The presentation gives overview of the biomimetics medical devices.These devices have a potential to overcome drawbacks of traditional medical devices. Intensive research is going on biomimicking natural process in designing the devices in order to get effective treatment of patient, or discovering novel devices.
Biomimetics involves imitating nature to address human needs. It deals with developing innovations by studying natural structures, functions, processes and systems. Nature acts as a model. Some key points of biomimetics include mimicking nature through natural or synthetic substitutes, and studying nature's solutions to problems like the lotus plant's water resistance. Biomimetics has applications in areas like energy efficient buildings, bionic vehicles, tissue engineering and more. It is a growing field with potential for developing new materials, technologies and applications.
The document provides an overview of biomaterials and their applications. It discusses various biomaterial types including metals, polymers, and ceramics. It describes how biomaterials are used for implant and transplant purposes to replace or repair soft and hard tissues. The document also mentions some of the ethical issues regarding biomaterials and transplants. It provides examples of implant usage statistics and discusses challenges with transplants including limited availability and immunological problems.
1. Tissue engineering involves growing tissues or organs in vitro to replace damaged body parts. Cells are seeded onto a scaffold and bathed in growth factors to grow new tissue.
2. Common scaffolds include collagen, polymers like PLLA, and ceramics. Cells used include stem cells, keratinocytes for skin, and bladder cells.
3. The process involves obtaining cells, seeding them onto a scaffold, and incubating the construct to grow new tissue which can then be implanted.
The document discusses biomaterials, bio-implants, and biomedical devices. It provides:
1) Definitions of biomaterials, bio-implants, and biomedical devices and how they interact with human tissue.
2) A brief history of the advancement of biomaterials and biomedical devices from ancient times to modern developments.
3) Classification of biomaterials into biological, synthetic, and composite categories and how they are evaluated.
What are Organs-on-chips?
The Organs-on-Chips are crystal clear, flexible polymers about the size of a computer memory stick that contain hollow channels fabricated using computer microchip manufacturing techniques.
These channels are lined by living cells and tissues that mimic organ-level physiology.
Biomaterials for tissue engineering slideshareBukar Abdullahi
An overview of Tissue Engineering with some basics in Biomaterials and Synthetic Polymers. Further references should be considered as I presented this a specific target audience.
This document provides an overview of biomimetics. It begins by defining biomimetics as the imitation of concepts found in nature to solve human problems. Examples are given such as airplanes modeled after birds and the Crystal Palace modeled after lilies. The document then discusses categories of biomimetics such as mimicking natural mechanisms and incorporating nature into devices. Several examples of biomimetics found in nature are described in more detail, including the self-cleaning properties of lotus leaves, the slippery surface of pitcher plants, and the tough structure of nacre. Applications of biomimetics in industries such as architecture, cars, and adhesives are also summarized.
Biomaterials can be used for tissue engineering and drug delivery applications. For tissue engineering, cells are seeded onto a scaffold material and allowed to grow to replace damaged tissue. Common scaffold materials include collagen, gelatin and polymers. Hydrogels are a type of smart biomaterial that can be used as a scaffold. They are cross-linked polymeric networks that swell in water. For drug delivery, biomaterials can be engineered to release drugs at controlled rates or in pulses based on environmental stimuli to maximize the therapeutic effect. Examples include hydrogels that release encapsulated drugs as the gel swells. Biomaterials show promise for regenerative medicine and targeted cancer therapies.
Biomimetics involves imitating nature to address human needs. It deals with developing innovations by studying natural structures, functions, processes and systems. Nature acts as a model. Some key points of biomimetics include mimicking nature through natural or synthetic substitutes, and studying nature's solutions to problems like the lotus plant's water resistance. Biomimetics has applications in areas like energy efficient buildings, bionic vehicles, tissue engineering and more. It is a growing field with potential for developing new materials, technologies and applications.
The document provides an overview of biomaterials and their applications. It discusses various biomaterial types including metals, polymers, and ceramics. It describes how biomaterials are used for implant and transplant purposes to replace or repair soft and hard tissues. The document also mentions some of the ethical issues regarding biomaterials and transplants. It provides examples of implant usage statistics and discusses challenges with transplants including limited availability and immunological problems.
1. Tissue engineering involves growing tissues or organs in vitro to replace damaged body parts. Cells are seeded onto a scaffold and bathed in growth factors to grow new tissue.
2. Common scaffolds include collagen, polymers like PLLA, and ceramics. Cells used include stem cells, keratinocytes for skin, and bladder cells.
3. The process involves obtaining cells, seeding them onto a scaffold, and incubating the construct to grow new tissue which can then be implanted.
The document discusses biomaterials, bio-implants, and biomedical devices. It provides:
1) Definitions of biomaterials, bio-implants, and biomedical devices and how they interact with human tissue.
2) A brief history of the advancement of biomaterials and biomedical devices from ancient times to modern developments.
3) Classification of biomaterials into biological, synthetic, and composite categories and how they are evaluated.
What are Organs-on-chips?
The Organs-on-Chips are crystal clear, flexible polymers about the size of a computer memory stick that contain hollow channels fabricated using computer microchip manufacturing techniques.
These channels are lined by living cells and tissues that mimic organ-level physiology.
Biomaterials for tissue engineering slideshareBukar Abdullahi
An overview of Tissue Engineering with some basics in Biomaterials and Synthetic Polymers. Further references should be considered as I presented this a specific target audience.
This document provides an overview of biomimetics. It begins by defining biomimetics as the imitation of concepts found in nature to solve human problems. Examples are given such as airplanes modeled after birds and the Crystal Palace modeled after lilies. The document then discusses categories of biomimetics such as mimicking natural mechanisms and incorporating nature into devices. Several examples of biomimetics found in nature are described in more detail, including the self-cleaning properties of lotus leaves, the slippery surface of pitcher plants, and the tough structure of nacre. Applications of biomimetics in industries such as architecture, cars, and adhesives are also summarized.
Biomaterials can be used for tissue engineering and drug delivery applications. For tissue engineering, cells are seeded onto a scaffold material and allowed to grow to replace damaged tissue. Common scaffold materials include collagen, gelatin and polymers. Hydrogels are a type of smart biomaterial that can be used as a scaffold. They are cross-linked polymeric networks that swell in water. For drug delivery, biomaterials can be engineered to release drugs at controlled rates or in pulses based on environmental stimuli to maximize the therapeutic effect. Examples include hydrogels that release encapsulated drugs as the gel swells. Biomaterials show promise for regenerative medicine and targeted cancer therapies.
