This document provides information on the anatomy and physiology of the pupil, including:
- The normal features of a pupil such as size, shape, number, location and color.
- The sphincter pupillae and dilator pupillae muscles that control pupil size and their innervation by the parasympathetic and sympathetic nervous systems.
- Pupillary reflexes including the light reflex, near reflex and darkness reflex and their neural pathways.
- Abnormal pupils including causes of anisocoria, leukocoria and variations in shape, size and location.
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anatomy of optic nerve and its blood supply and clinical corelation
Presentation Layout: optic nerve anatomy
Embryology of optic nerve
Introduction
Parts of optic nerve
Blood supply
Clinical significance
For Further Reading
Wolff’s Anatomy of the eye and orbit by Bron, Tripathi and Tripathi
Anatomy and Physiology of eye by A.K. Khurana 2nd edition
Comprehensive Ophthalmology by A.K. Khurana 5th edition
AAO- Fundamentals & Principles of Ophthalmology : sec 2
Walsh and Hoyt’s Clinical Ophthalmology
Internet
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Dear viewers Check Out my other piece of works at ❤❤❤ https://healthkura.com/eye-ppt/❤❤❤
anatomy of optic nerve and its blood supply and clinical corelation
Presentation Layout: optic nerve anatomy
Embryology of optic nerve
Introduction
Parts of optic nerve
Blood supply
Clinical significance
For Further Reading
Wolff’s Anatomy of the eye and orbit by Bron, Tripathi and Tripathi
Anatomy and Physiology of eye by A.K. Khurana 2nd edition
Comprehensive Ophthalmology by A.K. Khurana 5th edition
AAO- Fundamentals & Principles of Ophthalmology : sec 2
Walsh and Hoyt’s Clinical Ophthalmology
Internet
The lacrimal apparatus is the physiological system containing the orbital structures for tear production and drainage. It consists of: The lacrimal gland, which secretes the tears, and its excretory ducts, which convey the fluid to the surface of the human eye;it is a serous gland located in lacrimal fossa.
LIMBUS… • The limbus forms the border between the transparent cornea and opaque sclera, contains the pathways of aqueous humour outflow, and is the site of surgical incisions for cataract and glaucoma
2. Anatomical Limbus: Circumcorneal transitional zone of the conjunctivocorneal & corneoscleral junction Conjunctivo-corneal junction: • Bulbar conjunctiva is firmly adherent to underlying structures • Substantia propria of the conjunctiva stops here but its epithelium continues with that of the cornea. Sclero-corneal junction: • Transparent corneal lamellae become continuous • With the oblique, circular and opaque fibres of sclera
3. CONTINUE…. • In the area near limbus, the conjunctiva, tenon’s capsule & the episcleral tissue are fused into a dense tissue which is strongly adherent to corneo scleral junction.It is preferred site for obtaining a firm hold of the eyeball during ocular surgery. • The limbus is a common site for the occurrence of corneal epithelial neoplasm. • The Limbus contains radially oriented fibrovascular ridge known as the palisades of Vogt that may harbour a stem cell population. The palisades of Vogt are more common in the superior and inferior quadrants around the eye
The lacrimal apparatus is the physiological system containing the orbital structures for tear production and drainage. It consists of: The lacrimal gland, which secretes the tears, and its excretory ducts, which convey the fluid to the surface of the human eye;it is a serous gland located in lacrimal fossa.
LIMBUS… • The limbus forms the border between the transparent cornea and opaque sclera, contains the pathways of aqueous humour outflow, and is the site of surgical incisions for cataract and glaucoma
2. Anatomical Limbus: Circumcorneal transitional zone of the conjunctivocorneal & corneoscleral junction Conjunctivo-corneal junction: • Bulbar conjunctiva is firmly adherent to underlying structures • Substantia propria of the conjunctiva stops here but its epithelium continues with that of the cornea. Sclero-corneal junction: • Transparent corneal lamellae become continuous • With the oblique, circular and opaque fibres of sclera
3. CONTINUE…. • In the area near limbus, the conjunctiva, tenon’s capsule & the episcleral tissue are fused into a dense tissue which is strongly adherent to corneo scleral junction.It is preferred site for obtaining a firm hold of the eyeball during ocular surgery. • The limbus is a common site for the occurrence of corneal epithelial neoplasm. • The Limbus contains radially oriented fibrovascular ridge known as the palisades of Vogt that may harbour a stem cell population. The palisades of Vogt are more common in the superior and inferior quadrants around the eye
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journey
Anatomy of pupillary pathways
1. A N A T O MY O F
PUPI L L ARY
P A T H WA Y S
AND
A B N O R MA L
PUPI L S
Dr. RAVULA HASIKA
M.S.OPHTHALMOLOGY ( 1ST YR)
14-3-13
2. NORMAL PUPIL
An aperture present in the centre of the iris.
