Are you REALLY tired? Have you tried EVERYTHING?
Is your baby/child waking multiple times throughout the night?
Does it take you ages to get them to go asleep?
Driving or rolling baby to sleep during the day and at night?
Rocking or walking baby to sleep?
Lying down with your child, holding hands, rubbing them to make them go to sleep?
Are they nursing or bottle feeding excessively at night?
Are you replugging the dummy multiple times during the night?
Do they have trouble STAYING asleep?
Suffering from Nightmares or Night Terrors?
Are you struggling with daytime naps?
Need to end co sleeping but don’t know how?
Want co sleeping to work but don’t know how?
I CAN HELP YOU!!!
Are you REALLY tired? Have you tried EVERYTHING?
Is your baby/child waking multiple times throughout the night?
Does it take you ages to get them to go asleep?
Driving or rolling baby to sleep during the day and at night?
Rocking or walking baby to sleep?
Lying down with your child, holding hands, rubbing them to make them go to sleep?
Are they nursing or bottle feeding excessively at night?
Are you replugging the dummy multiple times during the night?
Do they have trouble STAYING asleep?
Suffering from Nightmares or Night Terrors?
Are you struggling with daytime naps?
Need to end co sleeping but don’t know how?
Want co sleeping to work but don’t know how?
I CAN HELP YOU!!!
a presentation of Attention-Deficit/Hyperactivity Disorder. ADHD, most common neurobehavioral disorders of childhood. It is usually first diagnosed in childhood and often lasts into adulthood. Children with ADHD have trouble paying attention, controlling impulsive behaviors (may act without thinking about what the result will be), and in some cases, are overly active.
PP slides to accompany Teepa Snow's youtube video about her Gems Approach
https://www.youtube.com/watch?v=UXzJRZCNiRU&list=PLeu1xlHHkFCU_k85X1xBwjzayVIzNB12R&index=20
Teepa Snow, dementia and Alzheimer's care expert, was the guest speaker at a caregiving event sponsored by Home Instead Senior Care of Sonoma County, CA.
This all-day workshop was held on March 22, 2010, at the Scottish Rite Masonic Center in Santa Rosa, CA. CEU credits were available to attendees which included RPNs.
(c) 2010 TeepaSnow.com. All rights reserved. Use only with permission from Teepa Snow.
This presentation on the Tips for Bathing was given by Dementia and Alzheimer's expert, Teepa Snow, at a Home Instead Senior Care sponsored event on March 22, 2010.
The all-day workshop, with CEU credits available, was given at the Scottish Rite Masonic Center in Santa Rosa, CA. About 100 people including RPNs and CNAs were in attendance.
The event was sponsored by Home Instead Senior Care of Sonoma County and Brighton Gardens Assisted Living of Santa Rosa, CA.
Home Instead Senior Care of Sonoma County is based out of Rohnert Park and provides senior home care, personal care and companionship services to seniors in Petaluma, Santa Rosa, Sonoma, Windsor, Sebastopol, Rohnert Park and throughout Sonoma County.
Autism is a developmental disability significantly affecting verbal and nonverbal communication and social interaction, generally evident before age three
Stress Well for Schools: 2.3.1 FLOURISHNicola Morgan
This is the Powerpoint from Nicola Morgan's Stress Well for Schools course, Ppt 2.3.1 - FLOURISH. For details of the whole course, see here: https://www.nicolamorgan.com/product/stress-well-for-schools/
a presentation of Attention-Deficit/Hyperactivity Disorder. ADHD, most common neurobehavioral disorders of childhood. It is usually first diagnosed in childhood and often lasts into adulthood. Children with ADHD have trouble paying attention, controlling impulsive behaviors (may act without thinking about what the result will be), and in some cases, are overly active.
PP slides to accompany Teepa Snow's youtube video about her Gems Approach
https://www.youtube.com/watch?v=UXzJRZCNiRU&list=PLeu1xlHHkFCU_k85X1xBwjzayVIzNB12R&index=20
Teepa Snow, dementia and Alzheimer's care expert, was the guest speaker at a caregiving event sponsored by Home Instead Senior Care of Sonoma County, CA.
This all-day workshop was held on March 22, 2010, at the Scottish Rite Masonic Center in Santa Rosa, CA. CEU credits were available to attendees which included RPNs.