TISSUE DEVELOPMENT WITH TISSUE ENGINEERING APPROACHFelix Obi
Tissue Engineering is the development and practice of combining scaffolds, cells, and suitable biochemical factors (regulatory factors or Signals) into functional tissues. The goal of tissue engineering is to assemble functional constructs that restore, maintain, or improve damaged tissues or whole organs.
Cells are the building blocks of tissue, and tissues are the basic unit of function in the body. Generally, groups of cells make and secrete their own support structures, called extracellular matrix. This matrix, or scaffold, does more than just support the cells; it also acts as a relay station for various signaling molecules. Thus, cells receive messages from many sources that become available from the local environment. Each signal can start a chain of responses that determine what happens to the cell. By understanding how individual cells respond to signals, interact with their environment, and organize into tissues and organisms, Tissue Engineers are now able to manipulate these processes to amend damaged tissues or even create new ones.
Tissue engineering uses scaffolds, cells, and signaling molecules to regenerate tissues and organs. Scaffolds provide a structure for cell attachment, growth, and tissue formation. Natural polymers like collagen and hyaluronic acid, and synthetic polymers like poly-lactic-co-glycolic acid are commonly used as scaffold materials. Scaffolds can be fabricated using various methods including freeze drying, electrospinning, 3D printing, and textile technologies to produce scaffolds with desirable properties like porosity and pore size for tissue growth. Scaffolds seeded with stem cells or tissue-specific cells aim to repair and regenerate tissues for applications in skin, bone, cartilage, and other organs.
Biomaterials are materials that are used in medical devices and implants that are introduced into the human body. They must be biocompatible, meaning they are compatible with and accepted by the body, and must withstand the body's internal conditions like temperature, pH levels, and corrosive fluids. Common biomaterials include polymers like nylon and silicone, ceramics like aluminum oxide, and metals like titanium alloys. Examples of biomaterials in use include pacemakers which use titanium casings and polyurethane insulation, contact lenses made of soft hydrogel plastics, knee implants made of plastics and metals, and the latest artificial hearts which are made of titanium and special plastics.
This document discusses biomimetic materials, which are materials developed through mimicking biological structures found in nature. It provides examples of biomimetic materials like nacre-inspired materials and artificial muscles. Nacre-inspired materials are discussed that mimic the structure of mother-of-pearl to create strong, lightweight composites for bone repair. Different types of artificial muscles are also summarized, including electroactive polymers, shape memory alloys, and shape memory polymers that can contract, expand or change shape in response to electrical, thermal, or chemical stimuli like natural muscles. Biomedical applications of these biomimetic materials are highlighted such as SMPs for tissue engineering and controlling cell morphology.
The document discusses biomaterials, which are materials used in medical devices that interact with biological systems. Biomaterials are intended to replace or augment damaged organs, tissues, or vessels. Common biomaterial applications include joint replacements, dental implants, heart valves, blood vessel grafts, and intraocular lenses. The development of biomaterials involves identifying needs, designing devices, testing materials, fabricating devices, sterilization, packaging, testing devices, and clinical use. Key considerations for biomaterials include biocompatibility, toxicology, and mechanical performance requirements.
Role of growth factors in a tissue engineered.pptxNandhu34249
Growth Factors and its function is exaplained with the images, so even a new person can learn abou the growth factors of the cell in the tissue engineering. The tissue Engineering is the currently grwing area
3D BIO PRINTING USING TISSUE AND ORGANSsathish sak
3D bio printing is the process of creating cell patterns in a confined space using 3D printing technologies.
3D bio printing is the layer by layer method to deposit materials known as bioinks to create tissue like structure.
Currently, bioprinting can be used to print tissues and organs to help research drug and pills.
- Bioprinting uses 3D printing technology with living cells to produce tissues for surgery.
- Inkjet bioprinting is a common technique that prints cell spheroids layer-by-layer to build structures.
- The 3D bioprinting process involves pre-processing to design structures, processing to print layers of bioink, and post-processing for the structures to mature.
- Developing effective bioinks is a current challenge limiting bioprinting's potential to produce organs for transplants.
3D bioprinting is a technique that uses 3D printing technologies to precisely position biological materials, cells, and biochemicals in layers to fabricate 3D structures and tissues. The process involves imaging tissues to create digital models, selecting appropriate biomaterials, cell sources, and a bioprinting method (inkjet, microextrusion, or laser). Applications include producing skin, blood vessels, and other tissues for implantation and drug testing. However, fully functional 3D printed organs are still in development due to challenges with vascularization and matching native tissue complexity.
Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physicochemical factors to improve or replace biological functions.
The term has also been applied to efforts to perform specific biochemical functions using cells within an artificially-created support system (e.g. an artificial pancreas, or a bio artificial liver).
A commonly applied definition of tissue engineering, as stated by Langer and Vacanti is “An interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve [Biological tissue] function or a whole organ”
Tissue engineering aims to regenerate tissues by combining cells, scaffolds, and signaling molecules. There are two main strategies - in vitro construction of tissues in the lab prior to implantation, and in vivo regeneration of tissues at the implantation site. Successful tissue engineering requires the right cells, scaffolding for cell attachment and growth, and signaling to guide tissue development. Stem cells are promising cell sources due to their ability to differentiate into many cell types.
Biomaterials are any substances used in medical devices and implants that interact with biological systems. They include metals, ceramics, polymers, and composites. Biomaterials must be biocompatible and not elicit negative host tissue responses. Newer generations of biomaterials aim to regenerate tissues through cell-material interactions and tissue engineering approaches. The biomaterials field involves many disciplines working to develop safer and more effective materials for applications such as orthopedic and dental implants, vascular grafts, drug delivery devices, and more. Key challenges include replicating complex tissue structures in vitro and improving biocompatibility.
The document discusses 3D bioprinting. It introduces 3D bioprinting as the process of generating spatially-controlled cell patterns using 3D printing technologies while preserving cell function and viability. It states that 3D bioprinting has applications in different fields. It also mentions that the document will discuss adoptions of 3D bioprinting and provide forecasts for the technology in 2016. It lists three references related to 3D bioprinting applications and trends.
Introduction
Anatomy and Physiology of bone
Bone Tissue Engineering
Recent studies related to bone tissue engineering
Commercialized products and ongoing clinical trials
Biomedical start-ups
Concluding remarks
Introduction
Anatomy and Physiology of bone
Bone Tissue Engineering
Recent studies related to bone tissue engineering
Commercialized products and ongoing clinical trials
Biomedical start-ups
Concluding remarks
Introduction
Anatomy and Physiology of bone
Bone Tissue Engineering
Recent studies related to bone tissue engineering
Commercialized products and ongoing clinical trials
Biomedical start-ups
Concluding remarks
This document provides an overview of the field of tissue engineering. It defines tissue engineering as an interdisciplinary field that applies engineering and life science principles toward the development of biological substitutes that restore or improve tissue function. The key goals of tissue engineering are to repair, replace, or regenerate tissues and whole organs. Current clinical treatments involve grafting methods like autografts, allografts, and xenografts, but these have limitations like immune rejection and donor scarcity. Tissue engineering aims to address these issues by using scaffolds, cells, and growth factors to regenerate tissues. Challenges in the field include properly mimicking the tissue microenvironment, scaling up production, and developing vascularization within engineered tissues.
