Organic chemistry has two main divisions. One division deals with aliphatic (fatty) compounds, the first compounds you encountered in Organic Chemistry I. The second division includes the aromatic (fragrant) compounds, of which benzene is a typical example
Organic chemistry has two main divisions. One division deals with aliphatic (fatty) compounds, the first compounds you encountered in Organic Chemistry I. The second division includes the aromatic (fragrant) compounds, of which benzene is a typical example.
Organic chemistry has two main divisions. One division deals with aliphatic (fatty) compounds, the first compounds you encountered in Organic Chemistry I. The second division includes the aromatic (fragrant) compounds, of which benzene is a typical example
Organic chemistry has two main divisions. One division deals with aliphatic (fatty) compounds, the first compounds you encountered in Organic Chemistry I. The second division includes the aromatic (fragrant) compounds, of which benzene is a typical example.
Introduction to benzene, orbital picture, resonance in benzene, Huckel‟s rule
Reactions of benzene - nitration, sulphonation, halogenation- reactivity, Friedel- Craft‟s alkylation- reactivity, limitations, Friedel-Craft‟s acylation.
Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction.
Organic chemistry has two main divisions. One division deals with aliphatic (fatty) compounds, the first compounds you encountered in Organic Chemistry I. The second division includes the aromatic (fragrant) compounds, of which benzene is a typical example.
Organic chemistry has two main divisions. One division deals with aliphatic (fatty) compounds, the first compounds you encountered in Organic Chemistry I. The second division includes the aromatic (fragrant) compounds, of which benzene is a typical example
Organic chemistry has two main divisions. One division deals with aliphatic (fatty) compounds, the first compounds you encountered in Organic Chemistry I. The second division includes the aromatic (fragrant) compounds, of which benzene is a typical example.
Introduction to benzene, orbital picture, resonance in benzene, Huckel‟s rule
Reactions of benzene - nitration, sulphonation, halogenation- reactivity, Friedel- Craft‟s alkylation- reactivity, limitations, Friedel-Craft‟s acylation.
Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction.
Benzene has 6π electrons delocalized in 6p orbitals that overlap above and below the plane of the ring. Because benzene’s six pie electrons satisfy Huckel’s rule, benzene is especially stable. Reaction that keep the aromatic ring intact are therefore favoured
In organic chemistry, an alkane, or paraffin (a historical name that also has other meanings), is an acyclic saturated hydrocarbon. In other words, an alkane consists of hydrogen and carbon atoms arranged in a tree structure in which all the carbon-carbon bonds are single.[1] Alkanes have the general chemical formula CnH2n+2. The alkanes range in complexity from the simplest case of methane, CH4 where n = 1 (sometimes called the parent molecule), to arbitrarily large molecules.
Carbenes- octet defying molecules, its fate, reactions, synthesis of carbenoids,spin multiplicity of carbenes triplet, singlet carbenes, Fischer and Schrock carbenes
An organic species which has a carbon atom bearing only six electrons in its outermost shell and has a positive charge is called carbocation.
The positively charged carbon of carbocation is sp2 hybridized.
The unhybridized p-orbital remains vacant.
They are highly reactive and act as reaction intermediate.
They are also called carbonium ion.
Heterocyclic chemistry - Fused ring systemsNaresh Babu
Fused hetero cyclic ring systems like Quinoline, Isoquinoline, Indole, Acridine, Benzimidzole & Phenothiazine - Structure, Aromaticity, Preparations, Acidity-Basicity and characteristic chemical reactions
This is Power Point Presentation on Topic "Electrophilic Aromatic Substitution Reactions" as per syllabus of "University of Mumbai" for S.Y. B. Pharmacy (Sem.: IV) students.
Organic chemistry has two main divisions. One division deals with aliphatic (fatty) compounds, the first compounds you encountered in Organic Chemistry I. The second division includes the aromatic (fragrant) compounds, of which benzene is a typical example.
Benzene has 6π electrons delocalized in 6p orbitals that overlap above and below the plane of the ring. Because benzene’s six pie electrons satisfy Huckel’s rule, benzene is especially stable. Reaction that keep the aromatic ring intact are therefore favoured
In organic chemistry, an alkane, or paraffin (a historical name that also has other meanings), is an acyclic saturated hydrocarbon. In other words, an alkane consists of hydrogen and carbon atoms arranged in a tree structure in which all the carbon-carbon bonds are single.[1] Alkanes have the general chemical formula CnH2n+2. The alkanes range in complexity from the simplest case of methane, CH4 where n = 1 (sometimes called the parent molecule), to arbitrarily large molecules.
