This document discusses epilepsy and anti-epileptic drugs. It defines epilepsy as a chronic neurological disorder characterized by recurrent seizures. It notes that more than 40 forms of epilepsy have been identified. While drugs can prevent seizures, there is no cure currently available. Common causes of seizures are listed. The different types of seizures are classified and described. Finally, several commonly used anti-epileptic drugs are outlined, including their mechanisms of action and side effect profiles.
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A compiled Power point presentation on "Antipsychotic drugs" suitable for Undergraduate level medical students and also PG students in the subject of Pharmacology.
cholingeric and Anticholinesterase drug in detail .this ppt contains introduction ,mechanism of action ,pharmacological action ,uses and adverse effect of the drug
A group of chronic CNS disorders characterized by recurrent seizures.
Seizures are sudden, transitory, and uncontrolled episodes of brain dysfunction resulting from abnormal discharge of neuronal cells with associated motor, sensory or behavioral changes.
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. A group of chronic CNS disorders characterized by
recurrent, periodic and unpredictable seizures.
Seizures are sudden, transitory, and uncontrolled episodes of
brain dysfunction resulting from abnormal discharge of
neuronal cells with associated motor, sensory or behavioral
changes.
3. More than 40 forms of epilepsy have been
identified.
Therapy is symptomatic in that the majority
of drugs prevent seizures, but neither
effective prophylaxis or cure is available.
6. I. Partial (focal) Seizures
A. Simple Partial Seizures
B. Complex Partial Seizures
II. Generalized Seizures
A. Generalized Tonic-Clonic Seizures
B. Absence Seizures
C. Tonic Seizures
D. Atonic Seizures
E. Clonic Seizures
F. Myoclonic Seizures
G. Infantile Spasms
8. A. Simple Partial Seizures (Jacksonian)
Involves one side of the brain at onset.
Focal with motor, sensory or speech
disturbances.
Confined to a single limb or muscle group.
Seizure-symptoms don’t change during
seizure.
No alteration of consciousness.
9.
10. B. Complex Partial Seizures (Temporal Lobe
epilepsy or Psychomotor Seizures)
Produces confusion and inappropriate or dazed
behavior.
Motor activity appears as non-reflex actions.
Automatisms (repetitive coordinated movements).
Purposeless movements like lips smacking or
hand wringing
Wide variety of clinical manifestations and are
accompanied by sensory, motor, psychic
symptoms.
Consciousness is impaired or lost.
11.
12.
13. In Generalized
seizures, both
hemispheres are widely
involved from the
outset.
Manifestations of the
seizure are determined
by the cortical site at
which the seizure
arises.
Present in 40% of all
epileptic Syndromes.
14. Recruitment of neurons throughout the cerebrum
Major convulsions, usually with two phases:
1) Tonic phase
2) Clonic phase
Convulsions:
Motor manifestations
May or may not be present during seizures
Excessive neuronal discharge
Convulsions appear in Simple Partial and Complex Partial
Seizures if the focal neuronal discharge includes motor centers
They occur in all Generalized Tonic-Clonic Seizures regardless
of the site of origin.
Atonic, Akinetic, and Absence Seizures are non-convulsive
15. Tonic phase:
Sustained powerful muscle contraction(involving
all body musculature) which arrests ventilation.
Clonic phase:
Alternating contraction and relaxation, causing a
reciprocating movement which could be
bilaterally symmetrical or “running” movements.
16.
17. This is the most common and most severe form of
epilepsy.
It is characterized by an initial rigid extension of trunk
and limbs (tonic phase) lasting 10-20 sec, followed by a
rhythmic contraction of arms and legs (clonic phase).
There is loss of consciousness and autonomic signs
A period of confusion and exhaustion lasting several
minutes follows the seizure episode. ; not usually
improved by anticonvulsant therapy
18.
19. Brief and abrupt loss of consciousness, vacant
stare.
Sometimes with no motor manifestations.
Minor muscular twitching restricted to eyelids
(eyelid flutter) and face.
Typical 2.5 – 3.5 Hz spike-and-wave discharge.
Usually of short duration (5-10 sec), but may
occur dozens of times a day.
No loss of postural control.
20. Often begin during childhood (daydreaming
attitude, no participation, lack of
concentration).
Attacks may occur up to a hundred times a
day. Age of onset is 3-5 years; may last till
puberty.