The document discusses biomaterials, which are materials used in medical applications that interact with biological systems. It defines biomaterials and outlines their classification as natural or synthetic. Natural biomaterials discussed include proteins, cellulose, chitin, and polynucleotides. Synthetic biomaterials include polymers like PMMA, ceramics like calcium phosphate, and metals like titanium. Common applications of biomaterials are described like implants, prosthetics, and medical devices used in the skeletal, cardiovascular, and sensory systems.
Organ-on-chips are microfluidic cell culture chips that mimic organ-level physiology and functions. They allow for complex cell-cell and cell-matrix interactions in a controlled environment. Various organ models have been developed including lungs, liver, kidney, and skin. In India, researchers are working on skin, retina, placenta and infection models. Organ-on-chips could serve as alternatives to animal testing and help develop personalized disease models and therapies.
TISSUE DEVELOPMENT WITH TISSUE ENGINEERING APPROACHFelix Obi
Tissue Engineering is the development and practice of combining scaffolds, cells, and suitable biochemical factors (regulatory factors or Signals) into functional tissues. The goal of tissue engineering is to assemble functional constructs that restore, maintain, or improve damaged tissues or whole organs.
Cells are the building blocks of tissue, and tissues are the basic unit of function in the body. Generally, groups of cells make and secrete their own support structures, called extracellular matrix. This matrix, or scaffold, does more than just support the cells; it also acts as a relay station for various signaling molecules. Thus, cells receive messages from many sources that become available from the local environment. Each signal can start a chain of responses that determine what happens to the cell. By understanding how individual cells respond to signals, interact with their environment, and organize into tissues and organisms, Tissue Engineers are now able to manipulate these processes to amend damaged tissues or even create new ones.
Tissue engineering uses scaffolds, cells, and signaling molecules to regenerate tissues and organs. Scaffolds provide a structure for cell attachment, growth, and tissue formation. Natural polymers like collagen and hyaluronic acid, and synthetic polymers like poly-lactic-co-glycolic acid are commonly used as scaffold materials. Scaffolds can be fabricated using various methods including freeze drying, electrospinning, 3D printing, and textile technologies to produce scaffolds with desirable properties like porosity and pore size for tissue growth. Scaffolds seeded with stem cells or tissue-specific cells aim to repair and regenerate tissues for applications in skin, bone, cartilage, and other organs.
Biomaterials are materials that are used in medical devices and implants that are introduced into the human body. They must be biocompatible, meaning they are compatible with and accepted by the body, and must withstand the body's internal conditions like temperature, pH levels, and corrosive fluids. Common biomaterials include polymers like nylon and silicone, ceramics like aluminum oxide, and metals like titanium alloys. Examples of biomaterials in use include pacemakers which use titanium casings and polyurethane insulation, contact lenses made of soft hydrogel plastics, knee implants made of plastics and metals, and the latest artificial hearts which are made of titanium and special plastics.
This document discusses biomimetic materials, which are materials developed through mimicking biological structures found in nature. It provides examples of biomimetic materials like nacre-inspired materials and artificial muscles. Nacre-inspired materials are discussed that mimic the structure of mother-of-pearl to create strong, lightweight composites for bone repair. Different types of artificial muscles are also summarized, including electroactive polymers, shape memory alloys, and shape memory polymers that can contract, expand or change shape in response to electrical, thermal, or chemical stimuli like natural muscles. Biomedical applications of these biomimetic materials are highlighted such as SMPs for tissue engineering and controlling cell morphology.
The document discusses biomaterials, which are materials used in medical devices that interact with biological systems. Biomaterials are intended to replace or augment damaged organs, tissues, or vessels. Common biomaterial applications include joint replacements, dental implants, heart valves, blood vessel grafts, and intraocular lenses. The development of biomaterials involves identifying needs, designing devices, testing materials, fabricating devices, sterilization, packaging, testing devices, and clinical use. Key considerations for biomaterials include biocompatibility, toxicology, and mechanical performance requirements.
Role of growth factors in a tissue engineered.pptxNandhu34249
Growth Factors and its function is exaplained with the images, so even a new person can learn abou the growth factors of the cell in the tissue engineering. The tissue Engineering is the currently grwing area
3D BIO PRINTING USING TISSUE AND ORGANSsathish sak
3D bio printing is the process of creating cell patterns in a confined space using 3D printing technologies.
3D bio printing is the layer by layer method to deposit materials known as bioinks to create tissue like structure.
Currently, bioprinting can be used to print tissues and organs to help research drug and pills.
- Bioprinting uses 3D printing technology with living cells to produce tissues for surgery.
- Inkjet bioprinting is a common technique that prints cell spheroids layer-by-layer to build structures.
- The 3D bioprinting process involves pre-processing to design structures, processing to print layers of bioink, and post-processing for the structures to mature.
- Developing effective bioinks is a current challenge limiting bioprinting's potential to produce organs for transplants.
3D bioprinting is a technique that uses 3D printing technologies to precisely position biological materials, cells, and biochemicals in layers to fabricate 3D structures and tissues. The process involves imaging tissues to create digital models, selecting appropriate biomaterials, cell sources, and a bioprinting method (inkjet, microextrusion, or laser). Applications include producing skin, blood vessels, and other tissues for implantation and drug testing. However, fully functional 3D printed organs are still in development due to challenges with vascularization and matching native tissue complexity.
Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physicochemical factors to improve or replace biological functions.
The term has also been applied to efforts to perform specific biochemical functions using cells within an artificially-created support system (e.g. an artificial pancreas, or a bio artificial liver).
A commonly applied definition of tissue engineering, as stated by Langer and Vacanti is “An interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve [Biological tissue] function or a whole organ”
Tissue engineering aims to regenerate tissues by combining cells, scaffolds, and signaling molecules. There are two main strategies - in vitro construction of tissues in the lab prior to implantation, and in vivo regeneration of tissues at the implantation site. Successful tissue engineering requires the right cells, scaffolding for cell attachment and growth, and signaling to guide tissue development. Stem cells are promising cell sources due to their ability to differentiate into many cell types.
