The document discusses key aspects of immunity and the immune system. It defines immunology as the study of the immune system, including its components, functions, and interactions. The immune system protects the body from pathogens using both innate, nonspecific responses and adaptive, antigen-specific responses. The system includes cells, tissues, organs, and molecular responses. It also outlines the development of the immune system from stem cells and the roles of B cells, T cells, antibodies, and the mechanisms of both humoral and cell-mediated immunity.
Adaptive/Acquired Immunity
Antigens – Anything that cases a biological immune response by this system of cells
Specificity – Some antibodies are quite specific to an antigen others are general to a “type” or “form”
Memory – b-memory cells are formed and remain to combat future exposures quickly (Active vs Passive immunity
Antibodies – the proteins formed by b-cells that combat antigens whether chemical or biological
Lymphocytes – cells involved in this response
The cells of the immune system can be categorized as lymphocytes (T-cells, B-cells and NK cells), neutrophils, and monocytes/macrophages. These are all types of white blood cells. The major proteins of the immune system are predominantly signaling proteins (often called cytokines), antibodies, and complement proteins.
Adaptive/Acquired Immunity
Antigens – Anything that cases a biological immune response by this system of cells
Specificity – Some antibodies are quite specific to an antigen others are general to a “type” or “form”
Memory – b-memory cells are formed and remain to combat future exposures quickly (Active vs Passive immunity
Antibodies – the proteins formed by b-cells that combat antigens whether chemical or biological
Lymphocytes – cells involved in this response
The cells of the immune system can be categorized as lymphocytes (T-cells, B-cells and NK cells), neutrophils, and monocytes/macrophages. These are all types of white blood cells. The major proteins of the immune system are predominantly signaling proteins (often called cytokines), antibodies, and complement proteins.
CLONAL SELECTION THEORY IS AN SCIENTIFIC THEORY IN IMMUNOLOGY THAT EXPALINS THE FUNCTION OF CELLS OF THE IMMUNE SYSTEM IN RESPONSE TO SPECIFIC ANTIGEN INVADING THE BODY.
CLONAL SELECTION THEORY IS AN SCIENTIFIC THEORY IN IMMUNOLOGY THAT EXPALINS THE FUNCTION OF CELLS OF THE IMMUNE SYSTEM IN RESPONSE TO SPECIFIC ANTIGEN INVADING THE BODY.
immunity, types,Innate immunity and Adaptive Immunity, primary and secondary immune response, structure and functions of antibodies, immunoglobulins, hypergammaglobulinemia, multiple myeloma, bence jones protein, electrophoretic pattern of multiple myeloma.
Immunology is the study of the immune system and how it protects us from infection and disease123. It is a branch of biology and medicine2. Are you looking for something specific about immunology?
Navigating Challenges: Mental Health, Legislation, and the Prison System in B...Guillermo Rivera
This conference will delve into the intricate intersections between mental health, legal frameworks, and the prison system in Bolivia. It aims to provide a comprehensive overview of the current challenges faced by mental health professionals working within the legislative and correctional landscapes. Topics of discussion will include the prevalence and impact of mental health issues among the incarcerated population, the effectiveness of existing mental health policies and legislation, and potential reforms to enhance the mental health support system within prisons.
PET CT beginners Guide covers some of the underrepresented topics in PET CTMiadAlsulami
This lecture briefly covers some of the underrepresented topics in Molecular imaging with cases , such as:
- Primary pleural tumors and pleural metastases.
- Distinguishing between MPM and Talc Pleurodesis.
- Urological tumors.
- The role of FDG PET in NET.
Stem Cell Solutions: Dr. David Greene's Path to Non-Surgical Cardiac CareDr. David Greene Arizona
Explore the groundbreaking work of Dr. David Greene, a pioneer in regenerative medicine, who is revolutionizing the field of cardiology through stem cell therapy in Arizona. This ppt delves into how Dr. Greene's innovative approach is providing non-surgical, effective treatments for heart disease, using the body's own cells to repair heart damage and improve patient outcomes. Learn about the science behind stem cell therapy, its benefits over traditional cardiac surgeries, and the promising future it holds for modern medicine. Join us as we uncover how Dr. Greene's commitment to stem cell research and therapy is setting new standards in healthcare and offering new hope to cardiac patients.
