This document discusses transfusion therapy for a 22-year-old man with multiple penetrating chest wounds who has drained 1500mL of blood from his right chest. The most appropriate next step is to arrange transfusion and transfer to the operating theater. Transfusion therapy involves administering blood components like packed red blood cells, fresh frozen plasma, platelets, and cryoprecipitate to replace lost blood and clotting factors. The risks and complications of transfusion include acute reactions like hemolytic, febrile, allergic, and transfusion-related acute lung injury as well as delayed issues such as alloimmunization, iron overload, and transfusion-transmitted infections.
its sometime difficult to decide in urgent clinical scenarios - Trauma,active bleeding, surgery: What ; when ; how and why to transfuse? answering some of these queries here is my presentation especially made for PG students (will help in answer writing)
Leucodepletion is a technical term for the removal of leucocytes (white blood cells) from blood components using special filters.
The leucocytes present in donated blood play no therapeutic role in transfusion and may be a cause of adverse transfusion reactions.
Removal of leucocytes may therefore have a number of potential benefits for transfusion recipients.
its sometime difficult to decide in urgent clinical scenarios - Trauma,active bleeding, surgery: What ; when ; how and why to transfuse? answering some of these queries here is my presentation especially made for PG students (will help in answer writing)
Leucodepletion is a technical term for the removal of leucocytes (white blood cells) from blood components using special filters.
The leucocytes present in donated blood play no therapeutic role in transfusion and may be a cause of adverse transfusion reactions.
Removal of leucocytes may therefore have a number of potential benefits for transfusion recipients.
Guidelines on massive blood transfusion(lecture-6)charithwg
it is a very short guideline about massive transfusion. please further read about complications about blood transfusions. and all the recommended reading are mentioned in the last slide. please read.
It contains indications of blood and blood products and perioperative blood therapy that we usually follow in Aiims Patna ..its is most recent one made in April 2020
Autologous Blood Transfusion (ABT) means reinfusion of blood or blood products taken from the same patient
ABT is not a new concept, fear of transfusion- transmitted diseases stimulated the growth of autologous programme
Transfusion Medicine has evolved in last decade & many societies have given recommendations for safe transfusion practices. Compiling these recommendations is very useful academic & practical activity
Blood, Blood transfusion and Blood products bijay19
This presentation give idea about blood, blood transfusion importance and things to note during transfusion...It shows various blood products, its indications and contraindications. the complication of blood transfusion
most controversial topic in the field of transfusion medicine, most of the transfusions worldwide are associated with the deleterious effects of immunomodulation, simplified for PG students with latest article support
Lymphoma is a cancer of lymphocytes. The most common place for abnormal lymphocytes is in lymph nodes (glands) particularly
under the arms, in the neck and in the groin.
Lymphoma is solid tumors of the immune system arising from cells of lymphoid tissues; lymphocytes, histiocytes, and reticulum cells. It can happen anywhere in the immune system, but usually in lymph nodes, spleen, marrow, and tonsils. Location and the behavior of lymphomas separate them from leukemia.The malignancy starts and restricted to lymphoid tissues and progress to involve the BM and appears in PB, at this stage it may be named, “lymphosarcoma cell leukemia.
Guidelines on massive blood transfusion(lecture-6)charithwg
it is a very short guideline about massive transfusion. please further read about complications about blood transfusions. and all the recommended reading are mentioned in the last slide. please read.
It contains indications of blood and blood products and perioperative blood therapy that we usually follow in Aiims Patna ..its is most recent one made in April 2020
Autologous Blood Transfusion (ABT) means reinfusion of blood or blood products taken from the same patient
ABT is not a new concept, fear of transfusion- transmitted diseases stimulated the growth of autologous programme
Transfusion Medicine has evolved in last decade & many societies have given recommendations for safe transfusion practices. Compiling these recommendations is very useful academic & practical activity
Blood, Blood transfusion and Blood products bijay19
This presentation give idea about blood, blood transfusion importance and things to note during transfusion...It shows various blood products, its indications and contraindications. the complication of blood transfusion
most controversial topic in the field of transfusion medicine, most of the transfusions worldwide are associated with the deleterious effects of immunomodulation, simplified for PG students with latest article support
Lymphoma is a cancer of lymphocytes. The most common place for abnormal lymphocytes is in lymph nodes (glands) particularly
under the arms, in the neck and in the groin.
Lymphoma is solid tumors of the immune system arising from cells of lymphoid tissues; lymphocytes, histiocytes, and reticulum cells. It can happen anywhere in the immune system, but usually in lymph nodes, spleen, marrow, and tonsils. Location and the behavior of lymphomas separate them from leukemia.The malignancy starts and restricted to lymphoid tissues and progress to involve the BM and appears in PB, at this stage it may be named, “lymphosarcoma cell leukemia.
