Volume 17
Chondroid tumors (soft tissue)
  Synovial chondromatosis---------Case 364-370 & 1243-5
  Juxtaarticular chondroma---------Case 371-377 & 1246-7
  2ndary synovial chondromatosis-Case 378-382 & 1248
  Myxoid chondrosarcoma----------Case 383-385
Epithelioid sarcoma------------------Case 386-389
Soft tissue Ewing’s sarcoma--------Case 390-392
Clear cell sarcoma--------------------Case 393-394
Myositis ossificans-------------------Case 395-405
Pigmented villonodular synovitis---Case 406-416 & 1249
Intramuscular myxoma---------------Case 1258
Ganglion cyst--------------------------Case 1259-60
Soft tissue lympoma------------------Case 1261
Metastatic CA to soft tissue---------Case 1262-63
Chondroid Tumors
   (soft tissue)
Synovial
Chondromatosis
Synovial Chondromatosis
    Synovial chondromatosis is a rare dysplasia seen in younger
patients. It is associated with metaplastic cartilage within the
synovial lining of major joints such as the hip, knee, shoulder and
elbow. It is twice as common in males as females and usually
occurs in patients in the 20-40 age group. It is a monarticular
disease that presents with symptoms of crepitation in the affected
joint with mild, intermittent effusion sometimes associated with
pain. Because of chronic irritation to the joint and damage to the
articular cartilage, osteoarthritis is an ultimate problem with this
disease and can lead to a total joint replacement at a later age. In
rare instances this condition can mutate into a secondary chondro-
sarcoma, usually around the hip or knee joint but seldom in the
shoulder area. This usually occurs in the later years of life.
    In the early stages before the cartilage becomes calcified, the
synovial chondromatosis may be difficult to pick up on routine
radiographic examination. As time passes, the cartilage begins
to calcify in a typical chondroid pattern that suggests the diagnosis
of a chondroid tumor in or about a major joint. With excessive
proliferation, the cartilage can extrude out of the joint into adjacent
soft tissue, similar to what occurs with pigmented villonodular
synovitis. As the disease progresses, it is not unusual to see
enchondral ossification occurring within the cartilage when it is
still attached to the synovial lining and has access to a blood supply.
Multiple loose bodies are common with this disease and can run as
high as 200 pellets within a major joint that sometimes aggregrate
into a large mass that has the appearance of a chondrosarcoma.
    Treatment consists of a surgical resection of the loose bodies as
well as a subtotal synovectomy of the tissue that produces the loose
bodies. Multiple surgical procedures may be required because of a
high recurrence rate. As in PVNS, it is not unusual to see a solitary
focus of synovial chondromatosis with the remaining synovial
lining being normal in appearance with only a solitary mass of
cartilage attached to the synovial lining. This localized nodular form
is more common about the hip, knee and ankle area. It is very
common to find loose bodies in a major arthritic joint in older
patients secondary to osteoarthritis where the joint cartilage is
broken away from the joint surface and than becomes reattached
to the synovial lining and gives the pseudo-appearance of primary
synovial chondromatosis when, in fact, the primary etiology in
this so-called secondary form is degenerative osteoarthritis. The
secondary form is seen in patients past the age of 50 years, where-
as the primary dysplastic form arising from the synovial lining
is seen during the first three to four decades of life.
CLASSIC Case #364




33 year male with synovial chondromatoasis of shoulder
Sagittal T-2 MRI showing multiple calcified cartilage bodies
Coronal T-2 MRI
showing loose bodies
Surgical exposure showing loose bodies
Loose bodies and synovial lining following surgery
Cartilaginous bodies arising from synovial lining
Cartilaginous body formation in synovial villus
Case #365




26 year male with
synovial chondromatosis
knee joint
AP x-ray
Gross appearance of synovial chondromatosis
Microscopic evidence of cartilage elements in synovium
Case #366




   28 year female with synovial chondromatosis knee
Another view
Photomic showing cartilage in synovial lining
Case #366.1




63 year female with long history of synovial chondromatosis
Sag T-2




Sag Gad
Cor T-2   Axial Gad
Case #366.2                      Synovial chondromatosis




    42 year female with grinding sensations in knee for years
Case #367




  38 year male with synovial chondromatosis left hip
Frog leg lateral
Coronal T-2 MRI
Sagittal T-2 MRI cut
showing loose bodies
Surgical removal of cartilage bodies
Photo of largest cartilage body
Case #368




   24 year female with large cartilaginous pelvic mass
    arising from synovial chondromatosis of left hip
tumor
  tumor




Close up of deformed femoral neck
tumor



        Note deformity of medial femoral neck
femoral N




Exposure of large pelvic tumor by removal ant pubic ramus
pubic groove




Resected cartilage masses and loose hip joint bodies
Cut specimen of one mass formed from compressed pellets
Loose bodies from hip joint
cartilage




Photomic of cartilage forming in synovial lining
Post op x-ray showing ramus surgical defect
9 years later with DOA requiring THA
Case #369




59 year male with
synovial chondromatosis
right hip for 20 years
5 years later with 2ndary
chondrosarcoma in
femoral neck
Frog leg lateral showing chondrosarcoma
Femoral head & neck specimen from THA showing
       chondrosarcoma in lower neck area
chondrosarcoma




Synovectomy specimen obtained at time if THA
Photomic of chondrosarcoma
1 yr later we see recurrent tumor requiring hemipelvectomy
Case #370




50 year female with
25 year history of
synovial chondromatosis
Coronal T-2 MRI several years later with 2ndary chondrosarc
Case #370.1                  Synovial chondromatosis




29 yr female with grinding sensation in elbow for years without inj.
Dedifferentiated
Case #370.1
                   Cor T-1                  T-2     chondrosarcoma




60 yr male with swollen knee for years with recent increase in size
Cor T-2   Gad
Sag T-2   Gad   T-2
Axial T-2




Gad
Case #1243




20 year female with
synovial chondromatosis
hip
Frog leg lateral
CT scan showing loose bodies
Case #1244




26 year female with
synovial chondromatosis
hip
CT scan
CT scan at lower level
Photomic showing embryonic cartilage in synovial lining
Case #1245     Synovial Chondromatosis of Wrist




  49 year female with synovial chondromatosis wrist
AP view
Axial Gad contrast MRI
loose pellets




                     fluid




Sagittal T-1 MRI showing wrist effusion and loose pellets
Case #1245.1     Synovial Chondromatosis Wrist




   66 yr male with recurrent soft tissue mass volar aspect of wrist
        with two prior surgical resections over past 7 years
Cor PD




Cor Gad
Axial PD     Sag PD




 Axial Gad    Axial PD
Surgical
debriedment
Juxta-articular
 Chondroma
CLASSIC       Case #371




25 year old with juxta-articular chondroma posterior knee
AP view
Surgical excision
Surgical specimen
X-ray of resected
specimen
Photomic
Case #372




  41 year male with juxta-articular chondroma ant knee
Sagittal T-1 MRI
Sagittal T-2 MRI
Axial T-2 MRI
Photomic
Case #372.1                          Juxta-articular chondroma




      60 yr female with lump in anterior knee area for years
Sag T-1         T-2




          Gad
Axial T-1   PD




Gad
Case #373




58 year male with juxta-articular chondroma posterior knee
Sagittal T-2 MRI
Axial T-2 MRI
Case #374                 Sagittal T-1 MRI




                                tumor




 37 year male with juxta-articular chondroma post knee
Sagittal T-2 MRI
tumor




Sagittal gad contrast MRI with rim enhancement
tumor




Axial T-2 MRI
tumor




Axial gad contrast with rim enhancement
Case #1248




 36 year male with soft tissue chondrosarc behind knee
Sagittal T-2 MRI
Axial T-1 MRI
Axial T-2 MRI
Case #375




13 year male with juxta-articular chondroma posterior knee
Case #376




    18 year male with juxta-articular chondroma ankle
Case #376.1                      Juxta-articular chondroma




   38 old male with long history of catching sensations in ankle
Axial T-1   PD




            Gad
Sag T-1         PD




          Gad
Case #377




     19 year male with tenosynovial chondromatosis
Lateral view
Photomic
Case #377.1                 Tenosynovial chondroma




   45 yr. Female with a none tender lump in 2nd toe for years
Cor T-1   T-2




   Gad
Sag T-1
T-2




   Gad
Axial T-1   T-2




Gad
Surgical excision
Case #1247




44 year male with
solitary synovial
chondroma hip
Lateral view
Photomic from resected specimen
Secondary
   Synovial
Chondromatosis
CLASSIC
Case #378



49 year female with
2ndary synovial
chondromatosis from
osteoarthritis of knee


AP x-ray
Lateral view
Sagittal T-2 MRI
Axial proton
density MRI




               fluid
Axial T-2 MRI
Case 379                     Coronal T-1 MRI




                   osteoarthritis


 76 year male with 2ndary synovial chondromatosis knee
Sagittal T-2 MRI
showing loose
bodies in popliteal
synovial cyst
Axial T-2 MRI with loose body in popliteal cyst
Axial T-2 MRI with many loose bodies in popliteal cyst
Case #379.1                Secondary synovial chondromatosis




    57 year old soccer player with prior history of knee surgery
Sag T-1         T-2




          Gad
Axial T-2   Gad
Case #380




70 year female
2ndary synovial
chondromatosis from
osteoarthritis knee
Lateral view
Case #381




