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Parts of the brain
Sanjaya Adikari
Department of Anatomy
CNS PNS
Nervous sytem
Spinal cord
Foramen magnum
Central Nervous System
(CNS)
Skull
Vertebral column
Meninges
Dura mater
Arachnoid mater
Pia mater
Dura mater
Arachnoid mater
Pia mater
Ependymal cell layer
Ventricle
1
3
4
5
6
= forebrain
1
5
4
3
6
2
2
+
= midbrain
= hindbrain
Main divisions of the brain
1
6
Diencephalon
2
+
Cerebellum
4
3
5
= brainstem
midbrain
pons
medulla
Cerebrum
Cerebrum
• Cerebral hemispheres
– Left & right cerebral hemispheres
• Diencephalon
– Consists of thalamus, hypothalamus etc.
Cerebrum is the largest part of the brain.
It is situated in the anterior and middle cranial fossae and the whole
concavity of the vault of the skull
Has two parts;
Diencephalon
thalamus
hypothalamus
Spinal cord
Mid-sagittal section of brain
Diencephalon
thalamus
hypothalamus
Spinal cord
Cerebral hemispheres
• Largest part of the brain
• Separated by a deep mid-sagittal fisure called longitudinal
cerebral fissure
• The fissure contains the falx cerebri and anterior cerebral
arteries
• Tentorium cerebelli separates cerebral hemispheres from
the cerebellum
Falx cerebri
Tentorium cerebelli
Dura mater
Anterior cerebral arteries
Corpus callosum
Sulci and Gyri
• To increase the surface area of the brain the
cerebral hemispheres are thrown into folds - gyri
• The gyri are separated from each other by
fissures - sulci
• Hemispheres are divided into lobes (named
according to the cranial bones under which they
lie) by main sulci
– Central
– Parieto-occipital
– Lateral
Frontal
Lobe
Parietal
Lobe
Occipital
Lobe
Temporal
Lobe
Central sulcus
Parieto-
occipital sulcus
Lateral sulcus
Cranial Fossae
Main gyri
• Precentral gyrus
• Postcentral gyrus
• Superior/middle/inferior frontal gyri
• Superior/middle/inferior temporal gyri
• Cingulate gyrus
• Parahippocampal gyrus
Superior, middle,
inferior frontal gyri
Superior, middle, inferior temporal gyri
Precentral gyrus Postcentral gyrus
Cingulate gyrus
Parahippocampal gyrus
Functional areas of the brain
Homunculus
Homework
• Draw a labelled line diagram to illustrate a mid-
sagittal section of the brain including the brain
stem.
• Draw a labelled line diagram to illustrate a
horizontal section of the cerebrum through the
head of the caudate nucleus.
Study the above diagrams before you come for the
next lecture on parts of the brain
Lecture II
Gray matter and white matter
Gray matter
White matter
• Gray matter consists of nerve cells
• White matter consists of nerve fibres
Gray matter of the
cerebral cortex
• Five types of cells are
organized into six
cortical layers
Molecular layer
External granular layer
External pyramidal layer
Internal granular layer
Ganglionic layer
(Internal pyramidal layer)
Multiform layer
White matter
• Composed of myelinated nerve fibres
• Supported by neuroglia
• Classified into three groups according to their
connections
– Commissural fibers
– Association fibers
– Projection fibers
Commissural fibers
• Connects corresponding regions of the two
hemispheres
• Corpus callosum, fornix, anterior and
posterior commissures
• Corpus callosum, the largest commissure of
the brain, is divided into rostrum, genu, body
and the splenium
Corpus callosum
Genu
Rostrum
Splenium
Body
Association fibers
• Connects various cortical regions within the
same hemispheres
• Divided into short and long groups
• Short association fibers lie immediately
beneath the cortex and connect adjacent gyri
• Long association fibers are arranged into
named bundles - fasciculi
Projection fibers
• Afferent and efferent nerve fibers passing to
and from the brain stem to the cerebral
cortex
• Internal capsule, corona radiata, optic
radiation
Internal capsule
Corona radiata
Optic radiation
Cerebral peduncle
Optic tract
Pyramidal tract
Internal capsule and corona radiata
Cerebral peduncle
Internal capsule
Putamen
Amygdala
Basal ganglia
• Basal ganglia are collection of masses of gray matter
within the white matter of cerebral hemispheres
Gray matter of cerebral cortex White matter of cerebrum
Basal ganglia
Basal ganglia…..cont.