Carbenes- octet defying molecules, its fate, reactions, synthesis of carbenoids,spin multiplicity of carbenes triplet, singlet carbenes, Fischer and Schrock carbenes
An organic species which has a carbon atom bearing only six electrons in its outermost shell and has a positive charge is called carbocation.
The positively charged carbon of carbocation is sp2 hybridized.
The unhybridized p-orbital remains vacant.
They are highly reactive and act as reaction intermediate.
They are also called carbonium ion.
Heterocyclic chemistry - Fused ring systemsNaresh Babu
Fused hetero cyclic ring systems like Quinoline, Isoquinoline, Indole, Acridine, Benzimidzole & Phenothiazine - Structure, Aromaticity, Preparations, Acidity-Basicity and characteristic chemical reactions
This is Power Point Presentation on Topic "Electrophilic Aromatic Substitution Reactions" as per syllabus of "University of Mumbai" for S.Y. B. Pharmacy (Sem.: IV) students.
Organic chemistry has two main divisions. One division deals with aliphatic (fatty) compounds, the first compounds you encountered in Organic Chemistry I. The second division includes the aromatic (fragrant) compounds, of which benzene is a typical example.
Mechanism of interaction of Ethidium Bromide (EtBr) with DNAajithnandanam
Ethidium Bromide contains tricyclic phenanthridine ring system that is able to interact with stacked base pairs of double stranded DNA. Ethidium is capable of forming close van der Walls contacts with the base pairs and due to that it can bind to the hydrophobic interior of the DNA molecule. The peripheral phenyl and ethyl groups projects into the major groove of DNA helix.
Organic chemistry has two main divisions. One division deals with aliphatic (fatty) compounds, the first compounds you encountered in Organic Chemistry I. The second division includes the aromatic (fragrant) compounds, of which benzene is a typical example
Elaborated with my colleagues Nicole M. Cruz, Stephannie Rosario and Adriana N. Santiago, with the handfull collaboration of Prof. Dalvin Méndez, this presentation showcases our results and conclusions regarding the workshop of Computational Chemistry, where we applied skills and techniques of the branch of Chemistry.
A non-covalent interaction differs from a covalent bond in that it does not involve the sharing of electrons, but rather involves more dispersed variations of electromagnetic interactions between molecules or within a molecule.
This is the contents of this presentation-
• The arenium ion mechanism,
• Orientation and reactivity,
• Energy profile diagrams.
• o/p ratio,
• Orientation in benzene ring with more than one substituent, orientation in other ring systems.
• ipso attack
• Diazonium coupling,
• Gatterman-Koch reaction,
• Reimer-Tiemann reaction,
• Pechman reaction,
• Houben –Hoesch reaction,
• Kolbe Schmitt reaction,
• Recapitulation of halogenation, nitration, sulphonation, and F.C. reaction.
This powerpoint presentation will cover following aspects:
Kinds of Pericyclic Reactions and Brief details of their kinds
Molecular Orbitals and Orbitals Symmetry
Molecular Orbitals Description
Electrocyclic Reactions
Introduction to Dienes
Introduction to Dienophiles
Photochemical conditions
Ring Closure
Modes of Ring Closure
Diels- Alder Product recognition and Reversibility of Diels Alder Reaction
Conrotatory and Disrotatory arrangements
Cycloadditions in Complete Details
Dimerization , Frontier Orbitals Description, Endo Rule, Stereochemistry, Applications Hoffman's rule and a lot more……
The haloalkanes are a group of chemical compounds derived from alkanes containing one or more halogens. They are a subset of the general class of halocarbons, although the distinction is not often made. Haloalkanes are widely used commercially and, consequently, are known under many chemical and commercial names.
ORGANIC CHEMISTRY 2
AROMATIC COMPAOUNDS (ARENES)
These are organic compounds with benzene ring as functional group.
Molecular formula of benzene is C6 H6.
-It is highly unsaturated molecule but it does not undergo reaction readily and it tends to undergo substitution reaction.
STRUCTURES OF BENZENE
B.Pharm I Year II Sem. SN1 and SN2 reactions, kinetics, order of reactivity of alkyl halides, stereochemistry and rearrangement of carbocations.
SN1 versus SN2 reactions, Factors affecting SN1 and SN2 reactions.
Structure and uses of ethylchloride, Chloroform, trichloroethylene, tetrachloroethylene,
dichloromethane, tetrachloromethane and iodoform.