55 year female
2ndary synovial
chondromatosis from
osteoarthritis knee
Lateral view
Sagittal proton density MRI showing loose bodies
                 in popliteal cyst
Case #381.1    Secondary Synovial Osteochondromatosis




62 year old male with DOA and large
necrotizing mass over tibia
Sag T-1   T-2   Gad
T-2            Gad




       Axial
 T-2           Gad
Post op surgical
debriedment




Post op flap
coverage over
tibia
Case #381.2 Secondary Synovial Osteochondromatosis Knee




     85 yr male with mild pain & swelling in knee for 4 yrs
Sag T-1   T-2   Gad
Cor T-1   T-2
Axial T-1         T-2




            Gad
Case #382




69 year male with 2ndary
synovial chondromatosis
from traumatic arthritis
of elbow
Surgical removal of loose bodies
Loose bodies and pieces of synovium
Case #1246




46 year female 2ndary synovial chondromatosis talonarvicular
           second to old trauma of subtalar joint
Sagittal T-1 MRI showing traumatic arthritic changes
Sagittal T-2 MRI showing excessive synovial fluid
Coronal T-2 MRI
Myxoid
Chondrosarcoma
Myxoid Chondrosarcoma
                 (Chordoid Sarcoma)
    The extra-skeletal myxoid chondrosarcoma is a very rare soft
tissue tumor in the deep muscle belly, occurring most often in the
extremities in patients over 40 years of age. Males are affected
twice as often as females. The tumor is slow growing and may
cause local pain and tenderness. Common locations are the thigh,
popliteal fossa, and shoulder girdle. It presents with the clinical
appearance of a myxoid liposarcoma. Pathologically, the tumors
are greyish to tannish brown, depending on the amount of
hemorrhage into the tumor. Because hemorrhage often occurs, it
can be mistaken for a hematoma. Histologically, the tumor has a
myxoid appearance with chords and nests of anastomosing cells
that have a chondroblastic appearance. The histology is very
similar to that of chordoma of the sacrum. The tumor is considered
low grade in most instances; it is slow growing but has the potential
for local recurrence and pulmonary metastases in about one-third
of cases. Treatment consists of aggressive wide local resection or
amputation, if needed, followed by local radiation therapy. Chemo-
therapy is usually not indicated.
CLASSIC   Case #383          Coronal T-1 MRI




                       tumor




 55 year male with myxoid chondrosarcoma distal thigh
Coronal T-2 MRI
                  tumor
tumor




Axial T-2 MRI
Resected hemorrhagic surgical specimen
Photomic showing chordoid myxoid pattern like chordoma
Pathology similar to that of a chordoma
Case #384               Sagittal T-2 MRI




                              tumor




   41 year female with myxoid chondrosarcoma shoulder
tumor




Axial gad contrast MRI
Case #385




65 year male with
soft tissue myxoid
chondrosarcoma leg
eroding tibia



AP view
Lateral view
Sagittal T-2 MRI

                   tumor
tumor




Axial T-2 MRI
tumor




Another axial T-2 MRI
Epithelioid
 Sarcoma
Epithelioid Sarcoma
    The epithelioid sarcoma affects young adults and is most
commonly seen in the fingers, hand and forearm where it is
considered the most common soft tissue sarcoma next to the
alveolar rhabdomysarcoma and synovial sarcoma. It can also occur
in the popliteal area, the buttock, thigh, shoulder, foot and ankle
area. It affects twice as many males as females. These tumors are
frequently misdiagnosed as a benign granulomatous process and
are often attached to tendon sheaths and facial planes with
associated cutaneous ulcerations that may be multiple in nature.
Calcification or even bone formation can occur in about 15% of
cases. The histological appearance of this lesion displays a distinct
nodular growth pattern with epithelioid nests of cells at the center
surrounded by lymphocytic infiltration. The differential diagnosis
would include necrotizing infectious diseases such as tuberculosis
or granuloma annulare or rheumatoid nodules. Regional lymph
node involvement occurs in about 35% of cases and metastases to
the lung in about 50% of cases. Because of the benign clinical
appearance of this lesion, it is common for surgeons to attempt
local resection but there is a high recurrence rate that eventually
leads to amputation. Local radiation therapy can help to decrease
the chance of local recurrence.
CLASSIC
 Case #386




36 year male with
epithelioid sarcoma
foot
                      ulceration
Side view with ulcerated cap
tumor




CT scan
tumor




Another CT cut
necrotic center
     necrotic center




Scanning lens photomic
Close up outer edge
Higher power of epithelioid cells
Case #387




34 year male with
epithelioid sarcoma
forearm



Sagittal T-2 MRI
Sagittal Gad contrast MRI



                            tumor
tumor




Axial T-2 MRI
necrosis




                    tumor




Axial gad contrast MRI
Photomic showing epithelioid cells
Case #387.1                            Epithelioid sarcoma




 22 year old male with spontaneous fungating wound volar wrist
Cor T-1   T-2 FS   Gad
Sag T-1   T-2 FS   Gad
Axial T-1         T-2 FS




            Gad
Case #388




   27 year female with epithelioid sarcoma sole of foot
Case #388




Sagittal T-1 MRI
Axial proton density MRI
Axial T-2 MRI
                tumor
Case #389




  50 year male with epithelioid sarcoma middle finger
Case #389.1     Sag T-1                              T-2


                          Granuloma
                          Annularae




                       Gad




 35 yr female with tender red lump over patellar tendon many yrs
Axial T-1   PD FS




     Gad
Soft Tissue
Ewing’s Sarcoma
Extra-skeletal Ewing’s Sarcoma
    Ewing’s sarcoma is usually associated with primary tumor of
bone but in a small percentage of cases, Ewing’s sarcoma can
occur in soft tissue completely unattached to the skeletal system.
However, the histological appearance and the clinical picture
associated with soft tissue Ewing’s sarcoma is basically the same
as that of skeletal Ewing’s. This condition is seen in patients
between the age of 15 and 30 years. It occurs in males and females
equally and is rare in black patients. The most common location
is the chest wall, followed by the lower extremities, paraspinous
area, pelvis, hip and retroperitoneum. The least common location
is the upper extremity. The reciprocal translocation of the long
arm of chromosomes 11 and 22 is seen in soft tissue Ewing’s,
just as it is in skeletal Ewing’s. The prognosis for five year survival
is approximately 65%, similar to that of skeletal Ewing’s. Treatment
consists of wide local resection when possible, followed by
local radiation therapy if indicated. Adjuvant chemotherapy is
commonly used because of the excellent response, similar to
that of skeletal Ewing’s sarcoma.
CLASSIC
 Case #390




28 year female with
soft tissue Ewing’s
sarcoma anterior thigh


Coronal proton density
MRI
Coronal proton
density MRI
Coronal T-2 MRI


                  tumor
tumr




Axial T-2 MRI
Surgical specimen inked and cut in path lab
Photomic
Case #390.1                         Axial T-1 MRI




     38 year female with painful thigh mass 2 months
Axial T-2




Axial Gad
                        necrosis
necrosis




Coronal T-2   Coronal Gad contrast
Case #391




14 year male with
soft tissue Ewing’s
sarcoma distal thigh
Axial proton
density MRI

               tumor
Axial T-2 MRI


                tumor
Photomic
Case #391.1    T-1 Sag MRI              T-2 Sag




18 yr female with Ewing’s sarcoma in sciatic nerve looking
              like a benign neurilemoma
Axial Gad MRI at two different levels




Lower level                   Upper level
Coronal Gad MRI
Case #392




16 year female with
soft tissue Ewing’s
sarcoma thigh
Coronal T-1 MRI
tumor




    Axial T-2 MRI
Clear Cell
Sarcoma
Clear Cell Sarcoma
   The clear cell sarcoma is thought to be a deep, non-cutaneous
variant of the pigmented melanoma. It is a very rare tumor affecting
females more than males. It is typically seen between the ages of
20 and 40 years. It usually occurs in tendon sheaths and fascial
planes, especially around the foot and ankle area, similar to the
clinical appearance seen with synovial sarcoma with which it can
be confused. The tumor usually begins as a slow growing lump that
has a benign appearance but after a period of several years the tumor
will start growing more rapidly and become painful. It has a high
potential to metastasize to local lymph nodes and to the lung.
Approximately 50% of patients with this tumor will be dead in five
years. The microscopic appearance is similar to that of the epithelioid
sarcoma, especially if melanin is not found in the specimen.
Treatment usually consists of wide local resection, if possible, but a
high local recurrence rate is common because of its location in
extracompartmental structures such as tendon sheaths. If that
occurs, amputation is carried out for local control of the disease.
Local radiation therapy is utilized with attempts at wide resection.
Adjuvant chemotherapy has been advised because of the poor
prognosis but the response is usually not beneficial.
CLASSIC   Case #393




    35 year female with clear cell sarcoma hand
Surgical exposure reveals extensive tendon sheath involvement
Photomic
Case#394                Sagittal gad contrast MRI




                             tumor




     73 year female with clear cell sarcoma ankle
tibia
                          heel cord


            tumor




 Axial gad contrast MRI
Case #394.1    Cor T-1 Clear Cell Sarcoma   T-2 FS




                                   Gad

    52 yr female with painful
  mass over the posterior medial
      aspect of the knee
Sag T-1     T-2 FS