Blood transfusion therapy involves transfusing whole blood or blood components (specific portion or fraction of blood lacking in patient). One unit of whole blood consists of 450 mL of blood collected into 60 to 70 mL of preservative or anticoagulant. Whole blood stored for more than 6 hours does not provide therapeutic platelet transfusion, nor does it contain therapeutic amounts of labile coagulation factors (factors V and VIII).
09.12.08(b): An Introduction to Blood Gas Analysis Open.Michigan
Slideshow is from the University of Michigan Medical School’s M2 Respiratory sequence
View additional course materials on Open.Michigan:
openmi.ch/med-M2Resp
Blood product transfusion and massive transfusionpankaj rana
Blood transfusion
Plastic bag 0.5–0.7 liters containing packed red blood cells in citrate, phosphate, dextrose, and adenine (CPDA) solution
Plastic bag with 0.5–0.7 liters containing packed red blood cells in citrate, phosphate, dextrose, and adenine (CPDA) solution
ICD-9-CM 99.0
MeSH D001803
OPS-301 code 8-80
MedlinePlus 000431
[edit on Wikidata]
Blood transfusion is generally the process of receiving blood or blood products into one's circulation intravenously. Transfusions are used for various medical conditions to replace lost components of the blood. Early transfusions used whole blood, but modern medical practice commonly uses only components of the blood, such as red blood cells, white blood cells, plasma, clotting factors, and platelets.
Blood products Transfusion and related complications,
Types of cell salvage, blood warming and autologous blood,
With intraoperative blood lots monitoring and transfusion
Rational use of blood componenets and Safe blood-2.pptxZahid Noor Jan
A very detailed presentation about blood safe transfusions. Blood components, RCC, Platelets, FFPs, its indications, precautions, problems, complications etc.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
2. ???………….A mcq
A 22 yr old man sustain multiple penetrating wounds to
upper rt.chest,his wounds are all above the nipple. He is
intubated,closed tube thoracostomy is performed, and
1500ml of blood has drained from rt.chest,2 liters of
crystalloid are infused. His BP is now 60/?,HR-160b/m
The most appropriate next step in managing this pt. is
a. Perform FAST
b. Obtain a CT chest
c. Perform an angiography
d. Arrange transfusion & transfer to OT.
e. Infuse colloids
5. 1902– Karl Landsteiner
Won the 1930 Nobel
Peace Prize
Isolated the A, B, & O
blood types.
Type AB blood was
identified two years
later.
Beginning of safe and effective transfusion medicine
6. RELATIONSHIP BETWEEN BLOOD TYPE & ANTIBODIES
Blood type Antigen on RBC Can
donate to
Antibodies in
serum
Can receive
from
A A A & AB ANTI B A ,O
B B B & AB ANTI A B ,O
AB A &B AB NONE A ,B,O
O NONE ALL ANTI A & ANTI B O
7. Well, it gets more complicated here, because there's
another antigen to be considered –
the Rh antigen.
• Rh was 1st identified of a rhesus monkey → rhesus factor
• A person with Rh factor on his RBC said to be Rh+ve
• Will not make anti Rh antibodies
• A person with out Rh factor on his RBC said to be Rh –ve
• This will produce anti Rh antibodies
• Rh incompatibility dangerous in pregnancy.
8.
9. Term &Definitions
BLOOD PRODUCT :Any therapeutic substance prepared from
human blood
WHOLE BLOOD :Unseparated blood
BLOOD COMPONENT : A constituent of blood ,separated from
Red cell concentrate
PRBC
FFP
PLATELETS
CRYOPRECIPITATE
→ Leucoreduced / Irradiated / washed
10. Why Separation of blood components ????
• The storage life of whole blood is less than that
of individual components
• Allows optimal survival for each component.
• Allows transfusing specific blood components.
• Several patients can be treated from one unit.
12. So…whom you would transfuse !!!!
i. 23 yo asymptomatic, healthy woman with
menorrhagia,Hb 8.0 g/dl,MCV- 72 fl
ii. 61 yo,k/c/o Htn,with severe gram negative sepsis –
BP-100/70,cold periphery,AMS & Hb 8.0 g/dl.
iii. 54 yo woman post hemicolectomy Hb 8.0g/dl.
iv. 73 yo man presenting with acute upper GI bleed;
BP 80/60, Pulse 120 thready – Hb 8.0 g/dl,MCV- 90fl
13. Objectives of transfusion therapy
• Maintain blood volume
• Maintain O2 carrying capacity
• Maintain coagulation
• Red Cell Transfusion SHOULD not be solely used as a
‘plasma expander’ – but primarily as a method to
increase oxygen carrying capacity.
