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BODY ‘S IMMUNE RESPONSE
DR. ANANDRAJ
WHAT IS IMMUNE POWER??
IS IT ONLY POWER?/
OR ANYTHING ELSE?
REACTION TO HARMFUL AGENTS
RESPONSE OF BODY TO EXTERNAL
TOXIC SUBSTANCES
IS IT NATURAL
OR
ACQUIRED
IMMUNITY
INNATE IMMUNITY
(Ist Line Of Defense)
ACQUIRED /ADAPTIVE IMMUNITY
(Immunity stimulated by microbes)
-LYMPHOCYTES
-PLASMA CELLS
CELL MEDIATED
IMMUNITY
(T Cells)
HUMORAL
IMMUNITY
(B CELLS)
EPITHELIAL BARRIERS
PHAGOCYTIC CELLS (PMN ;
MACROPHAGES)
DENDRITIC CELLS (Destroy
viruses by producing Type 1 IFN)
NATURAL KILLER (NK) CELLS
PLASMA PROTEINS (esp.
COMPLEMENT PATHWAY)
What are the various immune organs
in our body
Tissues of Immune System
CENTRAL (GENERATIVE)
LYMPHOID
ORGANS
•THYMUS ( T Cells)
•BONE MARROW (B CELLS)
PERIPHERAL
LYMPHOID
ORGANS
LYMPH NODE
a) CORTEX (B Cell Zone) :
Germinal Centers
b) PARACORTEX (T Cell Zone)
SPLEEN
a) FOLLICLES ( B Cell Zone)
b) P A L S ( T Cell Zone)
CUTANEOUS ;
MUCOSAL
LYMPHOID
SYSTEM
a) Under skin
b) Under Respiratory Tact ; GI
Epithelium
WHAT IS THE ACTION
/FUNCTION OF IMMUNE
IS GOOD TO BODY
OR
HARMFUL??
IS IMMUNE POWER ALWAYS
GOOD??
NO
WHAT ARE THE COMPONENTS
OF IMMUNE RESPONSE
• INFLAMMATION
• CANCER
• HYPERSENSITIVITY
[ALLERGY]
• HEMODYNAMIC DISORDERS
Which cell is most commonly
involved in immune response
Lymphocytes
or
neutrophils
IN+FLAMME
• IN- INSIDE
• FLAME- BURNING
• BURNING = IMMUNE RESPONSE TO HARMFUL
• ‘It is’
INFLAMMATION= ‘ITIS’
Is inflammation same as infection
• IS INFLAMMATION GOOD OR BAD??
PLAYERS OF INFLAMMATION
• INFLAMMATORY CELLS
• PROTEINS
• VASCULAR WALL CELLS
• CONNECTIVE TISSUE CELLS
• EXTRACELLULAR MATRIX
• ANTGEN&ANTIBODY
CELLS INFLAMMATORY CELLS
• NEUTROPHILS
• EOSINOPHILS
• BASOPHILS
GRANULOCYTES
CONNECTIVE TISSUE CELLS
• LYMPHOCYTES [T CELLS]
• MACROPHAGES
• MAST CELLS
• FIBROBLAST
Which cell is most commonly
involved in immune response
Lymphocytes or Granulocytes
PROTEINS
• CIRCULATING PROTEINS
• -- CLOTTING FACTORS
• KINOGENS=KININS
• COMPLEMENTARY FACTORS
VASCULAR WALL CELLS
• ENDOTHELIAL CELLS
• SMOOTH MUSCLE CELLS OF BLOOD VESSEL
• [To control the tone of vessel]
ECM
• COLLAGE AND ELASTIN
• PROTEOGLYCANS
• GLYCOPROTEIN--FIBRONECTIN
• INFLAMMATORY CELLS
• PROTEINS
• VASCULAR WALL CELLS
• CONNECTIVE TISSUE CELLS
• EXTRACELLULAR MATRIX
• ANTGEN&ANTIBODY
BASIC REACTIONS INVOLVED IN
INFLAMMATION
• Antigen –antibody Reaction
• Chemotaxis
• Phagocytosis -MACROPAHGES
• Hyperemia
• Vasodilators & Vasoconstrictors
CHEMOTAXIS– CHEMICAL+MOVEMENT
PHAGOCYTOSIS
• PLAYERS OF INFLAMMATION
• Basic Mechanisms of inflammation
CARDINAL SIGNS OF INFLAMMATION
CAUSES OF INFLAMMATION
CLINICAL EXAMPLES OF
INFLAMMATION
Ag PRESENTING CELL
(APC) : MHC
T CELL : TCR
T CELL
RECEPTOR (TCR)
MAJOR
HISTOCOMPATIBILITY
COMPLEX (MHC)
Michelangelo : The Creation of Adam
MHC and TCR : INTERRELATIONSHIP
Ag
Does inflammation occurs in
newborn?
• What is the most common life threatening
condition
DOES INFLAMMATION OCCURS
AFTER SURGERY
• FACTORS INVOLVED IN INFLAMMATION
• CARDINAL SIGNS OF INFLAMMATION
• MECHANISM IN INFLAMMATION
• CAUSES OF INFLAMMATION
THANKS

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Body immune response