The document discusses digestion and absorption of carbohydrates, proteins, and lipids. It explains that digestion breaks down macromolecules into smaller absorbable units using enzymes. Absorption then transports these digestion end products into the bloodstream. Carbohydrates are broken down into monosaccharides like glucose and galactose. Proteins become amino acids and peptides. Lipids are broken into fatty acids, glycerol, and other products through the action of bile and lipases.
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Digestion and absorption of lipids ppt
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Absorption of proteins ppt
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Absorption of protein ppt
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Digestion and absorption of lipids ppt
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It's a brief article about digestion and metabolism in human body for premedical student .
Taking about digestion a long the GIT system and metabolism of carbohydrates , protein , lipids, and nucleoproteins.
Different types of solution, Properties of colloid particles, Brownian movement, Tyndall phenomenon, Solvent, Homogenous mixture, Heterogenous mixture, Normal saline, Dialysis, Mechanism of dialyzer, Gibbs-Donnan Equilibrium, Salient features of Donnan membrane equilibrium, Law of mass action, Adsorption,Adsorbents
Liver, Functions of liver, Liver damage, Enzymes of liver damage, Uses of liver function tests, What is bilirubin, Direct bilirubin, Indirect bilirubin, Bilirubin metabolism, Jaundice, Types of jaundice, Van den Bergh reaction, Conjugated bilirubin, Unconjugated bilirubin, Hemolytic jaundice, Obstructive jaundice, Hepatocellular jaundice, Difference between jaundice, Latent jaundice, Bilirubin level, Kernicterus, Congenital non-hemolytic hyperbilirubinemia, Congenital jaundice,
What is diabetes mellitus, Epidemiology of diabetes, Diabetes diagnosis, Features of diabetes, WHO classification of Diabetes Mellitus, Complications of diabetes, Metabolic alterations of diabetes, Oral glucose tolerance test, WHO criteria of OGTT interpretation, Classification of diabetes mellitus, Gestational diabetes, Pre-diabetes, Insulin, Biosynthesis of insulin, Insulin actions, Hypoglycemia, Impaired fasting glucose, Insulin structure
Food, Nutrition, Nutrients, Diet, Energy consumption & BMIDr.Subir Kumar
Chemistry of nutrition, Dietary principles of food, Basic energy consumption, Total calorie requirements, Energy providing foods, Nutrition balance, Body mass index
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
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ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
Biochemistry of Digestion & Absorption
1. Dr. Subir Kumar Mandal
MBBS, M.Phil
Biochemistry of
Digestion &
Absorption
2. Digestion & Absorption
Digestion is the Physico-chemical process by
which complex food materials are broken down to
simple absorbable units.
Basic process of digestion is hydrolysis catalyzed
by the hydrolases group of enzymes (digestive
enzymes).
Digestion occurs in the lumen of GIT aided by the
digestive enzymes of digestive juices.
Absorption is the chemical process by which the
end products of digestion pass through the
intestinal epithelium to enter the lymph or blood
stream.
3. Digestion & Absorption
Absorption through the gastrointestinal mucosa
occurs by active transport, Diffusion & Solvent
drag.
End products of carbohydrate digestion are
glucose, fructose & galactose.
End products of protein digestion are amino acids
& peptides.
End products of fat digestion are fatty acids,
glycerol, 2-MAG, cholesterol & lysophospholipid.
4. Digestion of Carbohydrate
Important dietary carbohydrates are starch,
lactose & sucrose.
Carbohydrate digestion starts from mouth.
In the mouth: Salivary α-amylase hydrolyzes
starch into maltose, maltotriose & α-limit dextrin.
In stomach: The function of ptyalin is lost. Here
some sucrose hydrolyzed by HCL.
HCL
Sucrose Glucose + Fructose
5. Digestion of Carbohydrate
In the duodenum:
Pancreatic α-amylase
Starch Maltose, maltotriose, α-limit dextrin
In the small intestine:
Maltose Glucose + Glucose (Maltase)
Maltotriose Glucose (Maltase)
Lactose Glucose + Galactose (Lactase)
Sucrose Glucose + Fructose (Sucrase)
α-limit dextrin Glucose (α-limit dextrinase)
6. Absorption of Carbohydrate
End products
of CHO
digestion
Transport from lumen to
enterocyte
Transport from enterocyte to
ECF & blood
Process Carrier
protein
Process Carrier
protein
Glucose
Galactose
Secondary
active
transport
SGLT-1 Facilitated
diffusion
GLUT-2
Fructose Facilitated
diffusion
GLUT-5 Facilitated
diffusion
GLUT-2
7. Lactose Intolerance
Lactose intolerance is an inability to digest &
absorb lactose that results in gastrointestinal
symptoms when milk or milk products are
consumed.
Causes:
1. Reduced or absent activity of the enzyme lactase.
2. A congenital absence of lactase enzyme from
birth due to mutation of lactase producing gene.
3. Some diseases e.g. celiac sprue.
9. Digestion of Proteins
In the mouth: No digestion of proteins occurs.
In the stomach: In stomach gastric HCL causes
protein denaturation & pepsin digest protein to
smaller polypeptides & amino acid.
In small intestine: Most protein digestion occurs in
lumen of duodenum & jejunum.
Smaller Polypeptides Oligopeptides + Amino acids
(trypsin, chymotrypsin, carboxypeptidase)
Oligopeptides Dipeptides, tripeptides, amino acid
(Aminopeptidase, dipeptidase, tripeptidase)
10. Absorption of Amino acid
Absorption of amino acids take place in
duodenum & jejunum.
