The Black Death was a bubonic plague pandemic that struck Europe between 1347 and 1351. It is estimated to have killed around 25 million people in Europe, reducing the population by around one third. The plague originated in Asia and was brought to Europe via trade routes. It had devastating effects on population levels and society, and contributed to increased wages for laborers as well as religious and social unrest across the continent.
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PowerPoint: Medieval Life: The Black Death - Bubonic Plague - Black PlagueYaryalitsa
PowerPoint looks generally at THE BLACK DEATH. It includes links to the History Channel's 18 part series: The Plague. It also includes an Assessment Task for students to complete.
Black Death
Firstly known as Justinian Plague in 541 AD.The second Epidemic in 1346 and 1351.cause of Bacteria Yersinia Pestis.Rodent to Human.Bubonic Plague.
Plague in Europe
Originated in China
Spread alone trade routes
Reached in southern England in 1346 and Northern Britain in1350
Had a great lose in Europe
Europe affected several times
It took 200 years to overcome from this epidemic
Effects of Black Death in Europe
Social
Social and Economical balanced had distroyed
Trade suffered for a ti,e and wars were temporarily abondoned
Many laborers died so that the cultivation was in vain at that time so that famin saw soon
Arts and Literature
Symbolic use of skeleton in arts
Dance of Death often shown in Literature and drama
Made satire with death
the major writers Petrarch, Geoffrey Chaucer and William Langland.
Belief and Religious Conflict
Lost Faith in Catholic Church
Persecution of minorities
Jews were blamed and killed by Christians
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MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. Black Death..cont
• Black Death: Outbreak of
bubonic plague that struck
Europe from 1347 through
1351.
• It was the first cycle of European plague epidemics that
continued until the early 18th century
• The term Black Death is not used to describe the plague
until much later in history.
3.
4. Black Death..cont
• The exact origin of where the Black Death originated from
is debatable, however most historians believe the
black death originated
somewhere in Asia
• The plague had spread west into the Middle East via trade
routes west from China
• It is believed that Genoese & Venetian traders brought it to
Europe from Egypt in 1347
• Or brought from the Black Sea port of Caffa
5. Black Death…cont
• Italy: The first Western
European country the Black
Death reached
• The Black Death was carried
by rodents, in particular the
fleas on rodents, and then
transmitted to humans
6.
7.
8.
9.
10. Black Death..cont
• Contemporary doctors and theologians
believed there were two
main causes
of the Black Death
• 1) Imbalance of the body’s
humors, fluids
• Emotional, dietary, or external factors like noxious orders
could result in sickness, death
• Individuals were to eat moderately & avoid anything that
11. Black Death..cont
• 2) God’s judgement on a sinful
humanity
• Flagellants: Term for those
who would ritually beat
themselves as penance for their
own & others’ sins
• These flagellants would hold processions through towns that
lasted as long as 33 days, each day representing one year in the life
12.
13.
14. Black Death..cont
• Overall, European population declined by
about 1/3, an estimated 25 million people
died between 1347 & 1352
• In many European cities population may
have declined by 50% or more
• Larger towns declined drastically, as their
workforces & merchant classes either died
or fled
15.
16.
17.
18.
19.
20. Black Death..cont
• Another effect of the Black Death was the rise of intolerance towards
outsiders or non-Christians
• Jews were accused of deliberately
poisoning the water supply or air,
and therefore, many were
viciously attacked
• Persecutions only ended when the deaths from the plague began to
decline
21.
22.
23. Black Death..cont
• The Black Death had a profound influence on the art & music of the
time
• Many paintings were filled with images related to death, such as
skelatons
• Grim Reaper: Character who
came to symbolize the one who
brings death during the Black
Death
24.
25.
26.
27.
28.
29.
30.
31.
32. Economic Effect of the Black
Death
• Wealth concentrated in the
hands of survivors
• Wage increases, especially for
skilled artisans
• Profits for landlords &
merchants declined
33. Black Death..cont
• Governments were forced to adjust to the social disruption
caused by the plague
• Governments attempted to regulate the movement & price
of foods & wages
• Peasants’ Revolt of 1351:
Reaction to the attempt by
landlords to collect higher fees
from tenant farmers
• According to some, the Black Death helped bring the end
Editor's Notes
Dead Bodies being collected in Mersailles, France
Doctor w/ primitive gas mask
Mass grave of plague victims uncovered on an island near Venice, Italy
Same mass grave
Exhumed skull of possible vampire in Italy, jaw forced open with a brick