      Gad
Axial T-1   T-2 FS




     Gad
Myositis
Ossificans
Myositis Ossificans
    Myositis ossificans is a heterotopic ossification within muscle
fascial planes seen typically in young athletic individuals in their
adolescence and early adult life. It occurs primarily in males and
usually results from a significant injury to a muscle, such as a
tearing of the quadriceps muscle which is the most common
location for this problem. It is also seen in the gluteus maximus
and the brachialis muscle at the elbow. The calcification is typically
noted on x-ray three to four weeks after the injury. It tends to occur
at the periphery of the damaged muscle and hematoma is usually
seen in the central area. As the lesion matures the calcific rim
around the damaged muscle will appear as fairly mature bone
and the central area will remain radiolucent, giving the so-called
zonal pattern that is almost diagnostic of traumatic myositis
ossificans. This is the opposite of osteosarcoma of soft tissue that
has the most dense portion of the calcifying lesion occurring centrally
and the more lytic portion at the periphery of the lesion. Myositis
ossificans can also be seen in older patients with no history of
trauma in which case the clinician becomes concerned about the
possibility of a neoplasm such as a synovial sarcoma or soft tissue
osteosarcoma. Histologically, the lesion will have the appearance
of a healing fracture, including immature cartilage and bone
formation, along with hematoma in the early stages. In rare cases,
after a period of 25 or 30 years, these dormant lesions can reactivate
and develop into an osteosarcoma. Treatment usually consists of
rest until the lesion matures after six months, at which point the
patient is usually asymptomatic. There is no reason to remove the
lesion unless there is significant clinical disability related to
stiffness of the adjacent joint.
    There is a hereditary congenital form of myositis ossificans
referred to as myositis ossificans progressiva, or the newer term-
inology is fibrodysplasia ossificans progressiva, that is typically
seen in children under the age of ten years. It presents with a
clinical picture of progressive fibroblastic proliferation and
subsequent calcification and ossification of subcutaneous fat,
muscles, tendons, appeneuroses, and ligaments. This condition can
be associated with symmetrical malformations of the digits with
microdactyly of the thumbs and great toes, sometimes associated
with a failure of segmentation of the digital bony structures. The
condition usually presents between birth and the first six years of
age. It is inherited as an autosomal dominant trait. Males and
females are equally affected and the calcification in soft tissues is
usually precipitated by a local injury to the soft tissue. It occurs
typically in the musculature of the back, shoulder, paravertebral
region and upper arms. Fusion of the tempromandibular joint can
be seen. If the respiratory muscles are affected, death can result
because of respiratory failure or pneumonia in early adult life. The
prognosis for survival is very poor and most patients die within the
first ten to fifteen years of life. Biopsy or trauma of the affected
areas should be avoided because of new lesions that might
develop. There is no effective treatment or this condition.
CLASSIC
 Case #395




12 year female with
myositis ossificans
medial thigh
fibrous tissue




Cut surgical specimen showing mature bone at periphery
Photomic showing reactive bone at periphery of lesion
Less bone maturity toward center of lesion
Healing rhabdomyoblasts in center of lesion
Case #396




59 year male with
early myositis
ossificans ant thigh
Lateral view
Axial T-2 MRI
Axial T-2 MRI
Macro section of resected specimen
bone




Reactive bone at periphery
Case #397
                          biopsy
                              biopsy



22 year male with early
myositis ossificans
anterior thigh
bone




                       fibrous




Biopsy specimen with typical benign zonal pattern
Mature myositis
ossificans 6 mos later
Case #398



                                            2 mos later
                early




17 year male with myositis ossificans of thigh 2 mos apart
Case #399




24 year female
myositis ossificans
2 months post injury
Axial T-1 MRI
Axial T-2 MRI
Coronal T-2 MRI
Biopsy specimen showing reactive bone
cartilage




                           bone




  Close up of reactive bone and cartilage
Case #400




14 month male with
myositis ossificans
brachialis muscle from
fall 2 weeks ago
Case #401




14 year male with
myositis ossificans
triceps muscle
mature
Case #402




10 year old female with myositis ossificans of shoulder
Case #403




  62 year female with old myositis ossificans teres major
Coronal T-1 MRI
Superficial biopsy specimen shows benign reactive bone
A deeper specimen reveals OGS arising from
      previous myositis ossificans
Myositis
 Ossificans
Progressiva
CLASSIC
 Case #404




22 year male with
myositis ossificans
progressiva
Heavy ossification of
latissimus dorsi muscle
X-ray showing
ossification of
latissimus dorsi muscle
Spontaneous fusion
cervical spine
Ossification psoas m
Heterotopic ossification seen muscle biopsy
Microdactyly both great toes
X-ray of feet showing failure of segmentation great toes
Hands showing stiff thumbs and hypoplastic 5th digits
X-ray showing hypoplasia of 1st and 5th digits
Case #405




26 year male with
myositis ossificans
progressiva with
spontaneous fusion
scoliotic spine
Spontaneous extra-articular fusion left hip
Pigmented
Villonodular
 Synovitis
Pigmented Villonodular Synovitis
    The etiology of pigmented villonodular synovitis (PVNS)
remains controversial. It presents as an inflammatory synovial
disease, usually involving only one joint, but histologically the
disease presents with histiocytic proliferation in the subsynovial
tissue that takes on the characteristics of a neoplastic condition
similar to that of a giant cell tumor. PVNS occurs typically in the
subsynovial tissue about major joints of the lower extremity in
patients between the ages of 20 and 40 years. The knee joint is the
most common site, followed next by the hip, ankle and foot. It is
rare to see this disease in the upper extremity. The histiocytic
proliferation in subsynovial tissues is similar to that seen in giant
cell tumor of tendon sheathes in the hand and foot., The clinical
picture in the knee joint is that of spontaneous swelling associated
with pain and synovial hypertrophy. Hemarthrosis can result in
massive swelling about the knee joint and can occasionally result
in juxta-articular erosion of bone, similar to what is seen in
rheumatoid synovitis. Other clinical conditions with a similar
presentation include hemophilia and coccydiomycosis. In fewer
than 10 % of cases this condition will present as a localized focal
mass in the suprapatellar pouch of the knee or high in the popliteal
space posteriorly that can masquerade as a neoplastic condition
such as a synovial sarcoma.
    Treatment for the more generalized synovial involvement of
the knee joint or other lower extremity joints consists of a subtotal
synovectomy that in many cases can be performed through an
arthroscope. In more extensive cases an open procedure may be
necessary. The recurrence rate is fairly high, in the range of 30%.
In cases where multiple recurrences result, treatment with radiation
therapy in the neighborhood of 1500-3000 centigray by external
beam is used. Injectable isotopes have also been used for radiation
treatment of recurrent cases. Secondary arthritic changes, especially
in the knee joint, can occur as a late complication of this disease
and these changes could lead to a total joint replacement at the
age of 50 or 60 years. On very rare occasion, this disease can
convert to a neoplastic sarcoma with a high degree of giant cell
activity. This is similar to the conversion of a giant cell tumor to
a malignant sarcoma.
CLASSIC
Case #406




36 year male with
PVNS knee
Lateral x-ray of knee
showing soft tissue
swelling
AP x-ray showing
early osteoarthritis
Sagittal T-1 MRI
showing hypertrophic
synovitis
                         bone
                       erosion
hemosiderin         cyst
                      laden


Sagittal T-2 MRI
                             erosion
Axial T-1 MRI showing hypertrophic synovitis
cyst




Coronal T-2 MRI
Brown discoloration of hypertrophic synovitis at surgery
Photomic showing giant cell activity
Photomic showing hemosiderin laden macrophages
Surgical appearance following subtotal synovectomy
Case #407             Sagittal proton density MRI




            41 year female with PVNS knee
fluid



hemosiderin laden
   synovitis




   Axial GRE T-2 MRI
Surgical exposure of brown hypertrophic synovitis
Photomic showing giant cell activity
Case #407.1




  38 year male with intermittent pain and swelling R knee 2 years
Sag T-2   T-2   Gad
Axial T-2   Gad
Case #407.2                        Recurrent PVNS




43 yr male with 5 scopes over 7 yrs for intermittent painful swelling
                      about the left knee
Sag PD   T-2 FS   T-2 FS
Axial T-2
Cor T-1   T-2
Case #407.3
              Sag T-1             T-2                    Gad




      28 male with painful swelling of both knees for 4 years
Cor T-1         T-2




T-2             Gad
Axial T-1         T-2




T-2               Gad
Sub total synovectomy
Case #407.4     PVNS with 2ndary synovial osteochondromatosis




    36 yr male with patellar injury
7 yrs ago and now swollen painful knee
Cor PD FS   Cor PD FS




Cor gad      Cor gad
Axial PD FS   Axial PD FS




Axial gad     Axil gad
Sag PD FS   Sag PD FS




 Sag T-2     Sag T-2
patella


Anterior arthrotomy
Case #408




55 year female
PVNS knee with
large subchondral
lytic granuloma
Coronal T-1 MRI
Case #409




38 year male with
PVNS hip joint with
large supra-acetabular
granuloma
Diffuse synovial
hypertrophic nodularity
seen with arthrogram
Treatment in the 60’s
with a cup arthoplasty
and bone graft to the
acetabular granuloma
Case #410            Sagittal proton density MRI




    17 male with localized nodular form of PVNS
Sagittal T-2 MRI
Axial T-2 MRI
Surgical specimen
Photomic showing hemosiderin laden macrophages
Case #410.1       Sag T-1                  PD    Nodular PVNS




