Cancer Chemo Radiation Concurrent Supplements
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This document discusses methods to differentiate between radiation necrosis and recurrent disease in glioma patients using magnetic resonance imaging and spectroscopy (MRS). It describes how radiation can damage both tumor and normal brain tissue similarly, making it difficult to distinguish the two. MRS is presented as a potential solution by measuring metabolite ratios that have been shown to discriminate between radiation necrosis and recurrent disease. The document outlines an imaging protocol that was awarded funding to enroll glioma patients and longitudinally collect MRI, diffusion weighted MRI and MRS scans over time to further evaluate the ability of these techniques to differentiate radiation necrosis from recurrent tumor.
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1. With a median follow-up of 59.6 months, the in-breast tumor control rate was 99.3% and 8 in-breast recurrences were observed.
2. Disease-free survival at 7 years was 87.7% and disease-specific survival was 94.5%.
3. True local recurrences accounted for 3 of the 8 in-breast recurrences, while the other 5 were out-of-quadrant recurrences.
Balanced Approach To Esophageal Cancer
This document discusses balanced treatment approaches for esophageal cancer. It recommends that surgery plus additional therapy is required for pT3 N1 tumors. Definitive chemoradiotherapy is an acceptable standard for squamous cell carcinoma. Preoperative and postoperative combination chemotherapy is also an acceptable approach for resectable esophageal or GEJ adenocarcinoma. Preoperative concurrent chemoradiotherapy is a standard for resectable adenocarcinoma of the esophagus or GEJ. The role of preoperative chemotherapy alone for resectable squamous cell carcinoma is unclear and not recommended.
Advancing The Prevention And Cure Of Cancer
The document discusses the shared missions and collaborations between the American Association for Cancer Research (AACR) and the National Cancer Institute (NCI) to advance cancer research and reduce the burden of cancer. It outlines their joint efforts in conferences, workshops, and think tanks. It also summarizes advances in cancer prevention, early detection, and treatment that have contributed to reduced cancer mortality rates in recent years but challenges remain.
Endobronchial High Dose Rate Brachytherapy
This document summarizes the use of endobronchial high dose rate brachytherapy (EHDR) on intubated lung cancer patients. It describes the EHDR procedure, which involves bronchoscopy, catheter placement across the tumor, imaging, planning, and treatment delivery. Three case studies are presented, where intubated patients with lung cancers received 2-4 fractions of EHDR over 1-2 weeks. All three patients achieved the endpoint of successful extubation after treatment, with average oxygen saturation levels maintained during treatment. The document concludes that EHDR is a safe option for intubated lung cancer patients with airway obstruction and can effectively lead to extubation.
Selective Use Of Postoperative Radiotherapy AftEr MastectOmy
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The Use Of High Energy Protons
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Pet And Lymphoma
- Positron emission tomography (PET) scans can help detect residual disease in lymphoma patients who appear to be in complete remission and predict relapse risk.
- For Hodgkin's lymphoma, interim PET scans after 2 cycles of chemotherapy can accurately predict treatment outcome and prognosis.
- For diffuse large B-cell lymphoma, a positive interim PET scan after 2 cycles is associated with lower event-free survival and overall survival rates compared to a negative scan. PET may help identify patients who would benefit from altered treatment intensity.
- Ongoing clinical trials are exploring the use of interim PET results to individualize chemotherapy regimens and determine whether patients should receive high-dose chemotherapy with stem cell transplantation.
Palliative Radiotherapy Using Cone Beam Ct
This document describes a one-step model for online planning and treatment of palliative radiotherapy using cone beam CT (CBCT). In phase A, CBCT image quality was found to be adequate for treatment planning. Phase B involved online planning with CBCT for 45 patients, showing good agreement with conventional planning CT. Treatment plans were delivered in an average of 28 minutes from patient arrival. Phase C is ongoing to further test the efficacy of this one-step CBCT planning approach in reducing planning time and improving patient satisfaction compared to conventional multi-step planning CT.
Heidelberg Ion Therapy Center
The document discusses ion beam therapy and the Heidelberg Ion Therapy Center. Some key points:
1) The Heidelberg Ion Therapy Center will provide carbon and proton ion beam therapy using raster scanning technology for precise dose delivery.
2) Clinical studies are underway to evaluate the effectiveness of carbon ion therapy for various cancers and determine optimal treatment protocols.
3) The center is scheduled to treat its first patient in early 2009 and will have the capacity to treat over 1,000 patients per year.
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Chemoprevention seeks to use natural, synthetic, or biological agents to prevent cancer development and progression. It can involve blocking cancer initiation through agents that prevent DNA damage from carcinogens. It can also suppress promotion and progression of initiated cells through inhibition of signal transduction pathways. The FDA has approved selective estrogen receptor modulators like tamoxifen and raloxifene for breast cancer chemoprevention and aspirin use has been associated with reduced colorectal cancer risk. However, some agents like beta-carotene and retinoids have been found to increase cancer risk in smokers.
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This document discusses cancer globally and in India. It provides statistics on cancer incidence and mortality worldwide and in different countries/regions. Some key points:
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Current and emerging biomarkers of breast cancer
The document summarizes current and emerging biomarkers for breast cancer. It discusses established biomarkers like p53, HER2, BRCA1, and BRCA2, which are involved in processes like DNA damage response and repair. Emerging biomarkers discussed include Ki-67, which is involved in cell proliferation, and Cyclin D1, which regulates cell cycle. The document also reviews how certain foods and dietary components can influence these biomarkers and potentially reduce breast cancer risk by promoting apoptosis, DNA repair, and reducing inflammation. Maintaining a healthy diet and lifestyle is recommended for breast cancer prevention and treatment.
