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ADRENALIN
JOHNY WILBERT, M.SC[N]
LECTURER,
APOLLO INSTITUTE OF HOSPITAL
MANAGEMENT AND ALLIED SCIENCE
Mechanism of action
The action of adrenalin may vary by the type
of tissue it act,
 It causes smooth muscle relaxation in the
airway
It causes smooth muscle contraction in the
arterioles
In cardiac muscles increase contractability
INDICATION:
• Anaphylaxis reaction
• Hypotension
• Bronchospasm
• Cardiac arrest
• Asystole
• DOSE:
For Infusion : 0.05 – 0.1 microgram/kg/minute
maximum dose: 1 – 1.5 microgram/kg/minute
For In arrest : 1 ml every 2 minutes
• Dilution
• 1 ampule =1ml/1mg
• Prepration : 4ml of adrenalin + 46 ml NS =50
ml
• Drug concentration = 4mg/50ml =0.8mg
• 0.8mg x 1000 = 80 mcg/ml
• Rate of infusion : desired dose x 60 =ml/hr
80 mcg
Example : 2 mcg x 60 min = 1.5
80
Drug interaction
• Interacts with β-blocking agents, digitalis
glycosides, antidepressants,
ADVERSE EFFECTS:
• Hypertension
• tachycardia
• Extravasations
• Anxiety, dysrhythmias
• dizziness
• pallor
• tremor,
• insomnia
• Headache, nausea
• palpitations
Nursing consideration:
• Inotropes must be adminstered in central line
• Do not cease infusion abruptly,
• Should be used with caution in patients with
atherosclerosis, mesentric and peripheral vascular
thrombosis or other occlusive vascular diseases,
metabolic acidosis, hypoxia or hyperthyroidism.
• It should be avoided in patients who are
hypersensitive to the drug.
• discard diluted solutions after 24 hours Protect
ampoules from light during storage and discard if
discoloured
• Follow ten rights
• Monitor for adverse effect
• Continuous BP using invasive arterial BP monitor
• connect the patient with cardiac monitor and
monitor ECG rythym
• Inotropes must be administered using infusion or
syringe
• Should follow standard dilution
• The lable on loaded drug should contain drug
concentration and dilution
• Monitor urine output
THANK YOU

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Adrenalin

  • 1. ADRENALIN JOHNY WILBERT, M.SC[N] LECTURER, APOLLO INSTITUTE OF HOSPITAL MANAGEMENT AND ALLIED SCIENCE
  • 2. Mechanism of action The action of adrenalin may vary by the type of tissue it act,  It causes smooth muscle relaxation in the airway It causes smooth muscle contraction in the arterioles In cardiac muscles increase contractability
  • 3. INDICATION: • Anaphylaxis reaction • Hypotension • Bronchospasm • Cardiac arrest • Asystole
  • 4. • DOSE: For Infusion : 0.05 – 0.1 microgram/kg/minute maximum dose: 1 – 1.5 microgram/kg/minute For In arrest : 1 ml every 2 minutes
  • 5. • Dilution • 1 ampule =1ml/1mg • Prepration : 4ml of adrenalin + 46 ml NS =50 ml • Drug concentration = 4mg/50ml =0.8mg • 0.8mg x 1000 = 80 mcg/ml • Rate of infusion : desired dose x 60 =ml/hr 80 mcg Example : 2 mcg x 60 min = 1.5 80
  • 6. Drug interaction • Interacts with β-blocking agents, digitalis glycosides, antidepressants,
  • 7. ADVERSE EFFECTS: • Hypertension • tachycardia • Extravasations • Anxiety, dysrhythmias • dizziness • pallor • tremor, • insomnia • Headache, nausea • palpitations
  • 8. Nursing consideration: • Inotropes must be adminstered in central line • Do not cease infusion abruptly, • Should be used with caution in patients with atherosclerosis, mesentric and peripheral vascular thrombosis or other occlusive vascular diseases, metabolic acidosis, hypoxia or hyperthyroidism. • It should be avoided in patients who are hypersensitive to the drug. • discard diluted solutions after 24 hours Protect ampoules from light during storage and discard if discoloured
  • 9. • Follow ten rights • Monitor for adverse effect • Continuous BP using invasive arterial BP monitor • connect the patient with cardiac monitor and monitor ECG rythym • Inotropes must be administered using infusion or syringe • Should follow standard dilution • The lable on loaded drug should contain drug concentration and dilution • Monitor urine output