The Black Death pandemic in the 14th century killed an estimated 30-60% of Europe's population. It originated in China and spread along trade routes, first reaching Europe in Sicily in 1347 through infected ships from Genoa. Symptoms varied but included respiratory issues, swollen lymph nodes, vomiting blood, and dark spots caused by bleeding under the skin. Around 170 million people in Europe and Asia ultimately died from the disease, with major social, economic, and religious impacts.