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 INDIAN DENTAL ACADEMY
  Leader in Continuing Dental Education

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Necrotizing ulcerative gingivitis is an
infectious
disease of the gingiva causing
gingival
bleeding, gingival ulceration and pain.




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History

    Necrotizing ulcerative gingivitis had been recognized
in the 4th century BC by Xenophon, who mentioned that
Greek soldiers were affected with “sore mouth and foul
smelling breath”. In 1778, Hunter described the clinical
features of this disease and differentiated it from scurvy
and chronic periodontitis.


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Synonyms

      Vincent’s disease
      Fusospirochetal gingivitis
      Trench mouth
      Acute ulcerative gingivitis
      Necrotizing gingivitis

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ETIOLOGY
                    Role of bacteria
•
       A specific infectious disease should be associated
with a specific etiology. The bacterial etiology of
Necrotizing ulcerative gingivitis provides one of our
strongest examples of a primarily bacterial etiology in a
periodontal disease.
    Plaut in 1894 and Vincent in 1896 first proposed this
bacterial etiology.
• They both reported that fusiform-spirochete bacteria
flora were associated with lesions of NUG.
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Loesche et al

 Constant flora            Variable flora

• P. intermedia             Heterogeneous
• Fusobacterium             array of bacteria
• Treponema

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Role of host response


•Nutritional
def.
•Alcohol/drug            immunodeficiency
abuse
•stress




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CLINICAL FEATURES
          
            Oral signs

Punched - out , craterlike depressions
at the crest of the interdental papillae


Surface of craters covered by gray ,
    psuedomembranous slough


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Other clinical signs


Spontaneous gingival hemorrhage

Fetid odor

Increased salivation


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Punched out
                           interdental papilla




Lesions with progressive
 tissue destruction

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Oral symptoms

  Lesions sensitive to touch

  Radiating , gnawing pain

  “Metallic” foul taste

  “Pasty” saliva

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Systemic signs & symptoms

        High fever

        Lymphadenopathy

        Pulse rate

        Leukocytosis

       Loss of appetite
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Clinical course

              Pindborg et al

•   Erosion of tip of papilla
•   Lesion extending to marginal gingiva
•   Lesion extending to attached gingiva
•   Exposure of bone


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Horning and cohen
•   Stage 1 : necrosis of tip of papilla
•   Stage 2 : necrosis of entire papilla
•   Stage 3 : necrosis ext to gingival margin
•   Stage 4 : necrosis ext to attached gingiva
•   Stage 5 : necrosis ext to labial or buccal mucosa
•   Stage 6 : necrosis exposing alveolar bone
•   Stage 7 : necrosis perforating skin of cheek



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Listgarten 1965

     Bacterial zone

     Neutrophil rich zone

     Necrotic zone

     Spirochetal infiltration zone

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Histopathology

Surface epithelium replaced by meshwork of
fibrin , necrotic epithelial cells , PMN’s etc

Connective tissue is extremely hyperemic ,
with engorged capillaries and dense
infiltration of PMN’s


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DIAGNOSIS


    Clinical findings

    Bacterial smear

    Biopsy specimen

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Clinical findings

   Gingival pain

   Ulceration

   Bleeding

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Bacterial smear       Differential diagnosis of ANUG from


                                      Diphtheria
                                      Thrush
                                      Actinomycosis


Biopsy specimen         Differential diagnosis of ANUG from


                                   Tuberculosis
                                   Neoplastic disease
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Differential diagnosis
 Herpetic gingivostomatitis
 Chronic periodontitis
 Desquamative gingivitis
 Diphtheritic & syphilitic lesions
 Agranulocytosis


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THANK YOU FOR WATCHING
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Anug / orthodontic courses by indian dental academy /certified fixed orthodontic courses by Indian dental academy

