase
opioid requirement
• Caution with renal failure
Pain at End-of-Life
26. • Pain is common in cancer. Undertreated pain worsens
prognosis
• On a good day, patients should not need PRNs, and on a
bad day, should not need it more than 4 times per day.
• When converting to IV from PO – don’t forget to include
the long-acting opioid.
• Opioid conversion is not mysterious
• Pain Crises is as serious as a code
• Methadone is a great drug – but is complicated
• Avoid morphine and hydromorphone in renal failure
• Match pain pattern with opioid pharmacology
• CMO ≠ continuous morphine only
• We’re here to help
Summary: Top 10
Cognition and memory play a large role in the experience of pain.10 Fear and depression reduce pain thresholds and produce anatomic changes that accentuate pain. Long-term neuroanatomic changes have been discovered in amygdala and hippocampus, sites that affect pain memory. These changes involve calcium-calmodulin–dependent protein kinases.17
Increased catabolic demands: poor wound healing, weakness, muscle breakdownDecreased limb movement: increased risk of DVT/PERespiratory effects: shallow breathing, tachypnea, cough suppression increasing risk of pneumonia and atelectasisIncreased sodium and water retention (renal)Decreased gastrointestinal mobilityTachycardia and elevated blood pressureDecreased functional statusDepression/anxietyIsolation – decreased intimacyExistential suffering
Increased catabolic demands: poor wound healing, weakness, muscle breakdownDecreased limb movement: increased risk of DVT/PERespiratory effects: shallow breathing, tachypnea, cough suppression increasing risk of pneumonia and atelectasisIncreased sodium and water retention (renal)Decreased gastrointestinal mobilityTachycardia and elevated blood pressureDecreased functional statusDepression/anxietyIsolation – decreased intimacyExistential suffering