              45 year female with knee pain for 5 months
Cor T-1   PD FS
Surgical excision
Case #410.2                    Localized nodular form of PVNS




          32 yr male with dull pain R knee for 5 months
Sag T-1   T-2




    Gad
Axial T-1         T-2




            Gad
Cor T-1    T-2 FS




     Gad
Case #411            Sagittal proton density MRI




                               tumor



                    bony
                   erosion
                   erosion




50 year male with PVNS knee with large popliteal mass
Sagittal T-2 MRI
Case #412            Sagittal T-1 MRI




            17 year female with PVNS ankle
Sagittal T-2 MRI
Another sagittal T-2 cut
Synovectomy specimen
Photomic
Case #413               Sagittal T-1 MRI




 39 year female with diffuse form of PVNS in the foot
Axial T-1 MRI
tumor




Axial T-2 MRI
Photomic
Case #413.1         Diffuse PVNS of Forefoot
      Cor PD                          Gad




         29 yr male with one yr of pain and swelling in foot
Sag T-1




          Gad
Axial PD




           Gad
Ray resection of 4th toe with tumor
Case #414




67 year female with
giant cell tumor of
tendon sheath
X-ray showing bony
erosion
Case #415




      14 year female with GCT tendon sheath
X-ray showing bony erosion
digital nerve




Surgical resection
Case #415.1               GCT Tendon sheath




    37 yr female with tender swelling base of 4th toe for 1 yr
Sag T-1   Sag Gad




Cor Gad    Axial Gad
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                            MP joint amputation of fourth toe
Case #416




 14 year female with xanthomatous variant of giant cell
        tumor of tendon sheath on index finger
Surgical resection
Photomic showing cholesterol laden foam cells
Case # 1249




              20 year female with PVNS knee
Lateral view
R               L




    Bone scan
Sagittal T-1 MRI
Coronal T-1 MRI
Coronal gad contrast MRI
Case #1250



                         PVNS




                          DOA




      68 year male with PVNS and DOA left knee
Lateral view showing subchondral erosions
Axial T-1 MRI with subpatellar synovial hypertrophy
Sagittal T-1 MRI showing extensive
  suprapatellar pouch involvement
Sagittal T-2 MRI showing fluid in suprapatellar pouch
Coronal T-2 MRI with
dark signal hemosiderin
laden synovitis and
bright signal synovial
fluid
Another coronal
T-2 MRI




Subchondral erosions
Case #1251




34 year male with
PVNS knee



Sagittal T-1 MRI
Sagittal T-2 MRI
Another sagittal
T-2 MRI
Coronal T-2 MRI
Case #1252




23 year male with PVNS
suprapatellar pouch area




Coronal T-1 MRI
Coronal T-2 MRI
Axial T-2 MRI
Case #1253             Sagittal T-1 MRI




 19 year male with localized nodular form of PVNS knee
Coronal T-1 MRI
Coronal T-2 MRI
Case #1254




         40 year female with PVNS hip joint
CT scan
Axial T-1 MRI
Axial T-2 MRI
Case #1255




32 year male with
PVNS hip joint
Case #1256



40 year female with
pigmented villonodular
tenosynovitis flexor
hallicus longus tendon
sheath


Sagittal T-1 MRI
Coronal T-1 MRI
Axial T-1 MRI
Axial T-2 MRI
hemosiderin




                                histiocytes


Photomic showing giant cell activity
Case #1256.1




     12 year old male with tender lump under heel cord 4 months
Sag T-1   PD   Gad
Axial T-1   T-2




Gad
Case #1257




8 year female with
GCT tendon sheath
2nd toe
Sagittal T-1 MRI
Coronal T-1 MRI
Case #1257.1              GCT tendon sheath




      53 yr female with tender and swollen 2nd toe for 1 yr
Cor T-1         T-2 FS




          Gad
Axial T-1   T-2 FS




    Gad
Sag T-1         T-2




          Gad
Intramuscular
   Myxoma
Case #1258           Intramuscular myxoma
               Axial T-2           Axial Gad




46 yr female with painless lump in post axilla for 8 years
Sagittal T-2   Sagittal Gad
Coronal Gad




              Surgical specimen
Case #1258.1
                          Intramuscular myxoma




     68 year old male with painless lump right shoulder for 1 yr
Cor T-1   T-2
Sag T-1   T-2
Case #1258.2      Axial T-1            T-2




59 year male with painless soft
tissue mass medial calf for 6 mos.

                                 Gad


   Intramuscular myxoma
Sagittal




T-1   T-2        Gad
Ganglion Cyst
Case #1259            Ganglion Cyst
                       Axial T-1




48 yr male with
painless lump in
anterior thigh 1 yr
                          T-2
Axial Gad



Shows rim enhancement
                        Sagittal Gad
Case #1259.1       Cor PD                       Gad




      60 year old male with painless lump in groin for 6 months
Axial T-2   Gad
Case #1259.1                            Ganglion cyst
               Cor T-1            T-2                   Gad




  57 year old female with painless lump inner aspect upper arm 1 yr
Sag T-1   T-2   Gad
Axial T-1   T-2




      Gad
Case #1260                              Ganglion cyst




 49 year female with tender lump medial knee for 6 mos
Cor T-1   Cor T-2
Case #1160.1                       Ganglion cyst




  65 year female with non tender mass over patellar ligament
Sag T-1   PD FS
Cystic lateral meniscus
Case #1261
               Axial T-1                        T-2




   49 year male with prior history of subcutaneous ganglion cyst
              removed from knee area 6 years ago
Cor T-1   T-2
Path specimen of resected cystic meniscus




    Photo of cyst            Macro section of cyst & meniscus




Macro section of cyst                 Micro of cyst
Case #1261.1              Ganglion cyst prox. fibula




     52 yr male with tender lump anterior below knee for 1 yr
           and recent weakness of dosiflexion at ankle
Sag PD FS   Gad
Axial T-1   PD FS




      Gad
Case #1261.1                     Spino-glenoid ganglion cyst




43 yr male sheet rock worker with shoulder pain for months
Axial CT   Axial




   Cor
Axial PD FS   Cor PD FS
Case #1261.2 Juxta articular ganglion cysts of shoulder




78 yr old male with mild shoulder pain and stiffness for years and now
     has a recent soft none tender mass over distal end of clavicle
2002                   2010




       Axial CT scan
Cor T-2   Gad
Axial T-2           Gad




            upper




            lower
Case #1261.3        Ganglion Cyst of Bone




           46 yr female with mild ankle pain for one year
Case #1261.1
                Axial T-1         T-2




                                  Gad



72 year male with painless lump
    lateral ankle for 1 year
Cor STIR   Surgical excision
Case #1261.2
                             Cor T-2                 Gad




  10 yr male with none tender lump beneath medial malleolus 6 mos
Axial T-1   T-2   Gad
Case #1261.3      Ganglion Cyst in Tarsal Tunnel




      Cor T-1                  T-2                      Gad

       53 yr male with tarsal tunnel symptoms for 8 months
Sag T-2   Gad
Ganglion cyst
Case #1261.2
                             Axial T-2




45 year male runner
With tender nodule in
Medial gastroc head

                                 Gad
Cor T-2   Gad
Case #1261.3                      Ganglion cyst




           60 year male with mild R hip pain for 1 year
Cor T-1   PD   Gad
Axial T-2
Case #1261.4             Baker’s cyst
          Cor T-2            Cor Gad                 Sag T-2




 34 yr female with prior history of myxosarcoma medial knee 17 yrs
          ago treated with surgery and post op RT
Axial T-2   Gad
Case #1261.5           Baker’sCyst




    Sag T-1                 T-2                     Gad
  62 yr female noticed non tender lump behind knee 3 weeks ago
AxialT-1   T-2




   Gad
Case #1261.6             Baker’s Cyst
               Sag PD                           Gad




    4 yr male with none tender lump on back of knee for 3 mos.
Axial T-1   T-2




     Gad
Soft Tissue Lymphoma
Case #1262         Axial T-1               T-2   Lymphoma




100 year old male with chronic edema
in legs but recent tender lump in calf
for 3 months



                                     Gad
Sag T-1   STIR   Gad
Case #1262.1        Lymphoma Sciatic Nerve
         Sag STIR               Sag Gad                 Cor Gad




                71 yr male with sciatica for 4 months
Axial STIR   Gad
Case #925                Sagittal T-1 MRI




        tumor                               tumor




    64 year female with soft tissue lymphoma forearm
tumor




Axial proton density MRI
Axial T-2 MRI
Metastatic CA to soft
       tissue
Case #1263                 Metastatic Breast
               Axial T-1                       T-2




62 year female with
history of breast CA




                   Gad
Sag T-1     T-2 FS




      Gad
Case #1264            Metastatic mesothelioma to arm




77 yr female with
recent diagnosis of
mesothelioma
Sag STIR                                Gad




