Arteriosclerosis is hardening and loss of elasticity of medium and large arteries due to thickening of arterial walls and deposition of calcium. It results from degeneration of elastic and muscle tissues in the arteries. Symptoms vary depending on the location of affected arteries and can include chest pain, impaired vision, dizziness, leg pain with walking, and skin changes in the legs. Risk factors include age, family history, smoking, high cholesterol, diabetes, and high blood pressure. Diagnostic tests include Doppler ultrasound, MRI, CT scans, and angiography. Treatment focuses on lifestyle changes and medication to control symptoms and risk factors.

1. *Arteriosclerosis
BY: SYED MASOOD RUBANI

2. • Arteriosclerosis is the disease of the
arteries characterized by thickening, loss
of elasticity and calcification of arterial
walls.
• Resulting in decreased blood supply
particularly to the cerebrum and lower
extremities.
• It is a degenerative process during which
elastic tissue is replaced by fibrous tissue
mainly tunica media becomes thickened.
• Arteriosclerosis is a general term
describing any hardening (and loss of
elasticity) of medium or large arteries .
• (from the Greek Arterio, meaning artery,
and sclerosis, meaning hardening)

3. *
*Degenerative changes begin
in the tunica media of
medium-sized arteries with
destruction of muscle and
elastic tissue. These changes
spread to affect the tunica
intima .
*Calcium is deposited in the
tunica media replacing the
degenerated tissues.
*Thus there is loss of elasticity
which leads to increased
peripheral resistance and
raised blood pressure.

4. *Progression of Arteriosclerosis

5. *
arteries in the:-
*brain,
*kidneys,
*heart,
*abdominal aorta,
*or legs

6. *
*These depend on the site of affected artery.
*Coronary artery disease cause angina and leads to
ischaemia of the cardiac muscle .
*Cerebral artery disease causes ischaemia of the
brain and clinical features depend on the area of
the brain affected .
*Vertebral artery disease may cause dizziness ,
faintness or impaired vision.
*The iliac, femoral and popliteal arteries are
commonly affected, and the clinical features r as
follows:

7. *
1. Intermittent claudication.
2. Rest pain.
3. Cold limbs.
4. Sensory changes.
5. Skin changes.
6. Loss of pulses.

8. 1.Intermittent claudication:
*Patient complains of severe
cramp like pain, commonly in calf
muscles, develops during exercise
, walking etc.
*At first the pain ceases when
exercise is stopped but as disease
progresses the pain is provoked by
less exercise and takes longer to
subside. It is due to inadequate
circulation to meet the demands
of working muscles. Other
muscles affected may be glutei ,
quadriceps, and tibialis anterior.

9. 2 Rest pain
*Severe burning pain in foot and toes occurs mostly
in night.
*Patient is frequently wakened by the pain which
may be relieved to a certain by the leg being
suspended over side of the bed.
3 cold limbs
*The toes and feet feel cold both to touch and to
the patient.
4 loss of pulses
*There may be partial or complete loss of one or
more pulses depending on the severity of
condition and the site of occlusion.

11. 5 sensory changes
*Pin, needle , tingling or complete
anaesthesia may be present especially
in the hands or feet and is increased by
exercise.
6 skin changes
*Owing to ischaemia there may be dryness, scaling,
brittle nails and loss of hair.
*Skin may have white shiny appearance or be
discolored after blanching.
*Gangrenous changes resulting in death of tissue
may be present in toes or heels n tropic ulcers
may develop on skin.

13. *
*Increasing age
*Family history
*Smoking
*High cholesterol
*Diabetes
*High blood pressure
*In activity
*Over-weight
*Stress

14. *Diagnostic tests.
• A number of imaging tests may be used to see
how well blood moves through your arteries.
• Doppler tests use ultrasound or sound waves.
• Magnetic resonance arteriography (MRA) is
a special type of MRI scan
• Special CT scans called CT angiography
• Arteriograms or angiography use x-rays to
see inside the arteries

15. Treatment
*To help prevent hardening of the arteries, make the following lifestyle
changes:
*Avoid fatty foods. Eat well-balanced meals that are low in fat and
cholesterol.
*Include several daily servings of fruits and vegetables.
*Limit alcohol intake.
*Exercise daily.
*Quit smoking -- this is the single most important change you can make to
reduce your risk of heart disease and stroke.
*Get your blood pressure checked every 1 - 2 years before age 50 and yearly
after age 50. Have your blood pressure checked more often if you have high
blood pressure, heart disease, or you have had a stroke.
*If your blood pressure is high, it is important for you to lower it and keep it
under control.
*Blood pressure should be kept below 140/90 mmHg
*Diabetic, kidney disease, or have had a stroke or heart attack, your blood
pressure should probably be less than 130/80 mm/Hg

16. *Wear warm loose clothes.
*Keep skin clean & free from infection or pressure.
*Avoid
1. cold
2. using hot bottles,
3. tight shoes, socks, belts.
4. Sitting with cross legs.
*Analgesics are prescribed to relieve pain.
*Anticoagulants to prevent blood coagulation.
*Medicine for high cholesterol levels if lifestyle changes do not work. This
will depend on:
1. Age
2. Heart disease or other blood flow problems
3. Smoker or overweight
4. High blood pressure or diabetes.
*Antiplatelet drugs.like
* Aspirin or another drug called clopidogrel (Plavix) to help prevent blood
clots from forming in your arteries.

17. Complications
• Aneurysm – especially in the arc of aorta.
• Rupture of artery from a trivial cause such as a slight
blow or injury or a sudden rise in blood pressure.
• Coronary artery disease
• Kidney disease
• Mesenteric artery ischemia
• Peripheral artery disease
• Renal artery stenosis
• Stroke
Expectations (prognosis)
 Hardening of the arteries cannot be reversed or turned
back once it has occurred. However, lifestyle changes and
treating high cholesterol levels can prevent or slow the
process from becoming worse.

18. *
*Given usually postopratively.
*Some patients on medicine may be referred
for physiotherapy. This means teaching
patient the walking pattern.
*Buerger’s exercises may be indicated.
*This is the pattern of positions designed to
encourage the development of a collateral
circulation in the legs. Procedure is as
follows

19. 1. Patient lies supine with legs supported in elevation (at
an angle of 45 degree to the horizontal) until the skin
blanches -about 2 minutes.
2. Patient sits up with the legs dependent until skin color
is bright red -about 3 minutes.
3. Patient lies with the legs horizontal until skin color
returns to normal -about 5 minutes.
This pattern is repeated 4 or 5 times for 3 times daily.
Improvement is seen by decreasing time required to return
color.
Buerger’s exercises