A program of research involves conducting a series of related studies to address a knowledge gap in a discipline. It is advantageous to have a program of research because it allows researchers to build expertise in an area and make meaningful contributions. To develop a program of research, one should choose an interesting topic of importance, start with small pilot studies, and continue building knowledge through additional studies while disseminating findings through publications and conferences. Launching, conducting, and analyzing patient safety and quality improvement research presents various challenges which must be addressed in an ethical manner.