This document discusses syncope, defined as a transient loss of consciousness due to decreased blood flow to the brain. It outlines several common causes of syncope including vasovagal, cardiac arrhythmias, orthostatic hypotension. It emphasizes taking a detailed patient history and physical exam. Common tests include ECG, tilt table test, and echocardiogram. Treatment depends on the underlying cause but may include medications to increase blood pressure, cardiac pacing for arrhythmias, and avoiding triggers.
Hemiparesis is unilateral paresis, that is, weakness of the entire left or right side of the body (hemi- means "half"). Hemiplegia is, in its most severe form, complete paralysis of half of the body. Hemiparesis and hemiplegia can be caused by different medical conditions, including congenital causes, trauma, tumors, or stroke
Hypenension: Commonest cause of intracerebral haemorrhage.
Rupture of an intracranial aneurysm, angioma or A-V malformation: commonest cause of subarachnoid haemorrhage.
Haemorrhagic blood diseases: purpura, haemophilia.
Anticoagulants.
Trauma to the head: commonest of subdural haematoma.
II. Infective: ;
Encephalitis
Meningitis – Brain abscess.
III. Neoplastic: e.g. Meningioma.
IV. Demyelination: multiple sclerosis may present with hemiplegia.
V. Traumatic: e.g. Cerebral laceration and subdural haematoma.
VI. Hysterical: patient suffering from paralysis in the absence of organic lesion.
This ppt describes various movement disorders found commonly in elderly persons. It also describes hyper and hypokinetic disorder categorization with cause and pathophysiology of movement disorders.
Hemiparesis is unilateral paresis, that is, weakness of the entire left or right side of the body (hemi- means "half"). Hemiplegia is, in its most severe form, complete paralysis of half of the body. Hemiparesis and hemiplegia can be caused by different medical conditions, including congenital causes, trauma, tumors, or stroke
Hypenension: Commonest cause of intracerebral haemorrhage.
Rupture of an intracranial aneurysm, angioma or A-V malformation: commonest cause of subarachnoid haemorrhage.
Haemorrhagic blood diseases: purpura, haemophilia.
Anticoagulants.
Trauma to the head: commonest of subdural haematoma.
II. Infective: ;
Encephalitis
Meningitis – Brain abscess.
III. Neoplastic: e.g. Meningioma.
IV. Demyelination: multiple sclerosis may present with hemiplegia.
V. Traumatic: e.g. Cerebral laceration and subdural haematoma.
VI. Hysterical: patient suffering from paralysis in the absence of organic lesion.
This ppt describes various movement disorders found commonly in elderly persons. It also describes hyper and hypokinetic disorder categorization with cause and pathophysiology of movement disorders.
Approach to Syncope in Children (Pediatric Syncope).pptxJwan AlSofi
Approach to Syncope in Children (Pediatric Syncope), includes:-
Introduction
Differential diagnosis of syncope
Syncope vs vertigo vs Presyncope vs light-headedness.
Comparison of Clinical Features of Syncope and Seizures
Neurocardiogenic (Vasovagal) syncope
MECHANISMS and Causes of Syncope
Cardiac causes of syncope
Life-threatening causes of syncope
Red Flags in Evaluation of Patients With Syncope
Non-cardiac causes of loss of consciousness.
Noncardiac Causes of Syncope
Differentiating Features for Causes of Syncope
EVALUATION of syncope:- History, Examination,Treatment.
Summary
syncope in children , vasovagal syncope , fainting in children , causes of syncope in children , how to manage syncope in children , cardiac syncope , differnetial diagnosis of syncope , approach to syncope
Syncope and arterial hypertension: emergence in cardiologyssuserb26cfc
What is syncope? Syncope (SINK-a-pee) is another word for fainting or passing out. Someone is considered to have syncope if they become unconscious and go limp, then soon recover. For most people, syncope occurs once in a great while, if ever, and is not a sign of serious illness.
Children's basic illnesses - a primer for mothersRAJESH EAPEN
Children's basic illnesses , primer for mothers, cough, cold, hand washing, temperature reading, nose bleeds, vomiting, diarrhea, fractures, ear infections, eye injury, sprains
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
1. DR. RAJESH T EAPEN
SPECIALIST – ANESTHESIA
ATLAS HOSPITAL
RUWI
2. What is Syncope?
• Common clinical problem and a primary
goal of evaluation is to determine
whether the patient is at increased risk of
death.
3. Definition
• Sudden, self-limited loss of
consciousness in postural tone caused by
transient global cerebral hypoperfusion
& followed by spontaneous complete
and prompt recovery
4.
5. History
• It is vital to establish exactly what
patients mean by 'blackout'
• Do they mean loss of consciousness
(LOC)?
• A fall to the ground without loss of
conscious-ness?
• A clouding of vision, diplopia, or vertigo?
• Take a detailed history from the patient
and a witness
6. Epidemiology
• Common in the general population
- 6% of medical admissions
- 3% of Emergency room visits
• Incidence: Male = Female
7.