• Corpus striatum
– Divided into two by internal capsule of white
matter
• Caudate nucleus
• Lentiform nucleus (putamen & globus pallidus)
• Amygdaloid
• Claustrum
Basal ganglia…..cont.
Anterior horn of lateral ventricle
Head of caudate nucleus
Tail of caudate nucleus
Thalamus
Lentiform nucleus
(putamen)
Internal capsule
Claustrum
External capsule
Lentiform nucleus
(globus pallidus)
Frontopontine
Corticobulbar
Corticospinal
Thalamocortical
Parieto/temporo/occipito pontine
Visual & auditory
Fiber tracts in the internal capsule
Basal ganglia…..cont.
• Some definitions include the following also
under basal ganglia
– Subthalamic nucleus
– Substantia nigra
Midbrain
Diencephalon
• Consists of the following
– Thalamus
– Subthalamus
– Hypothalamus
– Epithalamus
• Habenular nucleus
• Pineal gland
Corpus callosum
Fornix
Thalamus
Mamillary body
Thalamus
Hypothalamus
Epithalamus
Subthalamus
Fornix
Roof of 3rd ventricle
Interthalamic connection
Lentiform nucleus
Internal capsule
Optic chiasma
Pituitary
Thalamus
Hypothalamus
Mammillary body
Thalamus
• Large ovoid mass of gray matter
• Forms large part of diencephalon
• Very important cell station
• Receives main sensory tracts (except olfactory
pathway)
• Integrates information it receives and relays to
the cerebral cortex and subcortical regions
• Integrates visceral and somatic functions
Thalamic nuclei
Hypothalamus
• Part of the diencephalon that extends from the
optic chiasma to the posterior border of the
mammillary bodies
• Almost all physiological activities of the body are
influenced by hypothalamus
– Integration of autonomic functions
– Regulation of endocrine functions
– Maintaining body homiostasis
– Regulation of body temperature and body fluids
– Sexual behaviour, emosions, drive to eat and drink
Hypothalamus….
• Contains some important cell groups
– Supraoptic nucleus
– Paraventricular nucleus
• These have axons running down into the posterior
lobe of the pituitary gland
• Other cell groups deliver their neurosecretions
into the hypothalamo-hypophyseal poryal system
leading to the anterior lobe of the pituitary gland
Pineal gland (Pineal body)
• Projects backwards from the diencephalon to lie posterior
to the midbrain
• Progressive calcification with age becoming visible in x-ray
• Produces metatonin hormone in a circadian rhythm
influenced by light
• Indirectly controls the function of other endocrine organs,
including the pituitary
Lecture III
Development of the central
nervous system
Sanjaya Adikari
Department of Anatomy
Neural tube
& cavity
1
2
3
Prosencephalon
(forebrain)
Mesencephalon
(midbrain)
Rhombencephalon
(hindbrain)
1a
2
3a
1b
3b
Development of brain
1a
2
3a
1b
3b
Telencephalon Cerebral hemispheres
Diencephalon
Midbrain
tectum, tegmentum and
cerebral pedunculi
Metencephalon
pons, upper medulla
and cerebellum
Myelencephalon lower medulla
Thalamus, hypothalamus
subthalamus, epithalamus
Lateral ventricle
Foramen of Monro
Aqueduct
4th ventricle
Central canal of SC
3rd ventricle
Development of spinal cord and
brain stem
Mantle layer
Marginal layer
Neuroepithelial layer
Neuroepithelial cells
Gliablast cells
Neuroblast cells
Neurons
Glial cells
1
2
Oligodendroglia Astroglia Microglia
Ependymal cells
Alar plate (sensory)
Basal plate (motor)
Sulcus limitans
Mantle layer
Marginal layer
Neuroepithelial layer
Posterior horn
Lateral horn
Anterior horn
Motor
Sensory
Motor
Sensory
BE
BA
SE
VE
VA
GSA
Brainstem
• Consists of midbrain, pons and medulla oblongata
• Broad functions
– Conduit for ascending and descending tracts
– Contains reflex control centers of respiratory and
cardiovascular systems
– Associated with control of consciousness
– Contains nuclei of cranial nerves III to XII
Midbrain
• About 2 cm in length
• Connects the pons and cerebellum to forebrain by passing
through the opening of tentorium cerebelli
• On the posterior surface are superior and inferior colliculi
– SC: centers for visual reflexes. Connected to lateral geniculate