(c) 2010 TeepaSnow.com. All rights reserved. Use only with permission from Teepa Snow.
This presentation on the Tips for Bathing was given by Dementia and Alzheimer's expert, Teepa Snow, at a Home Instead Senior Care sponsored event on March 22, 2010.
The all-day workshop, with CEU credits available, was given at the Scottish Rite Masonic Center in Santa Rosa, CA. About 100 people including RPNs and CNAs were in attendance.
The event was sponsored by Home Instead Senior Care of Sonoma County and Brighton Gardens Assisted Living of Santa Rosa, CA.
Home Instead Senior Care of Sonoma County is based out of Rohnert Park and provides senior home care, personal care and companionship services to seniors in Petaluma, Santa Rosa, Sonoma, Windsor, Sebastopol, Rohnert Park and throughout Sonoma County.
Autism is a developmental disability significantly affecting verbal and nonverbal communication and social interaction, generally evident before age three
Stress Well for Schools: 2.3.1 FLOURISHNicola Morgan
This is the Powerpoint from Nicola Morgan's Stress Well for Schools course, Ppt 2.3.1 - FLOURISH. For details of the whole course, see here: https://www.nicolamorgan.com/product/stress-well-for-schools/
Steuerberatungskosten was ist eigentlich alles enthaltenkate Venvie
Die Inanspruchnahme eines Steuerberaters ist mit Kosten verbunden.
Allerdings kann sich eine Investition durchaus lohnen.
So erhalten Arbeitnehmer, Selbstständige und Freiberufler im Idealfall die maximale Steuerersparnis.
What is Attention Deficit Hyperactivity Disorder (ADHD.pptxKashishYadav76
Attention deficit hyperactivity disorder (ADHD) is one of the most common childhood disorders and can continue through adolescence and adulthood. Symptoms include difficulty staying focused and paying attention, difficulty controlling behavior, and hyperactivity (over-activity). ADHD has three subtypes:
Attention deficit hyperactivity disorder (ADHD, similar to hyperkinetic disorder in the ICD-10) is a neurodevelopmental psychiatric disorder in which there are significant problems with executive functions (e.g., attentional control and inhibitory control) that cause attention deficits, hyperactivity, or impulsiveness which is not appropriate for a person's age.
The ability to learn things is an essential part of the developer’s toolkit, which is only getting more important as we march into the future. New technologies and new tools are released constantly. Even if you’re on a fixed tech stack on a long-running project, you need to evaluate and adapt to new versions of your tools and new software idioms as they're released.
The thing is, we’re never really taught HOW to learn things - we’re expected to just figure it out ourselves. It is my opinion that this is Really Terrible. If you share that opinion, do something about it by coming to this talk! Do you wonder about learning types? We'll cover those. Do you wonder how learning a new framework is different than learning best practices for that framework? We’ll discuss that, too! We’ll also talk about the neuroscience of learning, how your brain connects cause and effect, the tricks your memory plays on you, and more. By the end, you’ll hopefully have the tools you need to learn anything efficiently and effectively.
The Whys and Hows of Impostor Syndrome and the Illusion of TransparencyArthur Doler
Impostor Syndrome is a quiet and subversive force in a lot of developer's lives. They feel like they're faking their way through their job, and they silently panic as they wait for everyone to find out they don't really know what they're doing. It can be crippling, and left alone it can develop into an anxiety disorder, or worse. If you can relate, or even if you just want to learn how to be a little more confident in yourself, come and listen as we cover what Impostor Syndrome is, some theories why it happens, and strategies you can use to eliminate it (that's right, you actually can)!
It’s a great time to be in technology. And yet despite the improvement in our tools, we somehow don’t spend time talking about how to maintain our most important tool - the one between our ears. Your mental health is arguably the single most important factor in your ability to perform well, avoid burnout, and build resiliency, but we shroud the topic in secrecy, stigma, and co-opted clinical language that makes us think we know what's going on. We often don't even speak of what we feel to family and friends until we're facing a crisis.
We need to change all of that. You don't have to stay in the dark, and you *don't* have to suffer alone. In this talk we’ll start with some basics about mental health, then cover the most common mental health challenges facing developers, and then learn about some techniques to supercharge your brain by improving your mental hygiene (whether you have a psychological disorder or not). Most importantly, you’ll learn how to have a conversation with your coworkers (and other people in your life) about supporting each other and finding your best selves.