The size of the pupil determines the amount of light that
enters the eye.
The pupil size is controlled by the dilator and sphincter
muscles of the iris.
3. NUMBER :
• Normally there is one pupil in each eye.
• Rarely, there may be more than one pupil. This congenital anomaly is
called POLYCORIA.
LOCATION :
• Normally, pupil is placed almost in the centre (slightly nasal) of the iris.
• Rarely it may be congenitally eccentric ( CORECTOPIA )
4. SIZE :
• Normal pupil size varies from 2.5-4mm depending upon the illumination.
- Miotic pupils are less than 2mm
- Mydriatic pupils are greater than 7mm
• Diameter of the pupil size should be estimated in light, using either a
normal room light or a hand held transilluminator.
• It should then be assessed in darkness using the dimmest possible room
light and then during near stimulation using an accomodative target to
achieve maximum constriction of pupils.
5. Owing to the refraction of the corneal surface the image of the
pupil is magnified by about 1/8 (an actual diameter of 3.5mm
appears clinically to be 4mm).
If the eye is viewed through a box with glass sides filled with water
so that the corneal refraction is eliminated, the pupil appears in its
natural form and position.
6. The size depends on :
Age : Smaller in infants and elderly
Sleep : Smaller due to parasympathetic dominance
Psychology of individual – smaller in placid people
Refraction : Hyperopes have smaller pupils
Colour : Darker iris have smaller pupils
Isocoria : Normally the two pupils are equal in size. A slight (one-tenth
of a millimeter) anisocoria is present in a significant percentage of
normal pupil.
Anisocoria : Difference in pupillary diameter of 2 eyes of the same
individual by 0.3mm or more.
• The most common cause of anisocoria is central anisocoria (occurs in
20% of normal individuals) and is due to asymmetric supranuclear
inhibition of Edinger-Westphal nucleus.
• It can be easily distinguished from other abnormal pupils by normal
reactions to bright light, near response and lesser degree of inequality
8. SHAPE :
• Normal pupil is almost circular in shape
• D - shaped in iridodialysis.
• Festooned on dilatation if there is posterior synaechia.
• Pear shaped in cases of leukoma adherent.
• Key hole shaped in cases of sector iridectomy.
• Oval in cases of acute congestive glaucoma, severe brain disease.
• Tadpole shaped pupils results from sector dilatation observed
sometimes in Horner’s syndrome.
• Scallop shaped pupils due to sector atrophy of the iris are seen
sometimes in amyloidosis and neuropathy of short ciliary nerves.
12. COLOUR :
• Normally, it is greyish black.
• It becomes jet black in aphakia
• Greyish white: - cataract.
• Brown in brown nuclear cataract.
• Whitish: - Retinoblastoma and pseudogliomas .
• Yellowish: - vitreous abscess (endo and panophthalmitis).
• Greenish: - Acute congestive glaucoma.
• Reddish in albinism.
13. The term leukocoria means whitish pupil. Its cause are classified
into:
A. Glioma (the old name of retinoblastoma).
B. Pseudoglioma (any other cause of leukocoria) as:
- Congenital cataract.
- Cyclitic membrane.
- Retinopathy of prematurity (retrolental fibroplasia): it occurs due to
oxygen toxicity of premature infants.
- Retinal detachment.
- Endo and panophthalmitis.
- Toxocariasis
- Coat´s disease
- PHPV
- Coloboma
- Retinal dysplasia
- Norrie´s disease
14. Functions of the pupil :
1. It is the opening through which light enters the eye.
2. It regulates the amount of light entering the eye by miosis in light
and mydriasis in darkness.
3. It improves the visual acuity because it prevents the irregular
refraction by the periphery of the cornea and lens, and increases
the depth of focus.
4. It allows passage of aqueous humour from the posterior chamber to
the anterior chamber.
16. SPHINCTER AND DILATOR PUPILLAE
Muscle tissue of the iris consists of
A. Sphincter pupillae
B. Dilator pupillae
17. A. SPHINCTER PUPILLAE
It is a narrow circular band, 1 mm wide, situated close to the
pupillary aperture, surrounding the pupil on the posterior aspect of
iris.
