Objective :
1 - compare between malignant and benign tumors.
2 - describe the stages and grading of tumor .
3 - describe dysplasia to carcinoma .
4 – list the different type of malignant adenoma in colon .
5 – what is metastasis and how it spread and the common sites of the metastasis adenocarcinoma in the colon .
6 - describe the CEA .
by asem shadid
Blood cancers, or hematologic cancers, affect the production and function of blood cells. Most of these cancers start in the bone marrow where blood is produced.
Objective :
1 - compare between malignant and benign tumors.
2 - describe the stages and grading of tumor .
3 - describe dysplasia to carcinoma .
4 – list the different type of malignant adenoma in colon .
5 – what is metastasis and how it spread and the common sites of the metastasis adenocarcinoma in the colon .
6 - describe the CEA .
by asem shadid
Blood cancers, or hematologic cancers, affect the production and function of blood cells. Most of these cancers start in the bone marrow where blood is produced.
Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor.
Cervical cancer is caused by sexually acquired infections with certain types of HPV. Two HPV types (16 and 18) cause 70% of cervical cancers and pre-cancerous cervical lesions. There is also evidence linking HPV with cancers of the anus, vulva, vagina, penis, and oropharynx
Kidney cancer -- also called renal cancer -- is a disease in which kidney cells become malignant (cancerous) and grow out of control, forming a tumor. Almost all kidney cancers first appear in the lining of tiny tubes (tubules) in the kidney. This type of kidney cancer is called renal cell carcinoma.
Cancer, also called malignancy, is an abnormal growth of cells.
There are more than 100 to 200 types of cancer, including breast cancer, skin cancer, lung cancer, colon cancer, prostate cancer, and lymphoma. Symptoms vary depending on the type.
Cancer treatment may include chemotherapy, radiation, and/or surgery.
Breast cancer in men is a rare cancer that forms in the breast tissue of men. Both boys and girls have breast tissue. The various hormones in girls' and women's bodies stimulate the breast tissue to grow into full breasts.
Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor.
Cervical cancer is caused by sexually acquired infections with certain types of HPV. Two HPV types (16 and 18) cause 70% of cervical cancers and pre-cancerous cervical lesions. There is also evidence linking HPV with cancers of the anus, vulva, vagina, penis, and oropharynx
Kidney cancer -- also called renal cancer -- is a disease in which kidney cells become malignant (cancerous) and grow out of control, forming a tumor. Almost all kidney cancers first appear in the lining of tiny tubes (tubules) in the kidney. This type of kidney cancer is called renal cell carcinoma.
Cancer, also called malignancy, is an abnormal growth of cells.
There are more than 100 to 200 types of cancer, including breast cancer, skin cancer, lung cancer, colon cancer, prostate cancer, and lymphoma. Symptoms vary depending on the type.
Cancer treatment may include chemotherapy, radiation, and/or surgery.
Breast cancer in men is a rare cancer that forms in the breast tissue of men. Both boys and girls have breast tissue. The various hormones in girls' and women's bodies stimulate the breast tissue to grow into full breasts.
An acute or chronic disease in humans and other warm-blooded animals characterized by an abnormal increase in the number of white blood cells in the tissues and often in the blood.
A brief presentation on the topic "Leukemia" from a scientific perspective, providing details about risk factors, classifications, Types, treatment, symptoms, diagnosis & risk data with it's concerned resource mentioned.
my reference
Clinical pharmacy and therapeutics, Roger Walker
Rang & Dale’s pharmacology
Essential of medical pharmacology, K D Tripathi
www.google.com
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...
Blood cancer
1. BLOOD CANCER
BY; Mustafa Asaad Hameed
The Supervision; ENG. Khaldun
Ibn Sina College Of Medical
And Pharmaceutical Science
2. What are blood cancers ?
Blood cancer, also known as leukemia, is one of the types of
cancers that affect the formation of blood cells and the lymphatic
system. According to statistics, it is ranked the ninth in terms of the
most common cancers in the United States, accounting for only
3.7% of all cancer cases That were recently diagnosed, and it
should be noted that more than 50% of leukemia cases affect
people over the age of 50, and the number of men with this cancer
is twice the number of women.
3. Cause of cancer of blood
Leukemia occurred as a result of DNA damage to immature blood cells,
especially white cells, as this leads to continued growth and division of blood
cells, and thus obtaining large numbers of them. It should be noted that
abnormal blood cells do not die as they are The situation in healthy blood cells
that die after a period of time, to replace them with new cells that are
produced in the bone marrow, and instead it continues to increase and
accumulate, in addition to occupying a larger area, and it should be noted that
the continued production of more cancer cells leads to limiting the growth of
cells Healthy white blood and its ability to function normally; Because cancer
cells occupy a large area of blood
4. Leukemia risk factors
Many factors contribute to an increase in the risk of developing leukemia, and here comes a
statement for the most prominent of them:
1- Undergoing cancer treatments in the past: The risk of developing leukemia increases if a
person is exposed to certain types of chemotherapy and radiation.
