Antibiotics are substances that kill or inhibit the growth of bacteria. They were discovered in the late 19th/early 20th century, including penicillin discovered by Alexander Fleming in 1928. Issues with antibiotics now include increasing bacterial resistance due to overuse and misuse of antibiotics, high prices of new antibiotics due to the large costs of research and development, and the need for more affordable generic versions of drugs. Addressing these challenges requires reducing inappropriate antibiotic use, encouraging new antibiotic development through public funding while also making essential medicines more accessible globally.