body
– IC:lower auditory centers. Connected to medial geniculate
body
• On the anterior surface are crus cerebri. Contains cerebral
aqueduct
• Contains cranial nerve nuclei III and IV
Transverse section of midbrain
Tectum
Tegmentum
Crus cerebri or
cerebral peduncles
Transverse sections of midbrain
Cerebral peduncle
Cerebral aqueduct
Superior colliculus
Red nuclues
Substantia nigra
Pons
• Anterior to the cerebellum
• Bridges the two hemispheres of the cerebellum
• On the anterior surface many transverse fibers that go
into the middle cerebellar peduncle
• Basilar groove in the midline anteriorly
• Motor and sensory roots of trigeminal nerve emerge
from anterior surface
• Posterior surface contains the upper part of the floor of
the 4th ventricle above
Medulla oblongata
• Connects to the spinal cord at the level of the
foramen magnum, where the first cervical spinal
nerve roots start
• Anterior surface contains the pyramids and the
olives
• Posterior surface contains cuneate and gracile
tubercles below and the lower part of the floor of
the 4th ventricle above
• Laterally are the inferior cerebellar peduncles
Motor and sensory decussations of medulla
sensory motor
Posterior surface Anterior surface
Arrangement of cranial nerve nuclei in the flow of
the 4th ventricle
• Extensive lateral spread of 4th ventricle during
embryonic development has caused the alar plates
to lie lateral to the basal plates
• Somatic motor (efferent) nuclei lie closer to the
midline and somatic sensory (afferent) nuclei lie
away from the midline
• Visceral nuclei lie in between, with visceral motor
more closer and visceral sensory more distant from
the midline
Cerebellum
• Lies posterior to the 4th ventricle, pons
and medulla
• Two cerebellar hemispheres joined by a
narrow median vermis
• Connected to brain stem by superior,
middle and inferior cerebellar peduncles
Cerebellum…..
• Has 3 lobes – anterior, middle and flocculonodular
• Primary fissure lies between anterior and middle
lobes
• Uvulonodular fissure lies between middle and
flocculonodular lobes
• Horizontal fissure lies within the middle lobe
separating superior and inferior surfaces
Cerebellum…cont.
• Has an outer cortex of cells. It has 3 layers – granular,
purkinje and molecular layers
• Four intracerebellar nuclei – dentate, emboliform,
globose and fastigial
• Afferent fibers enter through middle and inferior
cerebellar peduncles
• Efferent fibers (axons of purkinje cells) synapse with
cerebellar nuclei. Efferents from the nuclei leave
through the superior cerebellar peduncle
Molecular cell layer
Purkinje cell layer
Granular cell layer
Dentate nucleus
Middle cerebellar
peduncle
Emboliform nucleus
Function of the cerebellum
Cerebellar ataxia
• Diseases of the lateral cerebellar lobes
– Limb ataxia
– Gait broad-based and veered towards the
side of the lesion
• Diseases of the cerebellar vermis
– Truncal ataxia
– Tendency to fall backwards/sideways
– No limb ataxia
Limbic system
• Functionally important but not well defined
anatomically
• Surrounds the corpus callosum and the
diencephalon
• Deals with behaviour, imotion and memory
Components of the limbic system
• Cingulate gyrus
• Subcallosal gyrus
• Septal area and olfactory bulb
• Hippocampal formation
– Hippocampal gyrus
– Dentate gyrus
– Parahippocampal gyrus
• Amygdaloid body and mammillary body
• Anterior nucleus of thalamus
• Hypothalamus
Parts and connecting pathways
Ventricular system of the brain
Formation of CSF
1. Formed mainly in choroid plexus of the ventricles
2. Some is formed from the ependymal cells lining
the ventricles and at perivascular spaces
Blood-CSF barrier
Choroid plexus of
lateral ventricle
Circulation of CSF
Arachnoid granulations
Foramina of
Luschka &
Magendie
Lecture IV
How to draw different sections of the
brain stem
Anterior surface
Posterior surface
Main nerve tracts in the spinal cord
A
B
G
C
D
E
F
A. Posterior white columns
B. Lateral corticospinal tract
C. Anterior & posterior spinocerebellar tracts
