Weather is defined as the condition of the atmosphere at a particular time and place. Key factors that influence weather changes include temperature, wind, moisture, and precipitation. Insolation refers to the amount of sun energy reaching the Earth, and its angle is a measure of how high the sun is in the sky. As the angle of insolation increases, the intensity of sunlight increases due to being concentrated in a smaller area, while a decreasing angle spreads heat over a larger area. The angle and intensity of insolation varies across the Earth and is greatest near the equator and lowest at the poles, with the noon sun providing the maximum angle.
Seas and Oceans are blue beauties of the planet earth.
Oceans are vast body of saline water occupying the great depressions on the earth. The surface beneath the oceanic waters is characterized by a lot of relief features.
The structure, configuration and relief features of the oceans also vary from each other.On the basis of Bathymetry and other studies, the morphology of Ocean basins contains a lot of relief features. This module highlights many of those features.
Seas and Oceans are blue beauties of the planet earth.
Oceans are vast body of saline water occupying the great depressions on the earth. The surface beneath the oceanic waters is characterized by a lot of relief features.
The structure, configuration and relief features of the oceans also vary from each other.On the basis of Bathymetry and other studies, the morphology of Ocean basins contains a lot of relief features. This module highlights many of those features.
Oceanography is an interesting subject. Geological oceanography deals with a lot of unique aspects of the oceans including the ocean morphology and relief, continental margins, tectonic processes acting on the ocean bottoms, marine mineral resources, and the deep sea deposits. The subject also focuses on the never ending dynamic processes like ocean waters, ocean currents and their impacts with reference to space and time. Understanding the tectonic disposition and movement of crustal plates are an important part while studying the earth and atmospheric sciences, in general and oceanography, in particular. The continental margins and the deep ocean basins are the two major aspects to be understood in this subject. This lesson is on the characteristics of continental margins.
Seas and Oceans are dynamic ecosystems. Oceans are very vast bodies of water. Wind blowing on the surface of the ocean has the greatest effect on the movement of surface water. Vertical or horizontal movement of both surface and deep water masses happen in the world’s oceans. They are called as Ocean currents. Currents normally move in certain specific directions. Hence, they aid in the circulation of the moisture on Earth. Because ocean currents circulate water worldwide, they have a significant impact on the movement of energy and moisture between the oceans and the atmosphere. As a result, they are important to the world’s weather.
The reason for the occurrence of such a huge mass of water on the globe, is still a myth and reality. The reason goes back to the Origin of Earth itself. The exact mode of origin is not precisely known. Scientists assume, both Primary and secondary sources would have given rise to all both air and water on the earth. Two possible sources as internal source (or) external source have been proposed so far. Some of them are attributed towards the theories of origin of the earth.
Oceanography is an interesting subject. Geological oceanography deals with a lot of unique aspects of the oceans including the ocean morphology and relief, continental margins, tectonic processes acting on the ocean bottoms, marine mineral resources, and the deep sea deposits. The subject also focuses on the never ending dynamic processes like ocean waters, ocean currents and their impacts with reference to space and time. Understanding the tectonic disposition and movement of crustal plates are an important part while studying the earth and atmospheric sciences, in general and oceanography, in particular. The continental margins and the deep ocean basins are the two major aspects to be understood in this subject. This lesson is on the characteristics of continental margins.
Seas and Oceans are dynamic ecosystems. Oceans are very vast bodies of water. Wind blowing on the surface of the ocean has the greatest effect on the movement of surface water. Vertical or horizontal movement of both surface and deep water masses happen in the world’s oceans. They are called as Ocean currents. Currents normally move in certain specific directions. Hence, they aid in the circulation of the moisture on Earth. Because ocean currents circulate water worldwide, they have a significant impact on the movement of energy and moisture between the oceans and the atmosphere. As a result, they are important to the world’s weather.
The reason for the occurrence of such a huge mass of water on the globe, is still a myth and reality. The reason goes back to the Origin of Earth itself. The exact mode of origin is not precisely known. Scientists assume, both Primary and secondary sources would have given rise to all both air and water on the earth. Two possible sources as internal source (or) external source have been proposed so far. Some of them are attributed towards the theories of origin of the earth.
Climate is a long term condition happened in a specific place. While, weather is a short-term condition happened in a specific area and specific time. The factors affecting climate are latitude, altitude, topography, distance of bodies of water
An energy-efficient building creates comfortable living conditions inside the dwelling with the least possible amount of energy consumption maximizing efficiency in use of resources.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
2. Weather
• Weather it is the condition of the atmosphere
at a particular time and place .
3. What can cause the changes of
weather?
• Weather variables:
1) Temperature
2) Wind
3)Moisture
4)Precipitation
4. Insolation
• It is the amount of sun energy reaching the
Earth at a given time and place
5. What is the angle of insolation?
• a measure of how high the sun is in the sky
• measured from the horizon up to the position of
the sun
6. What happens as the angle increases or
decreases?
• As the angle of insolation increases, intensity
increases. (heat concentrated in smaller area.)
7. • As the angle of intensity decreases, heat is
spread out over a larger area.
8. Low angle: Less absorbed
High angle: More absorbed
• Intensity of insolation varies over the Earth because
of the curvature of the Earth.
Earth
9. Where is intensity the greatest and
lowest?
• Intensity greatest near
the Equator.
– Sun’s rays are direct
• Intensity low at the
poles
10. At what time is the angle and
intensity of insolation greatest?
•The noon sun has the greatest angle of insolation.
11. How to measure angle of insolation ?
• WE can measure ion angle of insolation
12. Why does the angle of insolation
change between midday and
evening?
The angle of insolation decreases because the
Earth’s rotation ,and the air temperature usually
decrease
