This document contains 53 cases of osteoid osteoma and osteoblastoma. Case 1-50 cover osteoid osteoma, with the typical presentation of a painful nidus most commonly in long bones visualized on CT or bone scan. Cases 51-94 cover osteoblastoma, a larger variant of osteoid osteoma most often in the spine. Later cases demonstrate recurrence, progression to aneurysmal bone cyst, and treatment with curettage or resection.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
In this presentation, radiological characteristics of different bone tumors has been explained in detail including MRI, CT scan, Bone scan, and plain radiography.
In this presentation, radiological characteristics of different bone tumors has been explained in detail including MRI, CT scan, Bone scan, and plain radiography.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
3. Osteoid Osteoma
The osteoid osteoma is the most common osteoid-forming tu
seen in the skeletal system, accounting for 10% of all benign
bone tumors. It is more common in males than females with the
peak incidence in the second decade of life. The lesions produc
symptoms of dull, aching pain that is more severe at night. The
pain is relieved with anti-inflammatory medication such as
aspirin or non-steroidal anti-inflammatory drugs (NSAID)
that inhibit the high concentration of prostaglandins found in
the nidus of the osteoid osteoma. The lesions occur typically in
the cortical structures of long bones such as the femur or tibia
but can also be found in the small bones of the ankle, wrist or
vertebral column. The lesion is characteristic for its dense,
sclerotic response in the cortical bone resulting in a fusiform
enlargement on the surface of the cortex as a response to the
small inflammatory nidus or granuloma (measuring up to one
4. centimeter in diameter) in the central area of the sclerotic
response. If the lesion is located in a central medullary area,
such as the metaphysis or on the very superficial surface of a
bone, the sclerotic response is less severe. If the nidus is
located close to or within a joint structure, as in the femoral
neck area, there will be a significant inflammatory synovitis
in the adjacent joint that gives the clinical appearance of a
pyarthrosis. In the spine, the lesions are usually located in the
posterior elements of the spine such as the laminae or pedicles
The lumbar spine is the most common location followed second
by the dorsal spine. Atypical secondary painful scoliosis will
develop with the convexity seen on the side opposite the
inflammatory lesion.
The two most significant diagnostic imaging studies are a CT
scan through the nidus area to identify its anatomic location and
bone isotope scan which is invariably positive, especially in a
symptomatic lesion. It is the current feeling that the osteoid
.
5. osteoma is a true benign neoplasm of bone in which a com-
bination of osteoclastic and osteoblastic activity are seen.
There are no inflammatory cells such as lymphocytes or
plasma cells as would be seen in a Brodie’s abscess. Non-
steroidal anti-inflammatory medications such as prostaglandin
inhibitors can be very effective in controlling the disabling
symptoms and helping the patient get thru a period of one or
two years during which time the lesion will typically involute
into a painless lesion that does not require surgery. However,
if the patient is unable to live with the pain during this time,
a surgical approach is indicated. Following exposure of the
lesion, a high speed burr is used to burr into the inflammatory
bone that is characterized by a pinkish hyperemia. When the
nidus is found, a small curette is used to core the inflammatory
nidus for pathological diagnosis and the cavity of the nidus
is burred an additional 2 or 3 mm which usually results in a very
dramatic relief of symptoms and a permanent cure from the
6. disease process. It is not necessary to remove the large
dense sclerotic bone surrounding the nidus; doing so could
result in a pathologic fracture following surgery. In the spine,
a simple laminectomy is frequently carried out. If the lesion is
located in the pedicle a simple burring into the pedicle will
relieve the patient of the inflammatory pain.
More recently, relatively non-invasive techniques have been
tried to remove the nidus of the osteoid osteoma by means of a
CT guided burr placed through a protective trocar or by place-
ment of a heat-producing radio frequency probe that, when
properly positioned, can destroy the nidus through thermal
coagulation. These techniques are particularly valuable for dee
seated lesions located in the acetabulum. For lesions located in
the pedicle of a vertebra one must be careful not to damage an
adjacent spinal root or spinal cord.