Biomaterials are any substances used in medical devices and implants that interact with biological systems. They include metals, ceramics, polymers, and composites. Biomaterials must be biocompatible and not elicit negative host tissue responses. Newer generations of biomaterials aim to regenerate tissues through cell-material interactions and tissue engineering approaches. The biomaterials field involves many disciplines working to develop safer and more effective materials for applications such as orthopedic and dental implants, vascular grafts, drug delivery devices, and more. Key challenges include replicating complex tissue structures in vitro and improving biocompatibility.
The document discusses 3D bioprinting. It introduces 3D bioprinting as the process of generating spatially-controlled cell patterns using 3D printing technologies while preserving cell function and viability. It states that 3D bioprinting has applications in different fields. It also mentions that the document will discuss adoptions of 3D bioprinting and provide forecasts for the technology in 2016. It lists three references related to 3D bioprinting applications and trends.
Introduction
Anatomy and Physiology of bone
Bone Tissue Engineering
Recent studies related to bone tissue engineering
Commercialized products and ongoing clinical trials
Biomedical start-ups
Concluding remarks
Introduction
Anatomy and Physiology of bone
Bone Tissue Engineering
Recent studies related to bone tissue engineering
Commercialized products and ongoing clinical trials
Biomedical start-ups
Concluding remarks
Introduction
Anatomy and Physiology of bone
Bone Tissue Engineering
Recent studies related to bone tissue engineering
Commercialized products and ongoing clinical trials
Biomedical start-ups
Concluding remarks
This document provides an overview of the field of tissue engineering. It defines tissue engineering as an interdisciplinary field that applies engineering and life science principles toward the development of biological substitutes that restore or improve tissue function. The key goals of tissue engineering are to repair, replace, or regenerate tissues and whole organs. Current clinical treatments involve grafting methods like autografts, allografts, and xenografts, but these have limitations like immune rejection and donor scarcity. Tissue engineering aims to address these issues by using scaffolds, cells, and growth factors to regenerate tissues. Challenges in the field include properly mimicking the tissue microenvironment, scaling up production, and developing vascularization within engineered tissues.
The document discusses biomaterials, which are materials used in medical applications that interact with biological systems. It defines biomaterials and outlines their classification as natural or synthetic. Natural biomaterials discussed include proteins, cellulose, chitin, and polynucleotides. Synthetic biomaterials include polymers like PMMA, ceramics like calcium phosphate, and metals like titanium. Common applications of biomaterials are described like implants, prosthetics, and medical devices used in the skeletal, cardiovascular, and sensory systems.
Organ-on-chips are microfluidic cell culture chips that mimic organ-level physiology and functions. They allow for complex cell-cell and cell-matrix interactions in a controlled environment. Various organ models have been developed including lungs, liver, kidney, and skin. In India, researchers are working on skin, retina, placenta and infection models. Organ-on-chips could serve as alternatives to animal testing and help develop personalized disease models and therapies.
Bionics is an aid to technology that is bridging the gap between human limitation and potential. This presentation deals with the details of bionics and different milestones implemented.
Bioelectronic medicine uses principles of electronics, biology, and neuroscience to develop technologies that can diagnose diseases and regulate biological processes through nerve stimulation and sensing. This includes using implanted devices powered by the body that can replace organ functions like pacemakers for the heart or provide prosthetics for limbs. Applications also include biosensors that can monitor things like body temperature, stress, and movement to provide health and performance data. The field holds promise for new treatments for conditions like heart disease by providing electrical alternatives to drugs or surgery.
A short paper on Bionics and its implications.
For the people without disability, technology makes things easier and for the people with disability, technology makes things possible.
Biochips were invented 9 years ago and can be used to assemble DNA molecules on a chip or perform thousands of biological reactions in seconds. Researchers are working to integrate biochips with the human body by implanting them under the skin to monitor health metrics like blood glucose or oxygen levels. However, implantable biochips raise significant privacy and ethical concerns if they are used to track or control individuals without their consent.
This document discusses methods for clinical testing, specifically 3D cell culture and organ-on-chip technologies. It notes that animal testing is time-consuming, costly, and often does not predict human outcomes. Organ-on-chip technologies use microfabrication and microfluidics to create microenvironments that better simulate human physiology and organs. This allows for testing of drugs and toxins using human cells in a way that may replace animal models. Examples discussed include a lung-on-a-chip to study pulmonary edema and a proposed "body on a chip" with 3D printed miniature organs to improve drug development and reduce costs.
Bionics is the study of biological systems and processes to adapt them for use in technology. It aims to understand how organisms function and apply those principles to engineering, especially in automation, electronics, and mechanics. By copying designs and details found in nature, bionics can help develop new technical solutions and reduce randomness in research. In medicine, bionics replaces or supports organs and body parts through implants and prosthetics that closely mimic natural functions, such as cochlear implants for deaf individuals. Bionics applications in medicine include implants and artificial organs to substitute non-functioning organs.
Bionics is an interdisciplinary science that studies biological structures to develop technological solutions and artificial organs. It involves imitating nature's designs in engineering, such as boats imitating dolphin skin for hulls or sonar technology imitating bats. Bionics has also been applied to artificial neurons, networks, and silicon miniaturization. While only 10% of nature's solutions may currently be imitated, bionics in medicine aims to restore functions through implants like cochlear implants that replace organs and body parts.
Introduction
Silicon for the smarts, but stomach acid for the power
Painless diabetes testing drug delivery and more
Function
Advantages
Disadvantages
Conclusion
Reference
The document discusses the history and state of biomaterials and their use in medical applications. It notes that while biomaterials were originally developed for other uses, more recent biomaterials have been specifically designed for use in the body. The document outlines some current biomaterials like titanium alloys and hydroxyapatite used in orthopedic and dental applications. It also discusses the need for new biomaterials that can better integrate with tissues and serve as scaffolds for tissue engineering and developing artificial organs.
contemporary views on functional appliances /certified fixed orthodontic cou...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
00919248678078
Prosthesis upper limb and lower limb.pptxBadalverma11
Physiotherapy- Complete details about prosthesis both upper and lower limb, and training and physiotherapy management #gait training #sports
Contents-
Introduction
Purpose
Components
Upper limb- above elbow And below elbow, socket, cable mechanism, elbow and wrist unit, hand/terminal device
Lower limb- above knee, below knee and syme prosthesis
Socket- quadrilateral, PTB
Knee and ankle unit
Foot
Physiotherapy management -
First therapy, muscle strengthening, mobility
Training of don and doff , care of. Stump and bandaging
Gait training and sports
@cpu
The document discusses bionics, which combines biology and electronics. It describes how bionic devices can replace organs like ears, arms, and eyes. Examples provided include a bionic arm that can rotate 360 degrees and artificial muscles made of materials that contract and expand like human muscles in response to electricity. The document also discusses developments in bionic eyes like an implantable artificial retina and bionic ears. It concludes by questioning whether future generations will be led by humans, robots, or bionic humans.