The dimensions of healthcare quality refer to various attributes or aspects that define the standard of healthcare services. These dimensions are used to evaluate, measure, and improve the quality of care provided to patients. A comprehensive understanding of these dimensions ensures that healthcare systems can address various aspects of patient care effectively and holistically. Dimensions of Healthcare Quality and Performance of care include the following; Appropriateness, Availability, Competence, Continuity, Effectiveness, Efficiency, Efficacy, Prevention, Respect and Care, Safety as well as Timeliness.
Veterinary Diagnostics Market PPT 2024: Size, Growth, Demand and Forecast til...IMARC Group
The global veterinary diagnostics market size reached US$ 6.6 Billion in 2023. Looking forward, IMARC Group expects the market to reach US$ 12.6 Billion by 2032, exhibiting a growth rate (CAGR) of 7.3% during 2024-2032.
More Info:- https://www.imarcgroup.com/veterinary-diagnostics-market
ICH Guidelines for Pharmacovigilance.pdfNEHA GUPTA
The "ICH Guidelines for Pharmacovigilance" PDF provides a comprehensive overview of the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines related to pharmacovigilance. These guidelines aim to ensure that drugs are safe and effective for patients by monitoring and assessing adverse effects, ensuring proper reporting systems, and improving risk management practices. The document is essential for professionals in the pharmaceutical industry, regulatory authorities, and healthcare providers, offering detailed procedures and standards for pharmacovigilance activities to enhance drug safety and protect public health.
CHAPTER 1 SEMESTER V PREVENTIVE-PEDIATRICS.pdfSachin Sharma
This content provides an overview of preventive pediatrics. It defines preventive pediatrics as preventing disease and promoting children's physical, mental, and social well-being to achieve positive health. It discusses antenatal, postnatal, and social preventive pediatrics. It also covers various child health programs like immunization, breastfeeding, ICDS, and the roles of organizations like WHO, UNICEF, and nurses in preventive pediatrics.
Global launch of the Healthy Ageing and Prevention Index 2nd wave – alongside...ILC- UK
The Healthy Ageing and Prevention Index is an online tool created by ILC that ranks countries on six metrics including, life span, health span, work span, income, environmental performance, and happiness. The Index helps us understand how well countries have adapted to longevity and inform decision makers on what must be done to maximise the economic benefits that comes with living well for longer.
Alongside the 77th World Health Assembly in Geneva on 28 May 2024, we launched the second version of our Index, allowing us to track progress and give new insights into what needs to be done to keep populations healthier for longer.
The speakers included:
Professor Orazio Schillaci, Minister of Health, Italy
Dr Hans Groth, Chairman of the Board, World Demographic & Ageing Forum
Professor Ilona Kickbusch, Founder and Chair, Global Health Centre, Geneva Graduate Institute and co-chair, World Health Summit Council
Dr Natasha Azzopardi Muscat, Director, Country Health Policies and Systems Division, World Health Organisation EURO
Dr Marta Lomazzi, Executive Manager, World Federation of Public Health Associations
Dr Shyam Bishen, Head, Centre for Health and Healthcare and Member of the Executive Committee, World Economic Forum
Dr Karin Tegmark Wisell, Director General, Public Health Agency of Sweden
Health Education on prevention of hypertensionRadhika kulvi
Hypertension is a chronic condition of concern due to its role in the causation of coronary heart diseases. Hypertension is a worldwide epidemic and important risk factor for coronary artery disease, stroke and renal diseases. Blood pressure is the force exerted by the blood against the walls of the blood vessels and is sufficient to maintain tissue perfusion during activity and rest. Hypertension is sustained elevation of BP. In adults, HTN exists when systolic blood pressure is equal to or greater than 140mmHg or diastolic BP is equal to or greater than 90mmHg. The
Deep Leg Vein Thrombosis (DVT): Meaning, Causes, Symptoms, Treatment, and Mor...The Lifesciences Magazine
Deep Leg Vein Thrombosis occurs when a blood clot forms in one or more of the deep veins in the legs. These clots can impede blood flow, leading to severe complications.
Empowering ACOs: Leveraging Quality Management Tools for MIPS and BeyondHealth Catalyst
Join us as we delve into the crucial realm of quality reporting for MSSP (Medicare Shared Savings Program) Accountable Care Organizations (ACOs).
In this session, we will explore how a robust quality management solution can empower your organization to meet regulatory requirements and improve processes for MIPS reporting and internal quality programs. Learn how our MeasureAble application enables compliance and fosters continuous improvement.