Recent onset of painful mass anterior to elbow
Axial T-1       T-2




        PD FS         Gad
Surgical specimen

Vol 17

  • 1.
    Volume 17 Chondroid tumors(soft tissue) Synovial chondromatosis---------Case 364-370 & 1243-5 Juxtaarticular chondroma---------Case 371-377 & 1246-7 2ndary synovial chondromatosis-Case 378-382 & 1248 Myxoid chondrosarcoma----------Case 383-385 Epithelioid sarcoma------------------Case 386-389 Soft tissue Ewing’s sarcoma--------Case 390-392 Clear cell sarcoma--------------------Case 393-394 Myositis ossificans-------------------Case 395-405 Pigmented villonodular synovitis---Case 406-416 & 1249 Intramuscular myxoma---------------Case 1258 Ganglion cyst--------------------------Case 1259-60 Soft tissue lympoma------------------Case 1261 Metastatic CA to soft tissue---------Case 1262-63
  • 2.
    Chondroid Tumors (soft tissue)
  • 3.
  • 4.
    Synovial Chondromatosis Synovial chondromatosis is a rare dysplasia seen in younger patients. It is associated with metaplastic cartilage within the synovial lining of major joints such as the hip, knee, shoulder and elbow. It is twice as common in males as females and usually occurs in patients in the 20-40 age group. It is a monarticular disease that presents with symptoms of crepitation in the affected joint with mild, intermittent effusion sometimes associated with pain. Because of chronic irritation to the joint and damage to the articular cartilage, osteoarthritis is an ultimate problem with this disease and can lead to a total joint replacement at a later age. In rare instances this condition can mutate into a secondary chondro- sarcoma, usually around the hip or knee joint but seldom in the shoulder area. This usually occurs in the later years of life. In the early stages before the cartilage becomes calcified, the synovial chondromatosis may be difficult to pick up on routine radiographic examination. As time passes, the cartilage begins
  • 5.
    to calcify ina typical chondroid pattern that suggests the diagnosis of a chondroid tumor in or about a major joint. With excessive proliferation, the cartilage can extrude out of the joint into adjacent soft tissue, similar to what occurs with pigmented villonodular synovitis. As the disease progresses, it is not unusual to see enchondral ossification occurring within the cartilage when it is still attached to the synovial lining and has access to a blood supply. Multiple loose bodies are common with this disease and can run as high as 200 pellets within a major joint that sometimes aggregrate into a large mass that has the appearance of a chondrosarcoma. Treatment consists of a surgical resection of the loose bodies as well as a subtotal synovectomy of the tissue that produces the loose bodies. Multiple surgical procedures may be required because of a high recurrence rate. As in PVNS, it is not unusual to see a solitary focus of synovial chondromatosis with the remaining synovial lining being normal in appearance with only a solitary mass of cartilage attached to the synovial lining. This localized nodular form
  • 6.
    is more commonabout the hip, knee and ankle area. It is very common to find loose bodies in a major arthritic joint in older patients secondary to osteoarthritis where the joint cartilage is broken away from the joint surface and than becomes reattached to the synovial lining and gives the pseudo-appearance of primary synovial chondromatosis when, in fact, the primary etiology in this so-called secondary form is degenerative osteoarthritis. The secondary form is seen in patients past the age of 50 years, where- as the primary dysplastic form arising from the synovial lining is seen during the first three to four decades of life.
  • 7.
    CLASSIC Case #364 33year male with synovial chondromatoasis of shoulder
  • 8.
    Sagittal T-2 MRIshowing multiple calcified cartilage bodies
  • 9.
  • 10.
  • 11.
    Loose bodies andsynovial lining following surgery
  • 12.
    Cartilaginous bodies arisingfrom synovial lining
  • 13.
    Cartilaginous body formationin synovial villus
  • 14.
    Case #365 26 yearmale with synovial chondromatosis knee joint
  • 15.
  • 16.
    Gross appearance ofsynovial chondromatosis
  • 17.
    Microscopic evidence ofcartilage elements in synovium
  • 18.
    Case #366 28 year female with synovial chondromatosis knee
  • 19.
  • 20.
    Photomic showing cartilagein synovial lining
  • 21.
    Case #366.1 63 yearfemale with long history of synovial chondromatosis
  • 22.
  • 23.
    Cor T-2 Axial Gad
  • 24.
    Case #366.2 Synovial chondromatosis 42 year female with grinding sensations in knee for years
  • 25.
    Case #367 38 year male with synovial chondromatosis left hip
  • 26.
  • 27.
  • 28.
    Sagittal T-2 MRIcut showing loose bodies
  • 29.
    Surgical removal ofcartilage bodies
  • 30.
    Photo of largestcartilage body
  • 31.
    Case #368 24 year female with large cartilaginous pelvic mass arising from synovial chondromatosis of left hip
  • 32.
    tumor tumor Closeup of deformed femoral neck
  • 33.
    tumor Note deformity of medial femoral neck
  • 34.
    femoral N Exposure oflarge pelvic tumor by removal ant pubic ramus
  • 35.
    pubic groove Resected cartilagemasses and loose hip joint bodies
  • 36.
    Cut specimen ofone mass formed from compressed pellets
  • 37.
  • 38.
    cartilage Photomic of cartilageforming in synovial lining
  • 39.
    Post op x-rayshowing ramus surgical defect
  • 40.
    9 years laterwith DOA requiring THA
  • 41.
    Case #369 59 yearmale with synovial chondromatosis right hip for 20 years
  • 42.
    5 years laterwith 2ndary chondrosarcoma in femoral neck
  • 43.
    Frog leg lateralshowing chondrosarcoma
  • 44.
    Femoral head &neck specimen from THA showing chondrosarcoma in lower neck area
  • 45.
  • 46.
  • 47.
    1 yr laterwe see recurrent tumor requiring hemipelvectomy
  • 48.
    Case #370 50 yearfemale with 25 year history of synovial chondromatosis
  • 49.
    Coronal T-2 MRIseveral years later with 2ndary chondrosarc
  • 50.
    Case #370.1 Synovial chondromatosis 29 yr female with grinding sensation in elbow for years without inj.
  • 51.
    Dedifferentiated Case #370.1 Cor T-1 T-2 chondrosarcoma 60 yr male with swollen knee for years with recent increase in size
  • 52.
  • 53.
    Sag T-2 Gad T-2
  • 54.
  • 55.
    Case #1243 20 yearfemale with synovial chondromatosis hip
  • 56.
  • 57.
    CT scan showingloose bodies
  • 58.
    Case #1244 26 yearfemale with synovial chondromatosis hip
  • 59.
  • 60.
    CT scan atlower level
  • 61.
    Photomic showing embryoniccartilage in synovial lining
  • 62.
    Case #1245 Synovial Chondromatosis of Wrist 49 year female with synovial chondromatosis wrist
  • 63.
  • 64.
  • 65.
    loose pellets fluid Sagittal T-1 MRI showing wrist effusion and loose pellets
  • 66.
    Case #1245.1 Synovial Chondromatosis Wrist 66 yr male with recurrent soft tissue mass volar aspect of wrist with two prior surgical resections over past 7 years
  • 67.
  • 68.
    Axial PD Sag PD Axial Gad Axial PD
  • 69.
  • 70.
  • 71.
    CLASSIC Case #371 25 year old with juxta-articular chondroma posterior knee
  • 72.
  • 73.
  • 74.
  • 75.
  • 76.
  • 77.
    Case #372 41 year male with juxta-articular chondroma ant knee
  • 78.
  • 79.
  • 80.
  • 81.
  • 82.
    Case #372.1 Juxta-articular chondroma 60 yr female with lump in anterior knee area for years
  • 83.
    Sag T-1 T-2 Gad
  • 84.
    Axial T-1 PD Gad
  • 85.
    Case #373 58 yearmale with juxta-articular chondroma posterior knee
  • 86.
  • 87.
  • 88.
    Case #374 Sagittal T-1 MRI tumor 37 year male with juxta-articular chondroma post knee
  • 89.
  • 90.
    tumor Sagittal gad contrastMRI with rim enhancement
  • 91.
  • 92.
    tumor Axial gad contrastwith rim enhancement
  • 93.
    Case #1248 36year male with soft tissue chondrosarc behind knee
  • 94.
  • 95.
  • 96.
  • 97.
    Case #375 13 yearmale with juxta-articular chondroma posterior knee
  • 98.
    Case #376 18 year male with juxta-articular chondroma ankle
  • 99.
    Case #376.1 Juxta-articular chondroma 38 old male with long history of catching sensations in ankle
  • 100.
    Axial T-1 PD Gad
  • 101.
    Sag T-1 PD Gad
  • 102.
    Case #377 19 year male with tenosynovial chondromatosis
  • 103.
  • 104.
  • 105.
    Case #377.1 Tenosynovial chondroma 45 yr. Female with a none tender lump in 2nd toe for years
  • 106.
    Cor T-1 T-2 Gad
  • 107.
  • 108.
    Axial T-1 T-2 Gad
  • 109.
  • 110.
    Case #1247 44 yearmale with solitary synovial chondroma hip
  • 111.
  • 112.
  • 113.
    Secondary Synovial Chondromatosis
  • 114.
    CLASSIC Case #378 49 yearfemale with 2ndary synovial chondromatosis from osteoarthritis of knee AP x-ray
  • 115.
  • 116.
  • 117.
  • 118.
  • 119.
    Case 379 Coronal T-1 MRI osteoarthritis 76 year male with 2ndary synovial chondromatosis knee