A low threshold Ca2+ current has been
found to govern oscillatory responses in
thalamic neurons (pacemaker)
24. C. Tonic Seizures
Opisthotonus, loss of
consciousness.
Marked autonomic
manifestations
D. Atonic Seizures (atypical)
Loss of postural tone, with
sagging of the head or falling.
May loose consciousness.
Most common in children
25. E. Clonic Seizures
Clonic Seizures: Rhythmic clonic contractions of
all muscles, loss of consciousness, and marked
autonomic manifestations.
F. Myoclonic Seizures
Myoclonic Seizures: Isolated clonic jerks, brief
shock like contraction of muscles restricted to
one part/ extremity associated with brief bursts
of multiple spikes in the EEG.
26. F. Infantile Spasms
An epileptic syndrome.
Attacks, although fragmentary, are often
bilateral.
Characterized by brief recurrent myoclonic jerks
of the body with sudden flexion or extension of
the body and limbs.
28. Goals:
Block repetitive neuronal firing.
Block synchronization of neuronal discharges.
Block propagation of seizure.
Minimize side effects with the simplest drug
regimen.
MONOTHERAPY IS RECOMMENDED IN MOST CASES
29. Strategies:
Modification of ion conductances.
Increase inhibitory (GABAergic) transmission.
Decrease excitatory (glutamatergic) activity.
31. 6/15/2014 Anti-epileptics 34
Chemical basedclassification of Anti-epilepticdrugs
(AED)
Chemical compound class Member Drug
Barbiturate Phenobarbitone
Deoxybarbiturate Primidone
Hydantoin Phenytoin
Iminostilbene Carbamazepine
Succinimide Ethosuximide
Aliphatic carboxylic acid Sodium valproate
Benzodiazepines Clonazepam,Diazepam,Clobazam
Phenyltriazine Lamotrigine
Cyclic GABA analogue Gabapentin
Newer drugs
Vigabatrin , Topiramate,Tiagabine,
Levitiracetam, Zonisamide
32. Largely target partial seizures
Fewer and less severe drug
interactions compared to older
drugs
33.
34. A. Resting State
B. Arrival of Action
Potential causes
depolarization and
channel opens allowing
sodium to flow in.
C. Refractory State,
Inactivation
45. Fetal Hydantoin Syndrome
Pre- and postnatal growth deficiency with psychomotor
retardation, microcephaly with a ridged metopic suture, hypoplasia
of the nails and finger-like thumb and hypoplasia of the distal
phalanges.
Radiological skeletal abnormalities reflect the hypoplasia and fused
metopic suture.
Cardiac defects and abnormal genitalia.
Teratogenicity of several anticonvulsant medications is associated with an
elevated level of oxidative metabolites that are normally eliminated by the
enzyme epoxide hydrolase.
46. CARBAMAZEPINE (Tegretol)
Tricyclic, antidepressant (bipolar)
3-D conformation similar to
phenytoin.
Mechanism of action, similar to
phenytoin. Inhibits high
frequency repetitive firing (Na++)
Decreases synaptic activity
presynaptically.
Inh. uptake and release of NE, but
not GABA.
Potentiates postsynaptic effects of
GABA.
Metabolite is active.
Toxicity:
•Auto induction of
metabolism.
•Nausea and visual
disturbances.
•Granulocyte suppression.
•Aplastic anemia.
•Exacerbates absence
seizures.
47. OXCARBAZEPINE
Closely related to
carbamazepine.
With improved toxicity profile.
Less potent than
carbamazepine.
Active metabolite.
Mechanism of action, similar to
carbamazepine It alters Na+
conductance and inhibits high
frequency repetitive firing.
Toxicity:
•Hyponatremia
•Less hypersensitivity
and induction of hepatic
enzymes than with carb.
48. PHENOBARBITAL
Toxicity:
Sedation.
Cognitive impairment.
Behavioral changes.
Induction of liver
enzymes.
May worsen absence
and atonic seizures.
It is the oldest antiepileptic drug.
Although considered one of the safest
drugs, it has sedative effects.
Many consider them the drugs of
choice for seizures only in infant
Useful for partial, generalized tonic-
clonic seizures, and febrile seizures
Prolongs opening of Cl- channels.
Blocks excitatory GLU (AMPA)
responses. Blocks Ca2+ currents (L,N).
Inhibits high frequency, repetitive firing
of neurons only at high concentrations.
49. PRIMIDONE
Metabolized to phenobarbital and
phenylethylmalonamide (PEMA),
both active metabolites.
