A presentation made about Sickle cell disease by Yara Mostafa, Yasser Osama, Yaser Mostafa ,Ain shams university, Medicine faculty, first year students.
A presentation made about Sickle cell disease by Yara Mostafa, Yasser Osama, Yaser Mostafa ,Ain shams university, Medicine faculty, first year students.
Autoimmune hemolytic anemia (or autoimmune haemolytic anaemia; AIHA) occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst (lyse), leading to insufficient plasma concentration.
This presentation is about anemia of chronic disease, nowadays also called as anemia of Inflammation. I have dealt with anemia in CKD and malignancy in detail.
Autoimmune hemolytic anemia (or autoimmune haemolytic anaemia; AIHA) occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst (lyse), leading to insufficient plasma concentration.
This presentation is about anemia of chronic disease, nowadays also called as anemia of Inflammation. I have dealt with anemia in CKD and malignancy in detail.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
2. Microcytosis can be documented from
1. the mean cell volume (MCV) on an automated hematology instrument (ie, MCV
below 80 femtoliters [fL] for an adult or below the age-appropriate value for children) or
2. from examination of the peripheral blood smear. Variation in cell size can be
assessed from the red blood cell (RBC) distribution width (RDW) or
3. from observing the degree of anisocytosis on the blood smear.
3. IRON DEFICIENCY ANEMIA
Occurs when the absorption of iron through dietary
intake does not match the needs of the body.
The mismatch occurs from inadequate dietary intake or
increased needs, which usually cause only mild anemia,
or from blood loss or malabsorption, which can lead to
more significant anemia.
Young children, women of childbearing age, and
pregnant women have the highest prevalence of the
condition.
Complications include developmental delays and
behavior disturbances in children and preterm delivery in
pregnant women.
Heavy menstrual losses leading to significant anemia
warrant additional evaluation for clotting disorders (e.g.,
4.
5. THALASSEMIA
Beta-thalassemia :-
an autosomal recessive genetic condition in which
the normal beta globin chains that make up
hemoglobin are underproduced.
Beta-thalassemia trait is the heterozygous form of
the disease.
Beta- thalassemia major (also known as Cooley
anemia) is the homozygous form. Both are more
common in black persons, and in persons of
Southeast Asian, Greek, Italian, or Mediterranean
6.
7. THALASSEMIA:-
Most patients with beta-thalassemia trait have mild
anemia (hemoglobin level is rarely less than 9.3 g per
dL [93 g per L]).
In addition, the mean corpuscular volume can
sometimes reach much lower levels than with iron
deficiency anemia alone.
Ultimately, the diagnosis of beta-thalassemia trait is
made when hemoglobin electrophoresis shows a
slight increase in hemoglobin A2.
Coexisting iron deficiency anemia can lower
hemoglobin A2 levels; therefore, iron deficiency
anemia must be corrected before hemoglobin
electrophoresis results can be appropriately
evaluated.
8. Alpha-thalassemia is caused by an underproduction of alpha
globin chains, and is most prevalent in persons of African or
Southeast Asian descent.
The production of alpha globin chains is controlled by four
genes on two chromosomes.
One gene deletion results in a silent carrier status with normal
hematologic findings.
Two gene deletions result in alpha-thalassemia trait, which
usually leads to microcytosis without anemia.
Hemoglobin electrophoresis is often normal in patients with
silent carrier status or with alpha-thalassemia trait.
The diagnosis is usually one of exclusion.
9. ANEMIA OF CHRONIC DISEASE
Caused by chronic infections or inflammatory processes.
Increased levels of cytokines cause a decrease in
erythropoietin production, a decreased response to
erythropoietin, and interference with iron metabolism.
Although anemia of chronic disease is usually normocytic,
about one fourth to one third of cases are mildly microcytic.
The anemia is usually mild and not progressive.
Additionally, although serum iron levels are decreased in
anemia of chronic disease (similar to iron deficiency
anemia), ferritin levels are increased because ferritin is an
acute phase reactant
10. Other causes:-
Rare acquired causes of
microcytosis include the
following:-
•Lead poisoning.
•Copper or zinc deficiency
•Some forms of drug-induced
anemia
•Inherited syndromes of
defective iron metabolism
•Myelodysplastic syndrome
(MDS)
Rare inherited microcytic anemias
include:-
•X-linked and other types of
sideroblastic anemia
•Hereditary hypotransferrinemia
•Hereditary aceruloplasminemia
•Erythropoietic protoporphyria
•Iron-refractory iron deficiency
anemia
•Other thalassemic mutations
such as hemoglobin E disease
11. History and Physical Examination
Important history information includes
Nutritional intake (especially whole milk intake in children); pica or
cravings for ice, which are symptoms of iron deficiency anemia;
Occupational or residential exposure to toxins, such as lead;
Family history of anemia or ethnicity suggestive of anemia due to an
underlying hemoglobinopathy; and
Systemic symptoms of an underlying chronic infectious or
inflammatory process.
