Preventive analgesia:
Broader definition of preemptive analgesia
Perioperative analgesic regimen that able to control pain-induced sensitization
Not the timing of the analgesic treatment but the duration and efficacy of an analgesic intervention are more important for an effective postoperative pain relief
Adequate preventive analgesia should include multimodal techniques and with a sufficient duration of tretment
Preventive analgesia:
Broader definition of preemptive analgesia
Perioperative analgesic regimen that able to control pain-induced sensitization
Not the timing of the analgesic treatment but the duration and efficacy of an analgesic intervention are more important for an effective postoperative pain relief
Adequate preventive analgesia should include multimodal techniques and with a sufficient duration of tretment
PCA is neither “ one size fits all “ or a “ set and forget “ therapy
An Anesthesiologist style ……….
no fixed dose of drug fits all patient
make patient analgesia and take care
Aggressive preemtive multimodal including epidural or nerve block not only produce optimal analgesia but also may prevent the occurrence of chronic pain after surgical
Paracetamol as a single analgesic is only for mild and moderate pain.
However it can be combined with many analgesics to provide strong effect.
So, it can be the basic regiment for Multimodal Analgesia.
The category shown barely scratches the surface of this beautiful presentation. What had humbly begun as a postscript to my other PowerPoint CONSUMERISM quickly took on a life of its own during Lent '09. I just had to share my traumatic discovery that my all-time favorite movie is really about my lifelong worst fear. This heartwrenching, unforgettable presentation is at the vanguard of film criticism, social medicine, psychology, and human rights. Its perspective is well over a half century overdue. STRONGLY RECOMMENDED: to hear the stunning Tchaikovsky soundtrack, go to my website http://assumetheopposite.com/Powerful_PowerPoints.html to download the 3 music files and follow the step by step instructions to add the links to the presentation. Don't forget to download the postscript in .doc format. Running time: approx. 45 min. Rated PG.
PCA is neither “ one size fits all “ or a “ set and forget “ therapy
An Anesthesiologist style ……….
no fixed dose of drug fits all patient
make patient analgesia and take care
Aggressive preemtive multimodal including epidural or nerve block not only produce optimal analgesia but also may prevent the occurrence of chronic pain after surgical
Paracetamol as a single analgesic is only for mild and moderate pain.
However it can be combined with many analgesics to provide strong effect.
So, it can be the basic regiment for Multimodal Analgesia.
The category shown barely scratches the surface of this beautiful presentation. What had humbly begun as a postscript to my other PowerPoint CONSUMERISM quickly took on a life of its own during Lent '09. I just had to share my traumatic discovery that my all-time favorite movie is really about my lifelong worst fear. This heartwrenching, unforgettable presentation is at the vanguard of film criticism, social medicine, psychology, and human rights. Its perspective is well over a half century overdue. STRONGLY RECOMMENDED: to hear the stunning Tchaikovsky soundtrack, go to my website http://assumetheopposite.com/Powerful_PowerPoints.html to download the 3 music files and follow the step by step instructions to add the links to the presentation. Don't forget to download the postscript in .doc format. Running time: approx. 45 min. Rated PG.
Pain results from a variety of pathological processes and is considered as a vital sign.
It is expressed differently by each patient depending on cultural background, age, etc,etc.
IT IS A HIGHLY SUBJECTIVE EXPERIENCE MEANING THAT ONLY THE INDIVIDUAL IS ABLE TO ASSESS HIS/HER LEVEL OF PAIN.....
yes this is my first presentation just prepared for my wkly presentation of oncology department RAJSHAHI MEDICAL COLLEGE. Though it was not that much good.
a detailed description of pain and therpaeutic options available and clinical assessment of pain, approach to the patient with pain, assessment of intensity of pain, nsaids and opioids, tca. WHO pain ladder, chronic opioid therapy
2. INTRODUCTION
IASP define pain as an unpleasant sensory
and emotional experience associated with
actual or potential tissue damage, or
described in terms of such damage.