Effective against partial and
generalized tonic-clonic seizures.
Absorbed completely, low binding
to plasma proteins.
Should be started slowly to avoid
sedation and GI problems.
Its mechanism of action may be
closer to phenytoin than the
barbiturates.
Toxicity:
•Same as phenobarbital
•Sedation occurs early.
•Gastrointestinal complaints.
50. VALPROATE
Fully ionized at body pH, thus active
form is valproate ion.
One of a series of carboxylic acids
with antiepileptic activity. Its amides
and esters are also active.
Mechanism of action, similar to
phenytoin.
levels of GABA in brain.
May facilitate Glutamic acid
decarboxylase (GAD).
Inhibits GAT-1.
Toxicity:
•Elevated liver enzymes
•Nausea and vomiting.
•Abdominal pain,
•heartburn.
•Tremor, hair loss,
•Weight gain.
•Idiosyncratic,hepatotox
•Teratogen: spina bifida
51. USES
A broad spectrum anti-seizure drug
(effective against most partial and generalized
seizures, including myoclonic and absence
seizures)
Non-seizure indications include:
Migraine (prophylaxis)
Bipolar disorder
52.
53. ETHOSUXIMIDE
Drug of choice for absence
seizures.
High efficacy and safety.
Mechanism of action involves
reducing low-threshold Ca2+
channel current (T-type channel)
in thalamus.
At high concentrations:
Inhibits GABA aminotransferase.
Phensuximide = less effective
Methsuximide = more toxic
Toxicity:
•Gastric distress,
including, pain, nausea
and vomiting
•Lethargy and fatigue
•Headache
•Hiccups
•Euphoria
•Skin rashes
54. CLONAZEPAM
A benzodiazepine.
Long acting drug with efficacy
for absence seizures.
One of the most potent
antiepileptic agents known.
Also effective in some cases of
myoclonic seizures.
Has been tried in infantile
spasms.
Doses should start small.
Increases the frequency of Cl-
channel opening.
Toxicity:
• Sedation is prominent.
• Ataxia.
• Behavior disorders.
55. LAMOTRIGINE
Presently use as add-on therapy with
valproic acid (v.a. conc. are be reduced).
Almost completely absorbed
T1/2 = 24 hrs
Low plasma protein binding
Also effective in myoclonic and
generalized seizures in childhood and
absence attacks.
Suppresses sustained rapid firing of
neurons and produces a voltage and use-
dependent inactivation of sodium
channels, thus its efficacy in partial
seizures.
Toxicity:
•Dizziness
•Headache
•Diplopia
•Nausea
•Somnolence
•Rash
56.
57. TOPIRAMATE
Toxicity:
Somnolence
Fatigue
Dizziness
Cognitive slowing
Paresthesias
Nervousness
Confusion
Urolithiasis
Rapidly absorbed, bioav. is > 80%,
has no active metabolites, excreted
in urine.T1/2 = 20-30 hrs
Blocks repetitive firing of cultured
neurons, thus its mechanism may
involve blocking of voltage-
dependent sodium channels
Potentiates inhibitory effects of
GABA (acting at a site different
from BDZs and BARBs).
Depresses excitatory action of
kainate on AMPA receptors.
Teratogenic in animal models.
58. ZONISAMIDE
Sulfonamide derivative
Good bioavailability, low pb.
T1/2 = 1 - 3 days
Effective against partial and
generalized tonic-clonic seizures.
Mechanism of action involves voltage
and use-dependent inactivation of
sodium channels(?).
May also involve Ca2+ channels.
Toxicity:
•Drowsiness
•Cognitive
impairment
•High incidence of
renal stones (?).
59. FELBAMATE
Effective against partial seizures
but has severe side effects.
Because of its severe side effects, it
has been relegated to a third-line
drug used only for refractory cases.
Toxicity:
•Aplastic anemia
•Severe hepatitis
60. VIGABATRIN (-vinyl-GABA)
Absorption is rapid, bioavailability
is ~ 60%, T 1/2 6-8 hrs, eliminated
by the kidneys.
Use for partial seizures and
Contraindicated if preexisting
mental illness is present.
Irreversible inhibitor of GABA-
aminotransferase (enzyme
responsible for metabolism of
GABA) => Increases inhibitory
effects of GABA.