The document discusses bionic eyes and their development. It begins by defining a bionic eye as an electronic device that replaces some or all of the eye's functionality. It then covers the anatomy and biology of the normal eye, common causes of blindness, and several technologies that have been applied to create bionic eyes, including the MIT-Harvard device, artificial silicon retina (ASR), Argus II, and holographic technology. A key technology discussed is MARC (Multiple Unit of Artificial Retinal Chipset System), which uses a chip implanted behind the retina to simulate remaining retinal cells. The document concludes by noting the challenges of powering implants and connecting them to the brain, but the promise of bionic devices
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Wearable biosensors combine wearable devices like smartwatches and patches with biosensors to continuously monitor physiological signals. They have various applications in healthcare for remote patient monitoring, sports, and military use. Key benefits include easy-to-use operation, low cost, and providing accurate real-time information. However, challenges remain around high initial costs, limited battery life, and potential device fouling over time.
This document summarizes research on artificial intelligence arms and prosthetic hands. It discusses how prosthetic limbs have advanced with developments in information technology, allowing them to more easily connect to a person's brain or muscles for movement. However, current prosthetic hands remain inferior to natural hands. The document also reviews the history of prosthetic hand development from pneumatic to myoelectric systems. Despite advances, rejection rates of upper limb prosthetics remain high. Future improvements may come from advances in areas like materials, battery life, control systems, surgical techniques, and 3D printing.
The document discusses various medical devices that can substitute or assist organs and tissues in the human body. It describes implantable heart pumps, oxygenators for lung function during surgery, components of cardiopulmonary bypass machines, mechanical ventilators, dialysis devices for kidney function like hemodialysis and peritoneal dialysis, insulin pumps for pancreas function, retinal and cochlear implants, and prosthetic joints and limbs for tissues like hips, knees, ankles, fingers and hands. The technologies can range from external machines to fully implanted devices.
Nuclear magnetic resonance (NMR) spectroscopy is an analytical technique that exploits the magnetic properties of atomic nuclei. It can be used to determine the structure of organic molecules and identify unknown compounds. NMR works by applying a strong magnetic field to align atomic nuclei, then applying a second radio frequency field to excite the nuclei and cause them to emit electromagnetic radiation that is detected and analyzed. The frequency of this radiation depends on the chemical environment of each nuclear species in the molecule. NMR provides detailed information about molecular structure and interactions.
The presentation gives overview of production of secondary metabolites using callus culture as well as tissue culture techniques. Various batch and continuous culturing process are described on the basis of secondary metabolite to be synthesised.
What are an expression vector? Detailed description of plant gene structure. Plant expression vector systems are generally consists of Ri and Ti plasmids.
The other vectors which are generally used are DNA and RNA viruses.
The document discusses the process of making protein isolates and concentrates from various sources such as soy, whey, peanuts, and fish. Protein isolates have a very high protein content (over 90%) and are refined to remove carbohydrates and fiber. Protein concentrates contain some carbohydrates and have a protein content over 80%. Common methods for extracting and purifying proteins include isoelectric precipitation, alkaline extraction, and ultrafiltration. Specific examples of production processes are provided for whey protein isolates, fish protein isolates, peanut protein isolates, and soy protein isolates and concentrates.
Review on green synthesis of silver nanoparticles using plant extract. Various green materials are used for the synthesis of Ag. Several synthesis method main emphasis on green method.
Selenite-F Broth was developed by Leifson to selectively inhibit normal gut bacteria like coliforms and allow for the recovery of Salmonella species from fecal specimens. The broth contains casein hydrolysate and lactose as nutrients, sodium phosphate to buffer the pH, and sodium selenite which inhibits many gram-positive and gram-negative bacteria. It is used to selectively enrich samples for Salmonella and some Shigella species. Proper handling of the toxic sodium selenite is required during preparation and use of the medium.
This document discusses various methods for screening recombinant clones, including:
1. Blue-white screening using X-gal to detect the presence or absence of insertions disrupting beta-galactosidase activity.
2. Insertional inactivation screening by inserting DNA fragments to disrupt antibiotic resistance or repressor genes.
3. Antibiotic sensitivity screening to detect circularized recombinant plasmids capable of conferring antibiotic resistance.
4. Auxotrophic yeast strain screening using yeast vectors containing selectable marker genes to complement host mutations.
5. Reporter gene assays using enzymes like luciferase, GFP, etc. fused to promoters to identify positive recombinant clones.
Polarography is an electromechanical technique invented in 1922 by Jaroslav Heyrovský to analyze solutions by measuring the current and applied voltage between two electrodes to determine the concentration and nature of a solute. The polarographic or Clark cell uses a noble metal cathode made negative compared to a reference anode so that any dissolved oxygen is reduced, with the cathode reaction being the reduction of oxygen and the anode reaction being the oxidation of silver and chloride ions.
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Production of amino acid tyrosine by conventional and modern method. And a case study of synthesis of tyrosine my using micro organism and its optimisation study. Clinical significance of tyrosine and Why there is need to produce it artificially?
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International Conference on NLP, Artificial Intelligence, Machine Learning an...gerogepatton
International Conference on NLP, Artificial Intelligence, Machine Learning and Applications (NLAIM 2024) offers a premier global platform for exchanging insights and findings in the theory, methodology, and applications of NLP, Artificial Intelligence, Machine Learning, and their applications. The conference seeks substantial contributions across all key domains of NLP, Artificial Intelligence, Machine Learning, and their practical applications, aiming to foster both theoretical advancements and real-world implementations. With a focus on facilitating collaboration between researchers and practitioners from academia and industry, the conference serves as a nexus for sharing the latest developments in the field.
2. In 1957, Otto Schmitt coined the term “Biomimetics” which
means, ‘The study of formation, structure or function of
biologically produced substances, materials, biological
mechanisms and processes especially for the purpose of
synthesising similar products by artificial mechanisms which
mimic natural ones’.
One of the finest example of biomimicry was set by Leonardo
da Vinci by making numerous sketches and notes of ‘flying
machine’.
Velcro is an another example of a biomimetic invention made
by Swiss engineer George de Mestral.
4. The natural shapes are highly aesthetic. The design of
objects found in nature is the result of prolonged
optimisation processes. There is nothing haphazard
about the shape of an edge or structure each single
one has been designed with a specific function in
mind.
In the similar way the bionically inspired surgical
instruments, prostheses and orthoses have a crucial
role in Medical Engineering to overcome the
drawbacks of traditional equipment.
