This document provides an overview of multiple regression analysis. It introduces the concept of using multiple independent variables (X1, X2, etc.) to predict a dependent variable (Y) through a regression equation. It presents examples using Excel and Minitab to estimate the regression coefficients and other measures from sample data. Key outputs include the regression equation, R-squared (proportion of variation in Y explained by the X's), adjusted R-squared (penalized for additional variables), and an F-test to determine if the overall regression model is statistically significant.