18. It is supplied by the PARASYMPATHETIC PATHWAY as follows
19. 1. From the Edinger Westphal nucleus, the preganglionic fibres for
both the ciliary muscle and the pupil go through the oculomotor
nerve.
2. At the anterior end of the cavernous sinus where the oculomotor
nerve divides into superior and inferior divisions, the
pupillomotor fibres go through the inferior division, then through
the branch to the inferior oblique muscle and synapse at the
ciliary ganglion, lying at the apex of the muscle cone between
the optic nerve and the lateral rectus muscle
3. From here, about 6-10 small postganglionic short ciliary nerves
originate and penetrate the posterior sclera and supply the
ciliary muscle and the pupillary sphincter. The ratio of fibres
innervating the ciliary body to those supplying the pupil is about
30:1.
20.
21. The effect of parasympathetic innervation is to bring about
Pupillary Constriction.
Initially in the third cranial nerve, these fibres are located on the
dorsomedial surface of the nerve, where they are vulnerable to
compression by aneurysms at the junction of posterior
communicating artery and internal carotid artery, as well as by
post traumatic uncal herniation.
22. B. DILATOR PUPILLAE
This is contributed by radially disposed muscle fibres which extend
from ciliary body to pupillary margin
24. Efferent pathway for pupillary dilatation :
The First Order Neurons start from the posterolateral hypothalamus
and their axons run uncrossed through the reticular formations, lateral
pons and medulla and finally synapse at the intermediolateral cell
column of C8 to T2 (ciliospinal centre of budge).
The Second Order Preganglionic Axons travel along the ventral roots
of C8 to T2 and depart as the white rami, ascend into the sympathetic
chain, travel over the lung apex and synapse at the superior cervical
ganglion at the carotid bifurcation.
25.
26.
27. The Third Order Neurons from here send their post ganglionic
fibres.
The sudomotor fibres course along with the external carotid to
innervate the sweat glands of the face.
Other fibers ascend in the cranium as a plexus around the sheath of
the internal carotid artery. These fibers leave the carotid at its
cavernous portion, join the ophthalmic division of the trigeminal and
enter the ciliary ganglion but without synapsing there, they finally
reach the dilator muscle as long ciliary nerves.
Some of the oculosympathetic fibres innervate the Muller’s muscle
in the upper and lower lids.
The effect of sympathetic stimulation is Pupillary Dilatation.
31. 1. LIGHT REFLEX
When light is shone in one eye, both the pupils constrict.
• Direct light reflex : contraction of the ipsilateral pupil when the ipsilateral
eye is stimulated by light
• Consensual light reflex : contraction of the contralateral pupil when the
ipsilateral eye is stimulated by light.
In normal subjects, the direct and consensual reactions are almost,
always identical in time, course and magnitude.
If both pupils are illuminated simultaneously, the response summates, i.e.
the constriction of each pupil is greater than the constriction noted when
only one pupil is illuminated.
32.
33. PATHWAY OF LIGHT REFLEX
The light reflex is mediated by the retinal photoreceptors and
subserved by four neurones
1. First (sensory) connects each retina with both pretectal nuclei in the
midbrain at the level of the superior colliculi. Impulses originating from
the nasal retina are conducted by fibres which decussate in the
chiasm and pass up the opposite optic tract to terminate in the
contralateral pretectal nucleus. Impulses originating in the temporal
retina are conducted by uncrossed fibres (ipsilateral optic tract) which
terminate in the ipsilateral pretectal nucleus.
2. Second (internuncial) connects each pretectal nucleus to both
Edinger-Westphal nuclei. Thus a uniocular light stimulus evokes
bilateral and symmetrical pupillary constriction. Damage to
internuncial neurones is responsible for light-near dissociation in
neurosyphilis and pinealomas.
34.
35. 3. Third (pre-ganglionic motor) connects the Edinger-Westphal
nucleus to the ciliary ganglion. The parasympathetic fibres pass
through the oculomotor nerve, enter its inferior division and reach
the ciliary ganglion via the nerve to the inferior oblique muscle.
4. Fourth (post-ganglionic motor) leaves the ciliary ganglion and
passes in the short ciliary nerves to innervate the sphincter
pupillae. The ciliary ganglion is located within the muscle cone, just
behind the globe. It should be noted that, although the ciliary
ganglion serves as a conduit for other nerve fibers, only the
parasympathetic fibers synapse there.
