Different type of Fungal infection Classify and explain antifungal agent

1. Diseases and Treatment
Fungal infection and Antifungal agent
Mr. Sujit T. Karpe
Head of Department
Sojar college of Pharmacy, Khandvi

2. Fungal infection
› Fungal infection can be discussed in three group
1. Dermatophytic Infection
2. Systemic Infection
3. Candidal infection

3. Fungal infection
› Dermatophytic Infection: - involves the skin, hair, nails.
› Systemic Infection: - Also called as Mycotic infection and
they are chronic and difficult to diagnose. This infection
is caused by eryptococcosis, aspergillosis,blastomycosis
etc.
› Candidal Infection: - caused by Candida albicans.
Candidiasis affects moist skin, mucous membrane and
may cause systemic infection

4. Antifungal agent
› An agent used to kill or inhibit the growth of common mycotic
infection at local and systemic level is called as Antifungal
agent.
› Ideal properties of Antifungal agent
 Should be fungicidal.
 Should be non staining and non irritating to the skin and free from
sanitation reactions.
 Should penetrate into hair, nails and layers of skin.
 Should have some antibacterial activity.

5. Antifungal agent - Griseofulvin
› An antibiotic is isolated from Penicillium griseofulvum.
› It selectively effective in Dermatophytic infections of skin, nails and
hair but is of no use in yeast infections or candidiasis.
› Orally effective but no use as local application
› It is taken by newly formed keratin of the skin, hair and nails
where it exerts it antifungal action.
› Contraindicated in liver disease and pregnancy.

6. Antifungal agent - Nystatin
› An antibiotic is isolated from Streptomyceus noursei.
› It is very effective in treatment of yeast such as candida.
› It has little effect on dermatophytes and bacteria.
› Nystatin is frequently used as a local preparation in the form of
powder, ointment or suppositories but it may be given parenterally.
› It is effective against aspergillus which may be present in some
otitis externa and for aspergillosis of lung.

7. Antifungal agent – Amphotericin - B
› This polyene antibiotic is isolated from
Streptomyceus nodosus.
› It is very effective in treatment of yeast infections.
› It may be used topically or by IV route.

8. Antifungal agent – other agent
› Compound Benzoic acid ointment BPC used for
Dermatophytic infection.
› Tolnaftate and Clotrimazole is used for skin and vaginal
infection.
› Candidicin and hamycin is used for candidal infection.
› Flucytocin is used for systemic infection.