The document summarizes the blood supply to the brain. The brain receives 15% of cardiac output despite making up only 2% of body weight. The two major arterial systems that supply the brain are the carotid system (via the internal carotid arteries) and the vertebro-basilar system (via the vertebral and basilar arteries). The carotid system contributes approximately 80% of total cerebral blood flow while the vertebro-basilar system contributes the remaining 20%. Several arteries branch off these main vessels to supply different regions of the brain, including the anterior, middle, and posterior cerebral arteries. The circle of Willis connects these arteries and acts as an alternate blood supply if one of the main arteries is occluded. Reduced blood flow