5. Biomimetic medical devices are designed to
imitate the function of the original organ or a
tissue which give patient ease in the recovery.
6. Biomimetic Hand Exotendon Device or BiomHED, which is
based on a bio-inspired design, in order to achieve effective
hand rehabilitation after stroke. The device is designed to
generate functional movements by actuating ‘exotendons’
that replicate the anatomical structure of the major extrinsic
and intrinsic muscle-tendons of the hand.
Accordingly, each exotendon assumes the kinetic function
of the corresponding muscle-tendon, and the independent
and synergistic actuation of the exotendons will enable
functional use of the hand by generating the coordination
patterns of the finger joints specific to manual tasks.
7. Function of finger muscle-tendons
The index finger is comprised of three joints: metacarpophalangeal (MCP), proximal
interphalangeal (PIP), and distal interphalangeal (DIP) joints. Motion about the joints is controlled
by seven muscle-tendons, including extensor digitorum communis (EDC), extensor indicis
proprius (EIP), flexor digitorum superficialis(FDS), flexor digitorum profundus (FDP), first dorsal
interosseous (FDI), first palmar interosseous (FPI), and lumbricalis (LUM).
They had mimic the function of the following muscle-tendons: EDC, FDP, FDI/LUM, and FPI, as
their functional importance during finger movements and fingertip force generation in grip tasks.
8. The BIOMHED employs four ‘exotendons’ for each finger, which approximately replicate the
function of five major muscle- tendons: EDC, FDP, FDI/LUM, FPI. The exotendons are
connected to the servo motors that provide appropriate tensions, and the motors are located on
the forearm in order to avoid adding additional bulky structure to the hand.
The four cables, i.e., exotendons, assume similar paths with five major muscle-tendons of the
finger
1) The first cable (ET1) runs on the dorsal side of each finger and creates concurrent extension
of all three joints
2) The second (ET2) runs on the palmar side of each finger, thereby creating concurrent flexion
of all joints.
3) The third and fourth cables (ET3/4) originate from the dorsal aspect of the DIP joint and run
laterally, i.e., ET3 on the radial side and ET4 on the ulnar side
9. Stroke is a leading cause of serious, long-term disability in
the world. While many stroke victims eventually regain use
of their lower extremities, upper limb recovery is slow and
often limited. The functional impairment of the hand and
upper extremity can significantly degrade the quality of life
of those affected.
A number of assistive devices have recently been developed
in an attempt to restore hand functions for the neurologically
impaired patients. However, the complexity of the motions
achieved by these systems is generally limited thereby
resulting in a fixed inter joint coordination pattern.
10. It is a device used for incorporating sensing,
control, and actuation for use in treating ankle
foot pathologies associated with neuromuscular
disorders.
The design mimics the muscle tendon ligament
skin architecture in the biological musculoskeletal
system of the human ankle.
11. The prototype is composed of three physical layers: base, actuation,
and sensing. The control hardware connects the actuation and
sensing layers to enable the execution of complex control rules. The
entire prototype, including electronics and batteries but not
including the mass of the air source, weighs approximately 950 g.
12. Ankle–foot pathologies in patients with neuromuscular
disorders, caused by cerebral palsy (CP), amyotrophic lateral
sclerosis, multiple sclerosis, or stoke, can result in abnormal
gaits over time, such as drop foot and crouch gait.
There have been various approaches for treating ankle– foot
pathologies. One of the most typical solutions is to wear rigid
ankle braces, such ankle foot orthoses (AFOs). These devices
improve gait abnormalities by forcing the ankle joint angle to be
close to 90◦
. However, long-term use of these passive devices
causes disuse atrophy of muscles and consequently makes the
user physically dependent on the device
13. Biomimetics is a science that uses natural designs
or mechanisms to solve human problems.
Accordingly, in a manner similar to orthodontic
correction, the judicious use of the vectors induced
in oral appliance therapy might provide an
alternative protocol for the resolution of obstructive
sleep apnea OSA, with the upper airway being the
target in mild to moderate cases. OSA can be
resolved in adults using a novel protocol that utilises
biomimetic oral appliance therapy (BOAT)
14. The BioFriend™ BioMask™ facemasks are identically
comprised of four layers of standard filtration materials used in
currently approved surgical face-masks and respirators.
a. An outer layer of spun-bond polypropylene.
b. A second layer of polyester.
c. A third layer of melt-blown polypropylene.
d. An inner (fourth) layer of spun bound polypropylene.
15. The first and second individual layers of the facemasks have been treated with two different anti-microbial
compounds that independently inactivate pathogens - the outer active layer with a low-pH hydrophilic plastic
coating, and the second active layer with copper/zinc ions.
The outer active layer of the BioFriend™ BioMask™ surgical facemask rapidly inactivates viruses through
exposure to the low pH environment. This induces structural rearrangement of lipids and other structures,
resulting in spontaneous virus denaturation.
The inner active layer, treated with positively charged copper/zinc ions, binds pathogens by binding negatively
charged groups e.g., sulfhydryl and carboxyl groups, which are present on all viruses, bacteria and fungi. This
activity is known as Ionic Mimicry. These metal ions exert a toxic effect upon pathogens, known as the
Oligodynamic Effect
16. Biofilm is a biologically glycocalyx like antiadhesive coatings which
is used to inhibit Staphylococcus aureus and Pseudomonas aeruginosa
colonization on commercial totally implantable venous access ports
(TIVAPs).
Catheters improve patients’ healthcare but, the hydrophobic nature of
their surface material promotes protein adsorption and cell adhesion.
Catheters are therefore prone to complications, such as colonisation by
bacterial and fungal biofilms, which causes infections.
There is currently, no fully efficient method for treating catheter
related biofilms besides traumatic and costly removal of colonised
devices.
17. The external layer of a cell membrane, known as the glycocalyx, is
composed of polysaccharides and prevents undesirable protein
adsorption and nonspecific cell adhesion.
Thus, mimicking the nonadhesive properties of a glycocalyx may provide
a solution to the clinical problem associated with device colonisation. In
this context, regarding the advantage of optimising the polysaccharide
structure, the preparation of glycocalyx like hydrophilic methyl-cellulose
(MeCe) polymer nanofilms grafted onto polydimethylsiloxane.
18. Each year over 6 lakh people lose there lives due to colon
cancer in the world. Even though the colonoscopy
examination procedures are applied, there is a certain
amount of miss rate in colonoscopy procedures due to
narrow field of view (FOV) imagery employed in current
systems.
Since the human colon has a folded structure, while the
colonoscope moves toward the colon, it misses the behind-
fold regions at the peripheral areas with respect to the
forward and backward movement of the colonoscope.