Alcohols, Qualitative tests for Alcohol, Structure and uses of Ethyl alcohol, chlorobutanol, Cetosterylalcohol, Benzyl alcohol, Glycerol, Propylene glycol
Phenomics assisted breeding in crop improvementIshaGoswami9
As the population is increasing and will reach about 9 billion upto 2050. Also due to climate change, it is difficult to meet the food requirement of such a large population. Facing the challenges presented by resource shortages, climate
change, and increasing global population, crop yield and quality need to be improved in a sustainable way over the coming decades. Genetic improvement by breeding is the best way to increase crop productivity. With the rapid progression of functional
genomics, an increasing number of crop genomes have been sequenced and dozens of genes influencing key agronomic traits have been identified. However, current genome sequence information has not been adequately exploited for understanding
the complex characteristics of multiple gene, owing to a lack of crop phenotypic data. Efficient, automatic, and accurate technologies and platforms that can capture phenotypic data that can
be linked to genomics information for crop improvement at all growth stages have become as important as genotyping. Thus,
high-throughput phenotyping has become the major bottleneck restricting crop breeding. Plant phenomics has been defined as the high-throughput, accurate acquisition and analysis of multi-dimensional phenotypes
during crop growing stages at the organism level, including the cell, tissue, organ, individual plant, plot, and field levels. With the rapid development of novel sensors, imaging technology,
and analysis methods, numerous infrastructure platforms have been developed for phenotyping.
ESR spectroscopy in liquid food and beverages.pptxPRIYANKA PATEL
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...University of Maribor
Slides from talk:
Aleš Zamuda: Remote Sensing and Computational, Evolutionary, Supercomputing, and Intelligent Systems.
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Inter-Society Networking Panel GRSS/MTT-S/CIS Panel Session: Promoting Connection and Cooperation
https://www.etran.rs/2024/en/home-english/
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
Aromatic Comp. Lec.5
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Aromatic Compound
I. Topics of to understand& handle the following pathways of
CONVERSION& Pre-steps Rx.
1. Alkylbenzene, Alkenylbenzene
-Stability;
**As a RULE;
"Alkenylbenzene that have their side-chain double bond conjugated with
the benzene ring are more stable than those that do not."
-Reactivity;
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*Explanation of the above Rx.
*Mechanism "TO UNDERSTAND AND AVOID MISUSING IN
CONVERSION STEPS"
1. In case of Peroxides
-"Free Radical mechanism"
-Depends mainly on the bond energy as which can reactive the others.
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2. In case of NO Peroxides
-"Ionic mechanism"
2. Oxidation of the side chain
-Using hot alkaline 𝐾𝑀𝑁𝑂4, alkyl, alkenyl, alkynyl and acyl grp.s all
oxidized to -COOH grp.
-For alkylbenzene, 3°alkyl grp. can resist oxidation. GIVE REASON!
---Answer; Need to benzylic hydrogen for alkyl grp. oxidation.
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*Note;
to oxidize the benzene ring itself;
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**Application;
Chemistry of Industrial Styrene
Styrene is one of the most important industrial chemicals—more than
11billion pounds (5billionKg=5millionton) is produced each year.
-How to prepare it ?!
II. Aralkylhalides; Side-Halogen Comp.
Hint; memorize the mentioned comp. in their common names, please!
1. examples;
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2. Synthesis;
- Free radical halogenations of alkylbenzene.
- Addition of HX to alkenylbenzene.
- Reaction of HX with aromatic alcohols.
3. Reactions
Remember the general points of 𝑆 𝑁1& 𝑆 𝑁2.
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-Nucleophilic substitution reactions either 𝑆 𝑁1 or 𝑆 𝑁2.
-1°& 2° benzylic halide typically react via an 𝑆 𝑛2.(NO Elimination)
-3° benzylic halide typically react via an 𝑆 𝑁1. GIVE REASON!
---Answer; due to the resonance stabilized carbocation& steric effect.
-Unlike allylic systems, NO benzylic rearrangement.
GIVE REASON!
---Answer; I would result in loss of aromaticity.
-We can shift from one mechanism to the other by changing reaction
conditions.
1. 𝑆 𝑁2 Rx Mechanism.
1°& 2° benzylic halides typically react via an 𝑆 𝑁2 pathway.
Allylic and benzylic halides exhibit enhanced 𝑆 𝑁2 reactivity thanks to
conjugation of the newly formed and breaking bonds with the adjacent π-
electron system.