Let's Talk About Mental Health - KCDC 2018Arthur Doler
It’s a great time to be in technology. And yet despite the improvement in our tools, we somehow don’t spend time talking about how to maintain our most important tool - the one between our ears. Your mental health is arguably the single most important factor in your ability to perform well, avoid burnout, and build resiliency, but we shroud the topic in secrecy, stigma, and co-opted clinical language that makes us think we know what's going on. We often don't even speak of what we feel to family and friends until we're facing a crisis.
We need to change all of that. You don't have to stay in the dark, and you *don't* have to suffer alone. In this talk we’ll start with some basics about mental health, then cover the most common mental health challenges facing developers, and then learn about some techniques to supercharge your brain by improving your mental hygiene (whether you have a psychological disorder or not). Most importantly, you’ll learn how to have a conversation with your coworkers (and other people in your life) about supporting each other and finding your best selves.
Let's Talk About Mental Health - NDC Oslo 2018Arthur Doler
It’s a great time to be in technology. And yet despite the improvement in our tools, we somehow don’t spend time talking about how to maintain our most important tool - the one between our ears. Your mental health is arguably the single most important factor in your ability to perform well, avoid burnout, and build resiliency, but we shroud the topic in secrecy, stigma, and co-opted clinical language that makes us think we know what's going on. We often don't even speak of what we feel to family and friends until we're facing a crisis.
We need to change all of that. You don't have to stay in the dark, and you *don't* have to suffer alone. In this talk we’ll start with some basics about mental health, then cover the most common mental health challenges facing developers, and then learn about some techniques to supercharge your brain by improving your mental hygiene (whether you have a psychological disorder or not). Most importantly, you’ll learn how to have a conversation with your coworkers (and other people in your life) about supporting each other and finding your best selves.
Let's Talk About Mental Health - Nebraska.Code 2018Arthur Doler
It’s a great time to be in technology. And yet despite the improvement in our tools, we somehow don’t spend time talking about how to maintain our most important tool - the one between our ears. Your mental health is arguably the single most important factor in your ability to perform well, avoid burnout, and build resiliency, but we shroud the topic in secrecy, stigma, and co-opted clinical language that makes us think we know what's going on. We often don't even speak of what we feel to family and friends until we're facing a crisis.
We need to change all of that. You don't have to stay in the dark, and you *don't* have to suffer alone. In this talk we’ll start with some basics about mental health, then cover the most common mental health challenges facing developers, and then learn about some techniques to supercharge your brain by improving your mental hygiene (whether you have a psychological disorder or not). Most importantly, you’ll learn how to have a conversation with your coworkers (and other people in your life) about supporting each other and finding your best selves.
The Developer's Guide to Learning - 200OK 2018Arthur Doler
The ability to learn things is an essential part of the developer’s toolkit, which is only getting more important as we march into the future. New technologies and new tools are released constantly. Even if you’re on a fixed tech stack on a long-running project, you need to evaluate and adapt to new versions of your tools and new software idioms as they're released.
The thing is, we’re never really taught HOW to learn things - we’re expected to just figure it out ourselves. It is my opinion that this is Really Terrible. If you share that opinion, do something about it by coming to this talk! Do you wonder about learning types? We'll cover those. Do you wonder how learning a new framework is different than learning best practices for that framework? We’ll discuss that, too! We’ll also talk about the neuroscience of learning, how your brain connects cause and effect, the tricks your memory plays on you, and more. By the end, you’ll hopefully have the tools you need to learn anything efficiently and effectively.
The Developer's Guide to Learning - Codestock 2018Arthur Doler
The ability to learn things is an essential part of the developer’s toolkit, which is only getting more important as we march into the future. New technologies and new tools are released constantly. Even if you’re on a fixed tech stack on a long-running project, you need to evaluate and adapt to new versions of your tools and new software idioms as they're released.
The thing is, we’re never really taught HOW to learn things - we’re expected to just figure it out ourselves. It is my opinion that this is Really Terrible. If you share that opinion, do something about it by coming to this talk! Do you wonder about learning types? We'll cover those. Do you wonder how learning a new framework is different than learning best practices for that framework? We’ll discuss that, too! We’ll also talk about the neuroscience of learning, how your brain connects cause and effect, the tricks your memory plays on you, and more. By the end, you’ll hopefully have the tools you need to learn anything efficiently and effectively.
