The document describes a process used by the Center for Medical Technology Policy (CMTP) to prioritize topics for comparative effectiveness research on cardiac technologies. CMTP first identified a broad list of emerging cardiac technologies and refined it to a top ten list. An expert workgroup then ranked these technologies using pre-defined criteria. The workgroup identified genetic tests for warfarin dosing, catheter ablation for atrial fibrillation, and percutaneous aortic valve replacement as the top priorities for coverage with evidence development initiatives and comparative effectiveness research studies.