D. Anterior & posterior spinothalamic tracts
E. Olivospinal, vestibulospinal, tectospinal tracts
F. Anterior corticospinal tract
G. Rubrospinal tract
Closed medulla at the level of decussation of pyramids
Fasciculus gracilis
Fasciculus cuneatus
Nucleus gracilis
Nucleus cuneatus
Spinal tract of trigeminal
nerve
Spinal nucleus of
trigeminal nerve
Decussation of pyramids
Pyramid
Posterior
spinocerebellar
tract
Anterior
spinocerebellar
tract
Spinothalamic tract
Spinal root of the
accessory nerve
Central canal
Medial longitudinal
fasciculus
Closed medulla at the level of decussation of medial lemnisci
Fasciculus gracilis
Fasciculus cuneatus
Nucleus gracilis
Nucleus cuneatus
Spinal tract of trigeminal
nerve
Spinal nucleus of
trigeminal nerve
Decussation of medial
lemnisci
Pyramid
Posterior
spinocerebellar
tract
Anterior
spinocerebellar
tract
Spinothalamic tract
Hypoglossal nerve
Spinal root of the
accessory nerve
Central canal
Medial longitudinal
fasciculus
Medulla Oblongata at the level of middle of the olivary nuclei
Inferior medullary velum
Cavity of 4th ventricle
Inferior
cerebellar
peduncle
Vestibular &
cochlear nuclei
Olivary nucleus
Olive
Pyramid
Anterior
spinocerebellar tract
Spinothalamic tract
Spinal tract & nucleus of
trigeminal nerve
Vagus nerve
Hypoglossal
nerve
Reticular formation
Medial longitudinal fasciculus
Tectospinal tract
Medial lemniscus
Pons at the level of facial colliculus
Superior medullary velum
Cavity of 4th ventricle
Inferior
cerebellar
peduncle
Spinal lemniscus
Reticular formation
Medial lemniscus
Superior cerebellar
peduncle
Spinal tract & nucleus
of trigeminal nerve
Medial longitudinal fasciculus
Facial colliculus
Abducent nerve
Facial nerve
Pontine nuclei
Transverse
pontine fibres
Corticospinal &
corticonuclear fibres
Vestibular nuclei
Midbrain at the level of inferior colliculus
Trochlear nerve
Inferior colliculus
Cerebral aqueduct
Medial longitudinal
fasciculus
Mesencephalic nucleus
of trigeminal nerve
Trigeminal lemniscus
Spinal lemniscus
Medial lemniscus
Substantia nigra
Cerebral peduncle
Decussation of superior
cerebellar peduncles
Interpeduncular fossa
Reticular formation
Periaqueductal Gray Matter
Midbrain at the level of superior colliculus
Oculomotor nerve
Superior colliculus
Cerebral aqueduct
Medial longitudinal
fasciculus
Mesencephalic nucleus
of trigeminal nerve
Trigeminal lemniscus
Spinal lemniscus
Medial lemniscus
Substantia nigra
Cerebral peduncle
Red nucleus
Reticular formation
Periaqueductal Gray Matter
PPRF = Paramedian pontine reticular formation
Medial longitudinal fasciculus

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brain.ppsx

  • 1. Parts of the brain Sanjaya Adikari Department of Anatomy
  • 3. Spinal cord Foramen magnum Central Nervous System (CNS)
  • 6. Dura mater Arachnoid mater Pia mater Ependymal cell layer Ventricle
  • 7. 1 3 4 5 6 = forebrain 1 5 4 3 6 2 2 + = midbrain = hindbrain Main divisions of the brain
  • 9. Cerebrum • Cerebral hemispheres – Left & right cerebral hemispheres • Diencephalon – Consists of thalamus, hypothalamus etc. Cerebrum is the largest part of the brain. It is situated in the anterior and middle cranial fossae and the whole concavity of the vault of the skull Has two parts;
  • 12. Cerebral hemispheres • Largest part of the brain • Separated by a deep mid-sagittal fisure called longitudinal cerebral fissure • The fissure contains the falx cerebri and anterior cerebral arteries • Tentorium cerebelli separates cerebral hemispheres from the cerebellum
  • 13. Falx cerebri Tentorium cerebelli Dura mater Anterior cerebral arteries Corpus callosum
  • 14. Sulci and Gyri • To increase the surface area of the brain the cerebral hemispheres are thrown into folds - gyri • The gyri are separated from each other by fissures - sulci • Hemispheres are divided into lobes (named according to the cranial bones under which they lie) by main sulci – Central – Parieto-occipital – Lateral
  • 15.