Review of gastrointestinal symptoms, including abdominal
discomfort, hematochezia, and bright red rectal bleeding, is warranted
in adults, and
Menstrual history should be obtained in menstruating women.
12. Most patients with
microcytosis are
asymptomatic, and
physical examination
findings are often
limited.
As the severity of
anemia increases,
physical findings may
include a systolic
murmur and pallor of
the mucous
membranes, nail beds,
and palmar creases
13. Laboratory Evaluation
MCV
Red blood cell distribution width
using the CBC,
Serum iron levels,
Serum ferritin levels,
Total iron-binding capacity (TIBC),
Transferrin saturation,
Hemoglobin electrophoresis, and
Reticulocyte blood count and
Peripheral blood smears.
Stool RME
Endoscopy
Colonoscopy
Tissue transglutaminase
antibody
14.
15. Red blood cell distribution width
Measures the variation in red blood cell size
Is often increased in persons with iron deficiency, but
normal in those with anemia of chronic disease.
However, this measurement is not sensitive or
specific enough to differentiate iron deficiency and
beta-thalassemia trait.
The red blood cell count can help differentiate the two
causes because it is often in the high to normal range
with beta-thalassemia trait
16. Serum iron levels
Decreased in iron deficiency anemia and, to a
lesser extent, in anemia of chronic disease.
Serum iron levels can have diurnal variations
with higher concentrations later in the day.
Transient increases in serum iron levels may
occur with meat ingestion or iron
supplementation, but do not represent an
increase in true iron stores
17. Ferritin , transferrin saturation levels
and TIBC
Ferritin and transferrin saturation levels and TIBC are
useful in differentiating iron deficiency anemia and
anemia of chronic disease when the serum iron level
is decreased.
TIBC refers to the ability of unsaturated transferrin, the
transport protein for iron, to bind to iron.
This measure is usually increased in iron deficiency,
decreased in anemia of chronic disease, and normal
in the less severe thalassemias. Similar to iron, TIBC
18. Transferrin saturation is a percentage calculated
as
serum iron concentration/TIBC × 100.
Levels indicate the number of free binding sites on
transferrin.
A value less than 16 percent is often indicative of
iron deficiency anemia
19. Ferritin
Complex of iron and the binding protein apoferritin.
Reflects true iron stores and is not susceptible to the
short-term variations that occur with serum iron levels
and TIBC.
Also an acute phase reactant and can be elevated with
liver disease, malignancy, and chronic renal disease.
Iron deficiency anemia is likely if the ferritin level is less
than 15 ng per mL (15 mcg per L) in an otherwise
healthy person, or less than 50 ng mL (50 mcg per L) in
a person with an underlying source of chronic
inflammation.
Iron deficiency can usually be excluded when the ferritin
20.
21. Diagnostic Strategy
After confirmation of microcytosis on CBC, physicians
should first order a serum ferritin level.
If the ferritin level is consistent with iron deficiency
anemia, identifying the underlying cause of the
anemia is the priority.
It is critical to exclude gastrointestinal malignancy in
men and nonmenstruating women.
Gastrointestinal sources of blood loss should also be
considered in menstruating women and adolescent
girls when the anemia is refractory to iron treatment or
when gastrointestinal symptoms are present
22.
23. MANAGEMENT
The severity and cause of iron-deficiency anemia will determine the
appropriate approach to treatment.
For the majority of cases of iron deficiency (pregnant women,
growing children and adolescents, patients with infrequent episodes
of bleeding, and those with inadequate dietary intake of iron), oral
iron therapy will suffice.
For patients with unusual blood loss or malabsorption, specific
diagnostic tests and appropriate therapy take priority.
Once the diagnosis of iron-deficiency anemia and its cause is made,
there are three major therapeutic approaches.
24. RED CELL TRANSFUSION
Transfusion therapy is reserved for individuals who have symptoms of anemia,
cardiovascular instability, and continued and excessive blood loss from
whatever source and who require immediate intervention.
Intravenous iron
can be given to patients who are unable to tolerate oral iron; whose needs are
relatively acute; or who need iron on an ongoing basis, usually due to
persistent gastrointestinal or menstrual blood loss
The amount of iron needed by PARENTERAL IRON THERAPY
an individual patient is calculated by the following formula:
(Body weight (kg) × 2.3 × (15 – patient’s hemoglobin, g/dL) + 500 or
1000 mg (for stores).
25. ORAL IRON THERAPY
Typically, for iron
replacement therapy, up
to
200 mg of elemental
iron per day is given,
usually as three or four
iron tablets (each
containing 50–65 mg
elemental iron) given
over
the course of the day