3. PAIN MANAGEMENT
Applies to entire discipline of anaesthesiology, more
specifically involves management of pain throughout
the perioperative period as well as nonsurgical pain in
both inpatient and outpatient settings.
Broadly divided into
acute pain management (primarily deals with patient
recovering from surgery or with acute medical
conditions and mostly due to nociception) and
chronic pain management (includes diverse groups of
patients almost always seen in outpatient setting)
4. PRACTICE OF PAIN MANAGEMENT
The contemporary practice of pain management
is not limited to anesthesiologists but often
includes other physicians (physiatrists, surgeons,
internists, oncologists, psychiatrists, and
neurologists) and nonphysicians (psychologists,
physical therapists, acupuncturists, and
hypnotists).
The most effective approaches are
multidisciplinary,
5. ACUTE PAIN
Acute pain is caused by noxious stimulation due
to injury, a disease process, or the abnormal
function of muscle or viscera.
It is usually nociceptive.
Nociceptive pain serves to detect, localize, and
limit tissue damage.
Four physiological processes are involved:
transduction, transmission, modulation, and
perception.
This type of pain is typically associated with a
neuroendocrine stress response that is
proportional to the pain’s intensity.
10. TARGETS OF A PREVENTIVE
APPROACH TO ACUTE PAIN
MANAGEMENT
Perioperative period
Preoperative (days before surgery and
just minutes before skin incision)
Intraoperative (after incision to those
initiated just prior to the end of surgery)
Postoperative (after the end of surgery
and may extend for days thereafter)
Specific factors within these phases
contribute to the development of acute
operative pain
11. HISTORY AND PROGRESS
IN PRE-EMPTIVE
ANALGESIA
Pre-emptive analgesia would block the
induction of central neural
sensitization brought about by the
incision and reduce the intensity of acute
postoperative pain ( proposed first by
Crile and later by Wall)
General anesthesia may attenuate the
transmission of afferent injury barrage
from the periphery to the spinal cord and
brain, but it doesn’t block the
transmission
12. PREEMPTIVE
ANALGESIA :
It involves the introduction of an analgesic
regimen before the onset of painful stimuli,
with the goal of preventing sensitization
of the nervous system to subsequent stimuli
that could amplify pain
Windup: functional changes in the dorsal
horn because of pain.
This type of therapy, in addition to reducing
acute pain, attenuates chronic postoperative
pain/ chronic post-surgical pain (CPSP)
14. FACTORS THAT MODIFY PERI-
OPERATIVE PAIN
1- Site ,nature and duration of surgery.
2- Type, location extent of incision.
3- Physiologic and psychologic makeup
of the patient.
4- Pre operative preparation of the patient
including preoperative treatment of
painful stimuli.
5- Presence of complications of surgery.
6- Anesthetic management.
7- Quality of perioperative care.
15. MEDIATORS
Neurotransmitter Effect on nociception
Substance P Excitatory
Glutamate Excitatory
Aspartate Excitatory
ATP Excitatory
Somatostatin Inhibitory
Acetylcholine Inhibitory
Endorphins Inhibitory
Enkephalins Inhibitory
Norepeinephrine Inhibitory
Adenosine Inhibitory
Serotonin Inhibitory
GABA and glycine Inhibitory
Calcitonin gene related peptide Excitatory
16. Substance P synthesized in
dorsal root ganglion,
sensitisiating the neuron to
nociceptive signals; binding
NK1, resulting Ca ion influx;
induce NO production
serotonin
released
from
platelets ,
mast cells
and excite
afferents via
5HT1-3
Ketamine is
effective NMDA
antagonist
PERIPHERAL AND CENTRAL
SENSITIZATION
17. RATIONALE FOR
MULTIMODAL ANALGESIA
Goal
Providing effective pain relief, reducing
opioid-related side effects and surgical
stress response, and improve clinical
outcome
Concept
Combination various analgesic techniques
and different classes of drugs
Failure reason
Inappropriate timing of administration of
analgesic
18. TREATMENT
1-Systemic opiods.