14. So…what is threshold for transfusion ???
• Difficult to set a transfusion threshold that holds true for all
patients.
• Depends upon clinical status & co-morbidities.
• Use "10/30― rule.
15. STATEMENT
American society of Anaesthesiologists (ASA) state that:
“Red blood cell transfusion is rarely indicated when
the hemoglobin concentration is greater than 10
g/dl and is almost always indicated when it is less
than 6 g/dl”
16. Transfusion guidelines have been published by the
following societies:
• American Society of Anesthesiology
• British Committee for Standards in Hematology
• Australian and New Zealand Society of Blood Transfusion
• Eastern Association for Surgery of Trauma (EAST) & American
College of Critical Care Medicine of the Society of Critical Care
Medicine (SCCM)
• European Society of Cardiology (ESC)
• AABB (formerly the American Association of Blood Banks)
• American College of Physicians
17. Some recommended threshold
• Hgb <6 g/dL – Transfusion recommended .
• Hgb 6 to 7 g/dL – Transfusion generally likely to be indicated
• Hgb 7 to 8 g/dL – Transfusion should be considered in postoperative
surg.pts.
•
• Hgb 8 to 10 g/dL – Transfusion generally not indicated, but should be
considered for some populations (eg, those with symptomatic
anemia, ongoing bleeding, acute coronary syndrome with ischemia)
• Hgb >10 g/dL – Transfusion generally not indicated except in exceptional
circumstances
18. • Transfusion Requirements in Critical Care (TRICC)
Hebert PC, et al. N.Engl J Med. 1999;340(6):409-17
A multicenter, randomized, controlled clinical trial of transfusion requirements in
critical care has demonstrated that you can adopt a
• transfusion threshold of 7 g/dL and maintain critically ill
patients between 7 and 9 g/dL
• Patients with acute MI and unstable angina may possibly
benefit from Hb> 8 g/dL
21. component indication Approx / U typical
doses
Doses effects
PRBC
1 U=250ml
Acute ongoing hemorrhage
Sever symptomatic anaemia
RBC-80%
Hct-70%
2 units or
15ml/kg
↑Hb-2gm/dl
↑Hct-6%
Platelets
1 U=250ml
<10000/mm3 in asymptomatic pt.
<20000/mm3 in major bleeding
<50000/mm3 for invasive
procedure
<100,000/mm3 with neoro/cardiac
surgery
1 unit or
5 mL/kg
↑50,000/mm3
but less in
many cases
(↑consumption/
Active thrombosis/
Destruction due to
plt.antibodies.)
3–6 x 1011
FFP
1 U=250 ml
1 u of each
coagl.factor
&
Fibrinogen-
2mg/ml
Coagulation Factor
deficiency, fibrinogen
replacement, DIC, liver
disease, exchange transfusion
massive transfusion, warfarin
overcoagulation effect
Cryoprecipi
-tate
1U=50ml
Four units or
15 mL/kg
Raises most
coagulation
factors levels
approx. 20%
Fibrinogen /
factor VIII /
vWF / factor
XIII
/fibronectin.
10 units or
1 unit/5 kg
Raises fibrinogen
75 milligrams/dL
Bleeding with a fibrinogen level
of <100 milligrams/dL
Fibrinogen deficiency
vonWillebrands Disease
Factor VIII or XIII deficiency
22. Special processing of RBC
leukocyte-reduced PRBCs
•↓nonhemolytic febrile reactions.
•↓ risk of virus transmission.
•to prevent sensitization in pt. for bone
marrow transplantation
Irradiated PRBCs should be considered in transplant patients,
neonates, and immunocompromised
patients
washed PRBCs
•↓risk of anaphylaxis in IgA deficient pt.
•↓risk of reaction in pt.with recurrent /
severe allergic reaction to blood products.
23. Massive Transfusion
• 10 units of PRBCs within a 24-hour period.
• Replacement of a blood volume equivalent within 24hr
• >10 unit within 24 hr
• Transfusion > 4 units in 1 hr
• Replacement of 50% of blood volume in 5 hrs
• A rate of loss >150ml/hr
24. Importance of Massive Transfusion
• 39% of trauma related deaths – uncontrollable
bleeding (Leading cause of preventable death)
• 2% of trauma patients – need massive
transfusion
• Bleeding 2 main causes
• Vascular injury (surgical)
• Coagulopathy (non-surgical)
26. So.....What is Haemostatic /damage
control Resuscitation?
• A ground breaking concept!
• Prevents post traumatic coagulopathy
• Aims to reduce use of blood products in the intensive
care phase.