  • 120.
    Sagittal T-2 MRI showingloose bodies in popliteal synovial cyst
  • 121.
    Axial T-2 MRIwith loose body in popliteal cyst
  • 122.
    Axial T-2 MRIwith many loose bodies in popliteal cyst
  • 123.
    Case #379.1 Secondary synovial chondromatosis 57 year old soccer player with prior history of knee surgery
  • 124.
    Sag T-1 T-2 Gad
  • 125.
  • 126.
    Case #380 70 yearfemale 2ndary synovial chondromatosis from osteoarthritis knee
  • 127.
  • 128.
    Case #381 55 yearfemale 2ndary synovial chondromatosis from osteoarthritis knee
  • 129.
  • 130.
    Sagittal proton densityMRI showing loose bodies in popliteal cyst
  • 131.
    Case #381.1 Secondary Synovial Osteochondromatosis 62 year old male with DOA and large necrotizing mass over tibia
  • 132.
    Sag T-1 T-2 Gad
  • 133.
    T-2 Gad Axial T-2 Gad
  • 134.
    Post op surgical debriedment Postop flap coverage over tibia
  • 135.
    Case #381.2 SecondarySynovial Osteochondromatosis Knee 85 yr male with mild pain & swelling in knee for 4 yrs
  • 136.
    Sag T-1 T-2 Gad
  • 137.
  • 138.
    Axial T-1 T-2 Gad
  • 139.
    Case #382 69 yearmale with 2ndary synovial chondromatosis from traumatic arthritis of elbow
  • 140.
    Surgical removal ofloose bodies
  • 141.
    Loose bodies andpieces of synovium
  • 142.
    Case #1246 46 yearfemale 2ndary synovial chondromatosis talonarvicular second to old trauma of subtalar joint
  • 143.
    Sagittal T-1 MRIshowing traumatic arthritic changes
  • 144.
    Sagittal T-2 MRIshowing excessive synovial fluid
  • 145.
  • 146.
  • 147.
    Myxoid Chondrosarcoma (Chordoid Sarcoma) The extra-skeletal myxoid chondrosarcoma is a very rare soft tissue tumor in the deep muscle belly, occurring most often in the extremities in patients over 40 years of age. Males are affected twice as often as females. The tumor is slow growing and may cause local pain and tenderness. Common locations are the thigh, popliteal fossa, and shoulder girdle. It presents with the clinical appearance of a myxoid liposarcoma. Pathologically, the tumors are greyish to tannish brown, depending on the amount of hemorrhage into the tumor. Because hemorrhage often occurs, it can be mistaken for a hematoma. Histologically, the tumor has a myxoid appearance with chords and nests of anastomosing cells that have a chondroblastic appearance. The histology is very similar to that of chordoma of the sacrum. The tumor is considered low grade in most instances; it is slow growing but has the potential
  • 148.
    for local recurrenceand pulmonary metastases in about one-third of cases. Treatment consists of aggressive wide local resection or amputation, if needed, followed by local radiation therapy. Chemo- therapy is usually not indicated.
  • 149.
    CLASSIC Case #383 Coronal T-1 MRI tumor 55 year male with myxoid chondrosarcoma distal thigh
  • 150.
  • 151.
  • 152.
  • 153.
    Photomic showing chordoidmyxoid pattern like chordoma
  • 154.
    Pathology similar tothat of a chordoma
  • 155.
    Case #384 Sagittal T-2 MRI tumor 41 year female with myxoid chondrosarcoma shoulder
  • 156.
  • 157.
    Case #385 65 yearmale with soft tissue myxoid chondrosarcoma leg eroding tibia AP view
  • 158.
  • 159.
  • 160.
  • 161.
  • 162.
  • 163.
    Epithelioid Sarcoma The epithelioid sarcoma affects young adults and is most commonly seen in the fingers, hand and forearm where it is considered the most common soft tissue sarcoma next to the alveolar rhabdomysarcoma and synovial sarcoma. It can also occur in the popliteal area, the buttock, thigh, shoulder, foot and ankle area. It affects twice as many males as females. These tumors are frequently misdiagnosed as a benign granulomatous process and are often attached to tendon sheaths and facial planes with associated cutaneous ulcerations that may be multiple in nature. Calcification or even bone formation can occur in about 15% of cases. The histological appearance of this lesion displays a distinct nodular growth pattern with epithelioid nests of cells at the center surrounded by lymphocytic infiltration. The differential diagnosis would include necrotizing infectious diseases such as tuberculosis or granuloma annulare or rheumatoid nodules. Regional lymph
  • 164.
    node involvement occursin about 35% of cases and metastases to the lung in about 50% of cases. Because of the benign clinical appearance of this lesion, it is common for surgeons to attempt local resection but there is a high recurrence rate that eventually leads to amputation. Local radiation therapy can help to decrease the chance of local recurrence.
  • 165.
    CLASSIC Case #386 36year male with epithelioid sarcoma foot ulceration
  • 166.
    Side view withulcerated cap
  • 167.
  • 168.
  • 169.
    necrotic center necrotic center Scanning lens photomic
  • 170.
  • 171.
    Higher power ofepithelioid cells
  • 172.
    Case #387 34 yearmale with epithelioid sarcoma forearm Sagittal T-2 MRI
  • 173.
  • 174.
  • 175.
    necrosis tumor Axial gad contrast MRI
  • 176.
  • 177.
    Case #387.1 Epithelioid sarcoma 22 year old male with spontaneous fungating wound volar wrist
  • 178.
    Cor T-1 T-2 FS Gad
  • 179.
    Sag T-1 T-2 FS Gad
  • 180.
    Axial T-1 T-2 FS Gad
  • 181.
    Case #388 27 year female with epithelioid sarcoma sole of foot
  • 182.
  • 183.
  • 184.
  • 185.
    Case #389 50 year male with epithelioid sarcoma middle finger
  • 186.
    Case #389.1 Sag T-1 T-2 Granuloma Annularae Gad 35 yr female with tender red lump over patellar tendon many yrs
  • 187.
    Axial T-1 PD FS Gad
  • 188.
  • 189.
    Extra-skeletal Ewing’s Sarcoma Ewing’s sarcoma is usually associated with primary tumor of bone but in a small percentage of cases, Ewing’s sarcoma can occur in soft tissue completely unattached to the skeletal system. However, the histological appearance and the clinical picture associated with soft tissue Ewing’s sarcoma is basically the same as that of skeletal Ewing’s. This condition is seen in patients between the age of 15 and 30 years. It occurs in males and females equally and is rare in black patients. The most common location is the chest wall, followed by the lower extremities, paraspinous area, pelvis, hip and retroperitoneum. The least common location is the upper extremity. The reciprocal translocation of the long arm of chromosomes 11 and 22 is seen in soft tissue Ewing’s, just as it is in skeletal Ewing’s. The prognosis for five year survival is approximately 65%, similar to that of skeletal Ewing’s. Treatment consists of wide local resection when possible, followed by
  • 190.
    local radiation therapyif indicated. Adjuvant chemotherapy is commonly used because of the excellent response, similar to that of skeletal Ewing’s sarcoma.
  • 191.
    CLASSIC Case #390 28year female with soft tissue Ewing’s sarcoma anterior thigh Coronal proton density MRI
  • 192.
  • 193.
  • 194.
  • 195.
    Surgical specimen inkedand cut in path lab
  • 196.
  • 197.
    Case #390.1 Axial T-1 MRI 38 year female with painful thigh mass 2 months
  • 198.
  • 199.
    necrosis Coronal T-2 Coronal Gad contrast
  • 200.
    Case #391 14 yearmale with soft tissue Ewing’s sarcoma distal thigh
  • 201.
  • 202.
  • 203.
  • 204.
    Case #391.1 T-1 Sag MRI T-2 Sag 18 yr female with Ewing’s sarcoma in sciatic nerve looking like a benign neurilemoma
  • 205.
    Axial Gad MRIat two different levels Lower level Upper level
  • 206.
  • 207.
    Case #392 16 yearfemale with soft tissue Ewing’s sarcoma thigh
  • 208.
  • 209.
    tumor Axial T-2 MRI
  • 210.
  • 211.
    Clear Cell Sarcoma The clear cell sarcoma is thought to be a deep, non-cutaneous variant of the pigmented melanoma. It is a very rare tumor affecting females more than males. It is typically seen between the ages of 20 and 40 years. It usually occurs in tendon sheaths and fascial planes, especially around the foot and ankle area, similar to the clinical appearance seen with synovial sarcoma with which it can be confused. The tumor usually begins as a slow growing lump that has a benign appearance but after a period of several years the tumor will start growing more rapidly and become painful. It has a high potential to metastasize to local lymph nodes and to the lung. Approximately 50% of patients with this tumor will be dead in five years. The microscopic appearance is similar to that of the epithelioid sarcoma, especially if melanin is not found in the specimen. Treatment usually consists of wide local resection, if possible, but a high local recurrence rate is common because of its location in
  • 212.
    extracompartmental structures suchas tendon sheaths. If that occurs, amputation is carried out for local control of the disease. Local radiation therapy is utilized with attempts at wide resection. Adjuvant chemotherapy has been advised because of the poor prognosis but the response is usually not beneficial.
