This document discusses neonatal seizures, including their definition, classification, etiologies, diagnostic approach, treatment, and prognosis. It notes that seizures in newborns can be subtle, clonic, tonic, or myoclonic. Common causes include perinatal conditions like hypoxic-ischemic encephalopathy, intracranial hemorrhages, infections, developmental defects, and various metabolic derangements. The diagnostic approach involves taking a thorough history, conducting examinations, and ordering appropriate investigations. Treatment involves stabilizing the newborn, administering anticonvulsants like phenobarbital, and managing underlying conditions. Outcome depends on factors like etiology, maturity, and neurological status. Complications may
Presentation with extensive details of neonatal seizure. Covering its etiology, diagnosis and treatment . Neonatal seizure is one of the commonest clinical situation faced by any one working in a neonatal unit. Furthermore it is a favourite topic of many examiners in MD/DCH/DNB Pediatrics exams.
Presentation with extensive details of neonatal seizure. Covering its etiology, diagnosis and treatment . Neonatal seizure is one of the commonest clinical situation faced by any one working in a neonatal unit. Furthermore it is a favourite topic of many examiners in MD/DCH/DNB Pediatrics exams.
Neonatal seizures, dr amit vatkar, pediatric neurologistDr Amit Vatkar
In the presentaion i will give you a brief idea to apprach, diagnosis and management of neonatal seizures.
The most prominent feature of neurologic dysfunction in the neonatal period is the occurrence of seizures. Determining the underlying etiology for neonatal seizures is critical. Etiology determines prognosis and outcome and guides therapeutic strategies.
Neonatal seizures, dr amit vatkar, pediatric neurologist
Management of hypoxic ischemic encephalopathy (HIE) by Sunil Kumar Dahasunil kumar daha
Please find the power point on Management of hypoxic ischemic encephalopathy (HIE) . I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
Neonatal seizures, dr amit vatkar, pediatric neurologistDr Amit Vatkar
In the presentaion i will give you a brief idea to apprach, diagnosis and management of neonatal seizures.
The most prominent feature of neurologic dysfunction in the neonatal period is the occurrence of seizures. Determining the underlying etiology for neonatal seizures is critical. Etiology determines prognosis and outcome and guides therapeutic strategies.
Neonatal seizures, dr amit vatkar, pediatric neurologist
Management of hypoxic ischemic encephalopathy (HIE) by Sunil Kumar Dahasunil kumar daha
Please find the power point on Management of hypoxic ischemic encephalopathy (HIE) . I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
A seizure is a sudden, uncontrolled electrical disturbance in the brain. It can cause changes in your behavior, movements or feelings, and in levels of consciousness. If you have two or more seizures or a tendency to have recurrent seizures, you have epilepsy.
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Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
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The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
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As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
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In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
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5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
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2. DIAGNOSTIC CHOICES ;Reliance on clinical
v/s EEG seizures
ETIOLOGIC EXPLANATIONS; Multiple prenatal /neonatal conditions with
variable time of onset and duration.
TREATMENT DECISIONS; WhICH,When
ANDHOW long
PROGNOSTIC QUESTIONS ;
Mechanism of injury based on underlying disorder v/s vulnerability of
immature brain to seizures
3. Definition:-
A seizure is defined clinically as
a paroxysmal alteration in neurologic
function, i.e. motor, behavior and/or
autonomic function.
4. 1.EPILEPTIC SEIZURE phenomena associated
with
corresponding EEG seizure activity e.g. clonic seizures
2. NON EPILEPTIC SEIZURE: clinical seizures
without corresponding EEG correlate e.g. subtle
and generalized tonic seizures
3. EEG SEIZURES: abnormal EEG activity with
no clinical correlation.
5. Immature CNS cannot sustain a synchronized, well
orchestrated generalized seizure
Neurite outgrowth—dendritic and axonal ramifications—in
process
Synaptogenesis not complete
Deficient myelination in cortical efferent systems
6. CLINICAL CLASSIFICATION
SUBTLE SEIZURES;Clinical
manifestations are mild and often missed, most
common type
1. Ocular - Tonic horizontal deviation of eyes or
sustained opening with ocular fixation or cycled
fluttering
2. Oral–facial–lingual movements - Chewing,
tongue- thrusting, lip-smacking, etc.