  • 1.   INDIAN DENTAL ACADEMY Leader in Continuing Dental Education www.indiandentalacademy.com
  • 2. Necrotizing ulcerative gingivitis is an infectious disease of the gingiva causing gingival bleeding, gingival ulceration and pain. www.indiandentalacademy.com
  • 3. History Necrotizing ulcerative gingivitis had been recognized in the 4th century BC by Xenophon, who mentioned that Greek soldiers were affected with “sore mouth and foul smelling breath”. In 1778, Hunter described the clinical features of this disease and differentiated it from scurvy and chronic periodontitis. www.indiandentalacademy.com
  • 4. Synonyms Vincent’s disease Fusospirochetal gingivitis Trench mouth Acute ulcerative gingivitis Necrotizing gingivitis www.indiandentalacademy.com
  • 5. ETIOLOGY Role of bacteria • A specific infectious disease should be associated with a specific etiology. The bacterial etiology of Necrotizing ulcerative gingivitis provides one of our strongest examples of a primarily bacterial etiology in a periodontal disease.     Plaut in 1894 and Vincent in 1896 first proposed this bacterial etiology. • They both reported that fusiform-spirochete bacteria flora were associated with lesions of NUG. www.indiandentalacademy.com
  • 6. Loesche et al Constant flora Variable flora • P. intermedia Heterogeneous • Fusobacterium array of bacteria • Treponema www.indiandentalacademy.com
  • 7. Role of host response •Nutritional def. •Alcohol/drug immunodeficiency abuse •stress www.indiandentalacademy.com
  • 8. CLINICAL FEATURES   Oral signs Punched - out , craterlike depressions at the crest of the interdental papillae Surface of craters covered by gray , psuedomembranous slough www.indiandentalacademy.com
  • 9. Other clinical signs Spontaneous gingival hemorrhage Fetid odor Increased salivation www.indiandentalacademy.com
  • 10. Punched out interdental papilla Lesions with progressive tissue destruction www.indiandentalacademy.com
  • 11. Oral symptoms Lesions sensitive to touch Radiating , gnawing pain “Metallic” foul taste “Pasty” saliva www.indiandentalacademy.com
  • 12. Systemic signs & symptoms High fever Lymphadenopathy Pulse rate Leukocytosis Loss of appetite www.indiandentalacademy.com
  • 13. Clinical course Pindborg et al • Erosion of tip of papilla • Lesion extending to marginal gingiva • Lesion extending to attached gingiva • Exposure of bone www.indiandentalacademy.com
  • 14. Horning and cohen • Stage 1 : necrosis of tip of papilla • Stage 2 : necrosis of entire papilla • Stage 3 : necrosis ext to gingival margin • Stage 4 : necrosis ext to attached gingiva • Stage 5 : necrosis ext to labial or buccal mucosa • Stage 6 : necrosis exposing alveolar bone • Stage 7 : necrosis perforating skin of cheek www.indiandentalacademy.com
  • 15. Listgarten 1965 Bacterial zone Neutrophil rich zone Necrotic zone Spirochetal infiltration zone www.indiandentalacademy.com
  • 16. Histopathology Surface epithelium replaced by meshwork of fibrin , necrotic epithelial cells , PMN’s etc Connective tissue is extremely hyperemic , with engorged capillaries and dense infiltration of PMN’s www.indiandentalacademy.com
  • 18. DIAGNOSIS Clinical findings Bacterial smear Biopsy specimen www.indiandentalacademy.com
  • 19. Clinical findings Gingival pain Ulceration Bleeding www.indiandentalacademy.com
  • 20. Bacterial smear Differential diagnosis of ANUG from Diphtheria Thrush Actinomycosis Biopsy specimen Differential diagnosis of ANUG from Tuberculosis Neoplastic disease www.indiandentalacademy.com
  • 21. Differential diagnosis Herpetic gingivostomatitis Chronic periodontitis Desquamative gingivitis Diphtheritic & syphilitic lesions Agranulocytosis www.indiandentalacademy.com
  • 22. THANK YOU FOR WATCHING www.indiandentalacademy.com www.indiandentalacademy.com