Multi carotenoids report
This document summarizes research on the anticarcinogenic properties of various carotenoids. It finds that carotenoids beyond beta-carotene, such as alpha-carotene, lutein, zeaxanthin, and lycopene, show potent anticancer activity and in some cases more activity than beta-carotene. Specifically, it reviews studies finding that alpha-carotene more effectively suppresses tumor development compared to beta-carotene in models of skin, lung, liver, and colon cancer. Lutein and zeaxanthin also inhibited tumor promotion and development in the lung, skin, and colon. Lycopene was found to reduce tumor occurrence and growth in the
Nutrition in Cancer Prevention and Treatment
This presentation will help you to understand the influence that dietary and lifestyle factors play in the prevention and causation of cancer. It outlines the important nutritional considerations for patients undergoing treatment for cancer and reviews procedures to improve patient safety by knowing the risks and benefits of antioxidant supplementation during cancer treatment
MON 2011 - Slide 9 - M. Aapro - Antiemetics, growth factors, bone health
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Current concepts in the pathogenesis of cancer /certified fixed orthodontic c...
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Ovarian Cancer: Treatment Options after Diagnosis
This document summarizes treatment options for ovarian cancer after diagnosis. It discusses that most cases are advanced at presentation and surgery is used to stage and debulk the cancer. Chemotherapy with a taxane and platinum agent is recommended for early and advanced stage disease. For advanced cancer, intraperitoneal chemotherapy may provide a survival benefit compared to intravenous treatment alone. Recurrent cancer can be treated with additional chemotherapy or surgery depending on factors like time since last treatment and extent of recurrence. Future research aims to improve treatment tolerability and identify new targeted therapies.
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The document discusses the current medical paradigm that focuses on disease treatment rather than prevention. It notes America's declining health outcomes and rising rates of chronic diseases like cancer and cardiovascular disease. The new medical paradigm emphasizes healthy lifestyle choices, nutrition, supplementation and exercise to prevent disease. It provides examples of supplements and nutrients that can reduce risks of cancer and heart disease, such as omega-3 fish oil, vitamin E, CoQ10, grape seed extract and indole-3-carbinol. The document also discusses the obesity epidemic and metabolic syndrome/type 2 diabetes, highlighting the role of high glycemic diets and carbohydrate addiction. It compares different nutritional supplement products and ranks USANA Essentials as the highest scoring option
The More Than Ten Things You Should Do to Prevent or Treat Cancer
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This document summarizes statistics on cancer increases from 1973-1999 and potential causes and preventative measures. It finds that certain cancers have increased over 100% in this period. Factors that may contribute to cancer risk include refined carbohydrates, sugar, insulin levels, inflammatory eicosanoids, and lack of anti-inflammatory nutrients. Many natural compounds show promise in preventing or treating cancer, including curcumin, resveratrol, vitamin D, selenium, iodine, indole-3-carbinol, coenzyme Q10, lycopene, green tea, and artemisinin. Maintaining optimal levels of these and other antioxidants may help reduce cancer risks and progression.The More Than Ten Things You Should Do to Prevent or Treat Cancer
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The document discusses evaluation of anticancer agents and the anticancer effects of some materials and drugs. It provides an overview of the purpose and description of anticancer treatment, classifications of anticancer drugs, mechanisms of action, pre-clinical evaluation methods including in vitro and in vivo tests, and some modern treatments using plants and materials. Specifically, it summarizes the anticancer effects and molecular mechanisms of epigallocatechin-3-gallate, melatonin, and other compounds.
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The document discusses the role of vitamin D in preventing cancer. It provides an overview of vitamin D, its functions, and how it may prevent cancer development. Studies show vitamin D supplementation reduces risks of cancers like breast, colon, and prostate by 30-50%. However, randomized controlled trials are still needed to confirm potential preventative effects suggested by observational studies. Future research on vitamin D's cancer prevention properties holds promise.
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MON 2011 - Slide 9 - M. Aapro - Antiemetics, growth factors, bone health
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This document provides information on the evaluation and treatment of metastatic bone disease and spinal cord compression. It discusses:
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Pharmacology of 5-hydroxytryptamine and Antagonist
Cancer Chemo Radiation Concurrent Supplements
- 39. Silymarin, Glycine, Ginger VEGFR EGCG, silymarin, quercetin, resveratrol, soy isoflavones, curcumin, EPA Cu antagonists VEGF, AKs, bFGF, IL8, MMPs, TNF-1, heparinases, collagenases curcmin, artemsia, mistletoe, ginger scutellaria, resveratrol, grapeseed extract, green tea, gingko, squalamine, Vit D silymarin, glycine, ginger artemsia mistletoe curcumin scutellaria curcmin, scutellaria, cartilege, silymarin, green tea bFGFR and TNF-1: Cu antagonists Multifocal Angiostatic Therapy Growth Factors NFkB COX-2 Anti GFs: green tea quercetin magnolia resveratrol, soy, curcumin holy basil rosemary ganoderma licorice Vit E Anti- NFkB: poria, coriolus, ginger, resveratrol, green tea, artemsia, quercetin, carnosol, panax ginseng, silymarin, salicylates, curcumin, picentannol, basil, Cu antagonists rosemary Anti-COX-2: quercetin, scutellaria, EPA/DHA, licorice, ginger, resveratrol, grapeseed extract, curcumin, salicylates, garlic, green tea, panax ginseng, silymarin, bilberry, antioxidants, boswellia, aloe
- 41. We’ve all been waiting, wondering, Will we ever know the truth? What it’s like washing windows When you know that there are pigeons on the roof?