- The document discusses the topic selection process for the AHRQ Effective Health Care Program, which systematically reviews evidence on healthcare topics. - It outlines principles for topic selection including stakeholder involvement, defined criteria, transparency, and process evaluation. - An internal group reviews topic nominations using 18 selection criteria to identify important research topics in a structured, transparent manner. The process aims to prioritize topics that are relevant, non-redundant, and have sufficient evidence for review. - Early results of the revised 2008 nomination process and ongoing challenges in identifying and prioritizing review topics are presented.