  • 18. Main gyri • Precentral gyrus • Postcentral gyrus • Superior/middle/inferior frontal gyri • Superior/middle/inferior temporal gyri • Cingulate gyrus • Parahippocampal gyrus
  • 19. Superior, middle, inferior frontal gyri Superior, middle, inferior temporal gyri Precentral gyrus Postcentral gyrus
  • 21. Functional areas of the brain
  • 23. Homework • Draw a labelled line diagram to illustrate a mid- sagittal section of the brain including the brain stem. • Draw a labelled line diagram to illustrate a horizontal section of the cerebrum through the head of the caudate nucleus. Study the above diagrams before you come for the next lecture on parts of the brain
  • 25. Gray matter and white matter Gray matter White matter • Gray matter consists of nerve cells • White matter consists of nerve fibres
  • 26. Gray matter of the cerebral cortex • Five types of cells are organized into six cortical layers
  • 27. Molecular layer External granular layer External pyramidal layer Internal granular layer Ganglionic layer (Internal pyramidal layer) Multiform layer
  • 28. White matter • Composed of myelinated nerve fibres • Supported by neuroglia • Classified into three groups according to their connections – Commissural fibers – Association fibers – Projection fibers
  • 29. Commissural fibers • Connects corresponding regions of the two hemispheres • Corpus callosum, fornix, anterior and posterior commissures • Corpus callosum, the largest commissure of the brain, is divided into rostrum, genu, body and the splenium
  • 31. Association fibers • Connects various cortical regions within the same hemispheres • Divided into short and long groups • Short association fibers lie immediately beneath the cortex and connect adjacent gyri • Long association fibers are arranged into named bundles - fasciculi
  • 32. Projection fibers • Afferent and efferent nerve fibers passing to and from the brain stem to the cerebral cortex • Internal capsule, corona radiata, optic radiation
  • 33. Internal capsule Corona radiata Optic radiation Cerebral peduncle Optic tract Pyramidal tract Internal capsule and corona radiata
  • 35. Basal ganglia • Basal ganglia are collection of masses of gray matter within the white matter of cerebral hemispheres Gray matter of cerebral cortex White matter of cerebrum Basal ganglia
  • 36. Basal ganglia…..cont. • Corpus striatum – Divided into two by internal capsule of white matter • Caudate nucleus • Lentiform nucleus (putamen & globus pallidus) • Amygdaloid • Claustrum
  • 38.
  • 39. Anterior horn of lateral ventricle Head of caudate nucleus Tail of caudate nucleus Thalamus Lentiform nucleus (putamen) Internal capsule Claustrum External capsule Lentiform nucleus (globus pallidus)
  • 41. Basal ganglia…..cont. • Some definitions include the following also under basal ganglia – Subthalamic nucleus – Substantia nigra Midbrain
  • 42. Diencephalon • Consists of the following – Thalamus – Subthalamus – Hypothalamus – Epithalamus • Habenular nucleus • Pineal gland
  • 45. Fornix Roof of 3rd ventricle Interthalamic connection Lentiform nucleus Internal capsule Optic chiasma Pituitary Thalamus Hypothalamus Mammillary body
  • 46. Thalamus • Large ovoid mass of gray matter • Forms large part of diencephalon • Very important cell station • Receives main sensory tracts (except olfactory pathway) • Integrates information it receives and relays to the cerebral cortex and subcortical regions • Integrates visceral and somatic functions
  • 48.
  • 49. Hypothalamus • Part of the diencephalon that extends from the optic chiasma to the posterior border of the mammillary bodies • Almost all physiological activities of the body are influenced by hypothalamus – Integration of autonomic functions – Regulation of endocrine functions – Maintaining body homiostasis – Regulation of body temperature and body fluids – Sexual behaviour, emosions, drive to eat and drink
  • 50. Hypothalamus…. • Contains some important cell groups – Supraoptic nucleus – Paraventricular nucleus • These have axons running down into the posterior lobe of the pituitary gland • Other cell groups deliver their neurosecretions into the hypothalamo-hypophyseal poryal system leading to the anterior lobe of the pituitary gland
  • 51.
