introduction of Depression
what is Depressant
Anti depressant drugs example
1.Amitriptyline
2. Nor-tryptyline
3. Phenelzine
4. Tranylcypromine
5. Imipramine
This is a presentation I did last year in Chicago for Cook County juvenile probation officers. It is an update on patterns of drug abuse by adolescents. Among other things, it acquaints viewers with the problem of street drug misrepresentation. Not only are the same street drugs sold in different forms, but drugs that look the same may contain completely different drugs.
This presentation talks about addiction. It tells the viewer about the definition of addiction, how is it caused and how it affects the brain and hoe to get rid of it. It also tells about the emotional and physical behavior experienced when getting rid of addiction.
this is the introduction of narcotics and psychotropic substances. it is useful to all who want to learn about the narcotics and psychotropic substances
Drug Abuse & Misuse, Sedative-Hypnotics “Benzodiazepines”Asra Hameed
Benzodiazepine abuse is a growing problem and carries serious risks to health and society.
Benzodiazepines are commonly used by polydrug abusers, alcoholics and sometimes as primary recreational drugs.
People who abuse benzodiazepines often take very large doses orally, by injection or by snorting.
Benzodiazepine use leads to dependence and a withdrawal syndrome which may include convulsions and psychosis.
Further research is needed on the optimal short-term and long-term management of benzodiazepine abuse.
The primary source of illicit benzodiazepines is from doctors' prescriptions.
The Six Classifications of Drugs of Abuse (Grade 9 (Mapeh) Health Lesson)Jewel Jem
The Six Classifications of Drugs of Abuse
> Gateway Drugs
> Depressants
> Stimulants
> Narcotics
> Hallucinogens
> Inhalants
Along with meanings, types and pictures
The good and bad effects of each classifications of the drugs of abuse
Chapter 4 Pharmacology Diploma in Pharmacy Part -1 .pdfSumit Tiwari
Drugs Acting on the Central Nervous System
Definition, classification, pharmacological actions, dose,
indications, and contraindications of
General anaesthetics
Hypnotics and sedatives
Anti-Convulsant drugs
Anti-anxiety drugs
Anti-depressant drugs
This is a presentation I did last year in Chicago for Cook County juvenile probation officers. It is an update on patterns of drug abuse by adolescents. Among other things, it acquaints viewers with the problem of street drug misrepresentation. Not only are the same street drugs sold in different forms, but drugs that look the same may contain completely different drugs.
This presentation talks about addiction. It tells the viewer about the definition of addiction, how is it caused and how it affects the brain and hoe to get rid of it. It also tells about the emotional and physical behavior experienced when getting rid of addiction.
this is the introduction of narcotics and psychotropic substances. it is useful to all who want to learn about the narcotics and psychotropic substances
Drug Abuse & Misuse, Sedative-Hypnotics “Benzodiazepines”Asra Hameed
Benzodiazepine abuse is a growing problem and carries serious risks to health and society.
Benzodiazepines are commonly used by polydrug abusers, alcoholics and sometimes as primary recreational drugs.
People who abuse benzodiazepines often take very large doses orally, by injection or by snorting.
Benzodiazepine use leads to dependence and a withdrawal syndrome which may include convulsions and psychosis.
Further research is needed on the optimal short-term and long-term management of benzodiazepine abuse.
The primary source of illicit benzodiazepines is from doctors' prescriptions.
The Six Classifications of Drugs of Abuse (Grade 9 (Mapeh) Health Lesson)Jewel Jem
The Six Classifications of Drugs of Abuse
> Gateway Drugs
> Depressants
> Stimulants
> Narcotics
> Hallucinogens
> Inhalants
Along with meanings, types and pictures
The good and bad effects of each classifications of the drugs of abuse
Chapter 4 Pharmacology Diploma in Pharmacy Part -1 .pdfSumit Tiwari
Drugs Acting on the Central Nervous System
Definition, classification, pharmacological actions, dose,
indications, and contraindications of
General anaesthetics
Hypnotics and sedatives
Anti-Convulsant drugs
Anti-anxiety drugs
Anti-depressant drugs
ANALEPTICS Mrs Namrata Sanjay Mane Department of Pharmaceutical Chemistry...NAMRATAMANE8
ANALEPTICS
Mrs Namrata Sanjay Mane
Department of Pharmaceutical Chemistry
Nagpur College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441110,Maharashtra, India.
This presentation explain the knowledge about sedative and hypnotics drugs also its physical properties, storage ,uses,dose, brand name and marketed formulations.
Depression is a mental health disorder.
Characterized by symptoms like sad mood, loss of interest and pleasure, low energy, worthlessness, guilt, psychomotor retardation or agitation, change in appetite and/ or sleep, melancholia, suicidal thoughts, etc.