End products of protein digestion are a mixture of
free amino acids, dipeptides & tripeptides, all of
which are actively absorbed from lumen to cells
( enterocyte).
Free amino acids are absorbed from lumen to cell
by sodium dependent secondary active transport
process (sodium cotransport of amino acid).
11. Absorption of Amino acid
Within enterocyte dipeptides & tripeptides are
hydrolyzed to free amino acids by intracellular
dipeptidases & tripeptidases & then all amino
acids from enterocyte are absorbed to blood by
facilitated diffusion.
12. Digestion of lipid
Dietary fat: TAG, Phospholipid, Cholesteryl ester,
Free fatty acid, Free cholesterol (very small amount).
In stomach: Lipid digestion begins in stomach by acid
stable lingual lipase. Lingual lipase cannot start lipid
digestion in mouth because optimum pH for action of
lingual lipase is 4-4.5 whereas pH of saliva is about 7.0.
Here only milk fat is partially hydrolyzed by lingual
lipase associated with gastric lipase which is true only
in neonates & infants. 30% fat digestion occurs in
stomach by the action of lipases. This lipases are
specially important in case of cystic fibrosis with near
or complete absence of pancreatic lipase.
13. Digestion of lipid
In duodenum:
In duodenum fat undergoes emulsification process by
which large fat particles are broken down into smaller
fine particles that increase the surface area of fat/oil,
so that digestive enzymes can work effectively. This
process done by bile salts & lecithin that reduce the
surface tension of fat particles by detergent action.
After emulsification, pancreatic lipase with the help of
colipase digests TAG, removing FA from 1st & 3rd
carbon of glycerol & produces 2-MAG.
TAG 2-MAG + Fatty acid (Lipase + Colipase)
2-MAG Fatty acid + Glycerol (Lipase + Colipase)
14. Digestion of lipid
Dietary Cholesteryl ester is digested by pancreatic
Cholesteryl esterase to fatty acid & free
cholesterol. Bile salts enhance the activity of
Cholesteryl esterase.
Cholesteryl ester Cholesterol + Fatty acid
(Cholesteryl esterase).
Dietary Phospholipid is digested by pancreatic
phospholipase A2 removing fatty acid from 2nd
carbon of glycerol moiety & produces
lysophospholipid.
PL Lysophospholipid + Fatty acid
(Phospholipase-A2)
15. Digestion of lipid
Therefore final end product of lipid digestion is
fatty acid, glycerol, 2-MAG, free cholesterol &
lysophospholipid.
◑ The process of emulsification occurs by three
complimentary mechanisms-
⇒ Detergent action of bile salts.
⇒ Surfactant action of degraded lipids.
⇒ Mechanical mixing due to peristalsis.
16. Absorption of Lipid
Short chain fatty acid & glycerol are directly
absorbed to portal blood.
Long chain fatty acid, cholesterol, 2-MAG &
Lysophospholipid together interact with bile salts
to form globular water soluble molecular
aggregates called micelle with their hydrophobic
parts interior & hydrophilic parts exterior. This
arrangements makes the micelle to be friendly
with water & micelle becomes water soluble
because its whole surface is made of hydrophilic
groups.
17. Absorption of Lipid
Since micelles are water soluble, they allow the
products of lipid digestion including fat soluble
vitamins to be transported via aqueous media of
intestinal lumen, so that they can easily cross the
unstirred water layer & reach the brush border of
intestinal mucosal cells, from where they are
absorbed to enterocyte by simple diffusion. After
absorption of lipids, bile salts come back to lumen
to form micelle again & repeat the same process.
This function of bile salt is called ferrying function
in absorption of lipids.
18. Absorption of Lipid
Within the enterocyte 2-MAG is again acylated to
TAG, lysophospholipid & most of the cholesterol
are reacylated to PL & cholesteryl ester. Now TAG,
Cholesteryl ester, Phospholipid & free cholesterol
are packaged into globular Chylomicron
surrounded by a thin layer of apoprotein B-48
synthesized by enterocyte. This external protein
coating stabilizes the Chylomicron & increases its
solubility in aqueous media. From the enterocyte
Chylomicron is finally secreted to lymphatics by
the process of exocytosis. From lymphatics
through thoracic duct Chylomicron is absorbed to
blood.
19. Abnormalities of Lipid digestion & Abs
orption
Steatorrhea: It is a condition characterized by the
loss of lipids in the feces. Steatorrhea may be due
to
A defect in the secretion of bile or pancreatic
juice into the intestine.
Impairment in the lipid absorption by the
intestinal cells.
Steatorrhea is commonly seen in disorders
associated with pancreas, biliary obstruction,
severe liver dysfunction etc.
21. Abnormalities of Protein digestion & Am
ino acid absorption
Hartnup’s disease (neutral amino aciduria):
Hartnup is the name of the family in whom this
disease was first discovered.
It is characterized by the inability of intestinal and
renal epithelial cells to absorb neutral amino acids
(cysteine, methionine, tryptophan, glycine etc.).
Tryptophan absorption is most severely affected
with a result that typical symptoms of Pellagra are
observed in the patients of Hartnup’s disease.
22. Abnormalities related to HCL secretion
Achlorhydria: An absence of free HCL in the
stomach, is called achlorhydria. It occurs due to
gastric carcinoma, pernicious anemia,
adrenal insufficiency, chronic gastritis.
Hyperchlorhydria: An excess of free HCL in the
stomach. It founds in Zollinger-Ellison syndrome,
Duodenal ulcer.
Hypochlorhydria: Decrease free HCL concentration
in stomach. It founds in pernicious anemia, gastric
carcinoma.