2. 𝑆 𝑁1 Rx Mechanism.
3° benzylic halides typically react via an 𝑆 𝑁1 pathway,
A carbocation is formed as a high-energy intermediate, and this species
bonds immediately to nearby nucleophiles.
If the nucleophile is a neutral molecule, the initial product is an "onium"
cation.
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*Summary
-These halides give mainly 𝑆 𝑁2 Rx.
-These halides give either 𝑆 𝑁1 or 𝑆 𝑁2 Rx.
-These halides give mainly 𝑆 𝑁1 Rx.
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*SN reactions of Aralkyl halide
VIP examples;
-Benzaldehyde from Aralkylhalide via hydrolysis of benzylidene.
-Benzoic acid from Aralkylhalide via hydrolysis of benzotrihalides.
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III. Miscellaneous Reactions.
1. Oxidation of benzene ring
2. Reduction of Aromatic comp.
A. Hydrogenation of benzene.
-cyclohexane and cyclohexene cannot be isolated .
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B. Birch Reduction
to reduce benzene ring into 1,4-cyclohexadiene
-Rx.;
-Mechanism;
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IV. Aryl Halides
-Synthesis;
1. Direct Halogenation of arenes via Sigma complex mechanism.
2. Sandmeyer Reaction.
3. Balz-Schiemann Reaction.
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*Diazotisation
The nitrosation of primary aromatic amines with nitrous acid (generated
in situ from sodium nitrite and a strong acid, such as hydrochloric acid,
sulfuric acid, or HBF4) leads to diazonium salts, which can be isolated if
the counterion is non-nucleophilic.
Diazonium salts are important intermediates for the preparation of
halides (Sandmeyer Reaction, Schiemann Reaction), and azo compounds.
-Reactions of Aryl Halides
1. Electrophilic Aromatic Substitution
2. Formation of aryl Grignad reagent and organometalic compounds
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3. 𝑆 𝑛𝑢 𝐴𝑟
-Aromatic nucleophilic reaction do not occur except if there are electon
with drawing groups ortho or para to halogens likeNO2,..et.
GIVE REASON!
---Answer; Due to…
1. The benzene ring of an aryl halide prevents backside
attack in an 𝑆 𝑛2 reaction.
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2. Phenyl cations are very unstable; thus 𝑆 𝑛1 reactions do
not occur.
3. Due to stability of benzene ring and its electron cloud, the carbon-
halogen bonds of aryl and vinylic halides are shorter and stronger than
those of alkyl, allylic, and benzylic halides.
Stronger carbon-halogen bonds mean that bond breaking by either an
𝑆 𝑛1 or 𝑆 𝑛2 mechanism will require more energy.
4.More two points can affect the strength of carbon-hydrogen bond;
A. The carbon of either type of halide is 𝑆𝑝2
hybridized, and there for the
electrons of the carbon orbital are closer to the nucleus than those of an
𝑆𝑝3
-hybridized carbon.
B. Resonance can strengthen the carbon-halogen bond by giving it
double-bond character.
3.1. Activated 𝑆 𝑛𝑢 𝐴𝑟 "Addition-Elimination" mechanism
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Explanation;
Example;
Why EWG?!
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**Activator OR Deactivator**
-We should say activator (ordeactivator ) for either erlectophilic or
nucleophilc reactions.
-Activating and deactivating functions are applied to substituents effects.
"𝑁𝑂2"
-A strong deactivating substituent in electrophilic aromatic substitution.
-A strong activating substituent in nucleophilic aromatic substitution.
3.2. Factors affect 𝑆 𝑛𝑢 𝐴𝑟
1. # and the power of activating groups present at the o-and p-positions
of the leaving group.
-More EWG, less energy used.
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2.Leaving grp. type
-Due to the size of the atom itself which affect its ability to withdrawing
electron "electronegativity".
-You find that the opposite of that concept you have to apply in the simple
nucleophilic substitution.
3. EWG position effect
m-Fluoronitrobenzene reacts with sodium methoxide 105 times more
slowly (Consider no reaction) than do its ortho and para isomers.
Due to Non-Stabilized Meisinheimer intermediate (the –ve charge is
restricted to carbon in all resonance forms (Carbon has low EN).
The concept that Meisinheimer intermediate is a reactive intermediate so
the mentioned position of nito- and fluro- make the negative charge
restricted onto the stabilized carbon of the resonance system make the
system energy increase so the rate of the reaction decrease.
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𝐻3
𝑵𝑶 𝟐
*Remember;