2-Nonopioid analgesics
3-Patient-controlled analgesia.
4-Regional anesthetic techniques .
a : Intrathecal analgesia.
b :Patient-controlled epidural analgesia.
c :Combined spinal-epidural technique.
5-intraarticular analgesia.
6-Cryoanalgesia.
7-T.E.N.S.
8-Psychologic and other methods.
19.
20.
21. OPIOIDS
ESSENTIAL ELEMENT OF PAIN MANAGEMENT
Receptors
Mu (μ or OP3)
μ1
μ2
Kappa (κ or OP2)
Delta (δ orOP1)
Sigma(σ)
Clinical effect
Analgesia, sedation, euphoria
Resp. depression, physical dependence
Spinal analgesia, resp. depression
Analgesia, resp. depression
Dysphoria, hallucination, tachycardia
hypertension
22. OPIOIDS:
BACKBONE OF ANALGESIA
Pure Agonists
Morphine, oxymorphone, meperidine,
hydromorphone, fentanyl
Partial agonists, mixed agonist-antagonists
Buprenorphine
Butorphanol
Pure Antagonists (reversal of agonists)
Naloxone
23. OPIOID ADMINISTRATION
Systemic: IV, SC, IM, oral
Intra-articular injection
Local injection
Epidural or intrathecal injection
Transdermal fentanyl patch (patient-
activated electrically facilitated delivery)
25. OPIOIDS
2. Partial agonists
ceiling effects
eg.buprenorphine, butorphanol
can be used as adjuvants in
neuraxial anelgesia
26. OPIOIDS
3. Agonists-antagonists
: agonist-κ or σ receptor
but antagonist to μ receptor
: can used in mild to moderate pain
: ceiling effects
: precipitate withdrawal in opioids
dependent
: pentazocine, nalbuphine
27. MORPHINE
Dose: 0.1-0.2 mg/kg iv
•metabolism : liver
M-3-Glucoronide : no analgesic property
M-6-G : more potent than morphine(2X)
• histamine release
•INCLUDE liposomal extended release
preparations for epidural administration
34. NON-OPIODS
ACETAMINOPHEN
Action
Analgesic
Antipyretic
Anti-inflammatory agent
Effective for the musculoskeletal aches,joint
stiffness
Disadvantage
Dose-dependent hepatotoxicity, GI upset
Agranulocytosis
Dosage
650-1000 mg PO q 4 hr.
Max. 4 g/d
Reduce dose 50-70% in patient with significant
hepatic impairment
35. NSAIDS
The cornerstone on the treatment of acute
pain in the early postoperative period
Reduce local concentration of arachidonic
acid metabolites
Combination of ibuprofen and paracetamol
reduce the need for early analgesia
Cyclo-oxygenase-2 inhibitors(COX-2)
Parecoxib can be administrated introp and immediately
postop before oral medicaiton toleranted
37. NSAID
DrugDrug DosageDosage Maximum daily doseMaximum daily dose
NonselectiveNonselective
inhibitorinhibitor
DiclofenacDiclofenac
IndomethacinIndomethacin
IbuprofenIbuprofen
50 mg PO bid-tid50 mg PO bid-tid
75 mg PO bid75 mg PO bid
200-800 mg q 6 hr.200-800 mg q 6 hr.