  • 213.
    CLASSIC Case #393 35 year female with clear cell sarcoma hand
  • 214.
    Surgical exposure revealsextensive tendon sheath involvement
  • 215.
  • 216.
    Case#394 Sagittal gad contrast MRI tumor 73 year female with clear cell sarcoma ankle
  • 217.
    tibia heel cord tumor Axial gad contrast MRI
  • 218.
    Case #394.1 Cor T-1 Clear Cell Sarcoma T-2 FS Gad 52 yr female with painful mass over the posterior medial aspect of the knee
  • 219.
    Sag T-1 T-2 FS Gad
  • 220.
    Axial T-1 T-2 FS Gad
  • 221.
  • 222.
    Myositis Ossificans Myositis ossificans is a heterotopic ossification within muscle fascial planes seen typically in young athletic individuals in their adolescence and early adult life. It occurs primarily in males and usually results from a significant injury to a muscle, such as a tearing of the quadriceps muscle which is the most common location for this problem. It is also seen in the gluteus maximus and the brachialis muscle at the elbow. The calcification is typically noted on x-ray three to four weeks after the injury. It tends to occur at the periphery of the damaged muscle and hematoma is usually seen in the central area. As the lesion matures the calcific rim around the damaged muscle will appear as fairly mature bone and the central area will remain radiolucent, giving the so-called zonal pattern that is almost diagnostic of traumatic myositis ossificans. This is the opposite of osteosarcoma of soft tissue that has the most dense portion of the calcifying lesion occurring centrally and the more lytic portion at the periphery of the lesion. Myositis
  • 223.
    ossificans can alsobe seen in older patients with no history of trauma in which case the clinician becomes concerned about the possibility of a neoplasm such as a synovial sarcoma or soft tissue osteosarcoma. Histologically, the lesion will have the appearance of a healing fracture, including immature cartilage and bone formation, along with hematoma in the early stages. In rare cases, after a period of 25 or 30 years, these dormant lesions can reactivate and develop into an osteosarcoma. Treatment usually consists of rest until the lesion matures after six months, at which point the patient is usually asymptomatic. There is no reason to remove the lesion unless there is significant clinical disability related to stiffness of the adjacent joint. There is a hereditary congenital form of myositis ossificans referred to as myositis ossificans progressiva, or the newer term- inology is fibrodysplasia ossificans progressiva, that is typically seen in children under the age of ten years. It presents with a clinical picture of progressive fibroblastic proliferation and
  • 224.
    subsequent calcification andossification of subcutaneous fat, muscles, tendons, appeneuroses, and ligaments. This condition can be associated with symmetrical malformations of the digits with microdactyly of the thumbs and great toes, sometimes associated with a failure of segmentation of the digital bony structures. The condition usually presents between birth and the first six years of age. It is inherited as an autosomal dominant trait. Males and females are equally affected and the calcification in soft tissues is usually precipitated by a local injury to the soft tissue. It occurs typically in the musculature of the back, shoulder, paravertebral region and upper arms. Fusion of the tempromandibular joint can be seen. If the respiratory muscles are affected, death can result because of respiratory failure or pneumonia in early adult life. The prognosis for survival is very poor and most patients die within the first ten to fifteen years of life. Biopsy or trauma of the affected areas should be avoided because of new lesions that might develop. There is no effective treatment or this condition.
  • 225.
    CLASSIC Case #395 12year female with myositis ossificans medial thigh
  • 226.
    fibrous tissue Cut surgicalspecimen showing mature bone at periphery
  • 227.
    Photomic showing reactivebone at periphery of lesion
  • 228.
    Less bone maturitytoward center of lesion
  • 229.
  • 230.
    Case #396 59 yearmale with early myositis ossificans ant thigh
  • 231.
  • 232.
  • 233.
  • 234.
    Macro section ofresected specimen
  • 235.
  • 236.
    Case #397 biopsy biopsy 22 year male with early myositis ossificans anterior thigh
  • 237.
    bone fibrous Biopsy specimen with typical benign zonal pattern
  • 238.
  • 239.
    Case #398 2 mos later early 17 year male with myositis ossificans of thigh 2 mos apart
  • 240.
    Case #399 24 yearfemale myositis ossificans 2 months post injury
  • 241.
  • 242.
  • 243.
  • 244.
  • 245.
    cartilage bone Close up of reactive bone and cartilage
  • 246.
    Case #400 14 monthmale with myositis ossificans brachialis muscle from fall 2 weeks ago
  • 247.
    Case #401 14 yearmale with myositis ossificans triceps muscle mature
  • 248.
    Case #402 10 yearold female with myositis ossificans of shoulder
  • 249.
    Case #403 62 year female with old myositis ossificans teres major
  • 250.
  • 251.
    Superficial biopsy specimenshows benign reactive bone
  • 252.
    A deeper specimenreveals OGS arising from previous myositis ossificans
  • 253.
  • 254.
    CLASSIC Case #404 22year male with myositis ossificans progressiva
  • 255.
  • 256.
  • 257.
  • 258.
  • 259.
  • 260.
  • 261.
    X-ray of feetshowing failure of segmentation great toes
  • 262.
    Hands showing stiffthumbs and hypoplastic 5th digits
  • 263.
    X-ray showing hypoplasiaof 1st and 5th digits
  • 264.
    Case #405 26 yearmale with myositis ossificans progressiva with spontaneous fusion scoliotic spine
  • 265.
  • 266.
  • 267.
    Pigmented Villonodular Synovitis The etiology of pigmented villonodular synovitis (PVNS) remains controversial. It presents as an inflammatory synovial disease, usually involving only one joint, but histologically the disease presents with histiocytic proliferation in the subsynovial tissue that takes on the characteristics of a neoplastic condition similar to that of a giant cell tumor. PVNS occurs typically in the subsynovial tissue about major joints of the lower extremity in patients between the ages of 20 and 40 years. The knee joint is the most common site, followed next by the hip, ankle and foot. It is rare to see this disease in the upper extremity. The histiocytic proliferation in subsynovial tissues is similar to that seen in giant cell tumor of tendon sheathes in the hand and foot., The clinical picture in the knee joint is that of spontaneous swelling associated with pain and synovial hypertrophy. Hemarthrosis can result in massive swelling about the knee joint and can occasionally result
  • 268.
    in juxta-articular erosionof bone, similar to what is seen in rheumatoid synovitis. Other clinical conditions with a similar presentation include hemophilia and coccydiomycosis. In fewer than 10 % of cases this condition will present as a localized focal mass in the suprapatellar pouch of the knee or high in the popliteal space posteriorly that can masquerade as a neoplastic condition such as a synovial sarcoma. Treatment for the more generalized synovial involvement of the knee joint or other lower extremity joints consists of a subtotal synovectomy that in many cases can be performed through an arthroscope. In more extensive cases an open procedure may be necessary. The recurrence rate is fairly high, in the range of 30%. In cases where multiple recurrences result, treatment with radiation therapy in the neighborhood of 1500-3000 centigray by external beam is used. Injectable isotopes have also been used for radiation treatment of recurrent cases. Secondary arthritic changes, especially in the knee joint, can occur as a late complication of this disease
  • 269.
    and these changescould lead to a total joint replacement at the age of 50 or 60 years. On very rare occasion, this disease can convert to a neoplastic sarcoma with a high degree of giant cell activity. This is similar to the conversion of a giant cell tumor to a malignant sarcoma.
  • 270.
    CLASSIC Case #406 36 yearmale with PVNS knee
  • 271.
    Lateral x-ray ofknee showing soft tissue swelling
  • 272.
    AP x-ray showing earlyosteoarthritis
  • 273.
    Sagittal T-1 MRI showinghypertrophic synovitis bone erosion
  • 274.
    hemosiderin cyst laden Sagittal T-2 MRI erosion
  • 275.
    Axial T-1 MRIshowing hypertrophic synovitis
  • 276.
  • 277.
    Brown discoloration ofhypertrophic synovitis at surgery
  • 278.
  • 279.
  • 280.
    Surgical appearance followingsubtotal synovectomy
  • 281.
    Case #407 Sagittal proton density MRI 41 year female with PVNS knee
  • 282.
    fluid hemosiderin laden synovitis Axial GRE T-2 MRI
  • 283.
    Surgical exposure ofbrown hypertrophic synovitis
  • 284.
  • 285.