8. Risk Factors
• Cardiovascular disease, h/o stroke or TIA
& HTN
• Low BMI, ↑alcohol intake & diabetes or
elevated blood glucose concentration
9. Vasovagal (neuro-cardiogenic)
syncope
• Due to reflex bradycardia ± peripheral
vasodilatation provoked by emotion,
pain, fear or standing too long
• Onset is over seconds (not
instantaneous), and is often preceded
by nausea, pallor, sweating and closing
in of visual fields (pre-syncope)
• It cannot occur if lying down
10. Vasovagal (neuro-cardiogenic)
syncope …..contd.
• The patient falls to the ground, being
unconscious for ~2 min
• Brief clonic jerking of the limbs may occur
(reflex anoxic convulsion due to cerebral
hypo-perfusion), but there is no stiffening
or tonic → clonic sequence
• Urinary incontinence is uncommon (but
can occur), and there is no tongue-biting.
• Post-ictal recovery is rapid
11. Situation syncope
• Syncopal symptoms are as described for
vasovagal syncope
• Cough syncope: Syncope after a paroxysm
of coughing
• Effort syncope: Syncope on exercise;
cardiac origin, e.g. aortic stenosis, HOCM
• Micturition syncope: Syncope during or
after micturition. Mostly men, at night
• Even during swallowing & defecation!
12. Carotid sinus syncope
• Hypersensitive baroreceptors cause
excessive reflex brady-cardia ±
vasodilatation on minimal stimulation
(e.g. head-turning, shaving)
13. Epilepsy
• Attacks vary with the type of seizure,
• Certain features are more suggestive of
epilepsy:
attacks when asleep or lying down
aura
identifiable triggers. e.g. TV
altered breathing
cyanosis
typical tonic-clonic movements
incontinence of urine
tongue-biting (ask about a sore tongue after the fit)
prolonged post-ictal drowsiness, confusion, amnesia and
transient focal paralysis (Todd's palsy)
14. Stokes-Adams attacks
• Transient arrhythmias (e.g. bradycardia
due to complete heart block) causing
↓ cardiac output and LOC
• The patient falls to the ground (often
with no warning except palpitations),
pale, with a slow or absent pulse
• Recovery is in seconds, the patient
flushes, the pulse speeds up, and
consciousness is regained
15. Stokes-Adams attacks …contd.
• Injury is typical of these intermittent
arrhythmias
• As with vasovagal syncope, a few clonic
jerks may occur if an attack is
prolonged, due to cerebral hvpo-
perfusion (reflex anoxic convulsion).
• Attacks may happen several times a day
and in any posture
16. Drop attacks
• Sudden weakness of the legs causes the
patient, usually an older woman, to fall to
the ground
• There is no warning, no LOC and no
confusion after-wards
• The condition is benign, resolving
spontaneously after a number of attacks.
• Other causes: hydrocephalus (these
patients, however. may not be able to get up
for hours); cataplexy-triggered by emotion
(associated with narcolepsy)
17. Other causes
• Hypoglycaemia: Tremor, hunger, and
perspiration herald light-headedness or LOC;
rare in non-diabetics
• Orthostatic hypotension: Unsteadiness or LOC
on standing from lying in those with
inadequate vasomotor reflexes: the elderly;
autonomic neuropathy; antihypertensive
medication; over-diuresis; multi-system
atrophy (MSA)
• Anxiety: Hyperventilation. tremor, sweating.
tachycardia, paraesthesias, light-headedness,
and no LOC suggest a panic attack.
18. Other causes ……….contd.
• Factitious blackouts: pseudo-seizures,
Munchausen's
• Choking: If a large piece of food blocks
the larynx, the patient may collapse,
become cyanotic, and be unable to
speak. Do the Heimlich manoeuvre
immediately to eject the food
20. Investigations
• ECG ± 24h ECG (arrhythmia, long QT, e.g. Romano-
Ward)
• U&E, FBC. glucose
• Tilt-table tests
• EEG, sleep EEG
• Echocardiogram
• CT/MRI brain
• HUT (Head Up Tilt test)
• PaCO2 ↓ in attacks suggest hyperventilation as the
cause
• While the cause is being elucidated, advise against
driving
21. Treatment – Neurocardiogenic Syncope
• Counsel patients to take precautionary steps to
avoid injury by being aware of prodromal
symptoms & maintaining a horizontal position at
those times
• Avoid known precipitants & maintain adequate
hydration
• Employ isometric muscle contractions during
prodrome to abort episode
• Midodrine (start at 5mg PO Tid & can be increased
to 15mg Tid) probably helpful in the treatment
• Cardiac pacing for carotid sinus hypersensitivity is
appropriate in syncopal patients
22. Treatment – Orthostatic hypotension
• Adequate hydration & elimination of
offending drugs
• Salt supplementation, compressive stocking
& counselling on standing slowly
• Midodrine & fludrocortisone can help by
increasing systolic BP & expanding plasma
volume respectively
23. Treatment – Cardiovascular (arrhythmia or
mechanical):
• Treatment of underlying cause(valve replacement,
antiarrhythmic agent, coronary re-vascularisation
etc.)
• Cardiac pacing for sinus node dysfunction or high-
degree AV block
• Discontinuation of QT prolonging drugs
• Catheter ablation procedure in select patients with
syncope associated with SVT
• ICD for documented VT without correctable cause
and for syncope with EF < 35% even in absence of
documented arrhythmia