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CHOLINERGIC ANTAGONISTS
CLASSIFICATION
1.ATROPINE
• IT OCCURS AS COLORLESS CRYSTALS OR WHITE CRYSTALLINE POWDER.
• IT IS ODORLESS AND HAS BITTER TASTE
• SPARINGLY SOLUBLE IN WATER.
• FREELY SOLUBLE IN CHLOROFORM
• IN ACIDIC OR ALKALINE MEDIUM, IT IS HYDROLYZED TO GIVE TROPINE AND
TROPIC ACID.
USES
• IT IS USED TO TREAT PARKINSONISM
• IN SMALL DOSES, IT IS C.N.S STIMULANT
• AS A MYDRIATIC IN OPHTHALMOLOGY PRACTICE
• AS AN ANTISPASMODIC
• ATROPINE IS USED TO HELP REDUCE SALIVA, MUCUS, OR OTHER SECRETIONS
IN YOUR AIRWAY DURING A SURGERY.
2.HOMOTROPINE
• PROPERTIES
• IT OCCURS AS COLORLESS CRYSTALS OR WHITE CRYSTALLINE POWDER.
• IT IS ODORLESS AND HAS BITTER TASTE
• FREELY SOLUBLE IN WATER
• IN ACIDIC OR ALKALINE MEDIUM, IT IS HYDROLYZED TO GIVE TROPINE AND
MANDELIC ACID.
3.BENZTROPINE
• IT OCCURS AS WHITE CRYSTALLINE POWDER.
• IT IS ODORLESS AND HAS BITTER TASTE
• VERY SOLUBLE IN WATER.
• FREELY SOLUBLE IN ALCOHOL
• STABILITY AND STORAGE:
• IT IS HYGROSCOPIC ,HENCE STORED IN TIGHTLY CLOSED CONTAINERS.
• Uses :
• Benztropine is used to treat symptoms of Parkinson's disease
• helps decrease muscle stiffness, sweating, and the production
of saliva, and helps improve walking ability in people
with Parkinson's disease.
4.HYOSCINE
• HYOSCINE, ALSO KNOWN AS SCOPOLAMINE
• IT OCCURS AS COLORLESS CRYSTALS OR WHITE CRYSTALLINE POWDER.
• IT IS ODORLESS
USES
5. PROPANTHELINE
PROPERTIES
• IT OCCURS AS WHITE OR YELLOWISH WHITE POWDER.
• IT IS ODORLESS AND HAS BITTER TASTE
• IT IS SOLUBLE IN WATER.
• IT IS SLIGHTLY HYGROSCOPIC
• WHEN IT IS TREATED WITH SULPHURIC ACID, IT GIVES YELLOW SOLUTION
• STABILITY AND STORAGE:
• IT IS HYGROSCOPIC ,HENCE STORED IN TIGHTLY CLOSED CONTAINERS.
USES
6.TROPICAMIDE
THANKYOU

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Cholinergic antagonists

  • 1.
  • 4.
  • 5. 1.ATROPINE • IT OCCURS AS COLORLESS CRYSTALS OR WHITE CRYSTALLINE POWDER. • IT IS ODORLESS AND HAS BITTER TASTE • SPARINGLY SOLUBLE IN WATER. • FREELY SOLUBLE IN CHLOROFORM • IN ACIDIC OR ALKALINE MEDIUM, IT IS HYDROLYZED TO GIVE TROPINE AND TROPIC ACID.
  • 6. USES • IT IS USED TO TREAT PARKINSONISM • IN SMALL DOSES, IT IS C.N.S STIMULANT • AS A MYDRIATIC IN OPHTHALMOLOGY PRACTICE • AS AN ANTISPASMODIC • ATROPINE IS USED TO HELP REDUCE SALIVA, MUCUS, OR OTHER SECRETIONS IN YOUR AIRWAY DURING A SURGERY.
  • 7.
  • 8. 2.HOMOTROPINE • PROPERTIES • IT OCCURS AS COLORLESS CRYSTALS OR WHITE CRYSTALLINE POWDER. • IT IS ODORLESS AND HAS BITTER TASTE • FREELY SOLUBLE IN WATER • IN ACIDIC OR ALKALINE MEDIUM, IT IS HYDROLYZED TO GIVE TROPINE AND MANDELIC ACID.
  • 9.
  • 10. 3.BENZTROPINE • IT OCCURS AS WHITE CRYSTALLINE POWDER. • IT IS ODORLESS AND HAS BITTER TASTE • VERY SOLUBLE IN WATER. • FREELY SOLUBLE IN ALCOHOL • STABILITY AND STORAGE: • IT IS HYGROSCOPIC ,HENCE STORED IN TIGHTLY CLOSED CONTAINERS.
  • 11. • Uses : • Benztropine is used to treat symptoms of Parkinson's disease • helps decrease muscle stiffness, sweating, and the production of saliva, and helps improve walking ability in people with Parkinson's disease.
  • 12. 4.HYOSCINE • HYOSCINE, ALSO KNOWN AS SCOPOLAMINE • IT OCCURS AS COLORLESS CRYSTALS OR WHITE CRYSTALLINE POWDER. • IT IS ODORLESS
  • 13. USES
  • 15. PROPERTIES • IT OCCURS AS WHITE OR YELLOWISH WHITE POWDER. • IT IS ODORLESS AND HAS BITTER TASTE • IT IS SOLUBLE IN WATER. • IT IS SLIGHTLY HYGROSCOPIC • WHEN IT IS TREATED WITH SULPHURIC ACID, IT GIVES YELLOW SOLUTION • STABILITY AND STORAGE: • IT IS HYGROSCOPIC ,HENCE STORED IN TIGHTLY CLOSED CONTAINERS.
  • 16. USES