19. The insect eye mimicking approach, named as Panoptic is
taken as constructing a hemispherical multi-camera system
with many lenses and sensors placed on a hemispherical
frame similar to the insects’ natural lens-sensor designs.
20. The pacemaker is an electronic biomedical device
that can regulate the human heart beat when its
natural regulating mechanism breaks down. It is a
small box implanted in the chest cavity and has
electrodes that are in direct contact with heart.
First developed in 1950s, the pacemaker has
undergone various design changes and has found
new applications since its invention. Today
pacemakers are widely used, implanted in ten of
thousand patients annually.
21. Hearing restoration have a great impact on the psychological well being, quality
of life and economic independence for people with hearing impairments. In
cases of mild hearing impairment, it is possible to restore hearing through a
hearing aid. But, damage to the hair cells in the cochlea leads to sensorineural
hearing loss (SNHL), which results in serve hearing impairment with loss of
more than 90dB.
CL is a surgically implanted electronic device which stimulates the auditory
nerve, bypassing the damaged hair cells in the cochlea. Although CI are used
as a clinical solutions to restore hearing in patients with SNHL, it has a number
of drawbacks.
The extracorporeal unit can be inconvenient in daily life, in taking a shower,
participating in water sports, and sleeping. It is also associated with aesthetic
concerns and the social stigma of hearing impairment.
22. Artificial basilar membranes (ABMs) are an attractive option to overcome
the limitations of conventional CIs.
The ABM is an acoustic transducer that mimics cochlear tonotopy.
For mimicking the ABMs, mechanical frequency selectivity is achieved by
varying the structural parameters such as the width of the membrane, beam
length and beam thickness. In addition, acoustic-to-electrical energy
conversion is realised via piezoelectric effect
23. The authors aimed to insert the flexible ABM into the
cochlea and use it to detect vibration of the BM by
generating piezoelectric output from the PZT film. In the
simulation, the flexible PZT thin film can generate sufficient
electrical output (3 V) to stimulate the auditory nerve when
mechanical displacement of the BM is about 600 nm under
sound pressure.
The flexible iPANS was then fabricated on a film. The
fabricated iPANS was attached to the flexible trapezoidal
silicone membrane (SM) for mechanical frequency
selectivity.
24.
25. A biomaterial is regarded as any nondrug material that
can be used to treat, enhance or replace any tissue,
organ, or function in an organism. Any material
natural or man made can be a biomaterial as long as it
serves the stated medical and surgical purposes.
An ideal biomaterial is one that is non-immunogenic,
biocompatible, and biodegradable, which can be
functionalised with bioactive proteins and chemicals.
26. Material Applications Reference
Polymers Tissue engineering
scaffolds for skin
cartilage, liver etc
(Eaglstein, Falanga et. al
1998)
Metals and
alloy
Bone Implants ( M Saini 2015)
Composites Arteries (Wang et al. 2015)
Ceramics Tissue engineering
scaffolds
(Leong, Cheah et al. 2003)
Hydrogel Tissue engineering of
bladder
(Sivaraman 2015)
28. 1.Chong L, Zarith N and Sultana N “Poly(Caprolactone)/chitosan-based scaffold using freeze drying technique for bone tissue engineering
application.” Conference: 2015 10th Asian Control Conference (ASCC) May 2015.
2.Endogan Tanir, T., Hasirci, V. and Hasirci, N. “Preparation and characterization of Chitosan and PLGA-based scaffolds for tissue
engineering applications.” Polymer Composites 36 (2015): 1917–1930.
3.Fauzi MB, Chowdhury SR, Aminuddin BS and Ruszymah BHI “Fabrication of collagen type I scaffold for skin tissue engineering.”
Regenerative Research 3.2 (2014) 60-61.
4.Guiping Ma, Zhiliang Wang, et al. “Freeze-dried chitosan–sodium hyaluronate polyelectrolyte complex fibers as tissue engineering
scaffolds.” New Journal of Chemistry 38 (2014): 1211-1217.
5.Haugh MG, Murphy CM and O'Brien FJ “Novel freeze-drying methods to produce a range of collagen-glycosaminoglycan scaffolds with
tailored mean pore sizes.” Tissue Engineering Part C Methods 16.5 october (2010) :887-94.
6.Held M, Rahmanian-Schwarz A, et al. “A Novel Collagen-Gelatin Scaffold for the Treatment of Deep Dermal Wounds-An Evaluation in
a Minipig Model.” Dermatol Surg 42.6 (2016):751-6.
7.Liu,J, Lu F, et al. “Healing of skin wounds using a new cocoon scaffold loaded with platelet-rich or platelet-poor plasma.” RSC
Advances 7 (2017): 6474-6485.
8.Leong, K,. et al. “Solid freedom fabrication of three demential scaffold for engineering replacement and tissue organs”. Biomaterials
(2003) 24:(13): 2363:2378.
9.Lowe CJ, Reucroft IM, Grota MC and Shreiber DI “Production of Highly Aligned Collagen Scaffolds by Freeze-drying of Self-
assembled, Fibrillar Collagen Gels.” ACS Biomaterials Science
29. 9.Lowe CJ, Reucroft IM, Grota MC and Shreiber DI “Production of Highly Aligned Collagen Scaffolds by Freeze-drying of Self-
assembled, Fibrillar Collagen Gels.” ACS Biomaterials Science & Engineering 2.4 April (2016): 643-651.
10.Ma L, Gao C, et al. “Collagen/chitosan porous scaffolds with improved biostability for skin tissue engineering.” Biomaterials
24.26 November (2003): 4833-41.
11.Mahboudi S, Pezeshki-Modaress & Noghabi “The Study of Fibroblast Cell Growth on the Porous Scaffold of Gelatin–Starch
Blend Using the Salt-Leaching and Lyophilization Method.” International Journal of Polymeric Materials and Polymeric
Biomaterials 64.12 (2015).
12.O'Brien FJ, “Biomaterials and scaffold for tissue engineering” Material today (2011) 14(3): 88-95.
13.O'Brien FJ, Harley BA, Yannas IV, Gibson L “Influence of freezing rate on pore structure in freeze-dried collagen-GAG
scaffolds.” Biomaterials 25.6 March (2004):1077-86.
14.Vishwanath V, Pramanik K and Biswas A “Optimization and evaluation of silk fibroin-chitosan freeze-dried porous scaffolds
for cartilage tissue engineering application.” Journal of Biomaterial Science, Polymer Edition 27.7 (2016):657-74.
15.Waghmare V, Wadke P, “Starch based nanofibrous scaffolds for wound healing applications.” Bioactive Materials (2017):1-12.
16.Wang H-M, Chou Y-T, et al. “Novel Biodegradable Porous Scaffold Applied to Skin Regeneration.” PLoS One 8.6 June (2013):
e56330.