131. Osteoblastoma
The so-called osteoblastoma is considered by most to be a la
or giant form of the similar clinical entity known as the osteoid
osteoma. As with the osteoid osteoma, it is found in children and
young adults, more often in males than females. It is less comm
than the osteoid osteoma, representing approximately 1% of all
bone tumors. It is found mostly in metaphyseal areas of long bo
and in the posterolateral elements of the axial skeleton where
nearly 50% of the lesions are identified. Radiographically these
lesions are more osteolytic than the osteoid osteoma and have
central nidus that measures more than 1.5 cm in diameter with
less reactive sclerosis seen at the periphery than an osteoid
osteoma. It is not unusual for an aneurysmal component to be
associated with the osteoblastoma, similar to the reaction seen
adjacent to chondroblastomas and giant cell tumors. The micro-
scopic appearance of the nidus material is almost identical to
132. that of the osteoid osteoma and under higher power cannot be
differentiated by even the most competent pathologists. The
major concern is a microscopic appearance similar to an osteo-
sarcoma and, for this reason, multiple samples must be evaluate
in order to establish the correct diagnosis in cases where these
lesions arise from the metaphyseal areas of long bone.
In the spinal area, the osteoblastoma is typically located in th
posterolateral elements where it can cause problems with spinal
cord or nerve root compression that may require aggressive
surgical decompression and even spinal stabilization. On occasi
an osteoblastoma will spontaneously convert into an osteo-
sacoma, especially if it has been treated with radiation therapy.
The primary treatment for the osteoblastoma is a surgical one w
a fairly aggressive curettement of the lesion. There is no particul
reason to take wide margins because the recurrence rate is quite
low and in some cases the lesions resolve spontaneously with o
any surgery at all, similar to what occurs with osteoid osteomas.
133. A variant of the osteoblastoma, the so-called aggressive or
“malignant” osteoblastoma, is a clinical entity halfway between th
classic benign osteoblastoma and a full blown malignant osteo-
sarcoma. This “malignant” osteoblastoma appears and behaves
clinically at the local site like an osteosarcoma but has no potenti
to metastasize to distant parts. In this situation, local treatment
must be more aggressive and probably would require a wide loca
resection to avoid a local recurrence because radiation therapy o
even systemic chemotherapy is not effective for this aggressive b
benign entity.
338. Osteofibrous Dysplasia
Osteofibrous dysplasia is a rare condition occurring
in children less than 10 years of age. This benign lesion
has radiographic and microscopic features similar to fibrous
dysplasia of the tibia, the main difference being the presence
of more heavily ossified tissue at the periphery of the lesion
giving it a soap-bubbly appearance on x-ray. Microscopically
it has a similar “alphabet-soup” metablastic bone appearance
in a benign fibrous tissue stroma but with the additional feature
of heavy osteoblastic rimming of the trabeculae not seen in
fibrous dysplasia. It typically arises from the anterior cortex of
the tibia at mid shaft and causes a progressive anterior bowing
of the tibia over time, creating a cosmetic deformity associated
with pain of a dull, aching nature. The radiographic appearance
Is very similar to and impossible to separate from that of the
Malignant adamantinoma that also affects the tibia in children
339. and, for this reason, a biopsy must be performed to rule out the
malignant possibility. Occasionally osteofibrous dysplasia of the
tibia can progress gradually into a well-differentiated form
of the adamantinoma, which will have the microscopic
features of both osteofibrous dysplasia and adamantinoma
in the same lesion. As far as treatment is concerned, early
surgical debriedment and bone grafting before age 15 years
results in a high local recurrence rate and thus should be
discouraged until the child reaches full bone maturity at which
time a definitive debriedment and bone grafting procedure
can be performed without significant risk of recurrence. This
lesion occurs bilaterally in a very small percentage of cases
and can also involve the fibula on the same side. This process
in newborns appears to be more osteolytic and destructive in
nature.
364. Ossifying Fibroma of Jawbone
Ossifying fibroma of jawbone is a benign condition similar to
osteofibrous dysplasia of the tibia in that histologically they are
almost identical. It is also a condition that is related to fibrous
dysplasia, which can have a very similar radiographic appearan
but in the case of fibrous dysplasia of jawbone osteoblastic
rimming of the trabecular bone is not seen under microscopic
evaluation. As with fibrous dysplasia, this condition is found in
children and is almost always an asymptomatic process resultin
in cosmetic deformation of the maxilla or mandible, usually on
one side but can be bilateral. The condition can result in
significant malocclusion of the teeth because of deformation
of the subadjacent alveolar ridge or maxillary structures. It also
can create problems with normal drainage from the air sinuses i
the maxilla that can lead to infection requiring surgical drainage
Most of the surgical treatment for this condition is for cosmetic
deformity.