Define Antiseptic and disinfectant Differentiate between Antiseptic and disinfectant Classify and explain Antiseptic and disinfectant

1. Antiseptic and Disinfectant
Mr. Sujit Trimbak Karpe
Head of Department
Sojar college of Pharmacy, Khandvi

2. Learning Outcome
After watching this video learner will able to
› Define Antiseptic and Disinfectant.
› Summarize therapeutic usage of it.
› Explain general mechanisms of action of antiseptic and
disinfectant.
› Differentiate between antiseptic and Disinfectant.
› Classify different classes of antiseptic and disinfectant.

3. Antiseptic
› Antiseptics are antimicrobial substances that are
applied to living tissue/skin to reduce the possibility
of infection, sepsis or putrefaction.
› Some antiseptics are true germicides, capable of
destroying microbes (bacteriocidal), while others
are bacteriostatic and only prevent or inhibit their
growth.

4. Uses of Antiseptic
› Hand washing.
› Disinfecting mucous membrane.
› Cleaning skin before an operation.
› Treating skin infection.
› Treating throat and mouth infection.

5. Disinfectant
› Disinfectants are antimicrobial agents designed to
inactivate or destroy microorganisms on inert
surfaces/ inanimate objects such as surgical
dressings, bed pans, rooms, lavatories and medical
devices.
› Bacterial endospores are most resistant
to disinfectants, but some fungi, viruses and bacteria
also possess some resistance.

6. Uses of Disinfectant
› Sterilization of surgical instruments and medical
devices prior to surgical procedure.
› Disinfection of rooms, bed pans, and lavatories.
› Disinfectants are frequently used in hospitals, dental
surgeries, kitchens, and bathrooms to kill infectious
organisms.

7. General Mechanism of action
Mechanism
of action
Coagulation of Bacterial
Protein
Alteration in
Bacterial cell
wall
Competing with essential
substrate
Binding to –SH
group
essential for
enzyme action

8. Antiseptic versus Disinfectant
Antiseptic Disinfectant
 Used on Living tissue of human and
animals
 Used on nonliving things like medical
devices, wards, kitchen and bathrooms
 Cleanses wounds and surgical surface
to prevent infection and other
complication
 Cleanses surgical instruments, rooms,
bed pans etc
 Includes in mouthwashes, gargles,
creams and ointments
 Includes in cleaning products used for
houses, hospitals and public places.
 Not harmful to human and animals  Harmful to human and animals
 E.g. – Iodine , Alcohols etc  E. g. – Formaldehyde, Potassium
Permanganate etc

9. Classification of Antiseptic and
Disinfectant
•Heat
•Ultraviolet light
Physical
•Further divided into
different classes
•Acids, Phenols, Alcohols etcChemical

10. Chemical Agents
1. Acids: - Boric acid, Benzoic acid, Salicylic acid
2. Oxidizing agents: - Potassium Permangnate, Hydrogen
Peroxide, Sodium Perborate
3. Phenolic Compounds: - Phenol, Cresol, Thymol
4. Surfactants: - Soap, Cetrimide
5. Alcohol: - Ethyl alcohol, Isopropyl alcohol
6. Halogens: - Iodine, Iodophores, Chlorine

11. Chemical Agents
7. Aldehyde: - Formaldehyde
8. Antiseptic Dye: - Crystal violet, Brilliant green
9. Heavy metals: - Zinc oxide, Silver Nitrate
10. Antibiotics: - Bacitracin, Neomycin, Polymixin - B
11.Miscellaneous: - Nitrofurazone

12. Commonly used anti infective agent
1. Heat: -
 Dry heat or moist heat is used for sterilization.
 Dressing packs, laboratory equipment's, culture
media are sterilized by moist heat sterilization
 Glass syringes, instruments, laboratory glassware's
are sterilized by dry heat sterilization

13. Commonly used anti infective agent
2. Acids: -
 It is weak bacteriostatic agent
 Boric acid is used in eye drops, eye ointment and
throat paint.
 Benzoic acid is used as food preservative
 Salicylic acid is used as antifungal agent and for
removal of corns and warts.

14. Commonly used anti infective agent
3. Oxidizing agents: -
 Potassium Permanganate is used as disinfectant to
disinfect ponds and wells and as deodorant.
 Hydrogen peroxide is used for cleansing wounds, in
mouthwash and deodorant.
 In dental practice as cleanser and help to remove
stains from teeth.

15. Commonly used anti infective agent
4. Phenolic compounds: -
 Phenol is used as disinfectant.
 Dettol is used for cleansing wound.
 Cresol is used as preservative in medicinal
preparation.
 Resorcinol is used in antiseptic ointment.

16. Commonly used anti infective agent
5. Surfactants: -
 Soap is a weak germicidal.
 Benzalkonium chloride is used for cleansing diapers,
bed linen, underclothes of pateints.
 Cetrimide is used as disinfection and cleansing
wounds, preoperative preparation for skin and
sterilization of surgical instruments.

17. Commonly used anti infective agent
6. Alcohols: -
 For cleansing of skin prior to parenteral injection.
 As a local antiseptic to prevent bed sores.
 Isopropyl alcohol is used as germicidal, antiseptic
for cleaning the skin and for sterilization of
syringes and needles.

18. Commonly used anti infective agent
7. Halogens: -
 Used as antiseptic and germicidal.
 As a disinfectant.
 As a deodorant.

19. Commonly used anti infective agent
8. Aldehydes: -
 Used as effective germicide.
 For disinfection of surgical instruments and
excreta.

20. Commonly used anti infective agent
9. Dyes: -
 Gentian violet is used for disinfection of skin, for
treatment of infectious eczema.
 Brilliant green is used in the treatment of burns.

21. Commonly used anti infective agent
10. Heavy metals: -
 Zinc oxide is used as antiseptic, astringent and to
treat eczema.
 Silver nitrate is used for gonnococcal opthalmia in
neonates.

22. Commonly used anti infective agent
11. Antibiotics: -
 As an antiseptic in creams and ointment to
prevent further infection caused by bacteria.
 As an antifungal agent.

23. If you have any query please fill free to ask me

24. https://youtu.be/4VafIPMpP0I