36. Normally, there is a tonic inhibitory input from the
cerebral cortex to the Edinger - Westphal nucleus, and it
is a diminution of this input that results in pupillary
constriction during sleep.
37. 2. NEAR REFLEX
The near reflex, a synkinesis rather than a true reflex, is
activated when gaze is changed from a distant to a near
target.
It comprises Accommodation, Convergence And
Miosis.
Vision is not a prerequisite and there is no clinical
condition in which the light reflex is present but the near
response absent.
Although the fiinal pathways for the near and light
reflexes are identical (i.e. 3rd nerve, ciliary ganglion,
short ciliary nerves), the center for the near reflex is ill-
defined
38. There are probably two supranuclear influences: the
frontal and occipital lobes.
The midbrain centre for the Near Reflex is probably
located more ventrally than the pretectal nucleus and
this may explain why compressive lesions such as
pinealomas, preferentially involving the dorsal
internuncial neurones involved in the light reflex, spare
the near reflex fibres until later.
39. 3. DARKNESS REFLEX
Lighted environment Darkness
pupils dilate
2 causes for dilatation :
First is simply abolition of light reflex with consequent
relaxation of the sphincter pupillae.
Second is contraction of dilator pupillae supplied by
sympathetic nervous system.
40. The pathways involved in dark reflex are presumably the
same as those of light reflex, since the redilatation at the
end of long light stimulation also involves both relaxation of
the sphincter pupillae and contraction of dilator pupillae.
41. 4. PSYCHOSENSORY REFLEXES
It refers to dilatation of pupil in response to sensory and
psychic stimuli.
The psychosensory reflexes are not seen in a newborn, but
appear in the first few days of life, developing fully by the age
of six months.
Their mechanism is very complex and their pathways have
still not been elucidated.
In general, it is believed that the mechanism of
psychosensory reflexes is a cortical one and apparently the
pupillary dilatation in these results from two components - a
sympathetic discharge to the dilator pupillae and an inhibition
of the parasympathetic discharge to the sphincter pupillae.
42. Pathway Of Sympathetic Discharge
It is believed that somehow sensations are conveyed to
the hypothalamus, from where the impulses descend to
intermediolateral cell column of the cervical and thoracic
parts of the spinal cord.
However, the Ciliospinal Reflex ( dilatation of pupil in
response to painful stimuli in the neck region ) has been
reported to be elicited from patients with damaged
sympathetic pathways in brainstem and even from patients
with cervical cord transections; indicating thereby that at
least sympathetic discharge related to some of the
psychosensory reflexes is mediated at the level of spinal
cord.
43. THE LID – CLOSURE REFLEX
It is a non-specific term, (since the lid-closure may be accompanied
by either pupillary contraction or pupillary dilatation), and hence
should be used sparingly.
1. Constriction of pupil associated with blinking :
• Following a blink, either voluntary or spontaneous, both pupils
constrict transiently.
• It has been observed that such a reflex does not occur in darkness,
so it has been assumed that perhaps this lid-closure reflex is
nothing but simply a type of darkness reflex.
44. 2. Homolateral pupillary constriction associated with closure of the
lid which is evoked if the lid is held open whilst the effort of closure is
made, is another entity which has also been referred to as lid-closure
reflex.
• The effect is not large, however, if the subject is instructed to keep his
gaze fixed on a distant object, while trying to close the eyes, this
reaction does not occur.
• From this, it has been concluded that perhaps the pupillary
contraction reported with this reflex is the result of an unconcious
attempt at near gaze during the lid closure effect.
3. Pupillary dilatation associated with lid-closure on touching the
cornea (oculopupillary reflex):
• It has been considered by some as lid-closure reflex.
• However, it has also been reported that it is simply a type of
psychosensory reflex.
45. P H A R MA C O L O G Y O F
T HE PUPI L
MI O T I C S
MY D R I A T I C S
46. MIOTICS
The drugs which constrict the pupil are known as miotics.
MIOTICS
PARASYMPATHOMIMETIC
SYMPATHOLYTICS
(SPHINCTER
(DILATOR INHIBITORS)
STIMULATORS)
47.
48. 1. PARASYMPATHOMIMETIC DRUGS
Also called as cholinergic drugs – either imitate or potentiate the
effects of acetylcholine.