What Makes You DO Stuff? The Psychology of Motivation - Codestock 2018Arthur Doler
Are you sick of the words "motivation", "empowerment", "engagement", or "incentivize"? Are you convinced that any attempt to actually motivate you, your coworkers, or your employees is doomed to end in a dystopian Dilbert-like nightmare? Do you suspect some of your coworkers - or even you - might be motivated by something other than money (and might even be replicants)? No need for a Voight-Kampff test... just come learn about the psychology of motivation, and how your brain responds to it! We'll cover the history of motivation theory, some more modern concepts that aren't often talked about, and then offer some suggestions about how to use your new knowledge to help your company - or at least you - finally get rid of those "Teamwork!" posters on the walls.
Let's Talk About Mental Health - DevUp 2017Arthur Doler
It’s a great time to be in technology. Computers keep getting better. More and more devices keep getting connected to the internet. Javascript frameworks are multiplying like bacteria. And yet despite the improvement in our tools, we somehow don’t spend time talking about how to maintain our most important tool - the one between our ears.
Constantly feeling worn down, experiencing anxiety over making decisions, and burning out are not just facts of a developer’s life! They’re challenges that can be dealt with. In this talk we’ll cover the most common mental health challenges facing developers, and then learn about some techniques to supercharge your brain by improving your mental hygiene (whether you have a psychological disorder or not). Most importantly, you’ll learn how to have a conversation with your coworkers (and other people in your life) about supporting each other and finding your best selves.
The Developer's Guide to Learning EffectivelyArthur Doler
The ability to learn things is an essential part of the developer’s toolkit, which is only getting more important as we march into the future. New technologies and new tools are released constantly - there will probably be at least one new Javascript framework released just in the time it takes you to read this abstract. Even if you’re on a fixed tech stack on a long-running project, you need to evaluate and adapt to new versions of your tools and new software idioms as they're released.
The thing is, we’re never really taught HOW to learn things - we’re expected to just figure it out ourselves. It is my opinion that this is Really Terrible. If you share that opinion, do something about it by coming to this talk! We’ll cover the types of learning and how to find which ones work for you. Do you wonder how learning a new framework is different than learning best practices for that framework? We’ll discuss that, too! We’ll also talk about the neuroscience of learning, how your brain connects cause and effect, the tricks your memory plays on you, and more. By the end, you’ll hopefully have the tools you need to learn anything efficiently and effectively.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
9. Psychiatric disorder of executive functions
Specifically: attentional control and inhibitory
control
6-7% of US children have ADHD
2-5% of adults have ADHD
Diagnosed 2.5x more in boys than girls
12. INATTENTION
• Easily distracted
• Miss details
• Forget things
• Swap activities frequently
• Become bored with tasks after mere minutes
• Difficulty focusing on non-enjoyable things
• Become easily confused
• Daydream
• Difficulty processing information quickly
• Problems directing attention
13. HYPERACTIVITY
• Fidget or squirm
• Talk excessively in social situations
• Trouble sitting still
• Constant motion
• Inability to relax
• Sensation-seeking behavior
• Short temper
14. IMPULSIVENESS
• Impatience
• Display emotion without restraint
• Difficulty waiting for things they want
• Often interrupt conversations
• Act without regard for consequences
• Start relationships on a whim
Ed Finkler
Being public about it; reducing stigma
Teaching and sharing techniques
Hyperactive child on a sugar high
(which doesn’t exist either)
Carelessness or lack of caring
Or Boredom
Spastic squirrel-chasing in all directions
Current models of ADHD suggest that it is associated with functional impairments in some of the brain's neurotransmitter systems, particularly those involving dopamine and norepinephrine.
The dopamine and norepinephrine pathways that originate in the Ventral Tegmental Area and locus coeruleus project to diverse regions of the brain and govern a variety of cognitive processes.
The dopamine pathways and norepinephrine pathways which project to the prefrontal cortex and striatum are directly responsible for modulating executive function (cognitive control of behavior), motivation, reward perception, and motor function; these pathways are known to play a central role in the pathophysiology of ADHD.
Larger models of ADHD with additional pathways have been proposed.
Distraction better in survival environment
Hunter vs Farmer hypothesis