17.Wang S, Goecke T, et al. “Freeze-dried heart valve scaffolds.” Tissue Engineering Part C Methods18.7 July (2012): 517-25.
18. Eaglstein W.H and Falanga V, “Tissue engineering and the development of Apligraf a human skin equivalent,” Advances in
Wound Care, vol. 11, supplement 4, pp. 1–8, 1998.
19.You C, Li Q, et al. “Silver nanoparticle loaded collagen/chitosan scaffolds promote wound healing via regulating fibroblast
migration and macrophage activation.” Scientific reports 7.1 September (2017): 10489.
31. “Biomimetic Oral Appliance Therapy
in Adults with Mild to Moderate
Obstructive Sleep Apnea”
By-
Abhishek R Indurkar
17PBT202
Under guidance of
PROF. G.D.YADAV
32. Obstructive sleep apnea (OSA) is a potentially
serious sleep disorder. It causes breathing to
repeatedly stop and start during sleep.
This type of apnea occurs when the throat muscles
intermittently relax and block your airway during
sleep.
A noticeable sign of obstructive sleep apnea is
snoring.
33.
34. For the management of obstructive
sleep apnea (OSA) in adults, some
healthcare professionals prefer to
prescribe continuous positive
airway pressure (CPAP) masks
while others prefer mandibular
advancement devices (MADs).
The drawbacks of these are
discomfort, dry mouth, excessive
salivation and ill-fitting appliances.
CPAP
MAD
35. Biomimetics is a science that uses natural designs or
mechanisms to solve human problems.
Accordingly, in a manner similar to orthodontic
correction, the judicious use of the vectors induced
in oral appliance therapy might provide an
alternative protocol for the resolution of obstructive
sleep apnea OSA, with the upper airway being the
target in mild to moderate cases. OSA can be
resolved in adults using a novel protocol that utilises
biomimetic oral appliance therapy (BOAT)
36. 10 consecutive patients were recruited for this
study. OSA following an overnight sleep study
that had been interpreted by a sleep physician.
The exclusion criteria included: age <21yrs.; lack
of oral appliance compliance; active periodontal
disease; tooth loss during treatment; poor oral
hygiene.
37. After careful history-taking and craniofacial examination, a bite registration was obtained in the
upright-sitting position with corrected jaw posture in the vertical axis specific for each subject.
Upper and lower polyvinyl siloxane impressions were also obtained.
Following a diagnosis of mild to moderate OSA, a biomimetic, upper DNA appliance® was
prescribed to each subject.
The BOAT needed to be professionally-adjusted approximately every 4 weeks, and all subjects
reported for review each month. Every 3 months, the overnight sleep studies were repeated.
38. The mean AHI fell by 65.9% to 4.5 ± 3.6. after BOAT with no
appliances in the mouth during sleep when the post-treatment sleep
study was undertaken, indicating enhanced upper airway function.
39. Improvements in sleep quality in the absence of
CPAP or MADs in patients diagnosed with OSA
have never been reported in the literature.
Therefore, the preliminary results obtained might
represent an alternative to CPAP and MADs for
the resolution of OSA.
The device is patient friendly, which overcome
the drawbacks of CPAP and MAD.
41. Title of paper: “Biomimetic Oral Appliance
Therapy in Adults with Mild to Moderate
Obstructive Sleep Apnea”
Indicate clearly about what they done
42. Summaries purpose of research, the principle,
results and major conclusions.
Gives a complete overview of work.
Provide overall result obtained
43. Paper is technically correct.
The assumption made by author are logical and
proven.
There is no unnecessary repetition of matter and
basic is very well illustrated. Therefore, the paper
is easy to follow and understand.
44. References cited in the paper are complete and as
per guidance.
References mentioned here are helpful to
understand the work.
All the references are genuine.
The references cited are adequate and support the
facts and observations.
45. The AHI of the patient H has increased after the
treatment. The reason behind this is not explained
by the author.
Author has mentioned that the therapy can be
efficiently used in children but didn’t give any
specification regarding this.
46. 1. Mayo clinic staff. (2017 August 02). Obstructive sleep apnea. Retrieved from https://www.mayoclinic.org/diseases-
conditions/obstructive-sleep-apnea/symptoms-causes/syc-20352090 on 23/01/18
2. Donovan J. (2015). How to Sleep Easier With Your CPAP Machine. Retrieved from https://www.webmd.com/sleep-disorders/sleep-
apnea/features/cpap-machine#1 23/01/18
3. Mandibular Advancement Devices – MAD’s. (2017). Retrieved from https://www.sleepassociation.org/mandibular-advancement-
device/ 23/01/18
4.Singh GD, Griffin TM and Chandrashekhar R. “Biomimetic Oral Appliance Therapy in Adults with Mild to Moderate Obstructive
Sleep Apnea”. Austin J Sleep Disord. 2014;1(1):
5 Aarab G, Lobbezoo F, Heymans MW, Hamburger HL, Naeije M. Long- term follow-up of a randomized controlled trial of oral
appliance therapy in obstructive sleep apnea. Respiration. 2011; 82: 162-168.
6 Doff MH, Finnema KJ, Hoekema A, Wijkstra PJ, de Bont LG, Stegenga B. Long-term oral appliance therapy in obstructive sleep apnea
syndrome: a controlled study on dental side effects. Clin Oral Investig. 2013; 17: 475-482.
7. De Almeida FR, Lowe AA, Tsuiki S, Otsuka R, Wong M, Fastlicht S, et al. Long-term compliance and side effects of oral appliances
used for the treatment of snoring and obstructive sleep apnea syndrome. J Clin Sleep Med. 2005; 1: 143-152.
8. Gindre L, Gagnadoux F, Meslier N, Gustin JM, Racineux JL. Mandibular advancement for obstructive sleep apnea: dose effect on
apnea, long-term use and tolerance. Respiration. 2008; 76: 386-392.
9 Chen H, Lowe AA, de Almeida FR, Fleetham JA, Wang B. Three-dimensional computer-assisted study model analysis of long-term oral-
appliance wear. Part 2. Side effects of oral appliances in obstructive sleep apnea patients. Am J Orthod Dentofacial Orthop. 2008; 134:
408-417.
10 Gong X, Zhang J, Zhao Y, Gao X. Long-term therapeutic ef cacy of oral appliances in treatment of obstructive sleep apnea-hypopnea
syndrome. Angle Orthod. 2013; 83: 653-658.
11 Tsuda H, Almeida FR, Masumi S, Lowe AA. Side effects of boil and bite type oral appliance therapy in sleep apnea patients. Sleep
Breath. 2010; 14: 227-232.