Depending upon the mode of action –
Direct acting or agonists : e.g: pilocarpine, structurally similar to Ach
and act directly on muscarinic receptors on muscle membrane
Indirect acting parasympathomimetics or cholinesterase
inhibitors: act indirectly by destroying the enzyme cholinesterase, thereby
sparing the naturally acting Ach for its actions. 2 subgroups :
- reversible cholinesterase inhibitors (e.g physostigmine)
- irreversible cholinesterase inhibitors (e.g ecothiophate
iodide, demecarium, DFP )
Dual action parasympathomimetics which acts as both
49.
50. 2. SYMPATHOLYTIC DRUGS
Dilator pupillae can be inhibited either by preventing transmitter release
at the NM Junction or by preventing the transmitter from affecting the
dilator fibres.
α- adrenergic blocker drugs such as
thymoxamine, phenoxybenzamine, dibenamine & tolazoline produce
miosis by preventing dilator contraction.
These drugs occupy α- receptor sites on the iris dilator muscle.
Guane-thidine is the commonly used sympatholytic drug.
It disrupts NE release from the nerve endings and depletes NE stores
Continued topical administration of this drug to the eye causes Horner’s
syndrome characterized by ptosis, miosis and supersensitivity to
adrenergic drugs.
51. Other Miotics
Histamine – acts as protoplasmic irritant and affects the sphincter
fibres directly. It even constricts the pupil of a thoroughly atropinized
eye.
Morphine causes miosis by cutting off cortical inhibition of the
Edinger-Westphal Nucleus
53. 1. SYMPATHOMIMETIC MYDRIATICS
(DILATOR STIMULATORS)
At the neuroeffector junction of the dilator pupillae, NE is stored in
vesicles at the presynaptic terminal and is constantly released.
After the release, some of the NE is taken up into the presynaptic
vesicle, some is metabolized & destroyed by monoamine oxidase, a
small portion is washed away & the last portion may be degraded by
the enzyme catechol-O-methyl transferase.
Sympathomimetics increase the dilator activity by any of the three
ways :
1. Increasing NE release
2. Preventing its reuptake by presynaptic vesicle, or
3. Directly stimulating the dilator fibres.
54.
55. Adrenaline (epinephrine) – acts directly on the α-receptors on the
dilator pupillae, produces dilation after instillation of four drops of 1
in 1000 solution. Instillation is repeated every 5 min. However
topically applied epinephrine is not very effective in normal
eyes, because it is readily taken up or inactivated. This makes it
useful in testing for certain denervation syndromes in which dilator
becomes hypersensitive.
Phenylephrine – synthetic analog of epinephrine. It stimulates the
normal dilator, when used in fairly high concentration (5%-10%).
Hydroxyamphetamine and ephedrine – cause NE to be rapidly
released from peripheral nerve terminals – mydriasis of short
duration.
Cocaine – Local anaesthetic – prevents the reuptake of NE at the
presynaptic terminal. Thus NE released from the nerve remains in
the synaptic cleft and activates the dilator fibres.
Cociane and hydroxyamphetamine are, therefore, ineffective
and adrenaline remains effective when the sympathetic nerve
is paralyzed.
56. 2. PARASYMPATHOLYTIC MYDRIATICS
These drugs compete with Ach at the myoneural junction and thus
cause mydriasis by blocking sphincter activity.
Atropine - strongest mydriatic which completely paralyses the
sphincter pupillae and ciliary muscle. Used as 1% drops or oint.
Causes complete dilatation in 30-40 mins and cycloplegia in about
2 hours. Its effect persist for a week or more.
Homatropine (2% drops) – acts more quickly than atropine.
Causes cycloplegia and mydriasis in about 45 mins to 1 hr. Its
effect passes completely in about 48 hrs.
Cyclopentolate (1% drops) – short acting cycloplegic. Causes
mydriasis and cycloplegia in about 1 hr and effect lasts for 6-12
hrs.
Tropicamide (1%) – quick and short acting.
58. AFFERANT PATHWAY DEFECTS
TOTAL AFFERENT PATHWAY DEFECT (TAPD) OR
AMAUROTIC PUPIL
Caused by a complete optic nerve or retinal lesion leading to total
blindness on the affected side.
Characterized by the following :
The involved eye is completely blind (i.e no light perception)
Absence of direct light reflex on the affected side and absence of
consenual light reflex on the normal side.
When the normal eye is stimulated, both pupils react normally.
In diffuse illumination, both pupils are equal in size.
The near reflex is normal in both eyes.