    Case #407.1 38 year male with intermittent pain and swelling R knee 2 years
  • 286.
    Sag T-2 T-2 Gad
  • 287.
  • 288.
    Case #407.2 Recurrent PVNS 43 yr male with 5 scopes over 7 yrs for intermittent painful swelling about the left knee
  • 289.
    Sag PD T-2 FS T-2 FS
  • 290.
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  • 292.
    Case #407.3 Sag T-1 T-2 Gad 28 male with painful swelling of both knees for 4 years
  • 293.
    Cor T-1 T-2 T-2 Gad
  • 294.
    Axial T-1 T-2 T-2 Gad
  • 295.
  • 296.
    Case #407.4 PVNS with 2ndary synovial osteochondromatosis 36 yr male with patellar injury 7 yrs ago and now swollen painful knee
  • 297.
    Cor PD FS Cor PD FS Cor gad Cor gad
  • 298.
    Axial PD FS Axial PD FS Axial gad Axil gad
  • 299.
    Sag PD FS Sag PD FS Sag T-2 Sag T-2
  • 300.
  • 301.
    Case #408 55 yearfemale PVNS knee with large subchondral lytic granuloma
  • 302.
  • 303.
    Case #409 38 yearmale with PVNS hip joint with large supra-acetabular granuloma
  • 304.
  • 305.
    Treatment in the60’s with a cup arthoplasty and bone graft to the acetabular granuloma
  • 306.
    Case #410 Sagittal proton density MRI 17 male with localized nodular form of PVNS
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  • 308.
  • 309.
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  • 311.
    Case #410.1 Sag T-1 PD Nodular PVNS 45 year female with knee pain for 5 months
  • 312.
    Cor T-1 PD FS
  • 313.
  • 314.
    Case #410.2 Localized nodular form of PVNS 32 yr male with dull pain R knee for 5 months
  • 315.
    Sag T-1 T-2 Gad
  • 316.
    Axial T-1 T-2 Gad
  • 317.
    Cor T-1 T-2 FS Gad
  • 318.
    Case #411 Sagittal proton density MRI tumor bony erosion erosion 50 year male with PVNS knee with large popliteal mass
  • 319.
  • 320.
    Case #412 Sagittal T-1 MRI 17 year female with PVNS ankle
  • 321.
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  • 323.
  • 324.
  • 325.
    Case #413 Sagittal T-1 MRI 39 year female with diffuse form of PVNS in the foot
  • 326.
  • 327.
  • 328.
  • 329.
    Case #413.1 Diffuse PVNS of Forefoot Cor PD Gad 29 yr male with one yr of pain and swelling in foot
  • 330.
  • 331.
  • 332.
    Ray resection of4th toe with tumor
  • 333.
    Case #414 67 yearfemale with giant cell tumor of tendon sheath
  • 334.
  • 335.
    Case #415 14 year female with GCT tendon sheath
  • 336.
  • 337.
  • 338.
    Case #415.1 GCT Tendon sheath 37 yr female with tender swelling base of 4th toe for 1 yr
  • 339.
    Sag T-1 Sag Gad Cor Gad Axial Gad
  • 340.
    QuickTime™ and a decompressor are needed to see this picture. QuickTime™ and a decompressor are needed to see this picture. QuickTime™ and a decompressor are needed to see this picture. QuickTime™ and a decompressor are needed to see this picture. MP joint amputation of fourth toe
  • 341.
    Case #416 14year female with xanthomatous variant of giant cell tumor of tendon sheath on index finger
  • 342.
  • 343.
  • 344.
    Case # 1249 20 year female with PVNS knee
  • 345.
  • 346.
    R L Bone scan
  • 347.
  • 348.
  • 349.
  • 350.
    Case #1250 PVNS DOA 68 year male with PVNS and DOA left knee
  • 351.
    Lateral view showingsubchondral erosions
  • 352.
    Axial T-1 MRIwith subpatellar synovial hypertrophy
  • 353.
    Sagittal T-1 MRIshowing extensive suprapatellar pouch involvement
  • 354.
    Sagittal T-2 MRIshowing fluid in suprapatellar pouch
  • 355.
    Coronal T-2 MRIwith dark signal hemosiderin laden synovitis and bright signal synovial fluid
  • 356.
  • 357.
    Case #1251 34 yearmale with PVNS knee Sagittal T-1 MRI
  • 358.
  • 359.
  • 360.
  • 361.
    Case #1252 23 yearmale with PVNS suprapatellar pouch area Coronal T-1 MRI
  • 362.
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  • 364.
    Case #1253 Sagittal T-1 MRI 19 year male with localized nodular form of PVNS knee
  • 365.
  • 366.
  • 367.
    Case #1254 40 year female with PVNS hip joint
  • 368.
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  • 370.
  • 371.
    Case #1255 32 yearmale with PVNS hip joint
  • 372.
    Case #1256 40 yearfemale with pigmented villonodular tenosynovitis flexor hallicus longus tendon sheath Sagittal T-1 MRI
  • 373.
  • 374.
  • 375.
  • 376.
    hemosiderin histiocytes Photomic showing giant cell activity
  • 377.
    Case #1256.1 12 year old male with tender lump under heel cord 4 months
  • 378.
    Sag T-1 PD Gad
  • 379.
    Axial T-1 T-2 Gad
  • 380.
    Case #1257 8 yearfemale with GCT tendon sheath 2nd toe
  • 381.
  • 382.
  • 383.
    Case #1257.1 GCT tendon sheath 53 yr female with tender and swollen 2nd toe for 1 yr
  • 384.
    Cor T-1 T-2 FS Gad
  • 385.
    Axial T-1 T-2 FS Gad
  • 386.
    Sag T-1 T-2 Gad
  • 387.
  • 388.
    Case #1258 Intramuscular myxoma Axial T-2 Axial Gad 46 yr female with painless lump in post axilla for 8 years
  • 389.
    Sagittal T-2 Sagittal Gad
  • 390.
    Coronal Gad Surgical specimen
  • 391.
    Case #1258.1 Intramuscular myxoma 68 year old male with painless lump right shoulder for 1 yr
  • 392.
  • 393.
  • 394.
    Case #1258.2 Axial T-1 T-2 59 year male with painless soft tissue mass medial calf for 6 mos. Gad Intramuscular myxoma
  • 395.
  • 396.
  • 397.
    Case #1259 Ganglion Cyst Axial T-1 48 yr male with painless lump in anterior thigh 1 yr T-2
  • 398.
    Axial Gad Shows rimenhancement Sagittal Gad
  • 399.
    Case #1259.1 Cor PD Gad 60 year old male with painless lump in groin for 6 months
  • 400.
  • 401.
    Case #1259.1 Ganglion cyst Cor T-1 T-2 Gad 57 year old female with painless lump inner aspect upper arm 1 yr
  • 402.
    Sag T-1 T-2 Gad
  • 403.
    Axial T-1 T-2 Gad
  • 404.
    Case #1260 Ganglion cyst 49 year female with tender lump medial knee for 6 mos
  • 405.
    Cor T-1 Cor T-2
  • 406.
    Case #1160.1 Ganglion cyst 65 year female with non tender mass over patellar ligament
  • 407.
    Sag T-1 PD FS
  • 408.
    Cystic lateral meniscus Case#1261 Axial T-1 T-2 49 year male with prior history of subcutaneous ganglion cyst removed from knee area 6 years ago
  • 409.
  • 410.
    Path specimen ofresected cystic meniscus Photo of cyst Macro section of cyst & meniscus Macro section of cyst Micro of cyst
  • 411.
    Case #1261.1 Ganglion cyst prox. fibula 52 yr male with tender lump anterior below knee for 1 yr and recent weakness of dosiflexion at ankle
  • 412.
  • 413.
    Axial T-1 PD FS Gad
  • 414.
    Case #1261.1 Spino-glenoid ganglion cyst 43 yr male sheet rock worker with shoulder pain for months
  • 415.
    Axial CT Axial Cor
  • 416.
    Axial PD FS Cor PD FS
  • 417.
    Case #1261.2 Juxtaarticular ganglion cysts of shoulder 78 yr old male with mild shoulder pain and stiffness for years and now has a recent soft none tender mass over distal end of clavicle
  • 418.
    2002 2010 Axial CT scan
  • 419.
  • 420.
    Axial T-2 Gad upper lower
  • 421.
    Case #1261.3 Ganglion Cyst of Bone 46 yr female with mild ankle pain for one year
  • 422.
    Case #1261.1 Axial T-1 T-2 Gad 72 year male with painless lump lateral ankle for 1 year
  • 423.
    Cor STIR Surgical excision
  • 424.
    Case #1261.2 Cor T-2 Gad 10 yr male with none tender lump beneath medial malleolus 6 mos
  • 425.
    Axial T-1 T-2 Gad
  • 426.
    Case #1261.3 Ganglion Cyst in Tarsal Tunnel Cor T-1 T-2 Gad 53 yr male with tarsal tunnel symptoms for 8 months
  • 427.
  • 428.
    Ganglion cyst Case #1261.2 Axial T-2 45 year male runner With tender nodule in Medial gastroc head Gad
  • 429.
  • 430.
    Case #1261.3 Ganglion cyst 60 year male with mild R hip pain for 1 year
  • 431.
    Cor T-1 PD Gad
  • 432.
  • 433.
    Case #1261.4 Baker’s cyst Cor T-2 Cor Gad Sag T-2 34 yr female with prior history of myxosarcoma medial knee 17 yrs ago treated with surgery and post op RT
  • 434.
  • 435.
    Case #1261.5 Baker’sCyst Sag T-1 T-2 Gad 62 yr female noticed non tender lump behind knee 3 weeks ago
  • 436.
    AxialT-1 T-2 Gad
  • 437.
    Case #1261.6 Baker’s Cyst Sag PD Gad 4 yr male with none tender lump on back of knee for 3 mos.
  • 438.
    Axial T-1 T-2 Gad
  • 439.
  • 440.
    Case #1262 Axial T-1 T-2 Lymphoma 100 year old male with chronic edema in legs but recent tender lump in calf for 3 months Gad
  • 441.
    Sag T-1 STIR Gad
  • 442.
    Case #1262.1 Lymphoma Sciatic Nerve Sag STIR Sag Gad Cor Gad 71 yr male with sciatica for 4 months
  • 443.
  • 444.
    Case #925 Sagittal T-1 MRI tumor tumor 64 year female with soft tissue lymphoma forearm
  • 445.
  • 446.
  • 447.
    Metastatic CA tosoft tissue
  • 448.
    Case #1263 Metastatic Breast Axial T-1 T-2 62 year female with history of breast CA Gad
  • 449.
    Sag T-1 T-2 FS Gad
  • 450.
    Case #1264 Metastatic mesothelioma to arm 77 yr female with recent diagnosis of mesothelioma
  • 451.
    Sag STIR Gad Recent onset of painful mass anterior to elbow
  • 452.
    Axial T-1 T-2 PD FS Gad
  • 453.