  • 52. Pineal gland (Pineal body) • Projects backwards from the diencephalon to lie posterior to the midbrain • Progressive calcification with age becoming visible in x-ray • Produces metatonin hormone in a circadian rhythm influenced by light • Indirectly controls the function of other endocrine organs, including the pituitary
  • 54. Development of the central nervous system Sanjaya Adikari Department of Anatomy
  • 57. 1a 2 3a 1b 3b Telencephalon Cerebral hemispheres Diencephalon Midbrain tectum, tegmentum and cerebral pedunculi Metencephalon pons, upper medulla and cerebellum Myelencephalon lower medulla Thalamus, hypothalamus subthalamus, epithalamus
  • 58. Lateral ventricle Foramen of Monro Aqueduct 4th ventricle Central canal of SC 3rd ventricle
  • 59. Development of spinal cord and brain stem Mantle layer Marginal layer Neuroepithelial layer
  • 60. Neuroepithelial cells Gliablast cells Neuroblast cells Neurons Glial cells 1 2 Oligodendroglia Astroglia Microglia Ependymal cells
  • 61. Alar plate (sensory) Basal plate (motor) Sulcus limitans Mantle layer Marginal layer Neuroepithelial layer
  • 62. Posterior horn Lateral horn Anterior horn Motor Sensory Motor Sensory
  • 64. Brainstem • Consists of midbrain, pons and medulla oblongata • Broad functions – Conduit for ascending and descending tracts – Contains reflex control centers of respiratory and cardiovascular systems – Associated with control of consciousness – Contains nuclei of cranial nerves III to XII
  • 65. Midbrain • About 2 cm in length • Connects the pons and cerebellum to forebrain by passing through the opening of tentorium cerebelli • On the posterior surface are superior and inferior colliculi – SC: centers for visual reflexes. Connected to lateral geniculate body – IC:lower auditory centers. Connected to medial geniculate body • On the anterior surface are crus cerebri. Contains cerebral aqueduct • Contains cranial nerve nuclei III and IV
  • 66. Transverse section of midbrain Tectum Tegmentum Crus cerebri or cerebral peduncles
  • 67. Transverse sections of midbrain Cerebral peduncle Cerebral aqueduct Superior colliculus Red nuclues Substantia nigra
  • 68. Pons • Anterior to the cerebellum • Bridges the two hemispheres of the cerebellum • On the anterior surface many transverse fibers that go into the middle cerebellar peduncle • Basilar groove in the midline anteriorly • Motor and sensory roots of trigeminal nerve emerge from anterior surface • Posterior surface contains the upper part of the floor of the 4th ventricle above
  • 69.
  • 70. Medulla oblongata • Connects to the spinal cord at the level of the foramen magnum, where the first cervical spinal nerve roots start • Anterior surface contains the pyramids and the olives • Posterior surface contains cuneate and gracile tubercles below and the lower part of the floor of the 4th ventricle above • Laterally are the inferior cerebellar peduncles
  • 71.
  • 72. Motor and sensory decussations of medulla sensory motor Posterior surface Anterior surface
  • 73.
  • 74. Arrangement of cranial nerve nuclei in the flow of the 4th ventricle • Extensive lateral spread of 4th ventricle during embryonic development has caused the alar plates to lie lateral to the basal plates • Somatic motor (efferent) nuclei lie closer to the midline and somatic sensory (afferent) nuclei lie away from the midline • Visceral nuclei lie in between, with visceral motor more closer and visceral sensory more distant from the midline
  • 75. Cerebellum • Lies posterior to the 4th ventricle, pons and medulla • Two cerebellar hemispheres joined by a narrow median vermis • Connected to brain stem by superior, middle and inferior cerebellar peduncles
  • 76. Cerebellum….. • Has 3 lobes – anterior, middle and flocculonodular • Primary fissure lies between anterior and middle lobes • Uvulonodular fissure lies between middle and flocculonodular lobes • Horizontal fissure lies within the middle lobe separating superior and inferior surfaces
  • 77.