3. Limb movements - Cycling, paddling, boxing-jabs,
4.Autonomic phenomena - Tachycardia or bradycardia
5. APNEA
7. CLONIC SEIZURES
They are rhythmic movements of muscle groups. They
have both fast and slow components, occur with a
frequency of 1-3 jerks per second
Tonic seizures:
refers to a sustained flexion or extension of axial
or
appendicular muscle group
8.
9. MYOCLONIC SEIZURE
single or multiple lightning fast jerks of limbs
Rapid speed
Absence of slow return and predilection for flexor muscle
groups
Myoclonic seizures carry the worst prognosis in
terms of neuro-developmental outcome and
seizure recurrence.
Focal clonic seizures have the best prognosis.
10.
11. Jitteriness or tremors
Normal movements seen more commonly
in preterm infants
1. Benign neonatal sleep myoclonus
2. Fragmentary myoclonic jerks
3. Eye movements: Roving or dys-conjugate
eye movements
12. Jitteriness Versus Seizure
CLINICAL FEATURE JITTERINESS SEIZURE
Abnormality of gaze or ey O +
movement
Movements exquisitely stimulus + O
sensitive
Predominant movement Tremor Clonic jerking
Movements cease with passive + O
flexion
Autonomic changes O +
------------------------------------------------------------------------------------------------------------------
13. Certain clinical seizures in the human newborn
originate deep cerebral structures (limbic
regions), or in diencephalic, or brain stem
structures and thereby are either not detected
by surface-recorded EEG or inconsistently
propagated to the surface
18. E.DRUGS-Narcotic withdrawal of mother
F.BENIGN FAMILIAL SEIZURE does not
continue after neonatal period
G.CEREBRO VASCULAR LESIONS
H.IDIOPATHIC 3- 25 %
23. Major Etiologies of Neonatal Seizures in
Relation to Time of
Seizure Onset and Relative Frequency
TIME OF ONSET* RELATIVE
FREQUENCY†
0-3 DAYS >3DAYS PREMATURE FULL
TERM
Hypoxic-ischemic + +++ +++
encephalopathy
Intracranial + + ++ +
hemorrhage‡
Intracranial infection + + ++ ++
Developmental + + ++ ++
defects
Hypoglycemia + + +
Hypocalcaemia + + + +
Other metabolic + +
Epileptic syndromes + + +
24. Aiims protocol:- identify and characterize seizure
Nurse the baby in TNZ( room temp 26’-28’ C)
Maintain airway ,breathing, circulation , start O2
Check blood glucose (<40mg) and give glucose @ 8mg/kg
(2ml/kg of D10 %)
Give 2ml/kg of 10% of ca gluconate over 10 minI(If s.ca
< 7)
0.25ml/kg of 50% mgso4 i/m
25. Phenobarbitone 20mg/kg over 20 min
Give phenobaritone again @ 10mg/kg
Give maintenance dose 3-5 mg/day
Phenytoin 20mg/kg over 20 min
Repeat phenytoin 10mg/kg
26. Benzodiazepines used
Lorazepam: 0.05 mg/kg IV bolus over 2-5 minutes or
Midazolam: 0.15 mg/kg IV bolus followed by infusion of 0.1 to 0.4 mg/kg/hour
In refractory seizurez second line drugs can be used
Lidocaine 4mg/kg iv followed by 2mg/kg/hr or
27. Sodium valproate 20-25mg/kg/day followed by 5-10mg/kg/day
Other drugs like vigabatrin. Topiramate, paraldehyde
Therapeutic trial of pyridoxine
1 ml of neurobion on both gluteus i/m
28. Weaning of anticonvulsant therapy
Newborn on anticonvulsant therapy
Wean all antiepileptic drugs except phenobarbitone
once seizure controlled
Perform neurological examination prior to discharge
normal Abnormal
33. Low APGAR score ≤ 6 at 5min
Onset o seizures within 24 hrs of life
Presence of myoclonic attacks
Abnormal EEG
3 or more days of uncontrolled seizures