60. RELATIVE AFFERENT PATHWAY DEFECT (RAPD) OR
MARCUS GUNN PUPIL
It is the paradoxical response of a pupil to light in the presence
of a relative afferent pathway defect (RAPD).
Caused by an incomplete optic nerve lesion or a severe retinal
disease.
It is best tested by ‘swinging flashlight test’
61. Swinging Flashlight Test
To perform this test, a bright flashlight is shone on to one
pupil and constriction is noted. Then the flashlight is quickly
moved to the contralateral pupil and response is noted.
This swinging to and fro of flashlight is repeated several
times while observing the pupillary response.
Normally, both pupils constrict equally and the pupil to which
light is transferred remains tightly consrticted.
In the presence of RAPD in one eye, the affected pupil will
dilate (paradoxical response) when the flashlight is moved
from the normal eye to the abnormal eye.
This response is called Marcus Gunn Pupil.
It is the earliest indication of optic nerve disease even in the
presence of a normal visual acuity.
62.
63. There are many different methods to measure an RAPD in
clinic. A common method is using a qualitative 1-4+ grading
scale.
Grading Scale: RAPD
Grade 1+: A weak initial pupillary constriction followed by
greater redilation
Grade 2+: An initial pupillary stall followed by greater
redilation
Grade 3+: An immediate pupillary dilation
Grade 4+: No reaction to light – Amaurotic pupil
64. EFFERANT PUPILLARY DEFECTS
Characterized by absence of both direct and consensual light reflex
on the affected side (say right eye) and presence of both direct and
consensual light reflex on the normal side (i.e left eye).
On the affected side, near reflex is also absent and pupils remains
fixed and dilated.
65. EFFERENT PUPILLARY DEFECT ETIOLOGIES:
Iris sphincter damage from trauma
Tonic pupil (Adie’s pupil)
Third-nerve palsy
Pharmacologic agents:
Unilateral use of dilating drops
Atropine, cyclopentolate, homatropine, scopolamine, tropicamide,
phenylephrine.
Handling/administrating of sympathomimetic or anticholinergic
agents :
Sympathomimetic agents:
OTC cold agents containing ephedrine
Illegal street drugs: cocaine, amphetamines, methamphetamine
Dietary supplements: ephedra alkaloids
Very popular illicit designer drugs: 3, 4-methylenedioxy methamphetamine
[MDMA, ”ecstasy”]
66. Anticholinergic agents including scopolamine patch.
Other drugs causing mydriasis:
LSD (lysergic acid diethylamide)
Alcohol
Marijuana
Mescaline
Jimson weed (Datura stramonium) containing belladonna alkaloids
(active ingredients are atropine and scopolamine). Some brands of eye
make-up contain belladonna alkaloids.
Traumatic iritis, uveitis, angle-closure glaucoma, pseudoexofoliation
syndrome and recent eye surgery
Benign episodic unilateral mydriasis
67. COMMON CAUSES OF EFFERENT PUPILLARY
DEFECTS ARE :
1. Brainstem lesions at the level of the superior colliculus and red
nucleus. Lesions here are often accompanied by long tract signs.
2. Fascicular third nerve lesions. Compressive third nerve lesions
classically have pupillary involvement, although an efferent defect is
not pathognomic of a compressive lesion, as 20% of microvascular
palsies will affect the pupillary fibres. An efferent pupillary defect may
be a false localizing sign when raised intracranial pressure causes
uncal herniation and compression of third nerve.
3. Lesions of the ciliary ganglion or short ciliary nerves.
4. Iris damage 2˚ to previous surgery or grossly elevated IOP.
5. Drugs: inadvertent exposure to mydriatic agent such as atropine is a
common cause of fixed dilated pupil. Pilocarpine 1% will constrict a
dilated pupil 2˚ to a neurological lesion; it ll have no effect on dilated
pupil caused by a mydriatic agent.
68. TONIC PUPIL
Damage to the ciliary ganglion or short ciliary nerves
produces tonic pupil which is characterized by following :
Reaction to light is absent and to near reflex is very slow
and tonic.
Accommodative paresis.
Cholinergic supersensitivity of the denervated muscle
(i.e constricts with 0.125% pilocarpine, while normal
pupil does not)
The affected pupil is larger.
69. Causes Of Tonic Pupil :
A. Local tonic pupil
• Viral ciliary ganglionitis (e.g Herpes zoster)
• Orbital or choroidal trauma or tumours
• Blunt trauma to the globe may injure branches of short ciliary
nerves at the iris root.
