Bootstrap 4 beta introduces support for IE10+, iOS 7+, and Android 5.0, with a new grid system including an 'xl' tier for screens over 1200px. Key updates include utility classes for spacing, image handling, and responsive tables, as well as enhancements for components like alerts, cards, and navbars. Additionally, there are improvements in form controls, jumbotrons, and scrollspy functionalities, ensuring more streamlined and modern design capabilities.