ALKAMAGIC PLAN 1350.pdf plan based of door to door delivery of alkaline water...rowala30
Alka magic plan 1350 -we deliver alkaline water at your door step and you can make handsome money by referral programme
we also help and provide systematic guideline to setup 1000 lph alkaline water plant
DECODING THE RISKS - ALCOHOL, TOBACCO & DRUGS.pdfDr Rachana Gujar
Introduction: Substance use education is crucial due to its prevalence and societal impact.
Alcohol Use: Immediate and long-term risks include impaired judgment, health issues, and social consequences.
Tobacco Use: Immediate effects include increased heart rate, while long-term risks encompass cancer and heart disease.
Drug Use: Risks vary depending on the drug type, including health and psychological implications.
Prevention Strategies: Education, healthy coping mechanisms, community support, and policies are vital in preventing substance use.
Harm Reduction Strategies: Safe use practices, medication-assisted treatment, and naloxone availability aim to reduce harm.
Seeking Help for Addiction: Recognizing signs, available treatments, support systems, and resources are essential for recovery.
Personal Stories: Real stories of recovery emphasize hope and resilience.
Interactive Q&A: Engage the audience and encourage discussion.
Conclusion: Recap key points and emphasize the importance of awareness, prevention, and seeking help.
Resources: Provide contact information and links for further support.
2. Immunology and the Immune system
• Immunology
– The study of the molecular and cellular components
that comprise the immune system, including their
function and interaction, is the central science
of immunology.
• Immune System
– Molecules, cells, tissues and organs which provide non-
specific and specific protection against
• Microorganisms
• Microbial toxins
• Tumor cells
– Crucial to human survival
3. Immune response and Immunity
• Immune response
– Innate (non-specific)
– Adaptive (specific)
• Primary
• Secondary
• Immunity
– State of non-specific and specific protection
• Acquisition of Immunity
– Natural
– Artificial
4. The Immune System
• Human immune system begins to develop in the embryo.
• Starts with hematopoietic (from Greek, "blood-making")
stem cells.
• Stem cells differentiate into major cells in the immune
system
– granulocytes, monocytes, and lymphocytes
• Stems cells also differentiate into cells in the blood that
are not involved in immune function, such as erythrocytes
(red blood cells) and megakaryocytes (for blood clotting).
• Stem cells continue to be produced and differentiate
throughout ones lifetime.
5. Principal function of the Immune system
• To protect humans from pathogenic microorganisms
• Pathogenic microorganisms (Pathogens)
– Microorganisms capable of causing infection and/or disease
• Infection
– Ability of pathogen to enter host, multiply and stimulate an
immune response
• Disease
– Clinical manifestations associated with infection
6. Naturally Acquired immunity
• Active
– Antigens enter body naturally with response of
• Innate and adaptive immune systems
– Provides long term protection
• Passive
– Antibodies pass from mother to
• Fetus across placenta
• Infant in breast milk
– Provides immediate short term protection
7. Artificially Acquired Immunity
• Active
– Antigens enter body through vaccination with response of
• Innate and adaptive immune systems
– Provides long term protection
• Passive
– Antibodies from immune individuals injected into body
• Referred to as
– Immune serum globulins (ISG)
– Immune globulins (IG)
– Gamma globulins
– Provides immediate short term protection
10. Innate Immune system
• Innate immunity refers to nonspecific
defence mechanisms that come into
play immediately or within hours of an
antigen's appearance in the body. These
mechanisms include physical barriers
such as skin, chemicals in the blood,
and immune system cells that attack
foreign cells in the body.
11. Cells of innate immunity
NK cells
Dendritic cells
Mast cells
Neutrophils
Monocytes/Macrophages
Phagocytosis, inflammation
Phagocytosis, inflammation,
T-cell activation, tissue repair
Killing of infected or tumor cells
Eosinophils
Inflammation
Defense against parasites
Phagocytosis, activation of naive T-cells
Cell type Pricipal function(s)
12. AntigensAntigens
Some chemical that creates immune response
Most are proteinsproteins or large polysaccharidespolysaccharides
from a foreign organism.
– MicrobesMicrobes: Capsules, cell walls, toxins, viral
capsids, flagella, etc.
– NonmicrobesNonmicrobes: Pollen, egg white , red blood cell
surface molecules, serum proteins, and surface
molecules from transplanted tissue.
13. EpitopeEpitope: AntigensAntigens
Small part of an antigen that interacts
with an antibody. 10-12 amino acids
Any given antigen may have several
epitopes.