B. Neuropathic tonic pupil
• Part of picture of peripheral neuropathy of diabetes, alcoholism.
C. Idiopathic tonic pupil with benign areflexia (Adie’s tonic pupil)
70. The Adie’s Tonic Pupil
Adie’s tonic pupil is caused by denervation of the postganglionic
supply of the sphincter pupillae and ciliary muscle of unknown
etiology.
Its characteristic features are :
It is usually unilateral (in 80%)
It typically effects healthy young women more often than men.
It may be assoc. with absent knee jerk.
The affected pupil is large and irregular (anisocoria)
The light reflex is absent or slow.
Near reflex is slow and tonic.
Accommodative paresis.
There may be assoc. mild regional impairment of corneal
sensations.
71.
72. Pharmacological testing helps in the diagnosis of Adie’s tonic pupil.
In 80-90% of patients with Adie’s tonic pupil, 0.125% pilocarpine
or 2.5% methacholine causes denervation supersensitivity. The
concentration is too weak to cause constriction of the normal pupil.
Pharmacologic testing steps:
0.125% pilocarpine (prepared by diluting one part 1% pilocarpine with 7
parts balanced salt solution)
Patient is fixating at a distance to prevent near accommodative
reflex. Measure the pupil size of each eye.
Instill a drop of 0.125 pilocarpine ophthalmic solution in each eye, and
recheck the pupils in 10-15 minutes.
A positive test result – The tonic pupil constricts significantly more than the
contralateral pupil
73. Right tonic
pupil: dilated pupil
with minimal reaction
to light (above); the
right pupil
constriction
(denervation
supersensitivity) and
no left pupil
constriction with
0.125 % pilocarpine.
74. PUPILLARY LIGHT - NEAR DISSOCIATION
The term pupillary light-near dissociation refers to any situation in
which the pupillary near reaction is present and the light reaction is
absent.
Bilateral light-near
dissociation caused by
the dorsal midbrain
syndrome: moderately
dilated pupils (above)
with brisk near reflex
(below).
CAUSES OF LIGHT – NEAR DISSOCIATION
Of course Argyll Robertson pupil is one of the important causes of light-
near dissociation; but it is not synonymous with the condition.
75. Causes Of Light Near Dissociation
Bilateral complete afferent pathway defect, e.g.in B/L old total
retinal detachment or B/L optic atrophy, the light reflex is absent
but near reflex is present.
Lesions in the midbrain : the light reflex path can be interrupted in
the pretectal area without damaging the more ventrally located
input for the near reflex. Causes incl. tumors (e.g pinealomas
manifesting as Parinaud’s syndrome), vascular lesions,
encephalitis and demyelinization. Neurosyphilis causing ARP also
causes damage in the area of pretectum to the intercalated
neuron.
Third nerve palsy with aberrant regeneration of medial rectus
innervation into the sphincter innervation pathway : pseudo-Argyll
Robertson’s Pupil.
Ciliary ganglion or short ciliary nerve lesions with aberrant
regeneration of accommodation impulse fibres into sphincter
pupillae.
76.
77.
78. Argyll Robertson Pupil ( ARP )
Argyll Robertson Pupil ( ARP ) – 1869 –in pts with Tabes Dorsalis.
Bilateral, miotic pupil with irregular margins and are asymmetrical.
Response to light and near reflex :
Light reflex is absent & accommodation is retained. The lesion is at
the pretectal area. Commonly seen in tertiary neurosyphilis
especially in Tabes.
Other causes include :
- Diabetes
- Wernicke’s encephalopathy
- Encephalitis,
- Midbrain tumours
- Hereditary neuropathies
79. The features of ARP are :
Small pupils < 2 mm
Often irregular
Near response is brisk and normal
Light reflex is absent
Iris atrophy is frequent with iris showing transillumination defects
and poor dilatation with mydriatics
Visual acuity is usually normal
82. HORNER’S SYNDROME
( OCULOSYMPATHETIC PARESIS )
It is of three types :
CENTRAL PREGANGLIONIC POSTGANGLIONIC
LESION :superior
LESION : C8-T2 to
LESION : cervical ganglion to ICA
superior cervical
hypothalamus to C8-T2 to cavernous sinus to
ganglion
V1
CAUSES: pancoast CAUSES :ICA
CAUSES : brainstem & tumour/carotid and dissection, cavernous
spinal cord/ aortic aneurysm & sinus mass,
vascular/demyelinating/ dissection/neck lesions- nasopharyngeal tumor,
tumors/syringomyelia glands,trauma & post otitis media, cluster
surgical headache
83. CLINICAL FEATURES OF HORNER’S SYNDROME
Ptosis – paralysis of muller muscle of upper eyelid ( usually 1-2mm )
Upside down ptosis – weakness of the inferior tarsal muscle.