2-Genetic disorders: Some genetic anomalies play a role in the development of leukemia, such
as: Down Syndrome.
5. Leukemia risk factors
3-Exposure to some chemicals, such as: benzene.
4- Smoking, as it contributes to an increased risk of some types of leukemia, especially acute
myelogenous leukemia
5-Having a family history of leukemia: As a family member has leukemia, the person increases
the risk of this disease
6. Symptoms of leukemia
The patient may not complain of any symptoms in the early stages of the disease, and in
general the symptoms of leukemia can be described as follows:
1- Anemia: This is represented by the presence of a number of red blood cells less than normal,
so this slows the arrival of Oxygen to the body’s organs and muscles, which causes pale skin,
easy fatigue, and low energy.
2-Bruising or bleeding occurs easily: these patients may suffer from bleeding gums or nose,
or they may notice blood in the stool or urine, and in many cases the bruises may develop
from very simple bumps, in addition to the possibility of small patches of different color
under the skin.
.
7. Symptoms of Leukemia
3- Vulnerability to infection: As leukemia affects the body's anti-infection cells, this causes the
development of different types of infections, such as: sore throat, or bronchopulmonary
inflammation. The infection results in suffering from several symptoms, such as: headache, or
low-grade fever Mouth ulcers, or rash.
4- Swollen lymph nodes: abnormal lymphocytes may accumulate in the lymph nodes in the
throat, armpit, or groin, causing it to swell. Loss of health in general: This is represented by loss of
appetite and weight,
5-feeling uncomfortable in the area under the lower left ribs, and feeling weak or tired all the
time, and some may experience night sweats, or fever that lasts for more than one to two weeks
8. Types of leukemia
Types of leukemia can be described as follows : The most common types: which include the
following:
1-Acute myelogenous leukemia, and represents the most common form of leukemia and may
develop in children and adults, according to the statistics of the United States About 21,000 new
cases of this type are diagnosed annually.
2-Acute lymphocytic leukemia, as it develops mostly in children, and according to statistics,
about 6000 new cases of this type are diagnosed annually.
9. Types of Leukemia
3-Chronic myelogenous leukemia, as it mostly affects adults, and about 9,000 new cases of this
year are diagnosed. Chronic lymphocytic leukemia, and this disease is rare in children. The
number of cases diagnosed annually is estimated at about 20 thousand cases
-
-4 Chronic lymphocytic leukemia, and this disease rarely appears in children. The number of
cases diagnosed annually is estimated at about 20 thousand cases.
10. Type of Leukemia
Less common types: Which can be described as follows
Downy leukemia (English: Hairy cell), and represents one of the chronic, uncommon types.
Chronic myelogenous leukemia (Chronic Myelomonocytic) represents a chronic blood
cancer that develops from the blood marrow cells.
Juvenile myeloid leukemia, it is a form of myelogenous leukemia that usually develops in
children under six years of age.
Large granular lymphocytic lymphoma, which is one of the chronic types that develop from
lymphocytes, may be slow, or fast growing.
Acute Promyelocytic Precursor Bleaching, an acute subtype of acute myeloid leukemia.
Treatment
11. Treating leukemia The treatment of leukemia includes a
number of methods, and the following is explained:
For chemotherapy: This includes the use of anti-cancer drugs; In order to destroy all cancer
cells, and to limit their growth and reproduction, taking into account the necessity that
damage to normal cells be minimal, it should be noted that these drugs are available in the
form of intravenous injection, subcutaneous injection, or oral tablets.
Stem cell transplantation: As this allows higher doses of chemotherapy to be used in some
cases, it also increases the chances of recovery, and despite its benefits, this procedure is
considered stressful except for being risky.
12. Treating leukemia The treatment of leukemia
Radiation therapy: depends on the use of high-energy X-rays; The goal is to
eliminate leukemia cells, or prevent them from growing. Biologic therapy:
This treatment helps the immune system to find and attack cancer cells.
Targeted therapy: This involves the use of medications to prevent specific
genes or proteins that cancer cells need to grow.
13. Treating leukemia The treatment of leukemia
Surgery: As the doctor removes the spleen in cases where it is filled with cancerous cells,
causing pressure on the organs near it