Each epitope is recognized by a
different antibody.
15. Cont….
• Epitope (Antigenic Determinant)
– Specific site on Ag that is recognized by the
immune system, where Ab binds
• Hapten: Small foreign foreign molecule that is not
antigenic antigenic. Must be coupled to a carrier molecule
to be antigenic. Once antibodies antibodies are formed
they will recognize hapten.
Karl Landsteiner Landsteiner discovered Hapten, who also
discovered blood group antigen and got noble prize.
17. AntibodiesAntibodies
• Proteins Proteins that recognize and bind to a
particular antigen with very high specificityspecificity.
• Made in response to exposure to the
antigen.
• One virus or microbe may have several
antigenic determinant sitesantigenic determinant sites, to which
different antibodies may bind.
• Each antibody has at least two identical
sites that bind antigen: Antigen bindingAntigen binding
sitessites.
• Belong to a group of serum proteins called
immunoglobulins (Igs).immunoglobulins (Igs).
19. How Do B Cells Produce Antibodies?How Do B Cells Produce Antibodies?
– B cells develop from stem cellsstem cells in the bone marrow of
adults (liver of fetuses).
– After maturation B cells migrate to lymphoid organs (lymph
node or spleen).
– Clonal SelectionClonal Selection: When a B cell encounters an antigen it
recognizes, it is stimulated and divides into many clones
called plasma cellsplasma cells, which actively secrete antibodies.
– Each B cell produces antibodies that will recognize only one
antigenic determinant.
20.
21. Immunoglobulin
• Heavy Chain – 110 amino acids longHeavy Chain – 110 amino acids long
– 100 distinct V segments100 distinct V segments
– 30 D segments30 D segments
– 6 J segments6 J segments
– Enzymes choose one V segment, one D segment and one JEnzymes choose one V segment, one D segment and one J
segment and fuse them togethersegment and fuse them together
– 18,000 combinations in encoding antibody molecule18,000 combinations in encoding antibody molecule
– Splice this variable region to the constant regionSplice this variable region to the constant region
• Light Chain – 211 amino acids longLight Chain – 211 amino acids long
– 10,000 combinations10,000 combinations
– Total of 180,000,000 distinct B cellsTotal of 180,000,000 distinct B cells
• Fusion is sloppy, can create other variantsFusion is sloppy, can create other variants
24. Immunity and Immune Response
Made up of two cellular systems:
• Humoral or circulating antibody system
– B cells
• Cell mediated immunity
– T cells
26. Humoral or B-Cell Mediated Immune
Response
Produces secreted antibodies (proteins)
• Bind to antigens and identify the antigen
complex for destruction.
• Antibodies act on antigens in the serum and
lymph
• B-cell produced antibodies may be
– attached to B-cell membranes or
– Free in the serum and lymph.
• Each B lymphocyte makes a unique antibody
molecule (immunoglobulin or Ig)
• Over a million different B lymphocytes are
produced in each individual
– So, each individual can recognize more
than a million different antigens
27. Cell Mediated Immune System:
T lymphocytes
• T-cells mature in the thymus (thus the name T-cell)
• Act on antigens appearing on the surface of individual cells.
• Over a million different kinds of T-cells
– Each produces a different receptor in the cell membrane
– Each receptor is composed of 1 molecule each of two
different proteins
– Each receptor binds a specific antigen but has only one
binding site
– Receptor only recognizes antigens which are
"presented" to it within another membrane protein of
the MHC type (major histocompatibility complex)
• Recognizes specific antigens bound to the antigen-
presenting structures on the surface of the
presenting cell.
• Recognizes antigens presented by B-cells,
macrophages, or any other cell type
28. T Cells and their Functions
• Have a specific receptor for a fragment of antigen
• Cytotoxic T-cells:
– Contain a surface protein called CD8
– Destroy pathogen infected cells, cancer cells, and foreign cells
(transplanted organs)
• Helper T-cells:
– Contain a surface protein called CD4
– Regulate both cellular and humoral immune systems
– This regulation reduces autoimmunity.
Study Guide
Why do soluble antigens and antibodies precipitate?
Study Guide
What is the difference between precipitation and agglutination?
Study Guide
Radioimmunoassays (RIA) and Immunfluorescence Assays (IFA) depend on the detection of a radionuclide or a fluorescent probe attached to the second antibody, instead of the enzyme. In those cases, no substrate is needed.
How would you use this assay to measure the concentration or detect the presence of an antigen?