200 mg200 mg
150 mg150 mg
3200 mg3200 mg
Cox-2Cox-2
inhibitorinhibitor
CelecoxibCelecoxib
100-200 mg PO bid100-200 mg PO bid
2-4mg/kg iv
400 mg400 mg
38. KETAMINE
An antagonist at NMDA receptor
An opioid sparing effect and improved
analgesia in opioid-resistant pain
Initial bolus(0.5 mg/kg) and continuous
infusion(3 microgm/kg/min) combined
with continuous femoral nerve block in
TKR
Transdermal ketamine patch
IM 2-4 mg/kg
iv 0.25 -0.5 mg/kg
39. CLONIDINE
An α2-adrenoceptor agonist with anti-
nociceptive activity via peripheral,
supraspinal and primary spinal cord
mechanism
Activation of postsynaptic α2-
adrenoceptors of descending
noradrenergic pathways
Epidural clonidine advantages over
epidural local anesthetics and opioids, no
adverse effects of motor block, urinary
retention, respiratory depression, and
pruritus
Dose 1-2 mics/kg
40. EPIDURAL ANALGESIA
Provides superior pain relief and
attenuate the stress response to
surgery, particularly continuous infusion
during and after surgery
Combined use of epidural local
anesthetics and adjuvants provides
introperative analgesia and postoperative
pain effectively
Associated problems: motor blockade,
incompatibility with anticoagulation,
urinary retention
44. PATIENT-CONTROLLED ANALGESIA
(PCA)
Patients are able to self administer precise
dose of opioid intravenously (or in epidural
space) on and as needed basis.
The physician programs the infusion pump
to deliver a specific dose,the minimum
interval between doses (lockout
period),maximum amount of opioid that can
be given in a given period(1-4h).
When PCA is first initiated a loading dose of
opioid must be given.
45. Most adults require 2-3mg/h of iv morphine
in the first 24-48 hrs and 1-2mg/h in the
following 36-72 hrs
PCA is a cost effective technique that
provides superior analgesia with high pt
satisfaction.
Drug consumption is less
Patients are able to adjust analgesia
according to their pain severity.
46.
47.
48. COMBINED SPINAL EPIDURAL
Has become popular in obstetrics and
in operating room.
Advantage: rapid onset of surgical
anesthesia with availability to continue
analgesia for post op. period.
49. REGIONAL ANESTHETIC
TECHNIQUES:
• Anelgesia superior to opioids
• Positive respiratory, cardiovascular and
neuroendocrine effects
• reduced thromboembolic complications and
blood loss; and reduced convalescence
Brachial plexus blocks :analgesia for upto 12 hrs.
Sciatic and Femoral n. blocks :similar results.
Paravertebral Blocks: equal to thoracic epidural
Intercostal n. blocks : 6-12 hrs. analgesia.
Interpleural block
Cryoanelgesia
Intra-articular Anelgesia: upto 24 hours
50. WOUND INFILTRATION WITH LOCALWOUND INFILTRATION WITH LOCAL
ANAESTHETICSANAESTHETICS
It’s commonly perfomed to achieve
wound analgesia
The routine use of adjuvants in wound
infiltration is currently not recommanded
52. TRANSCUTANEOUS ELECTRICALTRANSCUTANEOUS ELECTRICAL
NERVE STIMULATION (TENS)NERVE STIMULATION (TENS)
Used widely in chronic pain
Evidence in acute pain treatment is
inconclusive, due to lack of well-
conducted RCTs
All available trials used TENS as an
adjuvant to medication, and it’s possible
the effects of TENS was masked by the
analgesic effect of medication
54. MULTIMODAL APPROACH TO
PERIOPERATIVE RECOVERY
Principles of a multimodal strategy include
Control of post-op pain for early mobilization
Early enteral nutrition
Education
Attenuation of perioperative stress response
through regional anesthetic techniques
Multimodal analgesia
The use of epidural anesthesia and anelgesia
covers the last two
55. CONCLUSION
Multimodal pain therapy
Less post-op complications
Reduced duration of hospital stay
Improvement in post-op pain
Better clinical outcomes
The analgesic techniques used should be
individualised to the patient and the type
of surgery
56. Akknaesthesiologist should work as
perioperative physician, actively participate in
the management of perioperative pain for the
enhanced outcome of the patients after surgery.
Anaesthesia provider should practice multimodal
analgesia to control multiple perioperative
pathophysiological factor that lead to
postoperative pain and its sequelae.