Expert’s openion
RBC:FFP:PLT
1:1:1
Traditionally
PLT: <50,000/mm3
FFP : INR >1.5
Crypts : fibrinogen
<100ml/dl
27. Evidence of Haemostatic Resuscitation
• Massive transfusion practices around the globe and a
suggestion for a common massive transfusion protocol
Debra L Malone, John R Hess, Abe Fingerhut ;The Journal of trauma. 01/07/2006; 60(6
Suppl):S91-6.
Suggested – RBC:FFP - 1:1
• Indications for early fresh frozen
plasma, cryoprecipitate, and platelet transfusion in
trauma
Lloyd Ketchum, John R Hess, Seppo Hiippala; The Journal of trauma. 01/07/2006; 60(6 Suppl):S51-8.
Early use of FFP,PLT - ↓ incidence of coagulopathy
28. Transfusion’s Complications
• Up to 20% may lead to some type of adverse reaction.
• Mostly within 24 h.
• Most are minor reactions./ don’t miss the life threatening
• Acute vs Delayed reaction.
• Infectious & non infectious.
• Difficult to recognized in Critically ill patient
30. AHTR
1 to 4 per 1 million units transfused.
Most commonly by ABO incompatibility.
Transfused cells are destroyed
↓ ↓ ↓
Activation of the coagulation system
with DIC & release of Anaphylotoxins &
other vasoactive amines
↓ ↓ ↓
• High fever/chills
• Hypotension
• Back/abdominal pain
• Oliguria / Hemoglobinuria
• Dyspnea
• Pallor
• requires a high degree of
suspicion in critically ill
31. What to do? If an AHTR occurs
• STOP TRANSFUSION
• A /B /C’s
• Maintain IV
• Give diuretic
• Blood & urine transfusion reaction workup
• Send remaining blood back to Blood Bank
Renal st-BUN/ Creat
Coagl.st-PT/aPTT/fibrinogen/plt.
Hemolysis-Bill/LDH/haptoglobin
32. Febrile transfusion reaction
Commenst among all
1 per 300 units of PRBC infused & 20%
of plt.infusion.
Result from a combination of recipient
antibody against donor leukocytes
and the release of cytokines that are
produced during storage.
Pretreatment with acetaminophen can
mask this reaction.
• Rise in patient temperature >1 C
(associated with transfusion without
other fever precipitating factors)
• fever / chills,
• Headache / myalgias,
• Tachycardia /dyspnea /chest pain.
• difficult to differentiate from more
serious hemolytic transfusion
reaction or sepsis.
33. What to do?If an FNHTR occurs
• STOP TRANSFUSION
• Use of Antipyretics
• Suspect and manage as AHTR
• Initially difficult to distinguish
between the two.
• Use of Corticosteroids for severe
reactions
• Use of Narcotics for shaking chills
• Future considerations
• May prevent reaction with
leukocyte filter.
• Use single donor platelets
• Use fresh platelets.
• Washed RBC’s or platelets
34. Transfusion Related Acute Lung injury
(TRALI)
• Clinical syndrome similar to ARDS
• Transfusion related noncardiogenic pulmonary edema
• Usually after FFP & Platelets transfusion
• Rare but , most common cause of transfusion related death
• Caused by WBC antibodies present in donor blood that result in
pulmonary leukostasis
• Occurs 1-6 hours after receiving plasma-containing blood products
• High mortality
35. TRALI Criteria
• Acute onset dyspnea during or within 6 hours of
transfusion
• Clinical evidence of hypoxemia
• Bilateral infiltrates on frontal chest radiograph
• No evidence of left atrial hypertension (i.e. circulatory
overload)
• Absence of other attributable causes
Treatment is supportive
37. Alloimmunization
• Can occur with erythrocytes or platelets
• Erythrocytes
• Antigen disparity of minor antigens (Kell, Duffy, Kidd)
• Minor antigens D, K, E seen in Sickle patients
• Platelets
• Usually due to HLA antigens
• May reduce alloimmunization by leukoreduction
(since WBC’s present the HLA antigens)
38. Transfusion Associated GVHD
• Mainly seen in infants
• Etiology—Results from engraftment of donor
lymphocytes of an immunocompetent donor into an
immunocompromised host
• Symptoms—Diarrhea, skin rash, pancytopenia
• Usually fatal—no treatment
• Prevention—Irradiation of donor cells
39. Etiology Estimated Frequency: One Infection
per Number of Units Transfused
HIV-1 1 per 2–3 million
HIV-2 Unknown, but extremely low
Human T-cell lymphotrophic virus type I
and II
1 per 640,000
Hepatitis B 1 per 100,000–200,000
Hepatitis C 1 per 1–2 million
Parvovirus B19 1 per 10,000
Bacterial sepsis 1 per 6 million platelet concentrates
1 per 500,000 packed red blood cells