Miosis – accentuated in dim light
Pupillary reactions are normal to light and near
Dilatation lag
Facial anhydrosis – when the lesion is below the superior cervical
ganglion
Heterochromia irides – seen in congenital Horner’s syndrome – the
pigment of iris stroma fail to develop
84.
85.
86.
87. LOCALIZATION OF HORNER’S SYNDROME
CENTRAL HORNER’S SYNDROME
• Assoc. with brain stem signs, signs of cervical cord disease or signs
of syringomyelia
PREGANGLIONIC HORNER’S SYNDROME
• Lung or breast malignancies that has spread to thoracic outlet
• Facial anhydrosis
• Brachial plexus palsies may be present
POSTGANGLIONIC HORNER’S SYNDROME
• Ipsilateral vascular headache
• h/o head injury, intraaural or retroparotid trauma
• Tumor of middle cranial fossa or cavernous sinus
88. PHARMACOLOGICAL TESTS
1. COCAINE 4% :
• Rationale- cocaine blocks NE uptake at postganglionic sympathetic
nerve endings
• Result – Normal pupil will dilate but Horner pupil will not because in
Horner’s syndrome there is no NE being secreted. Therefore, a
post cocaine anisocoria of >0.8mm in a dimly lit room is significant.
C ocaine
C ontinues
C onstriction
in horners syndrome
Right Horner’s syndrome: the right pupil failed to
dilate while the left eye dilated to 7 mm with 10 %
cocaine.
89. 2. HYDROXYAMPHETAMINE 1% :
• Rationale : hydroxyamphetamine potentiates the release of NE from
post ganglionic nerve endings
• Result : in the preganglionic lesion, both pupils will dilate. In
postganglionic lesion, Horner’s pupil continues to constrict.
Left Horner’s syndrome with a postganglionic (third-neuron
order) lesion: the left pupil failed to dilated white the right eye
dilated with 1% hydroxyamphetamine.
90.
91. 3. ADRENALINE 0.1% :
• Rationale : the principle is based on denervation
hypersensitivity to adrenergic neurotransmittors
• Result : in preganglionic lesion, neither pupil will dilate
because adrenaline is rapidly destroyed by MAO. In
postganglionic lesion, Horner’s syndrome will dilate and
ptosis will be relieved because adrenaline is not broken down
due to absence of MAO.
4. APRACLONIDINE 0.5% OR 1% :
• Rationale – α1 receptors are upregulated in the denervated
dilator pupillae
• Result - Horner pupil will dilate but the normal pupil is
uneffected.
93. Right physiological anisocoria :
In dim light, right pupil is larger than the left.
In bright light, both pupils constrict normally.
After instillation of 4%cocaine to both eyes, both pupils dilate.
94. Right pharmacological mydriasis :
Right mydriasis in dim illumination.
In bright light the right pupil does not constrict.
On accommodation, the right pupil does not constrict.
After instillation of pilocarpine 0.1% into BE neither pupil constricts.
After instillation of pilocarpine 1% into BE, Rt pupil does not constrict, but
the left does.
95. In dim light
In bright light
On accommodation
Pilocarpine0.1%
Pilocarpine1%
96. Tectal (dorsal midbrain) pupils :
In dim light there is B/L mydriasis which may be asymmetrical.
In bright light, neither pupil constricts.
On accommodation, both pupils constrict normally.
After instillation of pilocarpine 0.1% to BE, neither pupil constrict.
97. In dim light
In bright light
On accommodation
Pilocarpine0.1%
98. Right episodic mydriasis :
In dim light the right pupil is larger than the left.
In bright light the right pupil does not constrict.
On accommodation, the right pupil does not constrict.
Instillation of 0.1%pilocarpine to BE fails to constrict either pupil.
Instillation of 1% pilocarpine to BE induces B/L miosis.
After 24 hrs, both pupils are equal.
99. In dim light
In bright light
On accommodation
Pilocarpine0.1%
Pilocarpine1%
After 24 hrs