Toxicity:
•Drowsiness
•Dizziness
•Weight gain
•Agitation
•Confusion
•Psychosis
63. GABAPENTIN (Neurontin)
Used as an adjunct in partial and
generalized tonic-clonic seizures.
Does not induce liver enzymes.not
bound to plasma proteins.
Drug-drug interactions are
negligible.
Low potency.
An a.a.. Analog of GABA that does
not act on GABA receptors, it may
however alter its metabolism, non-
synaptic release and transport.
Toxicity:
•Somnolence.
•Dizziness.
•Ataxia.
•Headache.
•Tremor.
64.
65. Status Epilepticus
Status epilepticus exists when seizures recur within a short
period of time , such that baseline consciousness is not
regained between the seizures. They last for at least 30
minutes. Can lead to systemic hypoxia, acidemia,
hyperpyrexia, cardiovascular collapse, and renal shutdown.
The most common, generalized tonic-clonic status
epilepticus is life-threatening and must be treated
immediately with concomitant cardiovascular, respiratory
and metabolic management.
66. DIAZEPAM (Valium) AND
LORAZEPAM (Ativan)
Benzodiazepines
Given I.V.
Lorazepam may be longer acting.
1° for treating status epilepticus
Have muscle relaxant activity.
Allosteric modulators of GABA
receptors.
Potentiates GABA function, by
increasing the frequency of channel
opening.
Toxicity
•Sedation
•Children may manifest a
paradoxical hyperactivity.
•Tolerance
67. Treatment of Status Epilepticus in Adults
Initial
Diazepam, i.v. 5-10 mg (1-2 mg/min)
repeat dose (5-10 mg) every 20-30 min.
Lorazepam, i.v. 2-6 mg (1 mg/min)
repeat dose (2-6 mg) every 20-30 min.
Follow-up
Phenytoin, i.v. 15-20 mg/Kg (30-50 mg/min).
repeat dose (100-150 mg) every 30 min.
Phenobarbital, i.v. 10-20 mg/Kg (25-30mg/min).
repeat dose (120-240 mg) every 20 min.
68. Treatment of Seizures
PARTIAL SEIZURES ( Simple and Complex,
including secondarily generalized)
Drugs of choice: Carbamazepine
Phenytoin
Valproate
Alternatives: Lamotrigine, Phenobarbital,
Oxcarbamazepine.
Add-on therapy: Gabapentin, Topiramate,
Tiagabine, Levetiracetam, Zonisamide.
69. Treatment of Seizures
PRIMARY GENERALIZED TONIC-
CLONIC SEIZURES (Grand Mal)
Drugs of choice: Carbamazepine
Phenytoin
Valproate*
Alternatives: Lamotrigine, Phenobarbital,
Topiramate, Oxcarbamazepine, Primidone,
Levetiracetam, Phenobarbital.
*Not approved except if absence seizure is involved
70. Treatment of Seizures
GENERALIZED ABSENCE SEIZURES
Drugs of choice: Ethosuximide
Valproate*
Alternatives: Lamotrigine, Clonazepam,
Zonisamide, Topiramate (?).
* First choice if primary generalized tonic-clonic seizure is also
present.
71. Treatment of Seizures
ATYPICAL ABSENCE, MYOCLONIC,
ATONIC* SEIZURES
Drugs of choice: Valproate**
Lamotrigine***
Alternatives: Topiramate, clonazepam,
zonisamide, felbamate.
* Often refractory to medications.
**Not approved except if absence seizure is involved.
*** Not FDA approved for this indication.
72. Na+ Channel Blockers Phenytoin
Carbamazepine
Oxcarbamazepine
Primione
Valproic acid
Lamotrigine
Topitramate
Zonisamide
Phenobarbital
Gabapentin
Felbamate
Ca2+ Channel Blockers Ethosuxamide
Phenobarbital
Zonisamide
Drugs that Potentiate
GABA
Increase opening time of channel Phenobarbital
Increase frequency of openings of
channel
Diazepam
Lorazepam
Clonazepam
Increase GABA in synapse Valproic Acid
Increase GABA metabolism Gabapentin
Increase GABA release Gabapentin
Block GABA transaminase Vigabatrin
Block GABA transporter
(GAT-1)
Valproic Acid
Tiagabine
73. Experimental evaluation
Partial seizures in human correlates with MES
test (maximal electroshock test) in animals.
Anti-epileptics effective against MES alters ionic
conductance across cell membrane.
Absence seizures : PTZ test (subcutaneous
administration of Pentyleneterazol.