  • 78. Cerebellum…cont. • Has an outer cortex of cells. It has 3 layers – granular, purkinje and molecular layers • Four intracerebellar nuclei – dentate, emboliform, globose and fastigial • Afferent fibers enter through middle and inferior cerebellar peduncles • Efferent fibers (axons of purkinje cells) synapse with cerebellar nuclei. Efferents from the nuclei leave through the superior cerebellar peduncle
  • 79. Molecular cell layer Purkinje cell layer Granular cell layer
  • 81. Function of the cerebellum
  • 82. Cerebellar ataxia • Diseases of the lateral cerebellar lobes – Limb ataxia – Gait broad-based and veered towards the side of the lesion • Diseases of the cerebellar vermis – Truncal ataxia – Tendency to fall backwards/sideways – No limb ataxia
  • 83. Limbic system • Functionally important but not well defined anatomically • Surrounds the corpus callosum and the diencephalon • Deals with behaviour, imotion and memory
  • 84. Components of the limbic system • Cingulate gyrus • Subcallosal gyrus • Septal area and olfactory bulb • Hippocampal formation – Hippocampal gyrus – Dentate gyrus – Parahippocampal gyrus • Amygdaloid body and mammillary body • Anterior nucleus of thalamus • Hypothalamus
  • 85.
  • 87.
  • 89.
  • 90. Formation of CSF 1. Formed mainly in choroid plexus of the ventricles 2. Some is formed from the ependymal cells lining the ventricles and at perivascular spaces Blood-CSF barrier
  • 92. Circulation of CSF Arachnoid granulations Foramina of Luschka & Magendie
  • 93.
  • 95. How to draw different sections of the brain stem
  • 96.
  • 98. Main nerve tracts in the spinal cord A B G C D E F
  • 99. A. Posterior white columns B. Lateral corticospinal tract C. Anterior & posterior spinocerebellar tracts D. Anterior & posterior spinothalamic tracts E. Olivospinal, vestibulospinal, tectospinal tracts F. Anterior corticospinal tract G. Rubrospinal tract
  • 100. Closed medulla at the level of decussation of pyramids Fasciculus gracilis Fasciculus cuneatus Nucleus gracilis Nucleus cuneatus Spinal tract of trigeminal nerve Spinal nucleus of trigeminal nerve Decussation of pyramids Pyramid Posterior spinocerebellar tract Anterior spinocerebellar tract Spinothalamic tract Spinal root of the accessory nerve Central canal Medial longitudinal fasciculus
  • 101. Closed medulla at the level of decussation of medial lemnisci Fasciculus gracilis Fasciculus cuneatus Nucleus gracilis Nucleus cuneatus Spinal tract of trigeminal nerve Spinal nucleus of trigeminal nerve Decussation of medial lemnisci Pyramid Posterior spinocerebellar tract Anterior spinocerebellar tract Spinothalamic tract Hypoglossal nerve Spinal root of the accessory nerve Central canal Medial longitudinal fasciculus
  • 102. Medulla Oblongata at the level of middle of the olivary nuclei Inferior medullary velum Cavity of 4th ventricle Inferior cerebellar peduncle Vestibular & cochlear nuclei Olivary nucleus Olive Pyramid Anterior spinocerebellar tract Spinothalamic tract Spinal tract & nucleus of trigeminal nerve Vagus nerve Hypoglossal nerve Reticular formation Medial longitudinal fasciculus Tectospinal tract Medial lemniscus
  • 103. Pons at the level of facial colliculus Superior medullary velum Cavity of 4th ventricle Inferior cerebellar peduncle Spinal lemniscus Reticular formation Medial lemniscus Superior cerebellar peduncle Spinal tract & nucleus of trigeminal nerve Medial longitudinal fasciculus Facial colliculus Abducent nerve Facial nerve Pontine nuclei Transverse pontine fibres Corticospinal & corticonuclear fibres Vestibular nuclei
  • 104. Midbrain at the level of inferior colliculus Trochlear nerve Inferior colliculus Cerebral aqueduct Medial longitudinal fasciculus Mesencephalic nucleus of trigeminal nerve Trigeminal lemniscus Spinal lemniscus Medial lemniscus Substantia nigra Cerebral peduncle Decussation of superior cerebellar peduncles Interpeduncular fossa Reticular formation Periaqueductal Gray Matter
  • 105. Midbrain at the level of superior colliculus Oculomotor nerve Superior colliculus Cerebral aqueduct Medial longitudinal fasciculus Mesencephalic nucleus of trigeminal nerve Trigeminal lemniscus Spinal lemniscus Medial lemniscus Substantia nigra Cerebral peduncle Red nucleus Reticular formation Periaqueductal Gray Matter
  • 106. PPRF = Paramedian pontine reticular formation Medial longitudinal fasciculus