It may be unipolar (only depression) or bipolar (cycle of mood swings from mania to depression).
It is the leading psychiatric disorder.
The mood change may have a psychotic basis with delusional thinking or occur in isolation.
Antidepresants are the drugs which can elevate mood in depressive illness.
Agents used for radiographic purpose /Radiopaque substance
Iopanoic acid
Propyl iodone
2. Agents used to test organ function
Sulphobromopthalein sodium
Indigo carmine/ Indigotin disulphonate sodium
Evans blue
Congo red
Fluorescein sodium
An introduction to advanced aseptic processing technology, Aseptic processing facility design, Innovations in aseptic processing technology, Sterile product manufacture using form fill seal technologies, Aseptic processing transfer systems, Qualification/validation of aseptic processing environments, systems and equipment.
Introduction to biopolymers,
Biocompatible and biodegradable polymers,
Applications of biopolymers,
Biopolymers used in advanced drug delivery systems-
Cellulose and its derivatives,
chitosan,
PLGA,
Polyanhydride,
polycaprolactone.
An introduction Aseptic processing facility design, Innovations in aseptic processing technology, Sterile product manufacture using form fill seal technologies, Aseptic processing transfer systems, Qualification/validation of aseptic processing environments, systems and equipment.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
3. Depression
It is a mental illnesses characterized by pathological changes in mood, loss of interest or
pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, low energy, and
poor concentration .
It can be severe and some times Fatal.
Types of Depression
1. Major depression
2. Chronic depression
3. Atypical depression
4. Bipolar disorder/Manic depression
5. Seasonal depression
4. What are depressants?
A depressant, or central
depressant, is a drug that
lowers neurotransmission
levels, which is to depress or
reduce arousal or
stimulation, in various areas
of the brain.
Depressants are also
occasionally referred to as
"downers" as they lower the
level of arousal when taken.
5. Antidepressants
Antidepressants are medications used to treat major
depressive disorder, some anxiety disorders, some
chronic pain conditions, and to help manage some
addictions.
Common side-effects of antidepressants include dry
mouth, weight gain, dizziness, headaches, sexual
dysfunction, and emotional blunting.
6. Antidepressants
1. Drug which enhance alertness and may result in an
increased output of behavior.
2. Potentiate directly or indirectly the action.
3. The purpose of antidepressants is to increase the
neurotransmitters in the synapse.
4. They are used for the relief of symptoms of moderate and
severe depression.
5. Antidepressants are taken for at least 4-6 months.
6. They can be used alone or in combination with other
medications
7. 1.Amitriptyline
It is tricyclic antidepressant .
Physical properties:
white crystalline powder or colorless
Odorless and bitter taste and burring taste causes numbness
Soluble in water and alcohol.
Stability & storage
It is affected by air ,hence it is stored in tight closed and light resistant container
8. Uses
This medication is used to treat mental/mood problems such as depression. It may help
improve mood and feelings of well-being, relieve anxiety and tension, help
you sleep better, and increase your energy level.
Pharmaceutical formulations:
Amitriptyline injection
Amitriptyline tablet
Brand name: Amitrip ,Tryptanol
9. 2. Nor-tryptyline
Physical properties:
white crystalline powder or colorless
Odorless and bitter taste and burring taste causes numbness
sparingly Soluble in water.
Uses :
1. Endogenous depression
2. Anxiety
3. Chronic tension headache
11. 3. Phenelzine
It is phenylethyl hydrazine
Phenelzine can improve your mood and feelings of well-being.
Physical properties:
white powder or colorless
Pungent Odor
Soluble in water
Slightly soluble in alcohol
13. Chemical properties
When its solution in aqueous NaOH is treated with fehlings solution, a
red precipitated of cuprous oxide is obtained.
Stability & storage
It is affected by air ,hence it is stored in tight closed and light resistant
container
Pharmaceutical formulations: tablet
Brand name: Nordil
14. 4. Tranylcypromine
Physical properties:
White crystalline powder
Odorless
Soluble in water
Slightly soluble in alcohol
Stability & storage
It is affected by air ,hence it is stored in tight closed and light resistant container
15. Chemical properties
When its suspension in alcohol is treated with ninhydrin , a purple color is
produces after 15 min.
Uses :
Anxiety state
Depressive disorders
Phobic state
Obsessive disorder
19. Physical properties
White or yellow crystalline powder.
Odorless and bitter taste causes sensation of numbness.
Soluble in water
Stability & storage
It is affected by air ,hence it is stored in tight closed and light resistant container
Brand name: Impratab, Depsonil
